• 정보처리학회논문지C
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• 제10C권4호
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• pp.433-440
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• 2003

실물 경제행위가 사이버 공간에서 이루어지게 되고 거래 상대방의 신원확인 문제가 대두되면서 전자서명이 보급되기 시작하였다. 인증서 폐지목록을 이용한 전자서명 검증방안이 실시간 검증에 대한 취약점을 내포하고 있었기 때문에, 온라인 인증서 상태검증이라는 방법이 도입되었다. 이 경우 사이버 거래의 전자서명 검증을 요구하는 모든 트랜잭션 부하가 한 곳의 서버노드에 집중되는 현상을 피할 수 없었다. 현재 국내 금융거래에서는 이 방법을 일부 도입하여 사용하고 있지만 곧 한계를 드러낼 전망이다. 본 논문에서는 실시간 검증을 보장하면서, 인증 검증을 요청하는 노드에서 실시간 인증서의 상태정보론 유지할 수 있는 방안을 제시하였다. 이 방법은 인증서를 폐지할 때 폐지관리 노드가 검증노드에 인증서 상태정보를 실시간으로 업데이트 시켜준다. 이 방법의 특징은 폐지관리 노드가 인증서 사용자들이 이용하는 검증노드의 리스트를 저장한다. 인증서 사용자가 처음으로 한 검증노드를 접속한다면 상위 폐지관리 노드까지 가서 인증서 상태정보를 확인하여야 하며 이 때 폐지관리 노드에 사용하는 검증노드가 저장한다. 그 이후에는 폐지관리 노드에 폐지요청이 발생할 때 그 인증서를 사용하는 모든 검증노드에 실시간으로 폐지정보를 전달한다. 제안한 방식의 장점은 인증서 검증이 검증 요청 노드에서 완료될 수 있어서 검증시간을 단축시킬수 있다는 점과 인증서 상태정보에 대한 요청이 폐지관리 노드 한 곳에 집중되는 것을 방지할 수 있다.

• Journal of Pharmaceutical Investigation
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• 제21권3호
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• pp.179-188
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• 1991

An HPLC assay method of a drug to be applied to the pharmacokinetic studies of the drug should be completely validated. The validation process for an HPLC assay method in a biological sample was discussed using the data obtained from the development of HPLC method for the simultaneous quantitation of verapamil and norverapamil in human serum. The validation criteria included were specificity, linearity, accuracy, precision, sensitivity, recovery, drug stability, and ruggedness of an assay method.

• 생약학회지
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• 제51권1호
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• pp.78-85
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• 2020

In this study, we shortly introduced the HPLC method validation guideline for the analysis of functional food which was released from the Ministry of Food and Drug Safety of Korea in Dec 2018. The HPLC method validation was performed through the aforementioned HPLC method validation guideline in order to quantitate scopoletin content from the hot-water extract powder of Artemisia annua Linné. The HPLC method was validated by evaluating specificity, accuracy, precision, limit of quantitation and linearity. All parameters were in the suitable ranges which are designated in the guideline, which indicated the current HPLC method is reliable to quantitate the scopoletin content from the hot-water extract of A. annua.

• 방사성폐기물학회지
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• 제17권4호
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• pp.363-373
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• 2019

Waste characterisation associated with nuclear site decommissioning relies on radiochemical analysis of a diverse range of sample types, requiring extensive validation of analytical techniques using matrix-matched materials. The absence of relevant reference materials has hindered robust method development and validation. The paper discusses how method validation in support of nuclear waste characterisation can be achieved without using reference materials. The key stages in an analytical procedure are evaluated and a multi-stage approach is proposed with the ultimate aim of determining an operational envelope for an analytical procedure.

• 한국시뮬레이션학회논문지
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• 제1권1호
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• pp.77-86
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• 1992

In this paper, we study validation test methods of DEVSA(Descrete Event system Specification) models using SPN(Stochastic Petri Net) models. We discuss conventional validation test methods, by which DEVS models can be transformed to SPN models, by reviewing the features of DEVS model. Based on the model transformation method, we define a new homogeneous function for validation test and suggest a new validation test method of DEVS models using the property of SPN models and the new homogeneous function.

• Nuclear Engineering and Technology
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• 제37권1호
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• pp.118-126
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• 2005

While emergency operating procedures (EOPs) occupy an important role in the management of various abnormal situations in nuclear power plants (NPPs), current technology for the validation of EOPs still largely depends on manual review. A validation method for EOPs of NPPs is thus proposed based on dynamic multi-level flow modeling (MFM). The MFM modeling procedure and the EOP validation procedure are developed and provided in the paper. Application of the proposed method to EOPs of an actual NPP shows that the proposed method provides an efficient means of validating EOPs. It is also found that the information on state transitions in MFM models during the management of abnormal situations is also useful for further analysis on EOPs including their optimization.

• 품질경영학회지
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• 제50권4호
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• pp.831-842
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• 2022

Purpose: This study carried out the Quality by Design (QbD)6σ process to verify the effectiveness and equivalence of the finished D-antigen quantitative test method, and compared the OFAT-based method validation and test result acceptance criteria with the Analytical Quality by Design (AQbD)-based method validation and test method. This is a study on how to reduce the risk of delay in permit change by increasing the reliability of permit data in the existing method by statistically analyzing the results. Methods: With the QbD6σ process, the effectiveness and equivalence of the D-antigen quantitative test method were verified with the data of the existing test method and the new test method. Results: Method validation tests are performed based on AQbD. Critical Method Parameters are identified through risk assessment, and single/combined actions are verified by designing and performing tests for Critical Method Parameters (analysis of variance, full factorial design method). Method validation can be effectively accomplished with the QbD6σ process. Conclusion: The use of QbD6σ can be used to achieve satisfactory results for both pharmaceutical companies and regulators by using appropriate statistical analytical methods for method validation as required by regulatory agencies.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1169-1175
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• 2008

The validation technique is classified with two methods whether to demand of additional experimental points. The method which requires additional experimental points such as RSME is actually impossible in engineering field. Therefore, the method which only use experimented points such as the cross validation technique is only available. But the cross validation not only requires considerable computational costs for generating metamodel each iterations, but also cannot measure quantitatively the fidelity of metamodel. In this research we propose a new validation technique for representative metamodels using an variance of metamodel and confidence interval information. The proposed validation technique computes confidence intervals using a variance information from the metamodel. This technique will have influence on choosing the accurate metamodel, constructing ensemble of each metamodels and advancing effectively sequential sampling technique.

• 한국전자거래학회:학술대회논문집
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• 한국전자거래학회 2001년도 International Conference CALS/EC KOREA
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• pp.155-163
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• 2001

There are cases that revoke the certification because of disclosure of private key, deprivation of qualification and the expiration of a term of validity based on PKI. So, a user have to confirm the public key whether valid or invalid in the certification. There are many method such as CRL, Delta-CRL, OCSP for the cert-validation of certification. But these method many problems which are overload traffic on network and the CRL server because of processing for cert-validation of certification. In this paper we proposed the realtime cert-validation of certification method which solved problems that are data integrity by different time between transmission and receiving for CRL, and overload traffic on network and the CRL server based on DARC.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제19권2호
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• pp.19-30
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• 2013

Purpose: The planning and design of hospital generally requires the participation and consultation of skilled experts since it has more complex space program than any other buildings. Therefore, the BIM systems for the planning of hospital have been tried continuously. The purpose of this study is to identify the precondition for space Program validation of healthcare architecture based on BIM, which is recently receiving wide attention. Method: For this study, United States, Australia and Finland's guidelines were analyzed among the description space program validation system in 14 overseas BIM Guidelines. And the propose precondition that can be applied to healthcare architecture from among these description of space program validation items, target, process etc for General building. Result: 1) spatial program validation is the following four evaluation phase. Step 1: Standard setting phase Step 2: BIM model accuracy assessment phase Step 3: space validation phase Step 4: Performance evaluation phase 2) The standards for the building elements at Standards Setting stage is considered to the standards for the architectural elements of General building. 3) Healthcare Architecture Area calculation method is considered to be reasonable that borrowing the area calculation standard of general architecture according to the UIA of international standards. However, Be proposed of measuring method that reflect the efficiency of the design process step-by-step area calculation method. The performance assessment indicators of reflect the Hospital uniqueness have to developed. And the research needs to be carried out continuously according to the purpose for healthcare architecture of feature-oriented. Implications: In this paper like to understanding that precondition of space program validation considering the BIM. As a result, understanding to condition about step of the evaluation, the evaluation standards. Is expected to keep the focus on the development of performance indicators that reflect the uniqueness of the hospital for the efficient evaluation of the Hospital building.