• Journal of Nutrition and Health
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• v.56 no.3
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• pp.231-246
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• 2023

Purpose: The aim of this study was to investigate the anti-osteoarthritic effect of the ethanol extract of Boswellia serrata gum resin (FJH-UBS) enriched with keto-β-boswellic acid and 3-O-acetyl-11-keto-β-boswellic acid compared to the conventional Boswellia serrata extract by adding the process of removing oil with hexane, in the monosodium iodoacetate (MIA)-induced osteoarthritis rat model. Methods: Sprague-Dawley (SD) rats were orally administered 0, 40, or 80 mg of FJH-UBS/kg body weight (BW)/day for 5 weeks and injected with MIA intra-articularly into right knee joints on day 15 to induce osteoarthritis. Changes in the knee joint microarchitecture, cartilage degradation, the expression of inflammatory mediators, cytokines, and matrix metalloproteinases (MMPs) in serum and synovia were observed. Results: Oral administration of FJH-UBS (80 mg/kg BW/day) reduced MIA-induced knee swelling and cartilage degradation and increased the expression of type II collagen and aggrecan in articular cartilage. Furthermore, FJH-UBS administration reduced MIA-induced increases in the serum levels of prostaglandin E2, leukotriene B4, interleukin (IL)-1β, IL-6, and MMP-13, and MIA-induced increases in the mRNA expressions of inducible nitric oxide synthase, cyclooxygenase-2, 5-lipoxygenase, IL-1β, IL-6, TNF-α, MMP-2, MMP-9, and MMP-13 in the synovia of knee joints. Conclusion: These results indicate that FJH-UBS exerts its anti-osteoarthritic effects by suppressing the expressions of inflammatory cytokines and MMPs and, thus, cartilage degradation. Furthermore, they suggest that FJH-UBS has potential use as a functional food that improves joint and cartilage health.

• Proceedings of the Korean Society of Computer Information Conference
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• 2013.01a
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• pp.181-184
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• 2013

의료기술이 나날이 발전해 감에 따라 인류의 평균수명이 늘어나고 건강한 삶에 대한 관심도 늘어가고 있으나 여전히 사각지대가 남아있다. 영유아나 고령/특정 질병으로 몸이 불편한 가족이 있는 이들을 위하여 복잡한 장비가 필요 없이 쉽게 구비할 수 있는 장비들을 이용하여 많은 비용을 쓰지 않고도 환자의 상태를 언제 어디서나 파악 가능한 시스템이 필요하다.

• KIPS Transactions on Software and Data Engineering
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• v.5 no.2
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• pp.95-106
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• 2016

Biometric data may appear different depending on the person and sasang Medicine has a close relationship with the Department. Biometric data not only mean a human heart rate, a blood pressure, a heart rate, and the past medical history, degree of aging, body mass index, but also is used as a reference measure for determining the state of health of the person. So biometric data should be reproduced for the application purposes, depending on their applications. In previous studies, because the biometric data is changed in real time and applies only to snap shut at the time of the continuity of the current time is excluded. Therefore, in this study in order to solve this problem, we propose a biometric data patton analysis model comprising a continuity of time in the big data environment consisting of biometric data. The proposed model can help determine the choice of needle position carefully when using the electronic acupuncture for care and health promotion.