• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.2
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• pp.197-205
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• 2015

Offshore structures for the gas production are exposed to the risk of gas leaks, and gas explosions can result in fatal damages to the primary structures as well as secondary structures. To minimize the damage from the critical accidents, the study of the dynamic response of structural members subjected to blast loads must be conducted. Furthermore, structural dynamic analysis has to be performed considering relationships between the natural frequency of structural members and time duration of the explosion loading because the explosion pressure tends to increase and dissipate within an extremely short time. In this paper, the numerical model based on time history data were proposed considering the negative phase pressure in which considerable negative phase pressures were observed in CFD analyses of gas explosions. The undamped single degree of freedom(SDOF) model was used to characterize the dynamic response under the blast loading. A blast wall of FPSO topside was considered as an essential structure in which the wall prevents explosion pressures from the process area to utility and working areas. From linear/nonlinear transient analyses using LS-DYNA, it was observed that dynamic responses of structures were influenced by significantly the negative time duration.

• Journal of Korean Society of Environmental Engineers
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• v.30 no.12
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• pp.1218-1224
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• 2008

A liquid culture of yeast "Candida tropicalis" was used in a fluidized bioreactor to achieve high removal efficiencies of volatile organic compounds (VOCs). In this study, granular activated carbon (GAC) was used as a fluidized material to improve adsorptive capacity as well as mass transfer of gaseous toluene, the model VOC. The GAC fluidized bioreactor demonstrated toluene removal efficiencies ranging from 50 to 80%, when inlet toluene loading varied in a range between 13.1 and 37.4 g/m$^3$-hr. The maximum elimination capacity determined in the GAC fluidized bioreactor was 172 g/m$^3$-hr at a toluene loading of 291 g/m$^3$-hr. Transient loading experiments revealed that the removal efficiency was remained unchanged during an increased loading period, and toluene introduced to the bioreactor was first absorbed to GAC and then slowly desorbed and became available to the yeast culture. Hence the fluidized GAC helped to achieve an improved mass transfer between the gas and liquid phases, resulting in high toluene removal capacity. Consequently, the GAC fluidized bioreactor using C. tropicalis can be successfully applied for the removal of VOCs, and is a feasible alternative over conventional processes such as packed-bed biofilters.

• YAKHAK HOEJI
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• v.58 no.4
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• pp.245-249
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• 2014

Murrayafoline-A (1-methoxy-3-methylcarbazole) is a monomeric carbazole alkaloid found in Murraya euchrestifolia HAYATA and Glycosmis stenocarpa. We have recently shown that murrayafoline-A has positive inotropic effect in isolated rat ventricular myocytes. To know possible mechanisms for the positive inotropic effect of murrayafoline-A we examined the effects of murrayafoline-A on in situ behavior of cardiac $Ca^{2+}$ release units ('$Ca^{2+}$ sparks') and sarcoplasmic reticulum (SR) $Ca^{2+}$ loading using confocal $Ca^{2+}$ imaging method in single rat ventricular myocytes. Murrayafoline-A significantly increased the frequency (events/($10^3{\mu}m^2{\cdot}s$)) of $Ca^{2+}$ sparks in a concentration-dependent manner, with an $EC_{50}$ of $28{\pm}6.4{\mu}M$ and a maximal ~twofold change. The $Ca^{2+}$ content in the SR, measured as caffeine (10 mM)-induced $Ca^{2+}$ transient, was significantly increased by murrayafoline-A (${\approx}$116% and ${\approx}$123% of control at 25 and 100 ${\mu}M$, respectively). In addition, murrayafoline-A significantly increased the fractional $Ca^{2+}$ release, suggesting increase in the efficacy of $Ca^{2+}$ release at given SR $Ca^{2+}$ loading. These results suggest that murrayafoline-A may enhance contractility via increase in $Ca^{2+}$ release from the SR through the ryanodine receptors in ventricular myocytes.

• Journal of Pharmaceutical Investigation
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• v.40 no.3
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• pp.167-173
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• 2010

Repeated oral administration of hydrochlorothiazide, a loop diuretic, due to transient high blood levels, may cause adverse effects such as gastric disturbance, nausea, high blood sugar, and hyper lipidemia. Transdermal administration could avoid some of these systemic side effects and gastric disorders. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible material, for transdermal delivery of hydrochlorothiazide. Drug solubility was highest at 40% PEG-400 volume fraction. Drug release increased as concentration increased with a linear relationship between the release rate and the square root of loading dose. Increasing temperature increased drug release from the EVA matrix. The activation energy, measured from the slope of log P versus 1000/T, was 11.9 kcal/mol for a 2.5% loading dose from EVA matrix. Diethyl phthalate had the highest plasticizing effects on the release of hydrochlorothiazide. To increase the skin permeation of hydrochlorothiazide from the EVA matrix, enhancers such as the saturated fatty acids, the unsaturated fatty acids, and the non-ionic surfactants were added to the EVA matrix, and skin permeation was evaluated using a modified Keshary-Chien diffusion cell fitted with intact excised rat skin. Polyoxyethylene 23-lauryl ether showed the highest enhancing effects. In conclusion, transdermal delivery of hydrochlorothiazide could be improved from an EVA matrix containing plasticizer and permeation enhancer.

• Journal of the Korean Society of Propulsion Engineers
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• v.8 no.2
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• pp.102-114
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• 2004

The present work has been developed the interpretation processor including the behavior of material failure and the separation phenomena under transient dynamic loading (the operation of explosive bolt) using AUTODYN V4.3, SoildWork 2003 and TrueGrid V2.1 programs. It has been demonstrated that the interpretation in ridge-cut explosive bolt under dynamic loading condition should be necessary to the appropriate failure model and the basic stress of bolt failure is the principal stress. The use of this interpretation processor developing the present work could be extensively helped to design the shape and the amount of explosives in the explosive bolt having a complex geometry. It is also proved that the interpretation processor approach is an accurate and effective analysis technique to evaluate the separation mechanism in explosive bolts.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.4
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• pp.283-292
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• 2013

The objective of this research is to evaluate of global and local damage for steel-concrete composite structures under highway bridge exposed to fire loading. To enhance the accuracy and efficiency of the numerical analysis, the proposed transient nonlinear thermal structure interaction(TSI) parallel fire analysis method is implemented in ANSYS. To validate the TSI parallel fire analysis method, a comparison is made with the standard fire test results. The proposed TSI parallel fire analysis method is applied to fire damage analysis and performance evaluation for Buchen highway bridge. The result of analysis, temperature of low flange and web are exceed the critical temperature. The deflection and deformation state show good agreement with the fire accident of buchen highway bridge.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.8
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• pp.706-711
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• 2015

The fighter aircraft uses several different loading configurations for air-to-surface and air-to-air combat missions. To maintain wings-level flight with an asymmetric weapon configuration, a pilot controls a roll trim system. However, it is difficult to apply an accurate roll trim input for wings-level flight in the actual flight under disturbance. The inaccurate roll trim input degrades the performance of the roll autopilot system. In this paper, to solve this problem, an integrator was additionally designed in the command part of the roll autopilot system. The initial transient response was improved by scheduling the limiter to restrict the roll attitude error. As a result of the evaluation of the simulation for the designed flight control law, the roll attitude following performance was found to be improved in the autopilot system operation under the inaccurate roll trim condition.

• Journal of the Society of Naval Architects of Korea
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• v.34 no.1
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• pp.77-86
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• 1997

The advanced development in many fields of engineering and science has caused much interests and demands for crashworthiness and non-linear dynamic transient analysis of structure response. Crash and impact problems have a dominant characteristic of large deformation with material plasticity for short time scales. The structural material shows strain rate-dependent behaviors in those cases. Conventional rate-independent constitutive equations used in the general purposed finite analysis programs are inadequate for dynamic finite strain problems. In this paper, a rate-dependent constitutive equation for elastic-plastic material is developed. The plastic stretch rate is modeled based on slip model with dislocation velocity and its density so that there is neither yielding condition, nor loading conditions. Non-linear hardening rule is also introduced for finite strain. Material constants of present constitutive equation are determined by experimental data of mild steel, and the constitutive equation is applied to uniaxile tension loading.

• Explosives and Blasting
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• v.37 no.1
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• pp.14-23
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• 2019

It has been an always issue for the blasting or the impact analysis to consider the strength characteristics of the rock materials associate with loading rate dependency. Due to the nature of transient loading, the dynamic rock test requires a careful technique to achieve the stress equilibrium state of the specimen. In this study, to investigate the relationship between the rock dynamic strength and the stress equilibrium state, a series of dynamic uniaxial compression tests for Pocheon granite were performed. As a result, the unbalanced stress state on the specimen can lead to the premature failure on the specimen and the less estimation of dynamic strength characteristic as well as the overestimation of strain rate. Consequently, a careful consideration of rock fracture process to achieve the dynamic force balance on the specimen should be required to make an reasonable evaluation of rock dynamic strength.

• Journal of the Korea institute for structural maintenance and inspection
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• v.26 no.3
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• pp.48-54
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• 2022

This research describes a quantitative procedure used to estimate the effect of concrete cracking on stiffness degradation of concrete shear walls and provides analytical references for the seismic design of concrete shear walls. As preliminary research on the seismic response of concrete shear walls, nonlinear transient analysis was performed with commercial FE software. The study presents the nonlinear time history analysis results in terms of concrete damage and cracking behavior induced by seismic input motions. By varying the input motions, concrete strength and shear wall thickness, the seismic responses of a shear wall were examined with nonlinear time history analysis, and the progressive cracking behavior and corresponding hysteresis loop were described. Based on the analysis results, frequency and stiffness degradation of the shear wall from progressive concrete damage and cracking were captured with respect to the seismic levels. The results of this study suggest that stiffness degradation from concrete cracking should be appropriately considered when determining the seismic capacity of RC shear wall structures.