• Journal of Microbiology and Biotechnology
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• v.19 no.9
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• pp.869-872
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• 2009

The cyclic undecapeptide cyclosporin A (CyA), one of the most valuable immunosuppressive drugs, is produced nonribosomally by a multifunctional cyclosporin synthetase enzyme complex by the filamentous fungus Tolypocladium niveum. To increase CyA productivity by wild-type T. niveum (ATCC 34921), random mutagenesis was first performed using an antifungal agar-plug colony assay (APCA) selection approach. This generated a mutant strain producing more than 9-fold greater CyA than the wild-type strain. Additionally, a foreign bacterial gene, Vitreoscilla hemoglobin gene (VHb), was transformed via protoplast regeneration and its transcription was confirmed by RT-PCR in the UV-irradiated mutant cell. This led to an additional 33.5% increase of CyA production. Although most protoplast-regenerated T. niveum transformants tend to lose CyA productivity, the optimized combination of random mutagenesis and protoplast transformation described here should be an efficient strategy to generate a commercially valuable, yet metabolite low-producing, fungal species, such as CyA-producing T. niveum.

• Journal of the Semiconductor & Display Technology
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• v.4 no.1 s.10
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• pp.61-64
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• 2005

This study presents a new algorithm to detect the facial feature in a color image entered from the mobile device with complex backgrounds and undefined distance between camera's location and the face. Since skin color model with Hough transformation spent approximately 90$\%$ of running time to extract the fitting ellipse for detection of the facial feature, we have changed the approach to the simple geometric vector operation, called a TS(Triangle-Square) transformation. As the experimental results, this gives benefit of reduced run time. We have similar ratio of face detection to other methods with fast speed enough to be used on real-time identification system in mobile environments.

• Journal of Korea Society of Digital Industry and Information Management
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• v.8 no.2
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• pp.131-143
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• 2012

This paper introduces the double-density discrete wavelet transform using 3 direction separable processing method, which is a discrete wavelet transform that combines the double-density discrete wavelet transform and quincunx sampling method, each of which has its own characteristics and advantages. The double-density discrete wavelet transform is nearly shift-invariant. But there is room for improvement because not all of the wavelets are directional. That is, although the double-density DWT utilizes more wavelets, some lack a dominant spatial orientation, which prevents them from being able to isolate those directions. The dual-tree discrete wavelet transform has a more computationally efficient approach to shift invariance. Also, the dual-tree discrete wavelet transform gives much better directional selectivity when filtering multidimensional signals. But this transformation has more cost complexity Because it needs eight digital filters. Therefor, we need to hybrid transform which has the more directional selection and the lower cost complexity. A solution to this problem is a the double-density discrete wavelet transform using 3 direction separable processing method. The proposed wavelet transformation services good performance in image and video processing fields.

• Journal of Korean Society of Archives and Records Management
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• v.3 no.1
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• pp.141-158
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• 2003

This paper examines new phenomenon and transformation that arise from the expansion of knowledge-based economy, envisions the meaning of e-government through comparing traditional administration with new governance, formulates the e-government model, and presents a direction for next e-government for the conclusion. These new phenomenon include a transformation to product and service convergence model, cyber sovereignty dilemma, privacy and information security threats, and various others. Also, there is a gradual transformation from government-oriented administrative approach to a new governance model that strengthens the role of NGO. And, e-government must work together to realize this new governance ideology. New e-government must be transformed where government and citizens can implement and manage e-government together. Therefore, expanding applications of Public Key Infrastructure (PKI) technologies, promotion of e-Democracy, and improvement of user interface to improve usability must be emphasized.

• Journal of electromagnetic engineering and science
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• v.13 no.2
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• pp.73-85
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• 2013

In this paper we present an alternative approach to addressing the problem of designing cloaks for radar targets, which have been dealt with in the past by using the transformation optics (TO) algorithm. The present design utilizes realistic materials, which can be fabricated in the laboratory, and are wideband as well as relatively insensitive to polarization and incident angle of the incoming wave. The design strategy, presented herein, circumvents the need to use metamaterials for cloak designs that are inherently narrowband, dispersive and highly sensitive to polarization and incident angle. A new interpretation of the TO algorithm is presented and is employed for the design of radar cross section-reducing absorbers for arbitrary targets, and not just for canonical shapes, e.g., cylinders. The topic of performance enhancement of the absorbers by using graphene materials and embedded frequency structure surfaces is briefly mentioned. The design procedure for planar absorbing covers is presented and their performance as wrappers of general objects is discussed. A number of test cases are included as examples to illustrate the application of the proposed design methodology, which is a modification of the classical TO paradigm.

• Journal of Institute of Control, Robotics and Systems
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• v.11 no.4
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• pp.304-313
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• 2005

The robots that will be needed in the near future are human-friendly robots that are able to coexist with humans and support humans effectively. To realize this, robot need to recognize his position and direction for intelligent performance in an unknown environment. And the mobile robots may navigate by means of a number of monitoring systems such as the sonar-sensing system or the visual-sensing system. Notice that in the conventional fusion schemes, the measurement is dependent on the current data sets only. Therefore, more of sensors are required to measure a certain physical parameter or to improve the accuracy of the measurement. However, in this research, instead of adding more sensors to the system, the temporal sequence of the data sets are stored and utilized for the accurate measurement. As a general approach of sensor fusion, a UT -Based Sensor Fusion(UTSF) scheme using Unscented Transformation(UT) is proposed for either joint or disjoint data structure and applied to the landmark identification for mobile robot navigation. Theoretical basis is illustrated by examples and the effectiveness is proved through the simulations and experiments. The newly proposed, UT-Based UTSF scheme is applied to the navigation of a mobile robot in an unstructured environment as well as structured environment, and its performance is verified by the computer simulation and the experiment.

• YAKHAK HOEJI
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• v.44 no.4
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• pp.308-314
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• 2000

Logarithmic transformation of pharmacokinetic parameters is routinely used in bioequivalence studies based on pharmacokinetic and statistical grounds by the United States Food and Drug Administration (FDA), European Committee for Proprietary Medicinal Products (CPMP), and Japanese National Institute of Health and Science (NIHS). Although it has not yet been recommended by the Korea Food and Drug Administration (KFDA), its use is becoming increasingly necessary in order to harmonize with international standards. In the present study, statistical procedures for the analysis of a bioequivalence based on the log transformation and a related SAS procedure were demonstrated in order to aid the understanding and application. The AUC parameters used in this demonstration were taken from the previous bioequivalence study for two aceclofenac tablets, which were performed in a single-dose crossover design. Analysis of variance (ANOVA), statistical power to detect 20% difference between the tablets, minimum detectable difference and confidence intervals were all assessed following log-transformation of the data. Bioequivalence of two aceclofenac tablets was then estimated based on the guideline of FDA. Considering the international effort for harmaonization of guidelines for bioequivalence tests, this approach may require a further evaluation for a future adaptation in the Korea Guidelines of Bioequivalence Tests (KGBT).

• Journal of Plant Biotechnology
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• v.37 no.4
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• pp.370-378
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• 2010

This review describes the stratagies of development of virus-resistant Alstroemeria plants using the genetic modification system. Despite of increasing of its importance in cut flower market, improvements of some horticultuirally important traits such as fragrance, long vase-life, virus resistance and tolerance against abiotic stresses are lack of the breeding program in Alstroemeria. Of these traits, virus-resistance is quite difficult to develop in Alstroemeria plants due to the limitations of genetic variation in the existed germplasm. To extend the genetic variation, plant biotechnological techniques such as genetic transformation and tissue culture should be combined to develop virus-resistant line in Alstroemeria. In this review, several strategies for the generation of virus-resistance by using natural resistance genes, pathogen-derived genes and other sources including pathogen-derived proteins, virus-specific antibodies and ribosome-inactivating proteins are presented. Also, brief histories of breeding, tissue culture, and transformation system in Alstroemeria plants are described to inderstand of the application of transgenic approach for the development of virus-resistance in Alstroemeria species.

• International Journal of Computer Science & Network Security
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• v.23 no.8
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• pp.199-203
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• 2023

Influential trend that widely reflected the software engineering industry is service oriented architecture. Vendors are migrating towards cloud environment to benefit their organization. Companies usually offer products and services with a goal to solve problems at customer end. Because customers are more interested in solution of their problem rather than focusing on products or services. In software industry the approach in which customers' problems are solved by providing services is known as software as a service. However, software development life cycle encounters enormous changes when migrating software from product model to service model. Enough research has been done on the overall development process but a limited work has been done on the factors that influence requirements elicitation process. This paper focuses on those changes that influence requirement elicitation process and proposes a systematic methodology for transformation of software from product to service model in a successful manner. The paper then elaborates the benefits that inherently come along with elicitation process in cloud environment. The paper also describes the problems during transformation. The paper concludes that requirement engineering process turn out to be more profitable after transformation of traditional software from product to service model.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.484-490
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• 2008

For CSLDV, the Chebyshev demodulation (or polynomial) technique and Hilbert transform approach have been used for mode shape reconstruction with harmonic excitation. In this paper, the Hilbert-Huang transform approach was applied as an alternative to impact excitation cases in terms of a numerical approach. The vibration of the tested structure is modeled using impulse response functions. In order to verify this technique, a simply supported beam was chosen as the test rig. With additional innovative steps which are the ideal-band pass filter and the nodal point determination, Hilbert-Huang transformation can be used for a good mode shape reconstruction even in the impact excitation case.