• Journal of Nutrition and Health
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• 제25권2호
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• pp.132-139
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• 1992

A study was conducted to compare urinary Ca excretion and factors influencing urinary Ca excretion in 30 young and 62 middle-aged Korean women. Mean daily intake levels of total protein and P were significantly higher in middle-aged women but Ca and animal protein intake levels of the two groups were similar. The average percentage of daily Ca intake from milk and milk products in young women was 45% while in middle-aged women it was about 24% The frequency of milk consumption was inversely correlated with blood pressures of the subjects. Mean 24-hour urinary calcium excretion in young and middle-aged women were 163.7mg and 174.9mg respectively. The difference was not significant. Menopause of the mid-dle-aged women did not affect urinary calcium levels. However the proportion of subjects with more than 250mg of Ca in 24-hour urine tended to be higher in middle-aged group Factors significnatly correlated with urinary Ca excretion of subjects were systolic and diastolic The study verifies the need for more systematic studies on Ca requirements and the interrelation-ship among Ca and na metabolism blood pressures and bone loss in the middle-aged Korean.

• 동아시아식생활학회지
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• 제3권2호
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• pp.41-50
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• 1993

This study was intended to investigate the relationship of dietary Na and Ca intake and excretion in blood pressure regulation of free-living adults. Two separate surveys were conducted for 294 subjects in Taegu area, The results of this study are as follows ; When subjects were divided into normotensive and hypertensive, there were significant differences in age, BMI between two groups, When dietary intake were compared between two groups, no significant differences in energy, carbohydrates, fat and protein intakes were shown. While Na intake of hypertensive groups was not signidicantly different from that of normotensive groups, While Na intake of hypertensive groups was not significantly different from that of normotensive groups, ca intake of hypertensive group was significantly lower than that of normotensive group(P<0.005), Urinary Na excretion was significantly higher(P<0.05) in hyperten sive group. However, urinary Ca and K excretion in both groups were not significantly different. Urinary sodium was significantly correlated with urinary Ca and Na intake. Multiple regression analysis of variables showed that urinary sodiumwas affected by Na index, age and Ca Index. While urinary Ca, was significantly correlated with urinary Na and K excretion, it did not show significant correlation with Ca intake

• Journal of Nutrition and Health
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• 제29권10호
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• pp.1096-1104
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• 1996

This study was performed to evaluate the effect of sodium cholride supplementation on bone metabolism in female rats consuming a low calcium diet. Twenty five female rats were divided into three dietary groups (control Na : 0.1038%, 1% Na : 1.036%, 2% Na : 2.072%). All experimental diets contained 0.27% Ca and were fed to rats with deionized water for 7 weeks. Bone mineral density(BMD) and bone mineral content(BMC) of total body, spine and femur were measured using energy x-ray absorptiometry(DEXA) by small animal software. Then Ca efficiency was calculated from BMD and BMC. Serum Ca, P, Na and urine Ca, P, Na were determined. Urinary pyridinoline, serum ALP were measured to monitor bone resorption. Following 7 weeks, sodium cholride supplemented groups had higher urinary Ca excreteion, urinary pyridinoline, crosslinks value and serum ALP. There was no significant difference in case of serum Ca among all groups. Sodium chloride supplemnted groups had lower Ca effciency of total, spine and femur BMD and BMC than that of control group. In conclusion high salt intake not only increases urinary Ca excretion as urinary Na excretion does but also increase bone resorption and decrease Ca efficiency of each bone. It is been suggested that high salt intake may be harmful for bone maintenance. Therfore, the decrease of salt intake to the level of recommendation would be desirable.

• Journal of Nutrition and Health
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• 제28권4호
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• pp.298-308
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• 1995

To investigate the effect of estrogen and dietary protein level on Ca metabolism, female rats were undergone ovariectomy or sham-operation. Ovariectomized rate were divided into either estrogen-or vehicle-treated groups. Each treatment group was again divided into 40%-casein(H) or 10%-casein(L) diet groups. All experimental diets contained 0.2% Ca, 0.4% P and fed to rats for 8 weeks. Apparant Ca absorption and Ca balance were not affected by dietary protein level and ovariectomy, however they were increased by estrogen injection and this effect was even higher in low protein groups. Urinary Ca excretion were higher in high protein groups. GFR was not affected by dietary protein level, ovariectomy, or by estrogen injection. Urinary protein excretion was higher in high protein groups, which implies that the kidney funtion was deteriorated by high protein diet, and this may account partly for the higher urinary Ca in high protein groups. Ovariectomy or estrogen treatment had no effect on urinary protein excretion. Urinary hydroxyproline was higher in ovariectomized rats and increased in high protein grous. Elevated value of ovarictomized rats was lowered by estrogen injection, especially in low protein group. Alkaline phosphatase tended to increase in ovariectomized groups and lowered with estrogen treatment, but this difference was not statistically significant. Serum PTH was not affected by ovariectomy and dietary protein level. Therefore the increased hydroxproline excretion does not seem to be attributed to PTH. Dietary protein level, ovariectomy and estrogen treatment did not affect the weights and components of femur, scapular, and 4th vertebra. Ash/wt ratio of femur was, however, lower in ovariectomized rats and increased with estrogen treatment. Therefore, among the bones studied, femur seemed to be the most vulnerable. The results of this study shows that estrogen treatment may alleviate or reduce bone loss in postmenopausal women somewhat, especially for those people with low protein diet.

• Journal of Nutrition and Health
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• 제31권4호
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• pp.716-728
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• 1998

To investigate the effect of dietary Ca levels on metabolic changes of Ca and skeleton in postmenopausal women, 10-month-old ovariectomized female rats were compared with 2 month old rats. The rats were fed either 0.2% or 1.2% Ca diets for 16 weeks. Food intake and weight gain as higher in rats fed high Ca diets and in ovariectomized rats. Apparent Ca absorption as higher, and Ca balance was lower in the low Ca groups. Vertebrae density was higher in old rats or those fed a high Ca diets. The old rats and ovariectomized rats showed decreased bone formation, increased bone resorption and kidney function deterioration resulting in increased urinary Ca excretion. Contradictory to the above observation, old rats and ovariectomized rats still showed higher bone mass and bone ash content. Therefore aging was not fully onging in 10-month-old rats. Bone weights, mineral contents, and mineral/wt ratio were lower in ovariectomized rats. Dietary Ca level did not affect urinary Ca excretion, urinary protein excretion, GFR, serum alkaline phosphatase, or urinary hydroxyporline excretion. This means that dietary Ca level did not influence kidney function or bone turnover. However Ca content and the ash content of femur, 4th vertebra, and scapula were increased in high Ca groups. Therefore, it is considered that decreased bone formation and accelerated bone resorption may account for the increased osteoporotic risk in women in menopause after middle age. However, Ca metabolism can be improved and bone components can be maintained if Ca is supplemented.

• 한국영양학회:학술대회논문집
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• 한국영양학회 1994년도 춘계심포지움 및 발표논문 초록
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• pp.48-48
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• 1994

• Journal of Nutrition and Health
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• 제28권5호
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• pp.415-425
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• 1995

This study was performed to investigate the effect of dietary protein level on the metabolic changes of Ca and skeletons in postmenopausal women, using ovariecotomized rats as an animal model. The female rats of 200∼250g were fed either 8%(L) or 50%(H) casein diet for 15 weeks(1st experiment). At 15th week, the rats of each diet group were undergone ovariectomy or sham-operation and they were continued to feed the same experimantal diet for 9 more months(2nd experiment). Ca metabolism, kidney function and bone composition were determined at the end of 1st experiment, 3rd and 9th month of 2nd experiment. After 1st experiment, high protein group showed higher urinary Ca and protein excretion, however, there was no difference in GFR and urinary hydroxyproline excretion. The weights, ash and Ca content of femur, scapular and vertebra tended to be higher in high protein groups which tells that high protein promoted skeletal growth. In 2nd experiment, high protein group showed higher urinary Ca and protein excretion and lower Ca absorption and balance. GFR was not affected by dietary protein and ovariectomy but increased with time, as well as kidney weight which shows the continuous development of kidney at this age of 15 month in rats. There were no difference in urinary hydroxyproline, serum ALP, and PTH among experimental groups. The weights of femur, scapular, 4th vertebra increased with time, showing the skeleton continues to grow at this age in rats. However, Ca contents, Ca/wt, Ca/ash were decreased with time and tended to be lower in high protein group especially in femur. In conclusion, prolonged feeding of high protein diet deteriorated Ca metabolism and induced bone loss as time after menopause is extended.

• Childhood Kidney Diseases
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• 제4권1호
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• pp.11-16
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• 2000

목 적 : 소변내 Ca 배설량을 측정하는데 있어 24시간 뇨 Ca 배설량 측정이 흔히 사용되어 왔으나, 이의 결과를 알기까지 많은 시간과 비용이 소모되는 단점이 있어 빠른 시간내에 결과를 알 수 있는 간편한 검사를 알아보기 위해 저자들은 소변내 Ca 배설량이 소변내 sodium(Na), potassium(K), creatinine(Cr)과 밀접한 관련이 있음에 착안하여 일회뇨(Spot urine) Na/K 비를 이용하여 요칼슘배설량을 예측할 수 있는지 알아보기 위하여 이 연구를 시행하였다. 대상 및 방법 : 1998년 5월부터 7월까지 고려대학교 의료원 구로병원 소아과에 비뇨기계 증상으로 입원한 환아 84명을 대상으로 spot urine에서 Na, K, Ca, Cr를 측정하여 Ca/cr비와 Na/K 비를 서로 비교하였다. 또한 고칼슘뇨증 (Ca/cr비 >0.21)으로 예측할 수 있는 Na/K 비의 cut off value를 계산하여 그 민감도, 특이도, 양성예측도, 음성예측도를 구하였다. 결 과 : 1) spot urine Ca/cr비와 Na/K비와는 통계적으로 의의있는 상관관계를 보였다(r=0.496,P<0.001, Ca/cr=Na/K x 0.01671-0.061). 2) 고칼슘뇨증으로 예측할 수 있는 spot urine Na/K비의 cut off value를 2.68로 정했을 경우 민감도 $100\%$, 특이도 $54.5\%$, 양성예측도 $37.5\%$, 음성예측도 $100\%$를 보였다. 결 론 : 소변내 Ca 배설량을 예측하는데 spot urine Na/K 비를 이용할 수 있으리라 생각되며,이는 고칼슘뇨증의 선별에도 유용하리라 생각된다.

• Journal of Nutrition and Health
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• 제22권6호
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• pp.516-530
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• 1989

A 44-day metabolic study was conducted to compare the effects of soy protein and meat protein on N, Ca, P, and Mg metabolism in young Korean males. Meat protein diet(MPD) and soy protin diet(SPD) were provided for 3 weeks each. For MPD, meat protein Supplied 50.3% of total protein and mean daily suplies of Ca, P, and Mg were 33.28mg, 1013.01mg, 226.81mg respectively. For SPD, soy protein supplied 51.8% of total protein and mean contents of Ca, P and Mg were 737.86mg, 1261.76mg, and 451.3mg. Mean daily fecal and urinary excretions of Ca were 350.6mg and 113.3mg for MPD and 515.0mg and 118.3mg for SPD. Apparent absorption rates in MPD and SPD were 4.2mg in MPD and 700.4mg and 475.1mg SPD. Apparent absorption rates were 65.6% in MPD and 44.5% in SPD(p<0.01). For Mg, fecal and urinary excretions were 144.8mg and 81.2mg in MPD and 292.4mg and 65.5mg in SPD. Apparent absorption rates were 37.5% in MPD and 35.2% in SPD. The correlations between urinary Ca, P, and their balance were significant (p<0.001) in MPD, but not in SPD. Urinary Ca was significantly correlated with urinary N, P, Mg(p<0.001) in MPD, but not in SPD. From these results, meat protein seems to increase the excretions of major minerals compared to soy protein.

• 한국영양학회:학술대회논문집
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• 한국영양학회 1994년도 춘계심포지움 및 발표논문 초록
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• pp.49-49
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• 1994