• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8405-8408
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• 2014

Background: This analysis was conducted to evaluate the efficacy and safety of temozolomide based chemotherapy in treating patients with glioma. Methods: Clinical studies evaluating the efficacy and safety of temozolomide based regimens for patients with glioma were identified using a predefined search strategy. Pooled response rates (RRs) were calculated. Results: In temozolomide based regimens, 5 clinical studies including 152 patients with advanced glioma were considered eligible for inclusion. Four clinical studies included temozolomide. Systematic analysis suggested that, in all patients, pooled CR was 21% (32/152), and PR was 21% (32/152). Grade 3/4 toxicity included neutropenia, thrombocytopenia, and anemia. No grade 3 or 4 renal or liver toxicity was observed. No treatment related death occurred with temozolomide based treatment. Conclusion: This systematic analysis suggests that temozolomide based regimens are associated with mild response rate and acceptable toxicity for treatment of glioma patients.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 춘계학술대회 논문집
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• pp.146-149
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• 2002

It is reported that the mechanical properties of vertebral trabecular bone depend on the density and the mass of bones. Osteoporosis is a systemic skeletal disease caused by low bone mass and microstructure deterioration of trabecular bone. Silva and Gibson (1997) studied the treatment of age-related bone loss using drug therapy. Vertebroplasty is a minimally invasive surgery for the treatment of osteoporosis vertebrae. This procedure includes puncturing vertebrae and filling with Polymethylmethacrylate (PMMA). However, the relative effect of drug therapy and bone cement for osteoporosis treatment is not reported yet. In this study, several 2D models of human vertebral trabecular bone are analyzed by finite element method. The mechanical behaviors of the vertebral trabecular bone treated by the drug therapy and the bone cement are compared. This study shows that bone cement treatment is more effective strategy than drug therapy to prevent the degradation of bone strength.

• Journal of Korean Neurosurgical Society
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• 제61권3호
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• pp.386-392
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• 2018

Radiation therapy is highly effective for the management of pediatric malignant central nervous system (CNS) tumors including embryonal tumors. With the increment of long-term survivors from malignant CNS tumors, the radiation-related toxicities have become a major concern and we need to improve the treatment strategies to reduce the late complications without compromising the treatment outcomes. One of such strategies is to reduce the radiation dose to craniospinal axis or radiation volume and to avoid or defer radiation therapy until after the age of three. Another strategy is using particle beam therapy such as proton beams instead of photon beams. Proton beams have distinct physiologic advantages over photon beams and greater precision in radiation delivery to the tumor while preserving the surrounding healthy tissues. In this review, I provide the treatment principles of pediatric CNS embryonal tumors and the strategic improvements of radiation therapy to reduce treatment-related late toxicities, and finally introduce the increasing availability of proton beam therapy for pediatric CNS embryonal tumors compared with photon beam therapy.

• Environmental Engineering Research
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• 제21권4호
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• pp.393-400
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• 2016

The aim of this study was to evaluate the biomass production and dairy wastewater treatment using Chlorella vulgaris. The results indicated that the maximum percentages of biochemical oxygen demand, chemical oxygen demand, suspended solids, total nitrogen, and total phosphorus removed were 85.61%, 80.62%, 29.10%, 85.47%, and 65.96%, respectively, in dairy effluent at 10 d. A maximum of 1.23 g/L dry biomass was obtained in 7 d. The biomass productivity was strongly influenced by the nutrient reduction in the dairy effluent. The biodiesel produced by the C. vulgaris in the dairy effluent was in good agreement with the American Society of Testing and Materials-D6751 and European Standards 14214 standards. Therefore, using dairy effluent for microalgal cultures could be a useful and practical strategy for an advanced, environmentally friendly treatment process.

• 대한장애인치과학회지
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• 제11권1호
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• pp.17-20
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• 2015

Autism is a life-long neurodevelopmental disorder characterized by qualitative abnormalities in reciprocal social interactions and patterns of communication. Patients with autism are difficult to manage during dental treatment. Thus they need special consideration like physical restraint, conscious sedation or general anesthesia. A 5-year-old male dental patient with autism was reffered to dental treatment under conscious sedation using intramuscular midazolam that creats anterograde amnesia. Dental procedure using midazolm which cause anterograde amnesia can be effective treatment strategy in autism patient.

• BMB Reports
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• 제51권11호
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• pp.545-546
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• 2018

With emerging evidence on the importance of non-cell autonomous toxicity in neurodegenerative diseases, therapeutic strategies targeting modulation of key immune cells. including microglia and Treg cells, have been designed for treatment of ALS and other neurodegenerative diseases. Strategy switching the patient's environment from a pro-inflammatory toxic to an anti-inflammatory, and neuroprotective condition, could be potential therapy for neurodegenerative diseases. Mesenchymal stem cells (MSCs) regulate innate and adaptive immune cells, through release of soluble factors such as $TGF-{\beta}$ and elevation of regulatory T cells (Tregs) and T helper-2 cells (Th2 cells), would play important roles, in the neuroprotective effect on motor neuronal cell death mechanisms in ALS. Single cycle of repeated intrathecal injections of BM-MSCs demonstrated a clinical benefit lasting at least 6 months, with safety, in ALS patients. Cytokine profiles of CSF provided evidence that BM-MSCs, have a role in switching from pro-inflammatory to anti-inflammatory conditions. Inverse correlation of $TGF-{\beta}1$ and MCP-1 levels, could be a potential biomarker to responsiveness. Thus, additional cycles of BM-MSC treatment are required, to confirm long-term efficacy and safety.

• 대한한의학회지
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• 제33권3호
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• pp.120-132
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• 2012

Objectives: This study aimed to analyze the current status of treatments and patients with interstitial cystitis, and then map out a strategy for development of generalized-treatments for interstitial cystitis in Traditional Korean Medicine. Methods: We selected research paper from various databases such as PubMed, Google, KStudy, KoreanTK, OIM, and KOMS. Also, to understand current tendencies of medical cost related with interstitial cystitis, we requested Health Insurance Review and Assessment Service clinical data from 2007 to 2011. Results: It was reported that treatment of interstitial cystitis using Traditional Korean Medicine was effective. However, patients of this usually visit a Western medical center rather than seek Traditional Korean Medicine. To take charge of clinical fields related with interstitial cystitis by Traditional Korean Medicine, we need more research and experiments of interstitial cystitis using Traditional Korean Medicine, and we must make a standardized protocol. Conclusions: Various studies related with interstitial cystitis using Traditional Korean Medicine will have to be undertaken. We expect that Traditional Korean Medicine will play a role in treatment of interstitial cystitis.

• 대한치과의사협회지
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• 제53권1호
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• pp.14-27
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• 2015

BMPs are multi-functional growth factors which are members of the transforming growth factor-beta super family and their ability is that plays a pivotal roll in inducing bone. About 18 BMP family members have been identified and characterized. Among of them, BMP-2 and BMP-7 have significant importance in bone development. In this case reports, patients of maxillary sinus graft were received who visited LivingWell Dental Hospital. We focused on the results of the surgical intervention. We suggest that new strategy of treatment used to rhBMP-2 and ${\beta}$-TCP scaffold for patients of sinus graft. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on rhBMP-2 and synthetic bone scaffold.

• 대한의생명과학회지
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• 제16권2호
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• pp.113-118
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• 2010

The purpose of this study was to investigate the effects of angular velocity on muscle strength and blood constituent. Subjects was classified into two groups, which were $60^{\circ}/sec$ angular velocity group (n=8), and $240^{\circ}/sec$ angular velocity group (n=8). Each group was applied to perform the isokinetic exercises on extensor muscle group for each 7 times in 10 set (3 days per a week for 3 weeks). Muscle strength was measured using peak torque of quadriceps femoris and blood constituent was measured using RBC, WBC and Hb. The peak torque was more significantly increased after 3 weeks application of $60^{\circ}/sec$ angular velocity group than $240^{\circ}/sec$ angular velocity group. The RBC and Hb were more significantly increased after 3 weeks application of $60^{\circ}/sec$ angular velocity group than $240^{\circ}/sec$ angular velocity group. But WBC was more significantly increased after 3 weeks application of $240^{\circ}/sec$ angular velocity group than $60^{\circ}/sec$ angular velocity group. These results indicate that $60^{\circ}/sec$ angular velocity isokinetic exercise application were effective treatment strategy on increase of muscle strength. But $240^{\circ}/sec$ angular velocity isokinetic exercise application were effective treatment strategy on immune protect system.

• 한국분무공학회지
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• 제16권3호
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• pp.134-139
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• 2011

Recent research has focused on engine combustion technology as well as application of after-treatment in order to comply with emission regulation. However, it is much more efficient way to control emissions from engine itself and furthermore research on engine control will provide the direction of after-treatment technology in future. Furthermore, emission standard regulation for passenger diesel vehicles has been stringent compared to others and nano-particles will be included in EURO6 regulation in Europe and similar emission standard will be introduced in Korea. A 3.0 liter high speed diesel engine equipped with by CRDI system of 160MPa injection pressure, and an intake/exhaust system of V type 6 cylinder turbo-intercooler was applied. The injection duration and injection quantity, pilot injection types which are related to CRDI and air/fuel ratio control applied by EVGT were changed simultaneously. Standard experiment procedure constituted dilution apparatus and CPC system to collect nano-particles and these test results were compared with regulated materials of CO, HC, NOx and investigated their relations and characteristics of nano-particles.