• Korean Journal of Biological Psychiatry
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• v.13 no.3
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• pp.152-161
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• 2006

Objective : The relationship between the total daily dose of clozapine given and the plasma concentrations of clozapine and its metabolites(N-desmethylclozapine and clozapine N-oxide) and the effect of Glu158Lys (wild-type : Glu, 'H' ; variant : Lys, 'h') and Glu308Gly(wild-type : Glu, 'D' ; variant : Lys, 'd') variation in FMO3 gene on plasma concentrations of clozapine and its metabolites was studied in schizophrenic patients. Methods : Trough plasma concentrations of clozapine and its metabolites were measured in 34 schizophrenic patients receiving clozapine. The genetic variation of 'h' and 'd' in FMO3 were analyzed in 21 among 34 patients. Results : A linear relationship between the total daily dose of clozapine given(mg/kg body weight per day) and the plasma concentrations(nM) of clozapine was revealed by regression analysis(p<0.001) in the 23 patients receiving a constant daily dose of clozapine for 8 days. The plasma molar concentration ratios of clozapine N-oxide/clozapine in 8 subjects with 'hh' or 'Hh' alleles were not different from those in 6 subjects with 'HH' alleles and the plasma molar concentration ratios in 6 subjects with 'dd' or 'Dd' alleles were not different from those in 8 subjects with 'DD' alleles. Conclusion : The effect of Glu158Lys and Glu308Gly variation in FMO3 gene on clozapine metabolism could not be shown.

• Journal of Satellite, Information and Communications
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• v.9 no.2
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• pp.7-11
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• 2014

In this paper, we designed resistive MMIC mixer using $0.5{\mu}m$ p-HEMT process. This Mixer is designed to have a similar performance in -4 ~ 4 dBm local oscillator signal power level and to maintain a constant conversion loss and linear performance due to the variation of local signal. In order to have such characteristics, we designed new feedback circuit topology by using FET, and minimized performance change for LO signal power level variation, also obtain MMIC mixer characteristics which is able to apply in wideband. In the design result, When the LO signal power is -4 ~ 4 dBm, there was 6 dB conversion loss and it came up with the excellent result that IIP3 got over 30 dBm in 0.5 ~ 2.6GHz frequency band.

• Journal of Environmental Health Sciences
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• v.22 no.3
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• pp.98-102
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• 1996

This study investigated performance of the phenol degradation and reaction characteristics according to variation of phenol volumetric loading rates and dilution rates in suspension and PACT reactors using Pseudomonas sp. B3. 1. Removal efficiencies of the PAC unit indicated about 100 % with phenol volumetric loading rates from 0.4 phenol $kg/ma^3\cdot d$ to 1.2 phenol $kg/m^3\cdot d$, however, which of the suspension reactor showed about 100% with from 0.2 phenol $kg/m^3\cdot d$ to 0.75 phenol $kg/ma^3\cdot day$. 2. The cell density slightly was decreased from 298.2 mg/l to 272 mg/l, when dilution rate for suspension was reactor increased from 0.4 to 1.41 1/d, and also the cell density suddenly was decreased to 145.5 mg/l and was washed out at the dilution rate higher than 1.60 1/d. But the cell density for the PAC unit was linearly decreased with dilution rate of from 0.8 to 3.0 1/d, and showed 220.75 mg/l at maximum dilution rate. 3. The phenol utilization rate was increased from 0.008 to 0.031 phenol g/l$\cdot$h, when dilution rate for suspension reactor was increased from 0.4 to 1.5 1/d, however, the rate for the PAC unit was linearly increased from 0.017 to 0.061 phenol g/l$\cdot$h as variation changes from 0.017 to 0.061 phenol g/l$\cdot$h dilution rate.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.3
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• pp.283-291
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• 2015

In this paper, the two-dimensional(2D) and three-dimensional(3D) analyses have been performed in order to evaluate the structural integrities and compare 2D and 3D results for nozzles attached to cylindrical shells. Three nozzles, which are currently used in the nuclear power plant, are chosen to evaluate the structural integrities, and each nozzle is subjected to internal pressure, temperature variation and external loads. It is found that the 2D analysis for internal pressure should be performed with a factor of more than 1.5 or a stress concentration factor; 2D and 3D analysis results for temperature variation are almost similar to each other regardless of cladding; and the analysis results for external loads by WRC Bulletin 297 are more conservative than the 3D analysis results.

• Journal of Plant Biology
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• v.33 no.3
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• pp.189-196
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• 1990

Suspension cell lines have been newly established from the calli derived from the immuature embryo culture of hexapolid (Triticum aestivum var. sicco), tetrapolid (T. durum) and diploid (T. tauchii or Aegilops squarrosa) wheat species. The chromosomal variation in suspension cultured cell lines was examined and old cell line, C82d, established from T. aestivum var. copain was also used. New method using 1-bromonaphthalene for metaphase rapping of suspension cells was developed. Variation in chromosome number was observed among all the suspension lines. Cells with doubled chromosome number and deleted chromosome were also observed. Extensive structural changes in chromosome were found in C82d line. Chromosome aberrations showed loss of chromosome arms and chromosome segment. The mean chromosome number in suspension cells of T. aestivum var. sicco was 40, in C82d line 33, in T. durum 28 and in T. tauchii 14. The stability of chromosome in suspension cells of diploid and tetrapolid wheats was higher than that of hexaploid wheat.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.4 no.2
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• pp.153-163
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• 2000

The non-dimensional convective heat losses from each surface are investigated as a function of the non-dimensional fin length, width and the ratio of upper surface Biot number to bottom surface Biot number (Bi2/Bi1) using the three-dimensional separation of variables method. Heat loss ratio in view of each surface with the variation of Bi2/Bi1 is presented. The variation of the non-dimensioal temperare profile along the fin center line for a thermally asymmetric conditions is also presented.

• Journal of Industrial Technology
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• v.19
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• pp.261-268
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• 1999

It is a main object to find out the effect of curvature of pipe on the thermal flow field in copper pipe. the toroidal coordinate system is chosen for this project. 3-D numerical works are done by a commercial code, PHOENICS. The flow and temperature field are simulated and analysed on the view point of variation of pressure and temperature with Dean number. The results show that the strong recirculation phenomena and secondary flow are established and then a lot of pressure drop along main flow direction occurs at the curved portion of pipe and the temperature variation has a reversed trend of pressure variation along the axis of pipe.

• Journal of the Korea Institute of Military Science and Technology
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• v.12 no.4
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• pp.452-459
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• 2009

A 6-bit MMIC digital attenuator applicable to X-band TR module has been developed by using $0.5{\mu}m$GaAs pHEMT processes. The Switched-T attenuator scheme and the switched-path attenuator scheme were adopted to obtain low insertion loss and small phase variation, respectively. Resistors and transmission lines are optimized to achieve the digital attenuator with high attenuation accuracy and small phase variation. The digital attenuator has RMS error of 0.4dB, resolution of 0.5dB and dynamic range of 31.5dB. The measurement results show that in-out VSWRs are less than 1.5, phase variation is from -7 to +2 degrees and IIP3 is 36.5dBm.

• Korean Journal of Plant Taxonomy
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• v.52 no.3
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• pp.144-155
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• 2022

Daphne kiusiana is an evergreen shrub with dense head-like umbels of white flowers distributed in southern Korea, Japan, China, and Taiwan. Plants in China and Taiwan are recognized as var. atrocaulis by having a dark purple stem, elliptic leaves, and persistent bracts. Recently, plants on Jejudo Island were segregated as a separate species, D. jejudoensis, given their elliptic leaves with an acuminate apex, a long hypanthium and sepals, and a glabrous hypanthium. Morphological variations of three closely related taxa, the D. kiusiana complex, were investigated across the distributional range to clarify the taxonomic delimitation of members of the complex. Twelve characters of the leaf and flower were measured from digitized herbarium specimens using the image analysis program ImageJ and were included in a morphometric analysis, the results of which indicate that the level of variation in the characters is very high. The results of a principal component analysis weakly separated D. jejudoensis from D. kiusiana according to their floral characteristics, such as a longer, glabrous hypanthium, and larger sepals. However, some individuals of D. kiusiana, particularly those from Bigeumdo Island, were included in D. jejudoensis. Recognition of D. kiusiana var. atrocaulis based on the leaf shape was not supported in the analysis, and D. jejudoensis may be recognized as a variety of D. kiusiana. Our morphometric analysis shows that digitized images of herbarium specimens could be useful and an additional method by which to investigate more diverse specimens.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.310-315
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• 2008

Authors design a rotary-type small-scaled linear induction motor(LIM) and a performance test machine before manufacturing a real-scaled LIM for a railway transit. The designed LIM is a single-sided, short primary type and its primary has 4 poles. The rated power is 10(kW). In order to analyze characteristics of the LIM, authors use a mixed 2D-3D FEM analysis. 3-D FEM analysis is used for calculating a distribution of eddy-current on the semi-caped AL-sheet of the secondary reaction. Authors calculate a correction factor of conductivity and an equivalent conductivity on the secondary AL-sheet using a normalized eddy-current. The equivalent conductivity which is calculated in this way includes a transverse edge-effect of the LIM. Authors apply the equivalent conductivity on the secondary AL-sheet of 2D-FEM model and get performance characteristics of the LIM. Basic characteristics such as thrust and normal force, input current, efficiency and power factor of the LIM have been analyzed with the variation of frequency and speed. In order to apply an air-gap control system, the variation of the basic characteristics have been analyzed with the air-gap length variation of the LIM. Finally, authors introduce an operation mode using the air-gap control system and conduct a research on feasibility of the system.