• Journal of the Society of Naval Architects of Korea
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• v.31 no.3
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• pp.12-18
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• 1994

Optimization in the engineering design is to select the best of many possible design alternatives in a complex design space. In order to optimize, various optimization methods have been used. One major problem of traditional optimization methods is that they often result in local optima. Recently genetic algorithm based on the mechanics of natural selection and natural genetics is used in many application fields for optimization. Genetic algorithm is more powerful to local optima, but it requires more calculation time and has difficulties in finding exact optimum point in design variable with real data type generally. In this paper. hybrid method was developed by coupling genetic algorithm and traditional direct search method. The developed method finds out a region for global optimum using genetic algorithm, and is to search global optimum using direct search method based on results obtained from genetic algorithm. By using hybrid method, calculation time is reduced and search efficient for optimum point is increased.

• Journal of Preventive Medicine and Public Health
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• v.54 no.4
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• pp.230-237
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• 2021

Objectives: This study explored changes in individuals' behavior in response to social distancing (SD) levels and the "no gatherings of more than 5 people" (NGM5) rule in Korea during the coronavirus disease 2019 (COVID-19) pandemic. Methods: Using survey data from the COVID-19 Behavior Tracker, exploratory factor analysis extracted 3 preventive factors: maintenance of personal hygiene, avoiding going out, and avoiding meeting people. Each factor was used as a dependent variable. The chisquare test was used to compare differences in distributions between categorical variables, while binary logistic regression was performed to identify factors associated with high compliance with measures to prevent transmission. Results: In men, all 3 factors were significantly associated with lower compliance. Younger age groups were associated with lower compliance with maintenance of personal hygiene and avoiding meeting people. Employment status was significantly associated with avoiding going out and avoiding meeting people. Residence in the capital area was significantly associated with higher compliance with personal hygiene and avoiding venturing out. Increasing SD levels were associated with personal hygiene, avoiding going out, and avoiding meeting people. The NGM5 policy was not significantly associated with compliance. Conclusions: SD levels, gender, age, employment status, and region had explanatory power for compliance with non-pharmaceutical interventions (NPIs). Strengthening social campaigns to inspire voluntary compliance with NPIs, especially focused on men, younger people, full-time workers, and residents of the capital area is recommended. Simultaneously, efforts need to be made to segment SD measures into substrategies with detailed guidance at each level.

• International Area Studies Review
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• v.18 no.3
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• pp.175-201
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• 2014

This paper analyses the effect of R&D investment on local economies. R&D investment contributes to the regional local economy by increasing employment and production activity of the investees. The investees may end up with increased productivity, sales and employment. At the regional R&D level, the central government R&D fund and firm self R&D budget will be the source of R&D investment. Further positive effects are inter-related with local industries. This study carried out an empirical analysis on the effect of R&D investment on local economies using Korean panel data after comparing international literatures. The dynamic panel estimator is used to estimate an autoregressive model with lagged dependent variable. Using the Da Silva method, mixed variance-component moving-average error process is estimated and selected. R&D investment is very important factor to improve the productivity of a region and the size of the effect is dependent on the time periods within the Korean economic history.

• Genes and Genomics
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• v.40 no.12
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• pp.1309-1317
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• 2018

It is well known that dopaminergic genes affect the development of attention deficit hyperactivity disorder (ADHD) in various populations. Many studies have shown that variable number tandem repeats (VNTRs) located within the 3′-untranslated region of DAT1 and in exon 3 of DRD4 are associated with ADHD development; however, these results were inconsistent. Therefore, we investigated the genetic association between two VNTRs and ADHD in Korean children. We determined the VNTRs using PCR. We examined genotype and allele frequency differences between the experimental and control groups, along with the odds ratios, using Chi square and exact tests. We observed a significant association between the children with ADHD and the control group in the 10R/10R genotype of DAT1 VNTRs (p=0.025). In addition, the 11R allele of DAT1 VNTRs showed a higher frequency in the control group than in the ADHD group (p=0.023). Also, the short repeat (without 11R) and long repeat alleles (including 11R) were associated with ADHD (p<0.05). The analysis of DRD4 VNTRs revealed that the 2R allele is associated with ADHD (p=0.025). A significant result was also observed in long and short repeats (p<0.05). Additionally, ADHD subtypes showed that the DRD4 VNTRs are associated with combined and hyperactive-impulsive subtype groups (p<0.05). Therefore, our results suggest that DAT1 VNTRs and DRD4 VNTRs play a role in the genetic etiology of ADHD in Korean children.

• Korean Journal of Veterinary Service
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• v.41 no.4
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• pp.257-262
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• 2018

Avian pathogenic E. coli (APEC) causes severe economic losses in the poultry farms, due to systemic infections leading to lethal colisepticemia. It causes a variety of diseases from air sac infection to systemic spread leading to septicemia. Secondary infection contains opportunistic infections due to immunosuppression disease. Collibacillosis causes the great problems in the poultry industry in Korea. Thus, it is necessary to identify and classify the characteristics of E. coli isolate of chicken origin to confirm the diversity of symptoms and whether they are transmitted among the farms. Fragment analysis is identify the difference in the number of Variable-Number Tandem-Repeats (VNTRs) for genotyping. VNTRs have repeating structure (Microsatellite, Short tandem repeats; STR, Simple sequence repeats; SSR) in the chromosome. This region can be used as a genetic marker because of its high mutation rate. And various lengths of the amplified DNA fragment cause the difference in the number of repetition of the DNA specific site. The number of repetition sequences indicates the separated size of fragments, so the each fragments can be distinguished by specific samples. The results of the sample show that there is no difference in six microsatellite loci (yjiD, aidB, molR_1, ftsZ, b1668, yibA). There are differences among the farms in relation of the number of repetitions of other six microsatellite loci (ycgW, yaiN, yiaB, mhpR, b0829, caiF). Four (ycgW, yiaB, b0829, caiF) of these six microsatellite loci show statistically significant differences (P<0.05). It means that the analysis using four microsatellite loci including ycgW, yiaB, b0829, and caiF can confirm among the farms. Five E. coli samples in one farm have same SSR repetition at all markers. But, there are significant differences from other farms at Four (ycgW, yiaB, b0829, caiF) microsatellite loci. These results emphasize again that the four microsatellite loci makes a difference in the amplified DNA fragments, enabling it to be used for E. coli genotyping.

• The Plant Pathology Journal
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• v.34 no.6
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• pp.506-513
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• 2018

Clubroot is one of the most economically important diseases of the Brassicaceae family. Clubroot disease is caused by the obligate parasite Plasmodiophora brassicae, which is difficult to study because it is nonculturable in the laboratory and its races are genetically variable worldwide. In Korea, there are at least five races that belongs to four pathotype groups. A recent study conducted in Korea attempted to develop molecular markers based on ribosomal DNA polymorphism to detect P. brassicae isolates, but none of those markers was either race-specific or pathotype-specific. Our current study aimed to develop race- and isolate-specific markers by exploiting genomic sequence variations. A total of 119 markers were developed based on unique variation exists in genomic sequences of each of the races. Only 12 markers were able to detect P. brassicae strains of each isolate or race. Ycheon14 markers was specific to isolates of race 2, Yeoncheon and Hoengseong. Ycheon9 and Ycheon10 markers were specific to Yeoncheon isolate (race 2, pathotype 3), ZJ1-3, ZJ1-4 and ZJ1-5 markers were specific to Haenam2 (race 4) isolate, ZJ1-35, ZJ1-40, ZJ1-41 and ZJ1-49 markers were specific to Hoengseong isolate and ZJ1-56 and ZJ1-64 markers were specific to Pyeongchang isolate (race 4, pathotype 3). The PCR-based sequence characterized amplified region (SCAR) markers developed in this study are able to detect five Korean isolates of P. brassicae. These markers can be utilized in identifying four Korean P. brassicae isolates from different regions. Additional effort is required to develop race- and isolate-specific markers for the remaining Korean isolates.

• 한국노년학
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• v.38 no.4
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• pp.945-962
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• 2018

This study was aimed to examine the association between resilience and mental health among individuals aged 65 and older. The number of the sample was 2,004 older people living in Chuncheon city. The dependent variables were measured with depression and mental well-being. Depression was measured by the Center for Epidemiological Studies-Depression(CES-D) 10 items. Mental well-being was measured by Korean version of the Mental Health Continuum-Short Form(K-MHC-SF). The independent variable, resilience, was measured with the Connor-Davidson Resilience Scale(CD-RISC). Adjusted for age, gender, region, education, living arrangement, religion, employment, income, and self-rated health, a logistic regression analysis result showed that resilience was negatively associated with depression among older adults. On the other hand, a multiple regression analysis result showed that resilience was positively associated with mental well-being among older adults. The study findings suggest that resilience can promote mental health in later life. Implications for older adults suffering from mental health problems are also discussed.

• Journal of the Korea Convergence Society
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• v.10 no.5
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• pp.43-50
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• 2019

The purpose of this study was investigate the association between birth age related health factors and metabolic syndrome in women. The data of 6743 women from Korean National Health and Nutrition Examination Survey(2012-2014 KNHANES) were analyzed. Dependent variable was metabolic syndrom related variables were collected. Menopause status was associated with metabolic syndrome [odds ratio of with post-menopause 1.44(95% CI: 1.09-1.90)]. First birth age was associated with metabolic syndrome [odds ratio of women with 26-30 year : 0.81 (95% CI: 0.68-0.98); odds ratio of women 31 year over: 0.62(95% CI: 0.45-0.87)] after adjusted for age, region, household income, smoking, occupation. In conclusion, the metabolic syndrome is closely related to menopause and first birth age, and will be used as a basic data in developing future educational programs for women.

• Animal Bioscience
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• v.34 no.4
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• pp.499-505
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• 2021

Objective: The objective of this study was to evaluate the genetic behavior of a population of Holstein cattle in response to the variation of environmental temperature by analyzing the effects of genotype by environment interaction (GEI) through reaction norms for the somatic cell score (SCS). Methods: Data was collected for 67,206 primiparous cows from the database of the Paraná Holstein Breeders Association in Brazil, with the aim of evaluating the temperature effect, considered as an environmental variable, distinguished under six gradients, with the variation range found being 17℃ to 19.5℃, over the region. A reaction norm model was adopted utilizing the fourth order under the Legendre polynomials, using the mixed models of analysis by the restricted maximum likelihood method by the WOMBAT software. Additionally, the genetic behavior of the 15 most representative bulls was assessed, in response to the changes in the temperature gradient. Results: A mean score of 2.66 and a heritability variation from 0.17 to 0.23 was found in the regional temperature increase. The correlation between the environmental gradients proved to be higher than 0.80. Distinctive genetic behaviors were observed according to the increase in regional temperature, with an observed increase of up to 0.258 in the breeding values of some animals, as well as a reduction in the breeding of up to 0.793, with occasional reclassifications being observed as the temperature increased. Conclusion: Non-relevant GEI for SCS were observed in Holstein cattle herds of southern Brazil. Thus, the inclusion of the temperature effect in the model of genetic evaluation of SCS for the southern Brazilian Holstein breed is not required.

• Journal of the Korea Society of Computer and Information
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• v.26 no.1
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• pp.179-188
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• 2021

This study investigated the purchase status, wearing status, purchase satisfaction, selection criteria, and improvement marin leports wear for subjects who enjoy marine leisure sports in the southwestern region of Jeollanam-do, and examines the correlation between age and body type and the correlation between variables. SPSS Ver. 26.0 program was used for analysis. In the correlation between the motivation for participation and the selection criteria, when participating to increase physical strength, it was selected based on the fit. When participating for leisure or hobbies, they were selected based on design and color. The relationship between the selection criteria and purchase satisfaction was not satisfied in terms of price when they were selected based on activity or utilization of other uses. As for the selection criteria according to the body type, clothing was selected based on price and fashion for large triangles and squares, and elasticity for inverted triangles. As for the preferred color by age, only those in their 40s preferred blue and other age groups preferred achromatic color. In future studies, it is thought that a study on the preference of each marine leisure sports item should be conducted.