• Journal of the Korean Society for Heat Treatment
• /
• v.30 no.5
• /
• pp.207-214
• /
• 2017

In this study, failure behavior of piercing plug for seamless tube manufacturing process was studied. Three different kinds of passed piercing plugs (10, 90, 215 times) were prepared. The shape deformation of the passed piercing plugs was observed by 3D coordinate measuring machine, and the oxidized layer on the surface of piercing plug was observed by optical microscopy. The length reduction of piercing plug presented at 215 times passed plug. It was found that the oxidized layer consisted of outer scale, inner scale and internal oxidation layers, and the inner scale layer had vertical cracks, and interfaces had horizontal cracks. We proposed the failure mechanism of piercing plug during seamless tube manufacturing process based on the formation of vertical and horizontal crack.

• Journal of Microbiology and Biotechnology
• /
• v.18 no.2
• /
• pp.377-382
• /
• 2008

Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.

• Bulletin of the Korean Chemical Society
• /
• v.26 no.4
• /
• pp.619-628
• /
• 2005

We attempted to replace a benzopyran ring of 4-[(N-imidazol-2-ylmethyl)-4-chloroanilino]benzopyran, previously discovered as anti-angiogenic agent with antitumor activity, with pyranopyridines. The [3,2-c]-, [3,2-b]-, [2,3-c]-, and [2,3-b]-pyranopyridines with -(imidazol-2-ylmethyl)aniline moiety at the 4-position, were synthesized respectively, and evaluated for primary anti-angiogenic properties through primary cultured HUVEC tube formation assay. From this study, we found that the pyranopyridine ring, especially [3,2-b]- and [2,3-c]-isomer, can replace the benzopyran ring of the compound 1 and can be optimized through the introduction of substituents both on the pyranopyridine ring and the aniline moiety for the identification of a novel anti-angiogenic agent.

• Archives of Pharmacal Research
• /
• v.25 no.5
• /
• pp.640-642
• /
• 2002

The ethyl acetate fraction of Bupleurum longiradiatum was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells. The active compounds, isolated from the fraction, were identified as acetylbupleurotoxin (P1) and bupleurotoxin (P2). The compounds P1 and P2 completely inhibited the tube-like formation of HUVE cells at 30 ${\mu}g$/ml, below the cytotoxic concentration. But, they did not exhibit antitumor activity on BDF1 mice bearing Lewis lung carcinoma cells despite their antiangiogenic activity.

• 한국가시화정보학회:학술대회논문집
• /
• 2002.11a
• /
• pp.27-30
• /
• 2002

An experimental study is performed to investigate the characteristics of near wake behind a circular cylinder with serrated fins using the constant temperature anemometer and through flow visualization. Previous report(Boo at al., 2001) shows that there are three different modes in vortex shedding behavior. This paper is focused on the identification of the physical reasons why the difference is occured in vortex shedding. The through flow velocity crossing fins decreases as increasing fin height and decreasing fin pitch mainly due to the flow resistence. Vortex shedding is affected strongly by velocity distribution around fin tube, especially by the velocity gradient. The velocity distribution at X/d=0.0 has lower gradient with increasing freestream velocity and fin height and decreasing fin pitch. Those differences in velocity gradients generate different vortex shedding mechanism.

• Journal of Advanced Marine Engineering and Technology
• /
• v.30 no.5
• /
• pp.597-607
• /
• 2006

This paper presents a numerical simulation of the behavior of the LiBr solution droplets and falling films in horizontal tube banks of absorber. The model developed here accounts for the details of the droplets formation and impact process for absorption on horizontal tubes including the heat transfer from solution film to the tube wall. Especially. the characteristic of unsteady behavior of solution flow has been investigated. Flow visualization studies shown that the solution droplets and falling films have some of the complex characteristics. It is found that. with the numerical conditions similar to the operating condition of an actual absorption chiller/heater, the outlet solution temperature and heat flux from solution film to the tube wall have a stable periodic behavior with time. The solution droplets and falling films in horizontal tube banks of absorber is a periodic unsteady flow. The results from this model are compared with previous experimental observation taken with a high-speed digital video camera and shown good agreement.

• Proceedings of the Korean Society of Laser Processing Conference
• /
• 2000.11a
• /
• pp.7-9
• /
• 2000

• Proceedings of the Korean Nuclear Society Conference
• /
• 2001.05a
• /
• pp.281.2-281
• /
• 2001

• Proceedings of the PSK Conference
• /
• 2000.04a
• /
• pp.179.3-180
• /
• 2000

• BMB Reports
• /
• v.55 no.7
• /
• pp.336-341
• /
• 2022

Narrowing of arteries supplying blood to the limbs provokes critical hindlimb ischemia (CLI). Although CLI results in irreversible sequelae, such as amputation, few therapeutic options induce the formation of new functional blood vessels. Based on the proangiogenic potentials of stem cells, in this study, it was examined whether a combination of dental pulp stem cells (DPSCs) and human umbilical vein endothelial cells (HUVECs) could result in enhanced therapeutic effects of stem cells for CLI compared with those of DPSCs or HUVECs alone. The DPSCs+ HUVECs combination therapy resulted in significantly higher blood flow and lower ischemia damage than DPSCs or HUVECs alone. The improved therapeutic effects in the DPSCs+ HUVECs group were accompanied by a significantly higher number of microvessels in the ischemic tissue than in the other groups. In vitro proliferation and tube formation assay showed that VEGF in the conditioned media of DPSCs induced proliferation and vessel-like tube formation of HUVECs. Altogether, our results demonstrated that the combination of DPSCs and HUVECs had significantly better therapeutic effects on CLI via VEGF-mediated crosstalk. This combinational strategy could be used to develop novel clinical protocols for CLI proangiogenic regenerative treatments.