• Herbal Formula Science
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• v.27 no.4
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• pp.237-244
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• 2019

Objectives : The purpose of this study was to investigate the effects of Carthami flos on pacemaker potentials of small intestinal and colonic Interstitial Cells of Cajal (ICC). Methods : To dissociate the ICC, we used enzymatic digestions from the small intestine and colon in mice. In the ICC, the electrophysiological whole-cell patch-clamp configuration was used to record pacemaker potentials in the cultured ICC. Results : 1. The ICC generated pacemaker potentials in the murine small intestine and colon. 2. Pretreatment with a Ca²⁺ free solution and thapsigargin, a Ca²⁺-ATPase inhibitor in the endoplasmic reticulum, stopped the pacemaker potentials. In the case of Ca²⁺-free solutions, Carthami flos did not induce membrane depolarizations in the murine small intestine and colon. However, when thapsigargin in a bath solution was applied, Carthami flos induced membrane depolarizations only in the murine colon. 3. Pretreatment with 2-APB (transient receptor potential melastatin (TRPM) channel inhibitor) abolished the pacemaker potentials and suppressed Carthami flos-induced effects in the murine small intestine and colon. 4. However, pretreatment with T16Ainh-AO1 (Ca²⁺ activated Cl- channel; anoctamin 1 (ANO1) inhibitor) did not affect the pacemaker potentials and induced Carthami flos-induced effects only in the murine small intestine. Conclusions : These results suggest that Carthami flos can modulate the pacemaker activity of ICC and the mechanisms underlying pacemaking in ICC might be different in the small intestine and the colon.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.25 no.2
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• pp.139-148
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• 2012

The MLS(Moving Least Squares) Difference Method is a numerical scheme that combines the MLS method of Meshfree method and Taylor expansion involving not numerical quadrature or mesh structure but only nodes. This paper presents an dynamic algorithm of MLS difference method for solving transient solid mechanics problems. The developed algorithm performs time integration by using Newmark method and directly discretizes strong forms. It is very convenient to increase the order of Taylor polynomial because derivative approximations are obtained by the Taylor series expanded by MLS method without real differentiation. The accuracy and efficiency of the dynamic algorithm are verified through numerical experiments. Numerical results converge very well to the closed-form solutions and show less oscillation and periodic error than FEM(Finite Element Method).

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.18 no.9
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• pp.1023-1029
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• 2007

In this paper, we propose the method to solve the BLT equations using Laguerre polynomials in time domain. The solution of BLT equations is obtained by recursive, differential and integral properties of Laguerre polynomials. The verification of the proposed method is tested by applying it to the two-wired transmission line with resistors and capacitors, which is illuminated by the electromagnetic plane wave pulse. And the result is compared with the corresponding transient responses obtained from inverse fast Fourier transform(IFFT) of the frequency domain solutions of BLT equations.

• Journal of Ocean Engineering and Technology
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• v.26 no.6
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• pp.7-13
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• 2012

This paper presents a numerical study of the wave loads acting on offshore structures using a Cartesian-grid-based flow simulation method. Finite volume discretization with a volume-of-fluid (VOF) method is adopted to solve two-phase Navier-Stokes equations. Among the many variations of the VOF method, the CICSAM scheme is applied. The body boundary conditions are satisfied using a porosity function, and wave generation is carried out by using transient (wave or damping) zone approaches. In order to validate the present numerical method, three different basic offshore structures, including a sphere, Pinkster barge, and Wigley model, are numerically investigated. First, diffraction and radiation problems are solved using the present numerical method. The wave exciting and drift forces from the diffraction problems are compared with potential-based solutions. The added mass and wave damping forces from the radiation problems are also compared with the potential results. Next, the wave-induced motion responses of the structures are calculated and compared with the existing experimental data. The comparison results are fairly good, showing the validity of the present numerical method.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.3
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• pp.311-320
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• 2005

In this paper an enhanced quadratic finite element for static and dynamic analysis of plate structures is presented. The performance of a proposed plate element is improved by the coupled use of non conforming displacement modes, the selective integration scheme, and the assumed shear strain fields. An efficient direct modification method is also applied to this element to solve the problem such as failure of the patch test due to the adoption of non conforming modes. The proposed quadratic finite element does not show any spurious mechanism and does not produce shear locking phenomena even with distorted meshes. It is shown that the results obtained by this element converged to analytical solutions very rapidly tough numerical tests for standard benchmark problems. It is also noted that this element is applicable to transient dynamic analysis of Mindlin plates.

• Journal of Electrical Engineering and Technology
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• v.9 no.2
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• pp.452-460
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• 2014

Due to increased concerns for rising oil prices and environmental problems, various solutions have been proposed for solving energy problems through tightening environmental regulations such as those regarding $CO_2$ reduction. Among them, Electrical Vehicles (EVs) are evaluated to be the most realistic and effective approach. Accordingly, research and development on EVs and charging infrastructures are mainly proceeding in developed countries. Since EVs operate using electric energy form a battery, they must be connected to the power system to charge the battery. If many EVs are connected during a short time, power quality problems can occur such as voltage sag, voltage unbalance and harmonics which are generated from power electronics devices. Therefore, when EVs are charged, it is necessary to analyze the effect of power quality on the distribution system, because EVs will gradually replace gasoline vehicles, and the number of EVs will be increased. In this paper, a battery for EVs and a PWM converter are modeled using an ElectroMagnetic Transient Program (EMTP). The voltage sag and unbalance are evaluated when EVs are connected to the distribution system of the Korea Electric Power Corporation (KEPCO). The simulation results are compared with IEEE standards.

• Journal of the Korean Solar Energy Society
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• v.35 no.1
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• pp.35-43
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• 2015

A numerical simulation on the wake flow of a wind turbine which is a scaled version of a multi-megawatt wind turbine has been performed. Two different inlet conditions of averaged wind speed including one below and one above the rated wind speed were used in the simulation. Steady-state pitch angles of the blade associated with the two averaged wind speeds were imposed for the simulation. The steady state analysis based on the Reynolds averaged Navier-Stokes equations with the method of frame motion were used for the simulation to find the torque of the rotor and the wake field behind the wind turbine. The simulation results were compared with the results obtained from the wind tunnel testing. From comparisons, it was found that the simulation results on the turbine power are pretty close to the experimental values. Also, the wake results were relatively close to the experimental results but there existed some discrepancy in the shape of velocity deficit. The reason for the discrepancy is considered due to the steady state solution with the frame motion method used in the simulation. However, the method is considered useful for solutions with much reduced calculation time and reasonably good accuracy compared to the transient analysis.

• The Korean Journal of Applied Statistics
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• v.34 no.4
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• pp.537-556
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• 2021

Properties of statistical process control procedures may not be derived analytically in many cases; however, the application of a Markov chain can solve such problems. This article shows how to derive the properties of the process control procedures using the generated Markov chains when the control statistic satisfies the Markov property. Markov chain approaches that appear in the literature (such as the statistical design and economic design of the control chart as well as the variable sampling rate design) are reviewed along with the introduction of research results for application to a new control procedure and reset chart. The joint application of a Markov chain approach and analytical solutions (when available) can guarantee the correct derivation of the properties. A Markov chain approach is recommended over simulation studies due to its precise derivation of properties and short calculation times.

• Journal of the Korean Chemical Society
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• v.26 no.6
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• pp.369-377
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• 1982

The technique of combined-measurement of reflectance and ellipsometric parameters was used for studying the anodic film formed on nickel surface in basic solutions. An ellipsometer was automated for transient measurements by way of modulating the plane-polarized light with the Faraday effect. Surface film was formed electrochemically by applying a potential step from the reduction potential range to the passivation range on a polished, high-purity, polycrystalline nickel specimen. From that instant, the changes in the reflectance(r) and the ellipsometric parameters(${\Delta},{\Psi}$) of the surface film were recorded by the automatic ellipsometer. Three exact simultaneous equations including these optical signals, ${\Delta},{\Psi}$ and r were solved numerically with a computer in order to determine the optical properties, n, k, and the thickness, ${\tau}$, of the surface film. From the computed results which showed dependence on pH and time, it was found that passivation of nickel can be effectively attained by surface film thinner than $15{\AA}$ and this passivation film has a small optical absorption coefficient. It seemed that a high pH environment enhances the rate of passivation and is favorable for a denser structure of the surface film. The experimental evidence is in accordance with the hypothesis that the composition of the passive film can be approximated by $Ni(OH)_2$ in the early stage of passivation and that as time passes the composition changes partially toward that of NiO through dehydration.

• 한국전산유체공학회:학술대회논문집
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• 2009.04a
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• pp.290-297
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• 2009

A two-phase (gas and liquid) flow analysis solver, named CUPID, has been developed for a realistic simulation of transient two-phase flows in light water nuclear reactor components. In the CUPID solver, a two-fluid three-field model is adopted and the governing equations are solved on unstructured grids for flow analyses in complicated geometries. For the numerical solution scheme, the semi-implicit method of the RELAP5 code, which has been proved to be very stable and accurate for most practical applications of nuclear thermal hydraulics, was used with some modifications for an application to unstructured non-staggered grids. This paper is concerned with the effects of interpolation schemes on the simulation of two-phase flows. In order to stabilize a numerical solution and assure a high numerical accuracy, the second-order upwind scheme is implemented into the CUPID code in the present paper. Some numerical tests have been performed with the implemented scheme and the comparison results between the second-order and first-order upwind schemes are introduced in the present paper. The comparison results among the two interpolation schemes and either the exact solutions or the mesh convergence studies showed the reduced numerical diffusion with the second order scheme.