• 제목/요약/키워드: treatment data

검색결과 11,273건 처리시간 0.05초

일 대학병원에서 외상 후 스트레스장애 입원환자의 약물 치료 경향 (A Trend in Pharmacotherapy for Inpatients with Posttraumatic Stress Disorder at a Single University Hospital)

  • 민정아;정영은;서호준;박원명;전태연;채정호
    • 대한불안의학회지
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    • 제4권1호
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    • pp.42-48
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    • 2008
  • 현재 PTSD와 관련한 여러 병태생리 기전들이 밝혀지고 있으며 이에 초점을 둔 다양한 약물치료가 행해지고 있다. 본 연구에서는 일 대학병원에서 PTSD로 진단된 환자들의 의무기록을 검토하여 약물치료의 경향에 대해 알아보았다.1998년 1월부터 2007년 12월까지 DSM-IV에 의해 PTSD로 진단된 입원 환자 75명이 대상군이 되었으며, 이들의 인구학적 요인들, 입원기간, 외상의 종류, 외상 후 경과시간 및 정신과적 공존병리 및 처방 받은 약물을 조사하였다. 조사 결과, 75명 중 남자는 33명, 여자는 42명이었다. 정신과적 공존병리는 총 50명(66.7%)에서 존재하였으며, 우울장애, 인지장애, 정신장애 및 불안장애 순이었다.73명(97%)의 대상군은 항우울제를 처방 받았으며, 그 중 paroxetine이 54.7%로 가장 많았고 두 가지 이상의 항우울제를 처방 받은 경우도 24%였다. 또 거의 대부분의 환자에서 비정형 항정신병약물(33.3%), 기분안정제(17.3%),항불안제(94.7%)가 항우울제와 병용 처방된 것으로 조사되었다. 여러 제한점에도 불구하고 본 연구에서 얻어진 약물 처방 경향은 향후 국내 실정에 맞는 치료 지침을 수립하는 데에 하나의 근거 자료가 될 수 있을 것이다.

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Breast Lymphoma Treatment Outcomes in a Pakistani Population: 20 Years of Experience at a Single Center

  • Bano, Razia;Zafar, Waleed;Khan, Amina Iqbal;Fiaz, Sohaib Adil;Abid, Mahwish;Chaudhary, Mohammad Zulqarnain;Siddique, Neelam;Khan, Huma Majeed
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권7호
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    • pp.3631-3635
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    • 2016
  • Background: Breast lymphomas constitute a rare disease entity. To date, limited relevant data have been reported. We therefore here present a review of breast lymphoma patients treated at a single center over a 20 year period, focusing on histological types, treatment modalities and outcomes. Materials and Methods: We identified patients who were diagnosed and treated for breast lymphoma at a single center from January 1995 to January 2014 and extracted data regarding patients' demographics and clinical data. Results: Twenty-seven patients with breast lymphoma were identified, of which 3 were males. The median age at diagnosis was 37 years (range: 22-76 years). Chemotherapy was the main stay of treatment and 55.6% patients also received radiation to the affected breast. At our institute, only 3 patients, all with progressive disease, had surgery performed to achieve local palliation. Complete response after chemotherapy was seen in 63% patients and partial response in 7.4%, while 26% patients demonstrated disease progression. The mean follow up was 46.8 months. Seven patients (33.3%) who were alive at last follow up, as well as 1 patient who died, survived more than 5 years after diagnosis. Conclusions: Patients with breast lymphoma should receive aggressive treatment, with combination of chemotherapy and radiation therapy. Surgery should be limited for diagnosis and palliation of local symptoms in cases of progressive disease.

Daily influent variation for dynamic modeling of wastewater treatment plants

  • Dzubur, Alma;Serdarevic, Amra
    • Coupled systems mechanics
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    • 제9권2호
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    • pp.111-123
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    • 2020
  • Wastewater treatment plants (WWTPs) with activated sludge system are widely used throughout the most common technologies in the world. Most treatment plants require optimization of certain treatment processes using dynamic modeling. A lot of examples of dynamic simulations require reliable data base of diurnal variation of the inflow and typical concentrations of parameters such as Chemical Oxygen Demand (COD), Total Kjeldahl Nitrogen (TKN), etc. Such detailed data are not available, which leads to problemsin the application of dynamic simulations. In many examples of plants, continuous flow measurements are only performed after the primary clarifier, whereas measurements from influent to the plant are missing, as is the case with the examples in this paper. In some cases, a simpler, faster and cheaper way can be applied to determine influent variations, such as the "HSG-Sim" method ("Hochschulgruppe Simulation"). "Hochschulgruppe Simulation" is a group of researchers from Germany, Austria, Switzerland, Luxembourg, Netherlands and Poland (see http://www.hsgsim.org). This paper presents a model for generating daily variations of inflow and concentration of municipal wastewater quality parameters, applied to several existing WWTPs in Bosnia and Herzegovina (B&H). The main goal of the applied method is to generate realistic influent data of the existing plants in B&H, in terms of flow and quality, without any prior comprehensive survey and measurements at the site. The examples of plants show the influence of overflow facilities on the dynamics of input flow and quality of wastewater, and a strong influence of the problems of the sewerage systems.

이산화염소수 처리에 의한 주요 식중독균의 불활성화에 관한 두 kinetic models의 비교 (Evaluation of Two Kinetic Models on the Inactivation of Major Foodborne Pathogens by Aqueous Chlorine Dioxide Treatment)

  • 이지혜;송현정;송경빈
    • 한국식품저장유통학회지
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    • 제18권3호
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    • pp.423-428
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    • 2011
  • 주요 식중독균인 E. coli O157:H7, L monocytogenes, S. aureus, S. Typhimurium과 S. Enteritidis를 주어진 이산화염소수 농도에서 시간별로 처리한 inactivation data를 first-order kinetic model과 Weibull model을 이용하여 kinetic parameter를 비교, 분석하였다. 그 결과 Weibull model이 first-order kinetic model보다 inactivation kinetic data에 더 적합한 것을 보였다. 또한 특정 농도의 이산화염소수에서 처리한 survival plot의 tR values(특정 이산화염소수 농도에서 미생물 90%를 감소시키기 위해 필요한 시간)는 Weibull model을 적용 시, E. coli O157:H7가 5 ppm에서 2.49 min, L. monocytogenes가 5 ppm에서 1.47 min, S. aureus가 5 ppm에서 0.94 min, S. Typhimurium이 1 ppm에서 0.87 min 그리고 S. Enteritidis가 1 ppm에서 0.08 min으로 측정 되었다.

갱년기 변증 진단 도구 CaPSPI(Diagnostic System for Climacteric and Postmenopausal Syndrome Pattern Identification) 임상적용 결과 분석 연구 (Study on the Data Analysis of CaPSPI for clinical application, a Diagnostic System for Climacteric and Postmenopausal Syndrome Pattern Identification)

  • 박영희;이인선
    • 대한한방부인과학회지
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    • 제34권4호
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    • pp.78-96
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    • 2021
  • Objectives: It is a statistical study to examine the data of CaPSPI (Diagnostic System for Climacteric and Postmenopausal Syndrome Pattern Identification), developed for diagnosis of menopause disorders and to record the status of treatment of it. Methods: From November 1, 2020 to June 19, 2021, 36 cases of data of 33 respondents of the CaPSPI were analyzed. For the use of the basic data of the clinical menopausal disorder, we investigated frequency of menopausal symptoms and the difference between them depending on the period of menopause, and the presentation of usage prescriptions. And the diagnostic results for three kinds' diagnosis [for examination (D1), for treatment (D2), by doctors (D3)] were compared. The diagnostic consistency of D1 and D3 and the statistical significance between DT and disease elements (證素) was investigated. Results: 1. Hot flush was the highest in the symptom survey of the menopause that the subjects complained of, followed by insomnia. There was no significant difference in symptom expression according to menopausal period. 2. The diagnostic consistency of D1 and D2 showed significant diagnostic consistency only in liver depression, and the diagnostic consistency of D1 and D3 showed significant consistency in liver depression and Dual Deficiency of Heart and Spleen. 3. D3' diagnosis and disease elements had statistical significance for cases of P<0.1 was found to be related to the theory of oriental medicine. Conclusions: It is needed to continue to accumulate diagnosis and treatment results through CaPSPI in the future to strengthen the basis for patten identification and treatment of menopause disorders.

Endovascular Treatment of Congenital Portosystemic Shunt: A Single-Center Prospective Study

  • Ponce-Dorrego, Maria-Dolores;Hernandez-Cabrero, Teresa;Garzon-Moll, Gonzalo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제25권2호
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    • pp.147-162
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    • 2022
  • Purpose: To design a prospective study on endovascular closure of congenital portosystemic shunts. The primary endpoint was to assess the safety of endovascular closure. The secondary endpoint was to evaluate the clinical, analytical and imaging outcomes of treatment. Methods: Fifteen patients (age range: 2 days to 21 years; 10 male) were referred to our center due to congenital portosystemic shunts. The following data were collected prior to treatment: age, sex, medical history, clinical and analytical data, urine trimethylaminuria, abdominal-US, and body-CT. The following data were collected at the time of intervention: anatomical and hemodynamic characteristics of the shunts, device used, and closure success. The following data were collected at various post-intervention time points: during hospital stay (to confirm shunt closure and detect complications) and at one year after (for clinical, analytical, and imaging purposes). Results: The treatment was successful in 12 participants, migration of the device was observed in two, while acute splanchnic thrombosis was observed in one. Off-label devices were used in attempting to close the side-to-side shunts, and success was achieved using Amplatzer™ Ductus-Occluder and Amplatzer™ Muscular-Vascular-Septal-Defect-Occluder. The main changes were: increased prothrombin activity (p=0.043); decreased AST, ALT, GGT, and bilirubin (p=0.007, p=0.056, p=0.036, p=0.013); thrombocytopenia resolution (p=0.131); expansion of portal veins (p=0.005); normalization of Doppler portal flow (100%); regression of liver nodules (p=0.001); ammonia normalization (p=0.003); and disappearance of trimethylaminuria (p=0.285). Conclusion: Endovascular closure is effective. Our results support the indication of endovascular closure for side-to-side shunts and for cases of congenital absence of portal vein.

행동조절장애 환자에서 치과치료를 위한 외래마취의 분석 (The Analysis of Outpatient Anesthesia for Dental Treatment in Handicapped Patients with Behavior Disorder)

  • 반민희;정성수
    • 대한치과마취과학회지
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    • 제14권1호
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    • pp.57-62
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    • 2014
  • Background: The aim of this study was to analyze outpatient anesthesia for dental treatment in handicapped patients with behavior disorder in order to use data for carrying out better and safe anesthetic management. Methods: The data were drawn from the 100 patients with behavior disorder who visited CNUDH dental clinic for disabled based on anesthesia record to investigate patient's systemic condition, cooperative level, anesthesia method according to patients cooperation, and side effects after recovery time. Results: Mental retardation (58%) is the most reason to choose general anesthesia. The methods of induction according to cooperative level are intravenous propofol injection in 22 cases and inhalation of sevoflurane in 78 cases. Induction time of anesthesia were within 10 seconds in cases of propofol induction and average $48.8{\pm}18.5$ seconds in cases of inhalation induction. The time spent on dental treatment was average $3.2{\pm}1.1$ hours. After the end of treatment, average time to move from unit chair to recovery bed, to recliner, and to discharge from hospital are $10.4{\pm}5.1$, $36.9{\pm}17.1$ and $72.4{\pm}16.0$ minutes, respectively. During recovery, there are nausea with 9%, vomiting with 4%, dizziness with 2%, finger injury with 1%. Conclusions: This study showed our successful anesthetic outcomes without any severe side effects or complications. Through this study, it will be used for safe anesthetic management as useful reference data.

Causes of Delay in Seeking Treatment in Patients with Breast Cancer in Iran: a Qualitative Content Analysis Study

  • Rastad, Hadis;Khanjani, Narges;Khandani, Behjat Kalantari
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권9호
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    • pp.4511-4515
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    • 2012
  • Background: In the Middle East, including Iran, breast cancer is the most frequent malignancy among women. Without treatment, a malignant breast tumor advances in stage, diminishing a woman's chances of survival. In this study we aimed to gain insight into the causes of delay in seeking treatment in patients with breast cancer. Methods: The participants in this qualitative, content analysis study were 10 women in whom a diagnosis of breast cancer in the stages of II b, III or IIV had been made. They were selected from patients of a major oncology clinic in Kerman, Iran. Data were collected by means of semi-structured interviews that lasted between 20 to 30 minutes. Sampling was discontinued when data saturation was achieved. Content analysis was conducted by classifying the data into themes and sub-themes. Results: The results of our study revealed several factors that interfered with patients' professional consultation seeking and prompt treatment. These factors included; lack of knowledge, fear of being diagnosed with cancer, not seeing oneself at risk, mental preoccupation and wrong diagnosis by physicians. Conclusions: This study suggests that women and even physicians need further information about breast cancer symptoms. Women need encouragement to seek medical advice when they encounter suspicious symptoms. Additionally, women may benefit from awareness of the pros of early detection and reassurance about the improvements in the success of breast cancer treatment.

전정 중심의 감각통합치료가 발달장애아동의 안구진탕, 시지각, 균형능력에 미치는 영향 (Effects of Vestibule-Oriented Sensory Integration Treatment on the Nystagmus, Visual Perception and Balancing Ability of Children with Developmental Disability)

  • 김현호;황보각;유병국;김명권
    • 한국콘텐츠학회논문지
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    • 제11권4호
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    • pp.290-302
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    • 2011
  • 이번 연구의 목적은 전정 중심의 감각통합치료가 발달장애아동의 안구진탕, 시지각, 균형능력에 미치는영향을 알아보기 위해서이다. 발달장애를 가진 23명의 아동이 이번 실험에 참여하였다. 대상은 12주동안 Ayres의 감각통합이론에 바탕을 둔 전정중심의 감각통합치료를 받았다. 치료 효과는 SCPNT, DTVP-2, P-CTSIB, SCSIT등과 BOT의 일부 평가항목을 사용하였다. 수집된 데이터는 Wilcoxon test를 사용하여 분석되었다. 연구결과는 회전후 안구진탕 측정에서 유의한 증가를 보였다. 시지각과 균형능력의 측정결과에서도 유의한 증가를 나타내었다. 따라서 전정중심의 감각통합치료가 발달장애를 가진 아동에서 안진, 시지각, 균형능력의 증진에 효과적이었다.

포공영(蒲公英) 분획(分劃)의 간암세포(肝癌細胞)에 대(對)한 항암활성(抗癌活性)과 항암제(抗癌劑)와의 병용투여효과(倂用投與效果)

  • 김동희;김성훈
    • 대한한의학회지
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    • 제16권2호
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    • pp.386-413
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    • 1995
  • In order to prove the antitumor effect of Taraxaci Herba experimentally, studies were done. The antitumor effect against hepatic cancers such as Hep G2. Hep 3B & PLC and also the synergstric action was evaluated in the combined treatment with anticancer drugs using chiefly for liver cancer. such as. The results were obtained as follows: 1.$IC_{50}$ against Hep G2. Hep 3B and PLC was $15.5{\mu}g/ml.\;25.4{\mu}g/ml,\;31.25{\mu}g/ml$ in Mitomycin C(MMC), $92.5{mu}g/ml,\;50.2{\mu}g/ml,\;62.5{\mu}g/ml $in cisplatin(CPT) and 125 in 5-flurouracil(5-FU) respectively. 2. In cytotoxic effect against Hep G2 every fractions showed the anti tumor effect as compared with the data of control but EE fraction of Taraxaci Herba was most effective and also hexane fraction was most effective in the combined treatment with anticancer drugs. 3. In cytotoxic effect against Hep 3B every fractions showed the antitumor effect as compared with the data of control but EE fraction of Taraxaci Herba was most effective and also hexane fraction was most effective in the combined treatment with anticancer drugs. 4. In cytotoxic effect against PLC every fractions showed the anti tumor effect in the concentrations of $10^{-5}g/ml$ above as compared with the data of control and also the combined treatment with MMC was most effective. 5. Fractions of Taraxaci Herba showed the most antitumor effect against Hep 3B and also the combined treatment with MMC was most effective. From the above result it was concluded that ethyl ether fraction of Taraxaci Herba was most effective fraction, every fraction showed more antitumor effect against Hep 3B and Hep G2 than PLC.

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