• Title/Summary/Keyword: tuguaconitine

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Studies on the Effect of Several Crude Drugs on Cultured Chicken Brain Cells (수종 생약이 일차배양한 계배의 뇌세포에 미치는 영향)

  • Park, Mi-Jung;Song, Jin-Ho;Kim, Young-Choong
    • Korean Journal of Pharmacognosy
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    • v.20 no.1
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    • pp.32-36
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    • 1989
  • Effects of Lycium chinensis, Epimedium koreanum and tuguaconitine which is isolated from Aconitum sibiricum on primary culture chicken embryonic brain cells were studied by microscopic observation and determined of the activity of pyruvate dehydrogenase complex(PDHC). Brain cells were prepared from the brain of 10-day-old chicken embryo and cultured with a medicine consisted of 90% Dulbecco's Modified Eagle Medium(DMEM) and 10% horse serum. It was observed that all substances studied seemed to show the tendency to stimulate the neurite outgrowth of brain cells which were cultured with a deficient medium under microscopic observation. The activity of PDHC in brain cells cultured with a deficient medium was increased by Lysium chinensis and Epimedium koreanum. However, tuguaconitine had not influence on the activity of PDHC.

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Studies on Korean Aconitum Species(I) -An Alkaloid of Aconitum sibiricum and the Comparison of Toxicities among Related Aconitum Species- (한국산(韓國産) 부자류(附子類) 생약(生藥)에 대한 연구(硏究)(I) -노랑투구꽃의 성분(成分) 연구(硏究) 및 관련된 부자류(附子類)의 독성(毒性) 비교(比較)-)

  • Chung, Bo-Sup;Kim, Sin-Keun;Lee, Hyung-Kyu;Kim, Seung-Han
    • Korean Journal of Pharmacognosy
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    • v.15 no.2
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    • pp.108-113
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    • 1984
  • The structure of tuguaconitine, MP $196{\sim}198^{\circ}C$, a new diterpene alkaloid isolated from the roots of Aconitum sibiricum P., was studied. Its empirical formula is $C_{23}H_{35}NO_7$ and spectroscopic evidence shows that the base contains three methoxyl, three hydroxyl and one N-ethyl groups. The acute toxicities of most of Aconitum species were strong and the acute toxicity of the alkaloid fraction of A. sibiricum was decreased by Glycyrrhizae, black bean or Zingiberis extract.

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