• 제목/요약/키워드: trial test

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Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled, clinical trial

  • Deore, Girish D.;Gurav, Abhijit N.;Patil, Rahul;Shete, Abhijeet R.;Naiktari, Ritam S.;Inamdar, Saurabh P.
    • Journal of Periodontal and Implant Science
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    • v.44 no.2
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    • pp.71-78
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    • 2014
  • Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity of immune function through the regulation of informational molecules such as cytokines. In the current study, we tested the hypothesis that herbal immunomodulator drugs act as an adjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improving clinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitis were enrolled in a double-blind, placebo-controlled, double-masked randomised controlled trial. The control group was treated with SRP and a placebo, whereas the test group was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated for all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the control group were found to be statistically significant only after 3 weeks (P<0.001). In contrast, the decrease in the sulcus bleeding index and pocket depth scores was statistically highly significant in the test group as compared to the control group after 3 weeks and 6 weeks (P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in the test group as compared to the control group, were not found to be statistically significant after both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementation with herbal immunomodulatory agents may be a promising adjunct to SRP and may aid in improving periodontal treatment outcomes.

An Analysis of The Science Inquiry Items in Scholastic Ability Test for College (대학수학능력시험에서 과학탐구 영역의 분석)

  • Kim, Sang-Cheol;Kwon, Jae-Sool
    • Journal of The Korean Association For Science Education
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    • v.14 no.2
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    • pp.214-224
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    • 1994
  • The Ministry of Education established the plan to adopt a new college enterance examination system, so called Scholastic Ability Test for college, from 1994. The National Board of Educational Evaluation had carried out 7 experimental trials for the new examination system. Eventhough, the governmental officials advertised the purpose and characteristics of the new examination system, many students and parents did not understand the essential point very well. In this study the researcher tried to analyze the 7 trial examination items and the first Scholastic Ability Test for college carried out 1993. In this study, the researcher tried to find out all the items appeared in the 7 trials. In the analysis, all the individual items from the 1st trial to the 7th trial were used. The research results showed that the items were evenly distributed in all the four areas(Physics, Chemistry, Biology and Earth Science) of science content; however, they were heavily concentrated on data or information analysis categoris in the inquiry domain. In the domain of context, laboratory context was the major item context. The scores were also analyzed. The results showed that no significant difference between male and female students. However, science track students showed higher achievement scores than the non-science track student. The examination result showed high correlation with the tests routinely have carried out in schools. The over all analysis showed the new examination system showed very different characteristics to the conventional tests. Therefore, for the student to get successful result in the Scholastic Ability Test, they should change the way of study. They should try to understand scientific concepts rather than to memorize them. They should invest their time to carry out real experiments rather than to focus on the princples and laws of science. One of the most important thing would be for the student to apply what they learned to real life situations.

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Safety of Soshihotang Soft Extract after Single Oral Administration in Healthy Male Volunteers, Single Center Study (소시호탕연조엑스의 단회 경구투여 후 안전성 평가에 대한 단일기관 연구)

  • An, Sung-Hu;Park, Kyungtae;Yeom, Seung-Ryong;Kwon, Young-Dal;Cho, Hea-Young
    • Journal of Korean Medicine Rehabilitation
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    • v.30 no.2
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    • pp.153-164
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    • 2020
  • Objectives This study is designed to evaluate the safety of Soshihotang soft extract in healthy male volunteers. Methods 12 healthy male volunteers were recruited and this study was carried out by a single center. Laboratory test results, vital signs of the volunteers were collected to evaluate safety. According to registration order, the 12 subjects were allocated by serial number. To evaluate safety, blood samples were taken and vital signs were checked 4 times-screening, pre administration, post administration and follow up-during the whole trial. The incidence of all adverse effects are shown in percentage. The mean and standard deviation were used to to describe and summarize continuous data. To evalate the effectiveness of the intervention, data of blood tests was analyzed by Wilcoxon signed rank test or paired T-test (p<0.05). Results In the case of red blood cell, hemoglobin, hematocrit, neutrophils, protein, albumin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase values, the normality test result of the variable for the difference value before and after the dosing has a significance level <0.05. But most of values did not deviate from the normal range, and the deviation from the normal range could not be regarded as the significance associated with this clinical trial. And adverse event wasn't observed associated with the clinical trial drug. Conclusions Soshihotang soft extract were considered to be safe for healthy male volunteers.

The Research of Corelation between Sasang Constitution and Pattern Identification through Clinical Research of the Patients of Menstrual Pain (임상연구를 통한 월경통 환자의 사상체질, 변증간의 상관성 연구)

  • Kang, Seok-Hwan;Jeon, Soo-Hyung;Lee, In-Seon;Kim, Kyu-Kon;Na, Young-Ju;Kim, Jong-Won
    • Journal of Sasang Constitutional Medicine
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    • v.28 no.4
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    • pp.320-329
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    • 2016
  • Objective We researched to analyze correlation between menstrual pain and Korean medical diagnosis - Sasang constitution and Pattern Identification - through clinical research of the patients of menstrual pain. Method Trial gruop who consists of women with menstrual pain is 193 people, and control group who consists of women without menstrual pain is 101 people. We producted analyzing of their Sasang Constitution and symptom with Diagnosis System of Oriental Medicine(DSOM). This study used chi-square test, two sample t-test, analysis of variance, Wilcoxon's rank sum test, Kruskal-Wallis test, correlation analysis. Results 1) In trial and control group, Soeumin was the largest and Soyangin was the least. There was'nt statistical significance between trial and control group. 2) In DSOM, deficiency of blood, stagnation of qi, blood stasis, coolness, spleen, kidney and phlegm pathogenic factors showed significant difference. Conclusion There were significant corelation between menstrual pain and Korean mdical diagnosis - Sasang constitution and Pattern Identification.

A Study on the Impacts of Women with Age-related Obesity on Skin Resistance Variability(SRV) (여성의 연령에 따른 비만도가 피부저항변이도에 미치는 영향)

  • Kim, Hyeon-Ju;Jung, Hyuk-Sang;Sohn, Young-Joo
    • The Journal of Korean Obstetrics and Gynecology
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    • v.25 no.1
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    • pp.79-92
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    • 2012
  • Purpose: Obesity affects dysfunction of Hypothalamus-Pituitary-Ovary(H-P-O) axis. Dysfunction of H-P-O axis could be related to Skin Resistance Variability (SRV). This study investigated the impacts of obesity which related to female age on SRV. Methods: We randomly selected 400 women who had taken CP-6000A test and InBody test on the same day at Oriental Hospital of Sangji University from Jan. 2008 to Jun. 2011. In this study, the Body Mass Index(BMI) range of normal group is 18.5~24.9, obesity group is over 25, the age range of childbearing age group is 24~34 years, post-menopause group is 50~65 years. 139 women that met the criteria of this study were assorted by their BMI and age. After detection of SRV, SPSS 19.0 has conjugated for data analysis and the independent samples t-test and paired samples t-test were used to verify the results. Results: At 1st and 2nd trial, the height of 3 area of childbearing age obesity group was significantly higher than that of childbearing age normal group. At 1st and 2nd trial, the height of 1, 2 area of childbearing age obesity group was higher than that of childbearing age normal group, but there were no significant difference. At 1st and 2nd trial, the height of 1, 2, 3 area of post-menopause obesity group was mostly higher than that of post-menopause normal group, but there were no significant difference. Conclusions: This study showed the SRV of obesity group was higher than that of normal group in most of 1, 2, 3 area. Further study will be needed.

A Study on the Improvement of the Mast Design for Wind Detector (풍향풍속 검출기 마스트 설계 개선에 관한 연구)

  • Kim, Dong-Young;Park, Hae-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.5
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    • pp.98-107
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    • 2021
  • During the sea trial test for the aerovane in AOE-II, a malfunction occurred in the wind detector movement around 40 to 90° on the starboard side and around 270 to 320° on the port side. The purpose of this study was to analyze and improve the cause of the above phenomenon. The wind detector was covered with a mast structure and was not affected directly by the blowing wind, and a vortex air current was formed behind the mast structure, causing the motion malfunction. The above problem was solved by moving and installing the wind detector on the newly installed mast yard. After conducting vibration analysis and reviewing the effects of vibration, the wind detector was installed in the new mast yard and verified by a sea trial test. Since the improvement plan was slightly effective, the position of the wind detector moved away from the mast on the new mast yard and was re-verified through a sea trial test. The movement malfunction of the wind detector did not occur, confirming that it is an appropriate improvement plan.

A Test to Compare the Water Resistance Sun Protection Factor of General Water, Artificial Seawater, and Natural Seawater of Sunscreen (자외선 차단제의 일반 물, 인공 해수, 자연 해수의 내수성 차단지수를 비교하기 위한 시험)

  • Hyoung Hoon Hwang;Eun Young Kang;Su Yeong Kim;Hui Jeong Jung;Jun Seong Yang;Won Kyu Hong;Hong Suk Kim
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.49 no.4
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    • pp.349-354
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    • 2023
  • Sunscreen is a product that protects against ultraviolet rays by blocking and scattering ultraviolet rays, and has now become a daily necessity beyond cosmetics. Applying sunscreen is a common and easy way to prevent skin damage caused by ultraviolet rays. Due to its significance, the evaluation of sunscreen has evolved since its regulation by the FDA in 1978, progressing to standardized methods established by ISO. Additionally, to assess the loss of sunscreen due to activities such as water exposure or sweating, the Ministry of Food and Drug Safety in Korea and ISO have established protocols for evaluating the water-resistant sun protection factor (SPF). However, existing evaluations of water resistance have been mainly confined to test methods involving plain water, and methods accounting for the impact of seawater during activities like beach leisure, sports, and recreation are yet to be established. Based on the existing guidelines for testing the water-resistant UV protection index, this study compared the water-resistant UV protection index in water, artificial seawater (salt water) and natural seawater (sea water) to evaluate the UV protection index in real-world situations such as marine leisure, sports, and leisure activities. Through these results, we were able to compare the differences between water resistance sun protection index tests in ordinary water, artificial seawater, and natural seawater, and suggest a method for water resistance sun protection index tests using natural seawater.

Trial Construction of FRP-Concrete Composite Deck for Cable-Stayed Bridge (사장교용 FRP-콘크리트 합성바닥판의 시험시공)

  • Kim, Sung-Tae;Park, Sung-Yong;Cho, Keun-Hee;Cho, Jeong-Rae;Kim, Byung-Suk
    • Proceedings of the Korea Concrete Institute Conference
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    • 2010.05a
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    • pp.43-44
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    • 2010
  • We developed a new FRP-concrete composite deck applicable to a cable-stayed bridge, and applied to a trial bridge for test purpose. From this trial construction, we verified constructability and structural performances of this deck system.

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Trial Installation and Performance Evaluation of Prefabricated Concrete Slab Track on Revenue Line (프리캐스트 콘크리트 슬래브궤도의 영업선 시험시공 및 성능평가)

  • Jang, Seung-Yup;Kang, Yun-Suk;Lee, Hu-Sam;Kim, Yu-Bong;Lee, Jong-Soo
    • Proceedings of the KSR Conference
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    • 2008.11b
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    • pp.840-845
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    • 2008
  • To develop our original technology of concrete slab track, being widely accepted for new track, prefabricated concrete slab track, or precast concrete slab track has been developed. They have two different types according to slab shape and its dimensions, connection of slabs and connecting structure onto substructure. After the system design and successful performance evaluation in the laboratory, the trial installation on revenue line has been carried out. This paper is presenting the result of the trial installation and the performance tests in field. The performance tests have been performed as visual inspection for cracks and damages, measurement of track alignment and elastic behavior of track under passing trains. The performance test results during last 2 years have shown that no remarkable damages and settlements were found, and track alignment and elastic track behavior both exhibits good status.

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Traction System Characteristics of Railway Vehicle

  • Han, Young-Jae;Kim, Ki-Hwan;Seo, Sung-Il;Park, Chun-Su;Han, Seong-Ho;Kim, Young-Mo
    • 제어로봇시스템학회:학술대회논문집
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    • 2005.06a
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    • pp.1351-1354
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    • 2005
  • Recently, as the feasibility study shows that trans-Korea railway and trans-continental railway are advantageous, interest in high speed railway system is increasing. Because railway vehicle is environment-friendly and safe compared with airplane and ship, its market-sharing increases gradually. Korean High Speed Train has been developed by KRRI for last 7 years to satisfy the need. Korean High Speed Train (350km/h), composed of 2 power cars, 2 motorized car and 3 trailer cars, has been developed and is under trial test. To verify the design requirements for the functions and traction performances of the train, KRRI (Korea Railroad Research Institute) decided to evaluate traction performances of the train during trial test. For this purpose, torque, velocity, voltage and current must be measured. KRRI has developed a measurement system that can measure vast and various signals effectively. In this paper, we introduce traction performances of Korean High Speed Train. The traction measurement items are focused on the verification of motor block performances. Motor block consists of 2 motors. By this test, we verified traction performances of Korean High Speed Train

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