• Title/Summary/Keyword: triterpene glycosides

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Seasonal variations of triterpene glycosides contents in the leaf of Centella asiatica (L.) Urban (병풀 잎에서 triterpene glycosides의 시기별 함량변화)

  • Kim, Ok-Tae;Kim, Min-Young;Kim, Soo-Joung;Kim, Yu-Jeong;Kim, Kwang-Soo;Ahn, Jun-Cheul;Kim, Si-Wouk;Hwang, Baik
    • Korean Journal of Medicinal Crop Science
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    • v.10 no.5
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    • pp.375-378
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    • 2002
  • The seasonal variation of two triterpene glycosides, madecassoside and asisaticoside, in the aerial parts of Centella asiatica from May through October was investigated. In leaves, the highest level of triterpene glycosides content was about 108.1 mg/g in September. In petiols, the content was as low as 19.02 mg/g. According to the experimental results obtained, we found that Centella asiatica leaf can accumulate the triterpene glycosides and September is the optimal season for the collection.

Synthesis of $^3H$-Labeled dammarane triterpene glycosides of Korean ginseng

  • Han, Byung-Hoon;Woo, Lin-Keun
    • Archives of Pharmacal Research
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    • v.1 no.1
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    • pp.27-32
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    • 1978
  • A procedure of $^3H$-radio labeling synthesis for the dammarane triterpene glycosides of Korean ginseng was established by using the ginsenoside $Rg_1$ as starting material. The protons in $C-{11}$ and $C_{13}$ of the aglycone moiety of the glycoside were exchanged with tritium by keto-enol tautomerization of 12-keto-ginsenoside $Rg_1$ which was prepared by partial acetylation, Sarett oxidation and saponification, producing nona-acetate, nonaside $Rg_1$. The acety1-ketone and 12-keto-derivative of ginsenotritated ketone was reduced by metallic sodium and isoproponol to produce the end product $^3H$-ginsenoside $Rg_1$ with 3% radio-chemical recovery in one experiment.

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A Triterpene Glucosyl Ester from the Roots of Rubus crataesifolius

  • Jung, Sung-Wook;Shin, Myung-Hee;Jung, Jee-H.;Kim, Nam-Deuk;Im, Kwang-Sik
    • Archives of Pharmacal Research
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    • v.24 no.5
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    • pp.412-415
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    • 2001
  • Along with five known triterpene glycosides, a new triterpene glucosyl ester, named crataegioside, was isolated from the roots of Rubus crataesifolius Bunge. The structure was established as ilexosapogenin A 28-O-$\beta$-D-glucopyranosyl ester by chemical and spectroscopic methods.

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Further Triterpene Glycosides from Echinosophora koreensis

  • Byun, Ji-Hye;Kim, Ju-Sun;Kang, Sam-Sik
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.135.1-135.1
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    • 2003
  • We have previously reported three new oleanene-type glycosides and kudzusaponin $A_3$ methyl ester and subproside II methyl ester from the roots of Echinosophora koreensis. Further study has now led to the isolation of three known oleanen-type glycosides. sophoraflavoside I, azukisaponin V, and kudzusaponin $SA_3$ as their methyl esters. The structures of theses compounds were characterized by spectroscopic and chemical methods.

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Production of Triterpene Glycosides from Whole Plant Cultures of Centella asiatica (L.) Urban (병풀 (Centella asiatica L. Urban) 식물체 배양을 이용한 Triterpene Glycoside 생산)

  • Kim, Ok-Tae;Kim, Min-Young;Park, Yoon-Jung;Hong, Min-Hee;An, Jun-Chul;Oh, Man-Ho;Hwang, Baik
    • Journal of Plant Biotechnology
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    • v.29 no.4
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    • pp.281-285
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    • 2002
  • Whole plant cultures of Centella asiatica (L.) Urban in vitro were established and the effects of basal media, some macro elements and sucrose concentration on productivity of triterpene glycosides (madecassoside and asiaticoside: M$\varepsilon$A) were investigated. Among the media (MS, B5, RCM) tested, MS and 0.5 RCM medium were the best for plant growth and M$\varepsilon$A production, respectively. However, taking into account the M$\varepsilon$A productivity, B5 medium was superior (M$\varepsilon$A: 14.28 mg/g dry wt.). Major macronutrients of B5 medium adjusted with the concentration of 25 mM KNO$_3$,1 mM NaH$_2$PO$_4$, 1 mM CaCl$_2$ and 1~10 mM MgSO$_4$, caused elevated or optimized levels of M$\varepsilon$A. On sucrose concentration, the highest yields of M$\varepsilon$A were obtained from 6% sucrose.

A New Lupane-Triterpene Glycoside from the Leaves of Acanthopanax gracilistylus

  • Liu, Xiang-Qian;Chang, Seung-Yeup;Park, Sang-Yong;Nohara, Toshihiro;Yook, Chang-Soo
    • Archives of Pharmacal Research
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    • v.25 no.6
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    • pp.831-836
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    • 2002
  • A new and two known lupane-triterpene glycosides were isolated from the hot MeOH fraction of the leaves of Acanthopanax gracilistylus W. W. Smith. Based on the physical properties and spectroscopic data, their chemical structures were determined as acankoreoside A (1), acankoreoside D (2), and $3{\alpha}-hydroxy-lup-23-al-20(29)-en-28-oic$ acid $28-O-{\alpha}-L-rhamnopyranosyl-(1{\rightarrow}4)-{$beta}-D-glucopyranosyl-(1{\rightarrow}6)-{\beta}-D-glucopyranosyl$ ester (3), respectively. To our best knowledge, compand 3 appears to be novel, which was named as wujiapioside A.