• 대한한의학회지
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• 제44권3호
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• pp.189-200
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• 2023

Objectives: The purpose of this study is to analyze the current state of quantitative literature evidence for the prescription of 56 herbal medicines covered by health insurance that have been studied in Korea for the past 30 years, to evaluate the reliability of the evidence, and to find out the research direction of herbal medicine prescription in the future. Methods: 56 kinds of herbal medicine prescriptions were searched in domestic literature search databases OASIS, DBpia, and overseas PubMed, classified into chemistry, toxicity, cells, animals, clinical cases, and clinical trial studies, and built into an EBM pyramid structure. Results: When classified according to research contents, there were 61 cases (7.5%) of physicochemical analysis to identify constituent substances, 80 cases (9.8%) of toxicity evaluation, and 672 cases (82.7%) of efficacy evaluation. The efficacy evidence was classified according to the evidence-based medical pyramid structure: 196 cell trials (29.1%), 372 animal trials (55.4%), 89 case and case reporting series (13.3%), 7 comparative case studies (1.1%), and 8 randomized control clinical trials (1.2%). In the pyramid composition, the basis for the validity of 56 kinds of herbal medicines prescribed was 568 cases (84.5%) in cell and animal units, which could not be said to be highly reliable. There was no relationship between the ranking of quantitative literature evidence for herbal medicine prescriptions and the ranking of salary administration. Conclusions: In an era that continues to require scientific evidence for herbal medicine, traditional herbal medicine should secure the basis for safety validity even for the 10th most frequent prescription among 56 herbal medicine prescriptions for consumers. In particular, traditional herbal medicine should increase the quantitative and qualitative level of case reports on related herbal medicine prescriptions, focusing on each clinical society, and move toward comparative case studies and randomized clinical trial so that traditional herbal medicine is positioned as Evidence-based medicine.

• 사상체질의학회지
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• 제22권3호
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• pp.29-42
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• 2010

1. Objective: Gastric Stuffiness (心下痞證) in the Soeumin Taeeum symptomatology (少陰人 太陰病) in Sasang Constitutional Medicine shows an interesting evolutionary process. Originally found in the texts of Sanghanlun (傷寒論), the perspectives regarding the symptoms of Gastric Stuffiness were expanded by many medical scholars and Lee Jema. To comprehend the Jema's concept of Taeeum symptomatology and utilize his prescription clinically, it deserves to study on the Gastric Stuffiness in Donguisuseowon (東醫壽世保元). 2. Methods: Many texts including Sanghanlun (傷寒論) and Dongeuibogam (東醫寶鑑) were reviewed in order to track the evolutionary process concerning the symptoms of Gastric Stuffiness. Also, Lee Jema's works including the different versions of Donguisuseowon (東醫壽世保元) were reviewed to examine the development of Lee's concepts regarding the Gastric Stuffiness in the Soeumin Taeeum symptomatology. 3. Results and Conclusions: 1) Most of the previous concepts on Gastric Stuffiness were generally similar to those found in Sanghanlun, especially in that they addressed Yang deficiency of the middle triple energizeer as the central pathogenic process. 2) Lee Jema's views on the epigastric discomfort in the Soeumin Taeeum symptomatology evoloved over time and culminated in the finalized pathology and therapeutics appearing in his last work, the Shinchuk version of Donguisuseowon (東醫壽世保元). 3) 4 kinds of prescription which invented by Lee Jema to treat the Gastric Stuffiness in the Soeumin Taeeum symptomatology can be matched to the prescription of Sanghanlun respectively. However through evolutionary process of Jema's prescriptions, the indication of them expanded: not only to treat Gastric Stuffiness but to diverse symptoms of Soeumin.

• 한방비만학회지
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• 제7권2호
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• pp.27-37
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• 2007

Background Clinical practice guidelines (CPG) are systematically developed statements to assist practitioners and patients on healthcare decisions. They provide recommendations for the average patient, which should take into account individual clinical judgment and the patient's values and expectations. Ephedra has sympathomimetic effect and has been used for weight loss worldwide. However, its safety is controversial especially in autonomic and cardiovascular systems. Therefore, the need of appropriate CPG for ephedra prescription in obesity was advocated in Korean Traditional Medicine. Methods The committee comprised of specialists of obesity, oriental herbology, oriental cardiology, constitutional medicine. The committee collected all relevant references about adverse effect and safety of ephedra in the forms of meta-analysis, systematic review, randomized controlled trial, case-control study and observational study from international and domestic databases and paper journals. 11 English- and 5 Korean-language references were gathered and categorized by PICO (Patient, Intervention, Comparison, Outcome) method. We could not complete strength of recommendation which should be clarified according to the evidence grade estimation. Result The first version of CPG for ephedra prescription in obesity was issued by Korean Oriental Association for Study of Obesity. It includes topics of introduction, pharmacokinetics, side effects and adverse events, constitutional aspect and recommendations for dose, indication and contraindication. Conclusion There should be periodic upgrade of this CPG from now on. Although there are some drawbacks in this version of CPG, it has significance as the first CPG in Korean Traditional Medicine.

• 대한한의학회지
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• 제26권2호
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• pp.195-200
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• 2005

Objecitves: Peel of Citrus unshiu (Rutaceae) has been used in traditional herbal prescriptions. Hesperidin and naringin contents of Citri Unshii Pericarpium were determined and compared to herbal prescriptions. Then, the different extractions from prescriptions are explained with traditional herbal theories. Methods: The herb and herbal prescriptions were extracted in boiled water. A quantitative analysis was made of hesperidin and naringin using HPLC with-reversed-phase CIS column and a UV detector at 204nm. Elution was carried out at 1.0ml/min with $38\%$ methanol. Results and Conclusions: The extract of Citri Unshii Pericarpium for 180 min was the better method for extracting naringin and hesperidin. The flavonoid contents in remedies are different among several traditional herbal prescriptions. The reason for the difference can be explained with traditional drug interaction theories.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2002년도 제37회 국제학술심포지움 및 추계학술대회
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• pp.53-54
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• 2002

• 한국의사학회지
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• 제21권2호
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• pp.29-39
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• 2008

"濟衆立效方" is the oldest Koryo dynasty medical document known to date. Despite its historical importance, due to the absence of its original copy, its true characters could not be understood. Through comparison of the many documents that cited 濟衆立效方, it could be found that 濟衆立效方 can be classified into two parts based on its contents and form. In Chinese medical texts, neither the name 交效散 nor any similar prescription is mentioned. 濟衆立效方 was the first in suggesting the usage of pine needles and salt for fomentation and not for internal use. Thus 交效散 can be thought of as the oldest indigenous prescription preserved in Korean history. 濟衆立效方 conveys records of the combination of the ancient origin pine needle fomentation and the creative addition of salt.

• 대한한의학원전학회지
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• 제26권4호
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• pp.89-94
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• 2013

Objective : To collect cosmetology text in Shang Han Za Bing Lun(伤寒杂病论), to analyze theory and prescription about cosmetology before HAN(漢) dynasty, so to allow records for modern cosmetology of Traditional Chinese Medicine. Method : Through the systematize for all terms about cosmetology, to reveal the regularity about cosmetology before HAN(漢) dynasty. Result : There were damage-appearance disease in HAN(漢) dynasty, there are lots of ideas about cosmetology in Shang Han Za Bing Lun(伤寒杂病论). Conclusion : Shang Han Za Bing Lun(伤寒杂病论) is a monograph about pattern identification and treatment, and is an important ancient book for research of cosmetology of Traditional Chinese Medicine. In the further, we will research in knowledge discovery about cosmetology of Traditional Chinese Medicine. to strengthen the guidance of the theory of Zhang Zhongjing(张仲景) for clinical practice of cosmetology of Traditional Chinese Medicine.

• Mass Spectrometry Letters
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• 제5권1호
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• pp.24-29
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• 2014

An advanced and reliable high performance liquid chromatography (HPLC)/ultraviolet detector (UV)/ion-trap time-of-flight (IT-TOF) mass spectrometry was developed for the simultaneous quantification of 19 marker compounds in Bang-poong-tong-sung-san (BPTS), a traditional oriental prescription. Various parameters affecting HPLC separation and IT-TOF detection were investigated, and optimized conditions were identified. The separation was achieved on a Capcell PAK C18 column ($1.5mm{\times}250mm$, $5{\mu}m$ particle size) using a gradient elution of acetonitrile and water containing 0.1% formic acid at a flow rate of 0.1 mL/min. The column temperature was maintained at $40^{\circ}C$ and the injection volume was $2{\mu}L$. IT-TOF system was equipped with an electrospray ion source (ESI) operating in positive or negative ion mode. The optimized electrospray ionization parameters were as follows: ion spray voltage, +4.5 kV (positive ion mode), or -3.5 kV (negative ion mode); drying gas ($N_2$), 1.5 L/min; heat block temperature, $200^{\circ}C$. Automatic $MS^n$ (n = 1~3) analyses were carried out to obtain structural information of analytes. Elemental compositions and their mass errors were calculated based on their accurate masses obtained from a formula predictor software. The marker compounds in BPTS were identified by comparisons between $MS^n$ spectra from standards and those from extracts. Moreover, the libraries of $MS^2$ and $MS^3$ spectra and accurate masses of parent and fragment ions for marker compounds were constructed. The developed method was successfully applied to the BPTS extracts and identified 17 out of 19 marker compounds in the BPTS extracts.

• 대한예방한의학회지
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• 제1권1호
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• pp.27-41
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• 1997

The degree of KAP study on oriental traditional medicine was examined with some korean from July 1st to August 30th in 1996. The result of the study for predicting health and ill patterns runs as fellows. 1) It is too weak to understand and adertise oriental traditional medicine doctors and the curable disease; moreover cured diseases rather preponderate. 2) Although most patients go to oriental traditional medical clinic for the purpose of medical herbs in package and acupuncture, they think the medical fee a high expensive. 3) The 77.9% of respondents recognize oriental traditional medical doctors as a profession and others think them only abundant workers; therefore it is rather low to think oriental traditional doctors a profession. 4) Most respondents ink that oriental traditional medicine should improved in the inside; such as the expensive fee, scientific reinforcement of theory, lack of univerality, improvement and enlargement of insurance, unkindness, shortage of publicity, dropped equipment, system of medical specialist, lack of integration with western medicine, exact diagnosis and confidence of remedy and low efficacy, etc. 5) The struggle against the government (1995-1996 about herbal prescription right by western pharmacy) has taken the change of affirmative recognition. 6) The degree that acknowleges of oriental traditional medicine through these basic contents is average 61.65 mark. To be brief, although the step of recognition and attitude of oriental me야cine is very affirmative aspect, actually considerable difficult factors is in the last chosen step.

• 사상체질의학회지
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• 제19권1호
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• pp.38-49
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• 2007

1. Objectives This Study is to find efficacy of Red Poria and White Poria used for Soyangin Prescriptions in Lee Je-Ma's writings. 2. Methods We analysed Soyangin Prescription with Poria in ${\ulcorner}$Dongyi Suse Bowon Chobonkwon(東醫壽世保元 草本卷)${\lrcorner}$ , ${\ulcorner}$Dongyi Suse Bowon Gabobon(東醫壽世保元 甲牛本)${\lrcorner}$ , ${\ulcorner}$Dongyi Suse Bowon Sinchukbon(東醫壽世保元 辛丑本)${\lrcorner}$ and ${\ulcorner}$Dongyi Sasang Sinpyun(東醫四象新編)${\lrcorner}$ based on the efficacy of Poria written in ${\ulcorner}$DongMugo YakSungGa(東武遺藁 藥性歌)${\lrcorner}$ . 3. Results and Conclusions 1) Red Poria and White Poria seems to be different in Sasang Constitutional Medicine. 2) Poria in Soyangin Prescription had used from the traditional medical point at the beginning, in ${\ulcorner}$Dongyi Suse Bowon Chobonkwon(東醫壽世保元草本卷)${\lrcorner}$ , but its usage was changing until ${\ulcorner}$Dongyi Suse Bowon Sinchukbon(東醫壽世保元辛丑本)${\lrcorner}$ as the point of Sasang Constitutional Medicine. 3. It is necessary to use Poria in Soyangin Prescription as the essence of Soyangin's life because it effects on the whole body without any distinction from body's upper part with lower part and body's exterior part with interior part.