• 대한약리학회지
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• 제17권2호
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• pp.37-45
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• 1981

The importance of thyroid hormones for the survival of rats in the cold is along-established fact. Hypothyroid animals are unable to survive in a cold environment. It was also reported that acute exposure of rats, guinea pigs and rabbits to cold produced an increased secretion of TSH and thereby thyroid hormone secretion within 10 to 30 min, but this increase of thyroid activity disappeared quite rapidly during warming. However, in human study no significant difference was found in the concentration of $T_4$, TSH and cortisol between summer and winter. But plasma $T_3$ concentration was increased significantly in winter in 56 adult men. On the other hand, it has been also known that catecholamines are important in the maintenance of body temperature of rat exposured to cold. Abundant evidences suggest that the sympathetic nervous system is involved in the activation of nonshivering thermogenesis and that thyroid hormone metabolism and secretion are influenced by catecholamines and consequently by the activity of the sympatheticadrenal system. Many of the metabolic effects of catecholamines are associated with an increase in the level of cAMP mediated through activation of adenylate cyclase which converts ATP to cAMP. Other studies have shown that thyroid hormones affect the amount of adenylate cyclase present in the adipose tissue. On the other hand. it was also reported that a particulate cAMP phosphodiesterase activity in fat cells was modulated by the action of thyroid hormones. The objective of the present study was to determine the interaction between thyroid activity and cyclic nucleotides during acute exposure to cold. Albino rats weighing around 200 g were used as the experimental animal. The room temperature group was kept at $25^{\circ}C$ and the cold-exposured group was kept at $4^{\circ}C$ for 1 week or 2 weeks. Each group was subdivided into three subgroups; control, KI, and MTU group. At the end of experiment the animals were etherized and blood was taken from abdominal aorta for $T_4,\;T_3$ and cyclic nucleotides. The determinations of $T_3,\;T_4$ and cyclic nucleotides were carried out with a radioimmunoassay(RIA) method. The results were summerized as followings. 1) A significant increase of thyroid weight was observed in rats exposured to cold for 2 weeks. Furthermore, in rats administered MTU while to exposure to cold the thyroid weight was also increased significantly. 2) After 2 weeks $T_3$ concentration in the plasma of cold-exposured rats was significantly increased in KI group and MTU group as well as in control group. On the contrary, after 2 weeks of cold exposure $T_4$ level was decreased in control group. 3) In the case of cyclic nucleotides, plasma cAMP was increased in the control group after 1 or 2 weeks of cold exposure. However, cAMP level in plasma was rather significantly decreased in KI group and MTU group as well as in control group.

• 한국농림기상학회지
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• 제20권3호
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• pp.252-261
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• 2018

이 연구는 월평균 기상자료를 이용하여 일 최고기온, 일 최저기온을 생성하는 방법을 개발하기 위하여 진행되었다. 전국 23개 기상관서의 과거 30년간의 일기상자료를 분석하여 일 최고기온 및 일 최저기온의 연간 변동 경향을 나타내는 모수(중심값($\hat{U}$), 진폭(C), 편이(T))와 일간 변동을 반영하는 모수(A, B)를 탐색하였다. 그 중 중심값은 지점간의 연 평균자료로부터 도출하였고, 중심값을 제외한 모수들은 전국 평균을 기상생성과정에 적용하였다. 먼저 강우발생 유무에 따라 일 기상자료를 생성한 후 월 자료를 이용하여 보정하고 마지막으로 일 최고기온 및 일 최저기온을 생성하였다. 이 방법으로 전체 23개 지역에 대하여 월별로 생성하였을 때 전체 월별 분포의 95% 이상 관측된 분포와 유사한 일 자료를 생성할 수 있었다. 또 이 방법에 의해 과거 자료와 유사한 생장도일(Growing Degree Day)를 생성할 수 있었고, 조사대상이 아닌 지역에도 충분히 적용할 수 있었다. 이 방법은 기후변화시나리오 등 월 자료가 확보되어 있는 경우에 일기상자료를 생성하는데 유용할 것으로 판단되었다.

• 한국동물위생학회지
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• 제32권1호
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• pp.61-76
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• 2009

At the present study, it was aimed to explore the molecular genetic characterization of multiple antimicrobial resistant Salmonella spp. isolates from pigs and cattle. A total of 138 Salmonella Typhimurium (S. Typhimurium) isolates were typed with phage, among them, 83.3% of S. Typhimurium tested could divide into a 10 phage types. Definitive type 193 (DT193) (25.4%) and DT195 (24.6%) were exhibited as the dominant types. DT104 and U302 were found from pigs and cattle. On the other hand, S. Enteritidis had 6 phage types, of them, phage type 21 (PT21) and PT11b were the popular types. In the plasmid profiles, 135 of S. Typhimurium isolates were exhibited 1 to 6 plasmid bands which molecular weight ranged from 90 to 2kb. 35 isolates (25.4%) harbored a 90kb plasmid which is thought to be the serotype specific virulence plasmid. Two of twenty five S. Enteritidis had common plasmids at 2 and 1.5kb. With multiplex polymerase chain reaction, virulence genes (invA and spvC) were detected from all Salmonella spp. from 167 of S. Typhimurium, S. Enteritidis and chloramphenicol resistant S. Schwarzengrund, but some drug resistant genes, such as PSE-1, cml/tetR and flo were not determined but other drug resistant genes, for example TEM and int were found. The detection rates of spvC, TEM and int gene was 35.3%, 29.3% and 72.5%, respectively. The TEM gene was highly popular in S. Typhimurium, which was detected from ampicillin and amoxicillin resistant strains as 95.9%. int gene was able to detect from all the isolates identified as multidrug resistsnt (MDR), particularly DT193 was thought as the most prevalent virulence and multidrug resistance isolate. The major plasmid profile and drug resistance pattern of DT193 were 90, 40, 10.5, 6.3, 3.0kb and ACCbDNaPSSuT, respectively. MDR was commonly found in other phage types, particularly DT104, U302 and DT203.

• 대한지리학회지
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• 제48권1호
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• pp.72-86
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• 2013

산업집적은 경제지리학에서 오랫동안 연구되어온 주제 중의 하나이며 지금까지 다양한 방법을 통해 산업집적 현상을 설명하고 이의 영향을 평가해왔다. 하지만 시계열 데이터를 이용해 집적의 추이를 살펴본 연구는 아직 활발히 이루어지지 않고 있다. 본 연구는 지난 29년 간의 데이터를 이용해 사례로 선정된 산업들의 집적 정도를 평가하고 이러한 시계열 패턴과 도로 네트워크의 확장이 어떠한 인과관계를 맺고 있는 지 살펴보고 있다. 집적 정도를 측정한 결과 사례로 선정된 산업의 종사자들은 지리적으로 균등하게 분포되지 않고 있었다. 또한 사례 산업들 간에 공통된 시계열적 변화 특성은 나타나지 않았으나 각 산업의 발전 단계 및 비즈니스 환경 변화가 개별 산업의 집적 정도에 영향을 주고 있는 것으로 보이고 있다. 집적 정도와 도로교통망 사이의 관계를 살펴보기 위해 각 산업 별로 Granger causality test를 실시하였고 도로 교통망이 산업 집적에 영향을 주고 있음을 몇몇 사례를 통해 확인할 수 있었다. 그러나 이와 반대의 경우 혹은 상호 간에 영향을 주는 사례도 나타나 교통망과 산업집적이 보다 복잡한 관계를 맺고 있음을 보여준다.

• 한국경제지리학회지
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• 제13권4호
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• pp.584-600
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• 2010

본 연구는 미국 동부 지역의 두 고속도로 회랑지대, I-95와 I-85 일대의 지식 기반 서비스업의 고용변화를 확장된 shift-share 분석을 통해 살펴보고 있다. 지식 기반 서비스업으로 선정된 산업은 금융, 보험, 비즈니스 서비스와 의료 산업이며 1977년부터 1990년, 1990년부터 2005년까지의 기간 동안의 대도시 지역이 연구 대상이다. 1977년부터 1990년 사이에는 생산량과 노동 생산성 측면에서 두 지역 모두 주변 지역 및 국가 전체 평균보다 월등한 성장세를 보였다. 그러나 1990년에서 2005년 사이에는 산업별 차이가 있었지만 평균에 미치지 못하는 성장 속도를 보이는 경우가 많이 나타났다. 또한 지리적으로 인접해 있거나 동일한 회랑지대에 위치한 대도시들도 유사한 고용 변화 패턴을 보이지는 않는다는 것이 밝혀졌다.

• 생태와환경
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• 제42권1호
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• pp.115-123
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• 2009

서로 다른 두 시기의 부영양호(일감호) 현장수에 대한 한국산 말조개(U. douglasiae)의 섭식특성을 비교 조사하였다. 두 실험수 모두 패류밀도가 클수록 엽록소 a 감소가 뚜렷하였으며, 동일한 패류밀도에서는 저온기 현장수에서 엽록소 a 감소가 더 뚜렷하였다. 저온기 현장수에서는 패류 밀도에 따른 여과율 및 식물플랑크톤 현존량 변화가 뚜렷하였으나, 고온기 현장수에서는 두 패류 밀도의 여과율 및 식물플랑크톤 현존량 변화가 유사한 경향을 보였다. 각 출현종에 대한 말조개의 조류제어능은 저온기 현장수의 S. ulna와 S. hantzschii, 고온기 현장수의 S. ecornis, T. regulare, P. simplex는 빠른 시간 내에 감소하는 경향을 보였으나, 저온기 현장수의 S. ecornis는 서서히 감소하는 경향을 보였으며, 고온기 현장수의 M. aeruginosa는 제어효율이 가장 좋지 않았다. 따라서 한국산 말조개는 저온기 규조류 대발생 수역의 생태친화적 제어에 효과적인 생물제재로서 활용이 가능할 것으로 판단되었다.

• 대기
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• 제19권3호
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• pp.237-242
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• 2009

The first domestic expert workshop on surface flux measurement and modeling was held on 10-12 June 2009 in Seoul to invigorate research cooperation on soil-vegetation-atmosphere interactions in Korea and to promote interdisciplinary studies. This article provides a summary of the workshop presentations and recommendations, and future research directions for surface processes in Korea.

• 간호행정학회지
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• 제22권5호
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• pp.471-479
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• 2016

Purpose: This study was conducted to evaluate the level of safety climate, fatigue, and safety performance and to identify the impact of safety climate and fatigue on the safety performance of operating room nurses. Methods: The study design was a descriptive survey. Participants were 174 operating room nurses from two general hospitals and two university hospitals in S and D cities. Three structurally designed questionnaires were used to evaluate their safety climate, fatigue, and safety performance. Collected data were analyzed using descriptive analysis, t-tests, ANOVAs, Pearson correlation coefficient, and stepwise multiple regression. Results: Safety performance of operating room nurses had a mean of 3.26 on a 5-point scale. 'Current department career'(${\beta}=.17$, p=.006) and 'safety climate (work-unit contribution) (${\beta}=.63$, p<.001) accounted for 39% of the variance in operating room nurses' safety performance. Conclusion: Findings indicate that work-unit contribution towards safety climate is an important factor in increasing operating room nurses' safety performance. Therefore, it is essential to find motivational properties consistent with the characteristics of the operating room environment.

• 대한한방내과학회지
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• 제26권2호
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• pp.398-408
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• 2005

Objective: Graves' disease encompasses hyperthyroidism and diffused goiter associated with auto-antibodies to the thyroid stimulating hormone(TSH) receptors. In clinical environment, treatments of Graves' disease have many side effects such as recurrence and hypothyroidism. We've studied the effects of Sipyukmiyukieum on DNA synthesis, cAMP synthesis, and MHC-class II expression of FRTL-5 thyroid cells were studied. Methods: DNA synthesis was investigated by using BrdU staining and cAMP synthesis by ELISA kit, and expression of $interferon-{\gamma}$ activated MHC class II by Flow cytometer. Results: After introduction of Sipyukmiyukieum, significant inhibition of DNA synthesis. cAMP synthesis, and expression of $interferon-{\gamma}$ activated MHC class II of FRTL-5 thyroid cells was observed. Conclusions: Judging from these results, Sipyukmiyukieum has potential as a potent herbal treatment for inhibiting the enlargement of goiter, synthesis of abnormal thyroidal hormones, and autoimmuine responses of Graves' disease.

• Reproductive and Developmental Biology
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• 제38권2호
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• pp.63-70
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• 2014

Plasminogen activators (PAs) are serine proteases that convert plasminogen to plasmin. Two type of PAs are urokinase-type PA (uPA) and tissue-type PA (tPA). Plasminogen is present in most extracellular fluids. PAs play in various reproductive processes including implantation, ovulation and fertilization. In the spermatozoa, PAs and PAIs play a role in sperm motility and fertilization. PAs in the sertoli cell are stimulated spermatozoa maturation and sperm activation through the phospholipase A2. The oocyte maturation is the process for fertilization and implantation. PAs in cumulus-oocyte complexes (COCs) are related to oocyte maturation by protein kinase A and C. In the ovulatory process, PAs activity are changed and it are related to reducing the tensile strength of ovarian follicle wall. The uterine environment is important for reproduction and the uterus undergo tissue remodeling. In the uterus and oviduct of mammals, expression and activity of PAs are changed during estrous cycle. Thus, expression and activity of PAs are concerned to many reproductive functions. Therefore, PAs seem to important factor of regulator in reproductive events.