Well testing in unconventional reservoirs, such as tight or shale gas formations, presents considerable challenges. It is difficult to estimate the reservoir properties in ultra-low permeability formation because of poor inflow prior to stimulation and excessive test duration. Moreover, radial flow may not develop in hydraulically fractured horizontal wells. For these reasons, the cost of test is high and the accuracy is relatively low. Accordingly, industry is turning to an alternate testing method, diagnostic fracture injection test (DFIT), which is conducted prior to the main hydraulic fracture treatments. Nowadays, DFIT are regarded as the most practical way to obtain good estimates of reservoir properties in unconventional reservoirs. Various methods may be used for interpreting DFIT data. This paper gives an explanation of those methods in detail and examines three actual field data. These show how various analysis methods can be applied to consistently interpret fracture closure pressure and time, as well as before and after closure flow regimes and reservoir properties from field data.
The aim of this paper is to discuss the effect of missing values in detecting differentially expressed genes in a cDNA microarray experiment in the context of a one sample problem. We conducted a cDNA micro array experiment to detect differentially expressed genes for the metastasis of colorectal cancer based on twenty patients who underwent liver resection due to liver metastasis from colorectal cancer. Total RNAs from metastatic liver tumor and adjacent normal liver tissue from a single patient were labeled with cy5 and cy3, respectively, and competitively hybridized to a cDNA microarray with 7775 human genes. We used $M=log_2(R/G)$ for the signal evaluation, where Rand G denoted the fluorescent intensities of Cy5 and Cy3 dyes, respectively. The statistical problem comprises a one sample test of testing E(M)=0 for each gene and involves multiple tests. The twenty cDNA microarray data would comprise a matrix of dimension 7775 by 20, if there were no missing values. However, missing values occur for various reasons. For each gene, the no missing proportion (NMP) was defined to be the proportion of non-missing values out of twenty. In detecting differentially expressed (DE) genes, we used the genes whose NMP is greater than or equal to 0.4 and then sequentially increased NMP by 0.1 for investigating its effect on the detection of DE genes. For each fixed NMP, we imputed the missing values with K-nearest neighbor method (K=10) and applied the nonparametric t-test of Dudoit et al. (2002), SAM by Tusher et al. (2001) and empirical Bayes procedure by $L\ddot{o}nnstedt$ and Speed (2002) to find out the effect of missing values in the final outcome. These three procedures yielded substantially agreeable result in detecting DE genes. Of these three procedures we used SAM for exploring the acceptable NMP level. The result showed that the optimum no missing proportion (NMP) found in this data set turned out to be 80%. It is more desirable to find the optimum level of NMP for each data set by applying the method described in this note, when the plot of (NMP, Number of overlapping genes) shows a turning point.
Journal of the Korean Society of Fisheries and Ocean Technology
/
v.47
no.4
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pp.435-442
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2011
In an attempt to respond to the increase in international oil prices and reduce operating expenses, ship remodeling was carried out on a 740ton class tuna purse seiner. To strengthen the competitiveness of the fisheries industry by improving vessel performance, a bulbous bow was newly equipped. The slipway and rudder area were also lengthened and enlarged with the propeller and main engine remained unchanged. To reduce the hull resistance, a circle type bulbous bow was attached on the hull behind bow thruster and thus the cost for exchanging electrical equipment for bow thruster was reduced. The new rudder area was expanded 15% more than the old one within the extent that the existing mechanical control part and rudder stock were not changed. To prevent fishing net damage and stabilize wake field, slipway was lengthened to the optimal position. All of the new design of remodeling parts went through the model tests in towing tank and CWC. Besides resistance test, all of necessary model test results were delivered for hydrodynamic character for the modified ship. The maneuvering simulation to verify that the remodeled ship satisfies the IMO rules was performed in both zigzag and turning tests. The estimated resistance with new bulbous bow and lengthened stern was reduced by 4.8% in the 2-dimensional analysis and 17.4% in the 3-dimensional analysis in comparison of conventional ship. The average reduction of resistance was estimated about 10%. Maneuvering character of modified hull form was found to satisfy all regulations under IMO. The remodeling of tuna purse seiner can not only improve fishing performance but also contribute to reduction of operating cost by saving energy for the fisheries industry.
Objectives: The purpose of the study is to investigate the musculo-skeletal pain prevalence and severity in the dental hygienists based on PRECEDE model. Methods: A self-reported questionnaire was completed by 483 dental hygienists in Gwangju from September 13 to October 12, 2013. Data were analyzed by frequency analysis, chi-square test, t-test, and multiple logistic regression analysis using SPSS 18.0 program. Musculo-skeletal pain severity was classified from 1 to 5 by PRECEDE model. The questionnaire consisted of six questions of the general characteristics of the subjects, one question of musculo-skeletal pain prevalence, one question of body part musculo-skeletal pain prevalence, one question of subjective health status, three questions of activities of daily living, six questions of working environment, one question of musculoskeletal system diseases knowledge, two questions of social support, two questions of education experience and data use method, and five questions of necessity of health education. Results: The prevalence rate of musculo-skeletal pain within a year was 83.9% and 22.8% of the dental hygienists complained of severe pain. The odds ratio of moderate pain severity was 1.99(95% CI, 1.10-3.60) and the odds ratio of unhealthiness was 3.27 (95% CI, 1.35-7.94). The odds ratio of pain severity in those working for 4-6 years was 0.21(95% CI, 0.08-0.57). The odds ratio of pain severity in those practicing 6-10 scaling cases per day was 0.33(95% CI, 0.17-0.65). The odds ratio of pain severity in wrist turning and bending was 3.56(95% CI, 1.19-10.62). Conclusions: The muscolu-skeletal pain severity in the dental hygienists was closely associated with subjective health condition, work duration, the number of scaling practice activity, and a treatment posture. Regular physical checkup for the dental hygienists will improve the musculo-skeletal pain due to scaling practice.
Magazine of the Korean Society of Agricultural Engineers
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v.34
no.1
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pp.41-48
/
1992
Various soil behaviors usually occurring in the geotechnical problems, such as, cutting and embankments, stability of slope, seepage, consolidations, shearing failures and liquefaction, should be predicted and analyzed in any way. An approach of these predictions may be followed by the development of the constitutive equations as first and subsequently solved by numerical methods. The purpose of this paper is develop the constitutive equation of sands uder monotonic or cyclic loadings. The constitutive equation which is based on elasto-plastic theory, modified anisotropic consolidated stress parameter by Sekiguchi et al and Pender's theory is derived. And the equation is included a new stress parameter, hardening function, Bauschinger's effects and Pender's theory. The model is later evaluated and confirmed the validity by the test data of Ottawa sand, Banwol sand Hongseong sand. The following conclustions may be drawn: 1. The consititutive equation which is based on elasto-plastic theory, modified anisotropic consolidated stress parpameter by Sekiguchi et al and Pender's theory is derived. The equation in included a new stress parameter, hardening function, Bauschinger's effect and Pender's theory. 2. For Ottawa sand, the result of the constitutive equation shows a better agreement than that of Oka et al. The result of axial strain agrees well with the tested data. However, the result of horizontal strain is little bit off for the cyclic loadings or large stress. It is thought that the deviation may be improved by considering Poisson's ratio and precise measurement of shear modulus. 3. Banwol sand is used for the strain and stress tests with different relative densitites and confining pressures. The predeicted result shows a good agreement with the tested data because the required material parameters were directly measurd and determined form this laboratory. 4. For Hongseong sand, the tests under same amplitude of cyclic deviatoric stress shows a similar result with the tested data in absolute strain. It shows the acute shape of turning point because the sine wave of input is used in the test but the serrated wave in prediction.
Purpose: This study was done to develop a postural-stability patient transfer technique for care helpers in nursing homes and to evaluate its effectiveness. Methods: Four types of patient transfer techniques (Lifting towards the head board of the bed, turning to the lateral position, sitting upright on the bed, transferring from wheel chair to bed) were practiced in accordance with the following three methods; Care helpers habitually used transfer methods (Method 1), patient transfer methods according to care helper standard textbooks (Method 2), and a method developed by the author ensuring postural-stability (Method 3). The care helpers' muscle activity and four joint angles were measured. The collected data were analyzed using the program SPSS Statistic 21.0. To differentiate the muscle activity and joint angle, the Friedman test was executed and the post-hoc analysis was conducted using the Wilcoxon Signed Rank test. Results: Muscle activity was significantly lower during Method 3 compared to Methods 1 and 2. In addition, the joint angle was significantly lower for the knee and shoulder joint angle while performing Method 3 compared to Methods 1 and 2. Discussion: Findings indicate that using postural-stability patient transfer techniques can contribute to the prevention of musculoskeletal disease which care helpers suffer from due to physically demanding patient care in nursing homes.
Transactions of the Korean Society of Mechanical Engineers
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v.13
no.3
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pp.433-442
/
1989
Owing to the development of CNC machine tools and automatic programing software, the milling process with ball-end mill has become the most widely used process where three-dimensional precision machining is important. In this study, the ball-end milling process has been analyzed and a cutting force model has been developed to predict the cutting force acting on the ball-end mill on given machining conditions. The development of the model is based on the analysis of geometry of a ball-end mill an the oblique cutting process. The cutting edges of ball-end mills are considered as a series of infinitesimal elements and the geometry of the cutting edge element each cutting edge element is straight. The oblique cutting process in the small cutting edge element has been analyzed as orthogonal cutting process in the plane containing the cutting velocity vector and chip-flow vector. Hence, with the orthogonal cutting data obtained from orthogonal turning test, the cutting forces can be predicted through the model. The predicted cutting forces has shown a fairly good agreement with the test results in various plane cutting conditions.
Purpose: The purpose of this study was to determine the effects of rotation direction during curved walking on gait parameters in stroke patients. Methods: A group of thirty subjects with stroke (Berg Balance Scale score${\geq}41$ were fifteen, Berg Balance Scale score${\leq}40$ were fifteen) were enrolled in this study. Testing indications included two directions for rotation in each subject. These indications were for rotation toward the affected and unaffected side in stroke patients. The gait speed, affected side single support duration, affected side double support duration were recorded. The obtained data were analyzed by using paired t-test and Wilcoxon signed rank test in the group that are below and above 40 points of Berg Balance Scale score. Results: There was significant increase affected side single support duration was turned the affected side in stroke patients that presented a Berg Balance Scale score${\geq}41$ (p<.05). There were significant increase gait speed, affected side single support duration, and significant decrease affected side double support duration while subjects were turned the affected side in stroke patients that presented a Berg Balance Scale score${\leq}40$ (p<.05). Conclusion: This result may be effective to rotate in the paralyzed direction to improve the ability of the paralyzed lower limb to gain weight during gait training for stroke patients with a Berg Balance Scale score<40. Therefore, walking training program for hemiplegic patient needs to be suggested in the direction of turning for suitable balance ability.
A submerged body with varied control inputs can execute large drift angles and large angles of attack, as well as basic control such as straight movement and turning. The objective of this study is to analyze the dynamic characteristics of a submerged body comprising six thrusters and six control planes, which is capable of a large drift angle and angle of attack motion. Virtual captive model tests via were analyzed via computational fluid dynamics (CFD) to determine the dynamic characteristics of the submerged body. A test matrix of virtual captive model tests specialized for large-angle motion was established. Based on this test matrix, virtual captive model tests were performed with a drift angle and angle of attack of approximately 30° and 90°, respectively. The characteristics of the hydrodynamic force acting on the horizontal and vertical surfaces of the submerged body were analyzed under the large-angle motion condition, and a model representing this hydrodynamic force was established. In addition, maneuvering simulation was performed to evaluate the standard maneuverability and dynamic characteristics of large-angle motion. Considering the shape characteristics of the submerged body, we attempt to verify the feasibility of the analysis results by analyzing the characteristics of the hydrodynamic force when the large-angle motion occurred.
Kim, Kiwon;Kim, Hoyong;Choi, Sungeun;Na, Ki-In;Lee, Hyuk;Seo, Jeonghwa
Journal of the Society of Naval Architects of Korea
/
v.59
no.3
/
pp.173-182
/
2022
The present study suggests a procedure of establishing a ship dynamics modeling by regression of free-running model test results. The hydrodynamic force and moment of the whole model ship is derived from the low-pass filtered acceleration in the turning circle and zigzag maneuver tests. Force and moment of the propeller and rudder are separated from that of the whole ship to acquire the hull force and moment terms, based on the principles of the component model. The low-pass filter frequency is verified in prior to dynamics modeling, to find the threshold frequency of 2.5 Hz. The dynamics modeling of the hull is compared with the component modeling by captive model tests. Because of strong correlation between sway velocity, yaw angular velocity, and heel angle, each maneuvering coefficient is not able to be validated, but the whole modeling shows good agreement with the captive model tests.
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