• YAKHAK HOEJI
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• v.41 no.1
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• pp.86-93
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• 1997

Even though both N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine have been widely used to establish the experimental model for dopaminergic neuronal ce ll death. mechanisms underlying this phenomenon have not been firmly explored. To investigate how these dopaminergic neurotoxins induce neuronal cell death, murine dopaminergic neuronal cell line, MN9D cells were treated with various concentration of either 6-hydroxydopamine or active form of MPTP, N methyl-4-phenylpyridinium (MPP$^+$). Treatment of cells with 5-100 uM 6-hydroxydopamine resulted in apoptotic cell death whereas cell death induced by 5~50 uM MPP$^+$ was not demonstrated typical apoptotic characteristics such as cell shrinkage, apoptotic body and nuclear condensation. Cell death induced by 6-hydroxydopamine was partially blocked in the presence of antioxidants including soluble form of vitamin E or desferrioxamine suggesting that generation of oxidative stress may be associated with 6-hydroxydopamine-induced cell death in MN9D cells. In contrast, MPP$^+$-induced cell death was not blocked by treatment with any of antioxidants tested. As previously demonstrated that MPP$^+$ caused metabolic alterations such as glucose metabolism, removal of glucose from the medium partially inhibited MPP$^+$-induced cell death suggesting excessive cycles of glycolysis may be associated with MPP$^+$-induced cell death. Taken together, these studies demonstrate that two types of dopaminergic neurotoxins recruit distinct neuronal cell death pathways.

• Journal of architectural history
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• v.13 no.4 s.40
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• pp.89-105
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• 2004

This paper investigates morphological theory as an intellectual framework for research and design. The first part of the paper will review morphological studies in the fields of urban geography, urban planning and architecture, particularly in England from the 1940s to the 1980s. While urban geographers and planners were concerned primarily with town plans, building forms and land use, architectural theoreticians were more interested in the topological relationship between urban and architectural space. The underlying premises and principles of these two approaches will be reviewed. The second part of the paper will focus on typology in Europe and North America. The reinterpretation of typology by Italian architects helped to bridge the gap between individual elements of architecture and the overall form of the city. However, typological theory became less accessible in post-war England and the United States. After 1980, the debate on typology became muted by the onset of vague notions such as functionalism, bio-technical determinism, and contextualism. This paper will propose a redefinition of morphology as a heuristic device, in contrast with the dichotomic view of urban morphology and architectural typology. Morphology will be shown to combine the geometrical and topological; the intentional and accidental; the real and abstract; and a priori and a posteriori. The last part of the paper discusses the lack of comparative theories and methods surrounding the physical form of architecture and the city by Korea commentators. Empirically rooted facility planning, non-comparative historical studies, and iconographic criticism emerged as a central preoccupation of architectural culture between the 1960s and 1980s, a time when international debate on architecture and urbanism was most intense. This paper will give consideration to the built environment as a dynamic physical entity and space as an epiphenomenon of daily urban life, such that collaboration between urban designers, architects, and landscape architects is seen as both beneficial and necessary.

• Journal of Intelligence and Information Systems
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• v.14 no.2
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• pp.63-82
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• 2008

Recommendation systems are widely used to help deal with the problem of information overload. Over the past decades, a variety of recommendation systems have been developed as the amount of information in the world increases far more quickly than our ability to process it. This paper aims to analyze existing developed recommendation systems, provide systemic review, and present some basic issues on improvement action. Through this, we also suggest useful implications for better recommendation systems and give some ideas to recommendation system developers to improve their system. Especially, this study focuses on researches on recommendation system. In our research, we analyze the studies along with four different keys dimensions : their domain, objective, underlying model, and evaluation method of recommendation systems and portray the results as statistics or statistical graphics or table form.

• Journal of the Korea Safety Management & Science
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• v.15 no.3
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• pp.133-141
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• 2013

As a work analysis technique, Work Domain Analysis (WDA) aims to identify the design knowledge structure of a work domain that human operators interact with through human-system interfaces. Abstraction hierarchy (AH) is a multi-level, hierarchical knowledge representation framework for modeling the functional structure of any kinds of systems. Thus, WDA based on AH aims to identify the functional knowledge structure of a work domain. AH has been used in a range of work domains and problems to model their functional knowledge structure and has proven its generality and usefulness. However, many of researchers and system designers have reported that it is never easy to understand the concepts underlying AH and use it effectively for WDA. This would be because WDA is a form of work analysis that is different from other types of work analysis techniques such as task analysis and AH has several unique characteristics that are differentiated from other types of function analysis techniques used in systems engineering. With this issue in mind, this paper introduces the concepts of WDA based on AH and offers a comprehensive list of references. Next, this paper proposes a set of principles for effectively applying AH for work domain analysis, which are developed based on the author's experiences, consultation with experts, and literature reviews.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.385-385
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• 2012

Understanding the thermodynamics and structural transformation during the Metal-Insulator Transition (MIT) is critical to better understand the underlying physical origin of phase transition in the vanadiumdioxide ($VO_2$). Here, through the temperature-dependent in-situ high resolutiontransmission electron microscopy (HR-TEM), and systematic electrical transport study, we have shown that the tunable MIT transition of $VO_2$ nanowires is strongly affected by interplay between strain and domain nucleation by ion beam irradiation. Surprsingly, we have also observed that the $VO_2$ rutile (R) metallic phase could form directly in a strain-induced metastable monoclinic (M2) phase. These insights open the door toward more systematic approaches to synthesis for $VO_2$ nanostructures in desired phase and to use for applications including ultrafast optical switching, smart window, metamaterial, resistance RAM and synapse devices.

• Journal of Yeungnam Medical Science
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• v.37 no.4
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• pp.269-276
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• 2020

Fibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis, advanced kidney disease, and liver cirrhosis. Idiopathic pulmonary fibrosis (IPF) is a common form of progressive and chronic interstitial lung disease of unknown etiology. Pathophysiologically, the parenchyma of the lung alveoli, interstitium, and capillary endothelium becomes scarred and stiff, which makes breathing difficult because the lungs have to work harder to transfer oxygen and carbon dioxide between the alveolar space and bloodstream. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis and scarring of the lung tissue. Recent clinical trials focused on the development of pharmacological agents that either directly or indirectly target kinases for the treatment of IPF. Therefore, to develop therapeutic targets for pulmonary fibrosis, it is essential to understand the key factors involved in the pathogenesis of pulmonary fibrosis and the underlying signaling pathway. The objective of this review is to discuss the role of kinase signaling cascades in the regulation of either TGF-β-dependent or other signaling pathways, including Rho-associated coiled-coil kinase, c-jun N-terminal kinase, extracellular signal-regulated kinase 5, and p90 ribosomal S6 kinase pathways, and potential therapeutic targets in IPF.

• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2679-2683
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• 2014

Mechanisms underlying the impacts of interactions between carbon nanoparticles (CNPs) and ionic liquids (ILs) on the physicochemical behavior of CNPs need to be more full worked out. This manuscript describes a theoretical investigation at multiple levels on the interactions of fullerene $C_{60}$ with 21 imidazolium-based ILs of varying alkyl side chain lengths and anionic types and their impacts on $C_{60}$ dispersion behavior. Results show that ${\pi}$-cation interaction contributed to mechanism of the $C_{60}$-IL interaction more than ${\pi}$-anion interaction. The calculated interaction energy ($E_{INT}$) indicates that $C_{60}$ can form stable complex with each IL molecule. Moreover, the direction of charge transfer occurred from IL to $C_{60}$ during the $C_{60}$-IL interaction. Quantitative models were developed to evaluate the self-diffusion coefficient of $C_{60}$ ($D_{fullerene}$) in bulk ILs. Three interpretative molecular descriptors (heat of formation, $E_{INT}$, and charge) that describe the $C_{60}$-IL interactions and the alkyl side chain length were found to be determinants affecting $D_{fullerene}$.

• Journal of Arbitration Studies
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• v.20 no.2
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• pp.91-130
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• 2010

This thesis, which mainly focuses on judicial supervision of commercial arbitration in China, will deal with the developing process of arbitration system and analyze the actual condition of judicial supervision in commercial arbitration. And it also focuses on the underlying problems attributed to the excessive judicial intervention and an effort that the related academic world, arbitration industry and legal circles in China start to make in order to improve the system, resolving them. About the time China became a member of the WTO and about the 10th anniversary of the enforcement of Arbitration Law, powerful demands to solve the problems started to exist intensively. Academic field in China integrated these demands into the form of "proposed amendment of arbitration law", which enhanced the independence of arbitration and the autonomy of the involved parties drastically, as it accepted major contents of UNCITRAL Model Law while preserving of original tool of Chinese arbitration system. Separately from the movement in academic field, Supreme People's Court starts to exert itself for the, improvement of arbitration system, by announcing a series of proposed judicial interpretation so that it could collect the public opinion continuously and reflect the gathered opinion in judicial interpretation efficiently. Notwithstanding, there still remains to be ameliorated that the Arbitration Law of the PRC won't be able to overcome original limit when valuating judicial intervention on arbitration in some ways.

• Journal of Information Processing Systems
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• v.13 no.3
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• pp.435-447
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• 2017

Associative and bidirectional associative memories are examples of associative structures studied intensively in the literature. The underlying idea is to realize associative mapping so that the recall processes (one-directional and bidirectional ones) are realized with minimal recall errors. Associative and fuzzy associative memories have been studied in numerous areas yielding efficient applications for image recall and enhancements and fuzzy controllers, which can be regarded as one-directional associative memories. In this study, we revisit and augment the concept of associative memories by offering some new design insights where the corresponding mappings are realized on the basis of a related collection of landmarks (prototypes) over which an associative mapping becomes spanned. In light of the bidirectional character of mappings, we have developed an augmentation of the existing fuzzy clustering (fuzzy c-means, FCM) in the form of a so-called collaborative fuzzy clustering. Here, an interaction in the formation of prototypes is optimized so that the bidirectional recall errors can be minimized. Furthermore, we generalized the mapping into its granular version in which numeric prototypes that are formed through the clustering process are made granular so that the quality of the recall can be quantified. We propose several scenarios in which the allocation of information granularity is aimed at the optimization of the characteristics of recalled results (information granules) that are quantified in terms of coverage and specificity. We also introduce various architectural augmentations of the associative structures.

• The Korean Journal of Applied Statistics
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• v.9 no.2
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• pp.55-72
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• 1996

It is essential in modern industry that quality and procuctivity are improved continuously. To accomplish this purpose, quality control must be maintained in all parts of a company. Recently, some tire manufacture companies are beginning to show interest in quality control. They have tried to achive some results through the statistical analysis for the experimental data which has accumulated up to now and then they strive to determine the structural relationship between the design factors in tire construction and tire performance characteristics. The measurement data obtained from the construction engineering is given in multivariate form owing to the various properties found in tire design components as wll as in performance. Also it may be existed the relationship among the multimple response variables. Thus we proposes the use of the biplot graphical display as an analytic tool of data matrices with complex respects. The proposed biplots are also availalbe to understand both the underlying structure of the data and the roles played by the different components. In particular, we consider the matter of how best to use the biplots in the maltivariate analysis of variance and multiple response data. Finally we apply this method to analyze the actual data.