• Korean Journal of Medicinal Crop Science
• /
• v.14 no.2
• /
• pp.101-106
• /
• 2006

We established a practical method for rapid and large-scale production of Valeriana fauriei var. dasycarpa Hara roots by bioreactor culture and confirmed valerenic acids and valepotriates production. We also compared valerenic acids and valepotriates production patterns according to various media conditions. Among the media tested, B5 medium gave the maximum biomass production of 101 g fresh weight, which was a 5.03-fold multiplication rate obtained 4 weeks after inoculation of 20 g of fresh weight. The best production of total valerenic acids $(7.86\;mg/l)$ and valepotriates $(8.96\;mg/l)$ was B5 medium.

• 한국약용작물학회:학술대회논문집
• /
• 2007.05a
• /
• pp.247-248
• /
• 2007

• Korean Journal of Medicinal Crop Science
• /
• v.15 no.4
• /
• pp.241-245
• /
• 2007

Effects of various concentrations of elicitors for enhancement in valepotriates and valerenic acids production in adventitious root culture of Valeriana fauriei were investigated. Although the growth of adventitious roots was suppresed by addition of biotic or abiotic elicitors, the production of valepotriates and valerenic acids was enhanced. Addition of $100\;{\mu}M$ methyl jasmonate or 1 $g/{\ell}$ yeast extract to the root culture of V. fauriei resulted in the optimal production of valepotriates ($12.56\;{\pm}\;0.78\;mg/{\ell}$) and valerenic acids ($10.63\;{\pm}\;1.1\;mg/{\ell}$), respectively.

• Journal of the Korean Society of Tobacco Science
• /
• v.25 no.1
• /
• pp.80-86
• /
• 2003

The contents of valepotriates, valerenic acid and their derivatives as mild sedative and antispamodic principles in two Korean valerian roots (Valeriana officinalis var. latifolia Miq. and V. fauriei var. dasycarpa Hara) were investigated and were compared with those in European valerian roots(Valeriana officinalis L.) by BPLC method. Among valepotriate compounds, valtrate was detected as a small amount in two Korean valerian roots, and iso-valtrate and dihydrovaltrate were detected as a trace amount. Among valerenic acid and their derivatives, valerenic acid were contained from 0.9∼3.46 mg/g base on dry weight. Over the vegetation periods investigated, the content of valepotriates remained more or less constant, hut the content of valerenic acid reached its maximum in 3-year old age. The compound isolated from Korean V. officinalis var. latifolia was elucidated as valerenic acid by spectroscopic data such as GC-MS, $^1$H-NMR and $^{13}$ C-NMR, and comparison of GC retention time with that of authentic compound.

• Proceedings of the Korean Society of Plant Biotechnology Conference
• /
• 2005.11a
• /
• pp.315-315
• /
• 2005