• Journal of Applied Biological Chemistry
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• v.48 no.4
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• pp.207-212
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• 2005

Prolyl endopeptidase (PEP, EC 3.4.21.26), also referred to as prolyl oligopeptidase, has been suggested to participate in learning and memory processes by cleaving peptide bonds on carboxyl side of prolyl residue within neuropeptides of less than 30 amino acids, and is abundant in brains of amnestic patients. Therefore, compounds possessing PEP inhibitory activity can be good candidate of drug against memory loss. Upon examination for PEP inhibition from traditional medicinal plants having tonic, stimulating, and anti-amnestic effects, Corni Fructus (Cornus officinallis) showed significant PEP inhibition. Ursolic and oleanolic acids, components of Corni Fructus, inhibited PEP with $IC_{50}$ values of $17.2\;{\pm}\;0.5$ and $22.5\;{\pm}\;0.7\;{\mu}M$, respectively.

• YAKHAK HOEJI
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• v.37 no.5
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• pp.532-537
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• 1993

Angiogenesis refers to the formation of new capillary blood vessels, or neovascularization occurring under various physical conditions, such as development of the embryo, formation of corpus luteum, wound healing and pathological conditions including tumor growth and metastases, hemangiomas, diabetic retinopathy, rheumatoid arthritis. There are many evidences that angiogenesis is important for the progressive growth of solid tumors and also permits the shedding of metastatic tumors from the primary site. Thus, treatment of angiogenesis inhibitors might be a novel strategy for tumor growth inhibition. Normal vascular endothelial cells are in a state of differentiation and angiogenic endothelial cells migrate and proliferate, and they subsequently differentiate into vessel-forming quiescent phenotype cells, Therfore, it was speculated that a modifier of cell differentiation could also affect angiogenesis. In order to identify new antiangiogenic factors, the research was conducted to estimate the inhibitory activities of cell differentiation agents by means of chick embryo chorioallantoic membrane(CAM) assay. Hence, we have established the CAM assay for the screening of antiangiogenic agents. Using the CAM assay, we found that ursolic acid, a tumor cell differentiation-inducing agent, showed a markedly inhibitory effect on chick embryonic angiogenesis.

• YAKHAK HOEJI
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• v.40 no.1
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• pp.36-40
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• 1996

Chemical constituents of Uncaria hooks were studied. Four compounds were isolated from the ether soluble fraction by chromatographic purification process. They were ident ified as isocorynoxeine-N-oxide, anti-isorhynchophylline-N-oxide, physcion and ursolic acid by spectral evidences. Their contents analyzed by HPLC or GC method were physcion 0.04%, ursolic acid 0.26%, isocorynoxeine-N-oxide 0.04% and anti-isorhynchophylline-N-oxide 0.03% respectively. Isocorynoxeine-N-oxide was not reported in nature so far.

• YAKHAK HOEJI
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• v.54 no.3
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• pp.168-173
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• 2010

We investigated whether three flavonoids including daidzein, baicalein, hesperidin and ursolic acid, a triterpene acid, affect proliferation of MCF-7 human breast cancer cells stimulated by estrogenic compounds. Ursolic acid and baicalein inhibited proliferation of MCF-7 cells induced by PhIP, a food-derived carcinogen with estrogenic activity. Daidzein and hesperidin inhibited estradiol-induced proliferation of MCF-7 cells. These compounds should be further investigated for the possible involvement in signaling pathway after estrogen receptor binding in breast cancer cells.

• Archives of Pharmacal Research
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• v.23 no.3
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• pp.243-245
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• 2000

The diethyl ether extract of isodon excisus var. coreanus exhibited significant inhibitory activity in aromatase assay. Bioactivity-guided fractionation of the extract led to the isolation of three active compounds: inflexin(ent-1${\alpha}$-hydroxy-3${\beta}$,6a-diacetoxykau r-16-en-11,15-dione) (1), ursolic acid (2), and ursolic acid 3-O-acetate (3).

• Korean Journal of Pharmacognosy
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• v.22 no.1
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• pp.18-21
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• 1991

Campanulin, ${\alpha}-amyrin$, ${\beta}-amyrin$, uvaol, simiarenol, ursolic acid and oleanolic acid were isolated from the ethyl acetate fraction of the leaves of Rhododendron brachycarpum and their structures were identified by spectroscopic and chemical methods.

• Natural Product Sciences
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• v.10 no.5
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• pp.237-239
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• 2004

Mallotus nepalensis (Euphorbiaceae) is a small tree found in central and eastern Himalayas, Nepal, Wallich and Sikkim. The 90% ethanolic extract of Mallotus nepalensis exhibited mild CNS depressant activity. Four compounds, lupeol (1), ${\beta}-sitosterol$ (2), ursolic acid (3) and ${\beta}-sitosterol-\;{\beta}-D-glucoside$ (4) were isolated from the 90% ethanolic extract of this plant of which 1, 3 and 4 are being reported for the first time from this species.

• Bulletin of the Korean Chemical Society
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• v.35 no.7
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• pp.2210-2212
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• 2014

• YAKHAK HOEJI
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• v.37 no.5
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• pp.476-482
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• 1993

For the investigation of medicinal resources in Crataegus species, the present study was carried out to evaluate the pharmaco-constituents in the leaves of Crataegus Pinnatifida var. psilosa (Rosaceae). Fruits has folk medicine in Korea. From the $Et_{2}$O fraction of MeOH extract, a new compound, apigenin-8-C-(6"-acetyl)-$\beta$-D-glucopyranoside, named psilosin and three known compounds, ursolic acid, phytosterol complex and (-)-epicatechin were isolated and identified on the basis of their physico-chemical properties and spectroscopic evidences (UN, IR, NMR and mass etc.) in comparison with authentics, respectively.

• Korean Journal of Pharmacognosy
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• v.22 no.3
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• pp.166-170
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• 1991

Four compounds were isolated from the leaves and stems of Lycopus lucidus and identified as $2{\alpha}-hydroxy$ ursolic acid, tormentic acid, ${\beta}-sitosterol$ glucoside and linarin by spectroscopic methods.