• 대한임상검사과학회지
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• 제44권3호
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• pp.124-127
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• 2012

Syphilis is an infectious and sexually transmitted chronic disease caused by Treponema pallidum. On the basis of clinical findings, the disease has been divided into a series of overlapping stages, which are used to help guide treatment and follow-up. Persons who have syphilis might seek treatment for signs or symptoms of primary infection, secondary infection and tertiary infection. Latent infections are detected by serologic testing. A presumptive diagnosis of syphilis is possible with the use of two types of serologic tests: nontreponemal tests and treponemal tests assay. The use of only one type of serologic test is insufficient for diagnosis, because each type of test has limitations, including the possibility of false-positive test results in persons without syphilis. KFDA published Koreans guideline of Sexually transmitted infections in 2011. Two hundred samples were tested by RPR card test and Mediace RPR test with simultaneously. The agreement between RPR card test and Mediace RPR test was 95%, the discrepant samples was 5%. The characteristics of 10 discrepant samples was RPR card Positive and Mediace RPR negative nine samples, RPR card negative and Mediace RPR positive one sample. The nine samples were confirmed as FTA-ABS by KFDA guideline of syphilis test algorism, all IgM test was Negative, all IgG test was reactive. So, these cases were past or latent syphilis. The one sample was false-positive reaction.

• Journal of Korean Neurosurgical Society
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• 제53권3호
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• pp.197-200
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• 2013

Diagnosis of cerebral syphilitic gumma is frequently determined at the time of surgery, because imaging and laboratory findings demonstrate the elusive results. A 59-year-old woman presenting dysarthria showed a mass on her brain computed tomography. She was first suspected of brain tumor, but histological results from surgical resection revealed cerebral gumma due to neurosyphilis. After operation, she presented fever and rash with an infiltration on a chest X-ray. Histological assessment of skin was consistent with syphilis. Fluorescent treponemal antibody absorbed test IgG in cerebrospinal fluid was positive. She was successfully treated with ceftriaxone for 14 days.

• 한국환경보건학회지
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• 제1권1호
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• pp.18-20
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• 1974

A Serological test for Syphilis by VDRL Slide tests were made to find the degree of treponemal infection. For this study sera were collected from 5, 312 Prostitutes of Seoul, Inchun, Euijungbu, Yangzoo, Pajoo and Pyungtaig from November 27, to December 7, 1972 and were examined on the following items. 1. VDRL Slide Qualitative test. 2. VDRL Slide Quantitative test. As the results of this study the following Conclusions were obtained. 1) This test were obtained average reactive 5.92% for 5, 312 prostitutes in Seoul 7.87% for 254 prostitutes, in Iuchun 6.77% for 354 prostitutes, in Euijungbu 6.62% for 740 prostitutes, in Yangjoo 5.82% for 1, 958 prostitutes, in Pajoo 6.08% for 937 prostitutes and in Pyungtaig 4.82% for 1, 069 prostitutes respectively 2) The highest Reagin titer was 1: 32 serum dilution.

• 대한임상검사과학회지
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• 제41권1호
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• pp.42-46
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• 2009

Unlike most bacteria, Treponema pallidum subspecies cannot be readily isolated or sustained in cell culture for numerous generations. In korea, two non treponemal tests are currently considered as standard; the VDRL slide test and RPR card test. These tests are based on an antigen composed of an alcoholic solution containing measured amount of cardiolipin, cholesterol, and sufficient purified lecithin to produce reactivity. The nontreponemal reagin tests measure immunoglobulin M (IgM) and IgG to lipoidal material released from damaged host cells as well as to lipoprotein-like material and possibly by cardiolipin released from the treponemes. The object of the evaluation was to evaluate the performance of the Mediace RPR kit on the automated biochemistry analyzer system as a method for screen method of syphilis as well as to identify BFP possibility. For evaluation of routine screening test, a total 2,380 specimens tested by Mediace RPR from 28th Oct, 2007 to 22th Feb, 2008. For evaluation of BFP possiblility, we measured samples which have potential BFP reaction in Syphilis test such as ANA (anti-nuclear antibody) positive (135 samples), CRP (C-reactive protein) positive (100 samples), RF (Rheumatoid factor) positive (26 samples), and other potential BFP cases (17 samples) including total 278 samples. These samples were tested quantitative test Mediace RPR with Hitachi 7600 P module. For comparison with current manual test, VDRL slide test were performed. Of these 2380 specimens, 2350 were negative, 30 were positive, and one were positive with TPHA. Both methods agreed for 2356 (98.9%) samples. Of the 30 samples showed positive results over 1.0 R.U, 6 samples showed positive results with VDRL test. Of these 6 samples, 1 samples showed positive with TPHA test. The combination of the Automated Biochemistry analyzer and VDRL test for retest can be increase efficiency of syphilis screening test.

• Pediatric Infection and Vaccine
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• 제29권3호
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• pp.161-165
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• 2022

We report a case of successful treatment of congenital syphilis in an extremely preterm baby. A 1,395 g female infant was born by emergency Caesarean section due to preterm labor and breech presentation at gestational age at 29 weeks and 3 days with an Apgar score of 2 and 4 at 1 minute and 5 minutes, respectively. The mother of the newborn, an illegal immigrant who did not receive any antenatal care, was diagnosed as active syphilis infection by reactive rapid plasma regain (RPR) (titer 1:128) just before the delivery. Upon birth, the newborn presented with various clinical manifestations, including severe respiratory distress syndrome, persistent pulmonary hypertension of the newborn, disseminated intravascular coagulopathy, desquamation and scaling of the whole body, and osteolytic changes of long bone ends. Results of laboratory tests showed signs of early congenital syphilis, including positive syphilis reagin test (12.7 R.U.), reactive with RPR titer of 1:64, and positive for immunoglobulin (Ig) M and IgG fluorescent treponemal antibody absorption test. However, after completion of penicillin G treatment for two weeks, laboratory results dramatically improved, showing a negative syphilis reagin test (0.5 R.U.) and non-reactive in RPR. In conclusion, the incidence of congenital syphilis is prone to be resurgent in South Korea, neonatologists should be fully aware of the clinical features of congenital syphilis because early diagnosis and prompt treatment are essential in order to reduce the social and economic burden due to congenital syphilis.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1976년도 제10차 학술대회연제 순서 및 초록
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• pp.85.3-86
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• 1976

돌발성난청은 만약청력이 구조될 가망이 있으면 즉각적인 검사와 치료가 필요하다. 이것은 이과적 비상사태이며 또 진단의 도전자이다. 감각신경성돌발성난청은 광범위한 종류의 병인으로 생길 수 있다. 종합적인 정밀검사를 곧 시행하여 치료를 지체없이 시작해야만 될 것이다. 감각신경성난청환자에 대해서 아무것도 할 것 없다는 관념은 버려야 되겠다. 돌발성난청을 일으키는 어떤 병인은 치료에 순응 않거나 또는 다만 일부만 정상회복이 가능하다. 그러나 그냥 두면 조금은 회복되거나 또는 스스로는 전연 회복되지 않고, 적절한 치료에는 반응하는 병인들도 있다. 이 병인들을 확인하여 그 처치에 대하며 전심 연구하는 것은 긴요하다. 연령 성별의 비율 및 병변의 편측 또는 양측성은 그 원인에 관련되며, 모은 환자군의 형에 의해서 다르다. 돌발성난청은 개별적으로는 드므나, 모이면 흔한데 외래신이과환자의 약 2.5%에 이르렀으며, 약 70%는 편측성이였다. virus, 세균 및 treponema 감염성은 약 30%였고, 약 16%는 cochlea의 혈관성병변에 의해서였다. 거의 22%는 원인불명(idiopathic)으로 이것은 청년층에서 주로 발생하였으며, 감각성이거나 신경성이였다. 12%는 외상성이고, 9%는 이중독성이였다. 기타가 11%였다. 이대중요요소는 병변의 부위와 청력장해의 기간인데 일찍 진단하여 치료하면 그만큼 치료반응이 좋다. 동시에 원인, 병리 및 치료에 대한 고찰을 더 하였다.