• 대한조현병학회지
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• 제24권1호
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• pp.36-43
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• 2021

Objectives: Despite the high discontinuation rate of clozapine in refractory schizophrenia, there is limited evidence regarding the suggested treatment after clozapine discontinuation. Methods: The medical records of 37 patients who discontinued clozapine were retrospectively reviewed. The prescription patterns of antipsychotics, mood stabilizers, and antidepressants were compared at three points before and after clozapine treatment and at the most recent visit. Results: After clozapine discontinuation, 75.6% of the subjects were receiving antipsychotic polypharmacy, and 32.4% were taking more than 3 antipsychotics. The frequently used antipsychotics were olanzapine (21.5%), quetiapine (21.5%), and paliperidone (12.7%). The rates of augmentation with mood stabilizers and antidepressants were 43.2% and 29.7%, respectively. Furthermore, valproate was the most commonly used mood stabilizer (87.5%). Conclusion: Antipsychotic polypharmacy and augmentation are inevitable in schizophrenia patients for whom clozapine has been discontinued. Further research is required to improve the outcomes of polypharmacy and augmentation in schizophrenia patients.

• 열처리공학회지
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• 제36권6호
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• pp.412-421
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• 2023

As the demand for mechatronic systems and high performance increases in the machinery industry, the importance of improving friction characteristics is emphasized. During relative movement of objects, friction and wear occur on two surfaces in contact, and various methods are being designed to increase the lifespan and energy efficiency of machines. The energy increase effect using lubricants is a well-known method. In this study, a micro-sized rectangular grid pattern was produced by applying a precise micro-pattern photo lithography process. Rectangular grid patterns of the same shape and friction behavior according to the size of the pattern were produced in convex and concave shapes, and the tribological characteristics of each were analyzed.

• 대한유전성대사질환학회지
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• 제23권2호
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• pp.21-30
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• 2023

Inherited metabolic disorders (IMD) are a group of disorders caused by defects in specific biochemical pathways. Up to 85% of IMD display predominantly neurological manifestations by affecting neurodevelopment or causing neurodegeneration. These neurometabolic disorders present with a variety of neurological and non-neurological manifestations. Early diagnosis of IMD is important because some disorders can be treated or improved with specific treatment if detected early. For prompt diagnosis and treatment, it is important to suspect IMD by being familiar with the clinical characteristics, biochemical abnormalities, and characteristic neuroimaging patterns that appear in IMD. Genetic testing, including next-generation sequencing, is also important in diagnosing IMD. During the follow-up of patients with IMD, it is necessary to conduct regular physical and neurological examinations in addition to disease-specific management.

• 한국비블리아학회지
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• 제9권1호
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• pp.153-179
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• 1998

이 논문의 연구목적은 공공도서관의 한정된 자원에서 늘어나는 수요를 수용하기 위하여 도서관의 운영방안을 개선하여 효율성을 제고하는 것이다. 이는 도서관을 직접이용할 수 없는 이용자들에게 유사분관도서관인 순회문고제도를 운영함으로써 공공도서관의 효율성 제고와 아울러 소외계층에 대한 적극적인 서비스를 할 수가 있다. 서울 소재 19개 공공도서관의 순회문고 담당자와 이용자들에게 각각 설문조사, 전화조사와 직접방문조사를 통하여 수집한 자료를 분석, 정리한 결과는 다음과 같다. 첫째. 공공도서관이 봉사대상기관에 대한 순회문고 대출기간은 ‘1개월’이 가장 적절한 것으로 나타났다. 둘째. 공공도서관이 순회문고의 1회 대출시의 대출권수는 ‘100권 이상~200권 미만’이 가장 높게 나타났다. 셋째, 순회문고 희망도서신청제도는 공공도서관의 순회문고 장서구성에 많은 도움이 되어 순회문고활성화에 영향을 미치는 것으로 나타났다. 넷째. 순회문고 장서구성은 소설류, 교양도서, 수필집 등이 높게 나타났으나. 순회문고 이용자는 소설류, 교양도서 뿐만 아니라 전문도서. 잡지류의 자료구성을 높일 것을 희망하고 있는 것으로 나타났다. 다섯째. 순회문고의 비치장소는 순회문고 이용의 활성화를 위하여 전문적인 자료봉사부서인 도서실에서 전담하는 것이 효율적인 것으로 나타났다. 여섯째, 공공도서관에서 순회문과 대출지역을 관할구역내로 한정로 것이 순회문고의 효율성을 높일 수 있다. 일곱째. 분실자료에 대한 자연감소처리에 대한 적절한 기준을 마련하는 것이 순회문고 활성화에 영향이 있는 것을 알 수 있다. 여덟째. 순회문고제도의 저해요인으로는 공공도서관의 인력부족, 도서분실, 이용자의 소극적 태도 순으로 나타났다. 아흡째. 순회무고제도의 활성화 요인으로써 최고관리자의 적극성과 전문성, 예산배정의 적정성, 기탁금제도의 활성화등이 주요한 요인으로 작용하고 있음을 알 수 있다. 열번째, 자료분실에 대한 자연감소율은 대출도서의 0.5-0.6%를 도서관규정에 정하여 처리할 수 있게 함으로써 순회문고 제도를 시행하는 양당사자들의 적극적 참여를 유도하여 순회문고를 활성화하여야 한다.

• 한국환경과학회지
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• 제17권10호
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• pp.1129-1137
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• 2008

We investigated the ecological characteristics of reed populations growing in Korea and tried to select reed populations showing better growth patterns in waste landfill leachate. To examine the growth characteristics, 14 reed populations from various habitats were collected. Four reed populations were from inland reclaimed habitats, 4 reed populations from brackish or salt marsh habitats, and 6 reed populations from fresh water habitats. Total plant biomass after the treatment with landfill leachate showed that Daebudo and Nanjido reed populations had the higher biomass with 3755 g DW/pot and 3305 g DW/pot, respectively. Reed populations being sampled from the higher salinity and landfill habitats had relatively higher total biomass than that of other reed populations. Especially reed populations from landfill habitats showed higher biomass. Reed populations from Songjiho and Daebudo, which were believed to have tolerance to salt stress, also showed good growth patterns. Population from the fresh water habitats exhibited relatively lower tolerance to leachate treatment compared to others. From the results, we could conclude that reed populations from Nanjido and Daebudo with higher biomass and better salt tolerance were able to good candidates for purification of waste landfill leachate.

• 한국토양비료학회지
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• 제49권1호
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• pp.44-52
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• 2016

Plants response to phosphate starvation include the changes of activity of some enzymes, such as phosphatases, fructose-1,6-bisphosphatase, sucrose-phosphate synthase and nitrate reductase. In this study, to determine the effects of phosphate starvation on the change of activities of acid and alkaline phosphatase, fructose-1,6-bisphosphatase, sucrose-phosphate synthase, and nitrate reductase were studied in melon seedlings (Cucumis melo L.). The content of the protein and chlorophyll tended to relatively reduced in melon seedlings subjected to phosphate starvation. Acid phosphatase activity in first and second leaves of melon seedlings was relatively higher than that of third and fourth leaves of seedlings in 14 days after phosphate starvation treatment, respectively. Active native-PAGE band patterns of acid phosphatase in melon leaves showed similar to activities of acid phosphatase, whereas alkaline phosphatase activity was different from the change in the activity of acid phosphatase. Inorganic phosphate content in melon seedlings leaves was constant. The changes of Fructose-1,6-bisphosphatase and sucrose phosphate synthase activities showed similar patterns in melon seedlings leaves, and between these enzymes activities and phosphate nutrition negatively related. Fructose-1,6- bisphosphatase and sucrose phosphate synthase activities showed significant difference in second and fourth leaves, but nitrate reductase showed significant difference in first and second leaves in 14days after phosphate starvation treatment. We concluded that phosphate nutrition could affect the distribution of phosphate, carbon and nitrogen in melon seedlings.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
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• pp.79-79
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• 2003

Embryonic stem cells are capable of differentiating into a variety of cell lineages. However, the ultimate results of differentiation in vitro greatly depend on the duration of treatment and kinds of differentiating inducers added. In order to investigate the efficiencies of various differentiation inducers and the methods of treatment, we examined differentiation patterns of human embryonic stem cell (hESC, MB03) according to several different protocols. Exp. I) Upon differentiation using retinoic acid and ascorbic acid (RA/AA), embryoid bodies (EB, for 4days) derived from hESC was exposed to Rh (10$^{-6}$ M) and AA (50 mM) for 4 days, and were allowed to differentiate in N2 medium for 7, 14, 21, or 28 days. Exp. II) When bFGF was used, neuronal precursor cells were selected for 8 days in N2 medium after EB formation. After selection, cells were expanded at the presence of bFGF (20 ng/ml) for another 6 days followed by a final differentiation in N2 medium for 7, 14, 21 or 28 days. Exp. III) In addition, to examine the effects of neurotrophic factors in the production of mature neurons, groups of cells were exposed to either BDNF (5 ng/ml) or TGF-$\alpha$(10 ng/ml) during the 28 days of final differentiation. Differentiation patterns of RA/AA or bFGF treated groups were very similar; approximately 82% and 83% of the cells, respectively, were positive for anti-NF200 antibody, while it was about 10% and 11%, respectively, for anti-NF160 antibody in 28 days in N2 medium. Alsor, cells expressing TH were as low as 5%, while the cells doubled when matured at the presence of either BDNF or TGF-$\alpha$. Cells immunoreactive to anti-GAD antibody were approximately 20%. These results suggest that a maturation step rather than differentiation induction step, which is formation of EB, effects more decisively to the ultimate differentiation pattern.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2639-2642
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• 2012

Background: The patterns of gastric cancer recurrence vary across societies. We designed the current study in an attempt to evaluate and reveal the outbreak of the recurrence patterns of gastric cancer and also prediction of time to recurrence and its effected factors in Iran. Materials and Methods: This research was performed from March 2003 to February 2007. Demographic characteristics, clinical and pathological diagnosis and classification including pathologic stage, tumor grade, tumor site and tumor size in of patients with GC recurrent were collected from patients' data files. To evaluate of factors affected on the relapse of the GC patients, gender, age at diagnosis, treatment type and Hgb were included in the research. Data were analyzed using Kaplan-Meier and logistic regression models. Results: After treatment, 82 patients suffered recurrence, 42, 33 and 17 by the ends of first, second and third years. The mean ( SD) and median ( IQR) time to recurrence in patients with GC were 25.5 (20.6-30.1) and 21.5 (15.6-27.1) months, respectively. The results of multivariate analysis logistic regression showed that only pathologic stage, tumor grade and tumor site significantly affected the recurrence. Conclusions: We found that pathologic stage, tumor grade and tumor site significantly affect on the recurrence of GC which has a high positive prognostic value and might be functional for better follow-up and selecting the patients at risk. We also showed time to recurrence to be an important factor for follow-up of patients.

• 한국임상약학회지
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• 제30권2호
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• pp.102-112
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• 2020

Objective: To analyze the prescription patterns for the treatment of ulcerative colitis (UC) and to investigate factors co-occurring with systemic corticosteroid use. Methods: We used patient-level data from Korean National Health Insurance claims database to identify patients diagnosed with UC (ICD-10 code : K51) and their medications prescribed for UC between January 1 and Decemeber 31, 2017. We found that medications for UC treatment were 5-aminosalicylic acid (5-ASA), immunomodulators, biologics, and corticosteroids. We presented the prescription pattern according to the sex, age group, type of health insurance, site of UC, type of medical institution, and concomitant medication. To evaluate factors associated with prescription of systemic corticosteroids for UC, we used a multivariate logistic regression model to estimate adjusted odds ratios (aORs) and their 95% confidence intervals (CIs). Results: Of 1,469 UC patients, 74.5% used 5-ASA and 15.2% used systemic corticosteroids. 5-ASA constituted 77.5% of all prescriptions and systemic corticosteroids accounted for 13.1%. The most widely used therapy was 5-ASA monotherapy (54.8%), followed by a double therapy with 5-ASA and immunomodulators (8.2%) or 5-ASA and systemic corticosteroids (7.2%). Systemic corticosteroids were more likely to be prescribed with immunomodulators (aOR=1.88, 95% CI=1.54-2.28) and biologics (aOR=2.82, 95% CI=2.28-3.50) than without them. Conclusions: We found that 15.2% of UC patients were prescribed with a systemic corticosteroid, which is less than reported previously. Systemic corticosteroids were more likely to be prescribed with immunomodulators and biologics.

• 근관절건강학회지
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• 제23권3호
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• pp.187-196
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• 2016

Purpose: The purpose of this study was to investigate the perception and utilization patterns of complementary and alternative medicines (CAM) in patients with fibromyalgia syndrome. Methods: A total of 92 fibromyalgia syndrome patients participated in this study. Data were collected using a structured questionnaire and were analyzed with SPSS/WIN 23.0 program. Results: As a result, 59.8% of subjects had an experience of CAM and 33.7% of subjects have used until now. There were significant differences of the use of CAM between the group of CAM users and non-CAM users by education ($x^2$=4.04, p=.044), period of illness ($x^2$=15.03, p=.001), and period of treatment ($x^2$=12.10, p=.002). Relatively large numbers of patients understanded as that CAM was effective (58.7%) and fibromyalgia syndrome was controllable (75.0%). Moreover, there were significant differences of the use of CAM by the perception of CAM effects ($x^2$=4.15, p=.042), fibromyalgia syndrome ($x^2$=6.55, p=.038), and best treatment for fibromyalgia ($x^2$=11.03, p=.001). Conclusion: These results could be utilized as a basic data for developing nursing intervention for fibromyalgia syndrome.