• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.6
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• pp.1359-1367
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• 2003

Through the historical and logical methodology, The historical development and extension of diagnostic concepts as chi(氣), shue(血), yin(陰), yang(陽) is analyzed. This study suggests the analystic methodology of diagnostic concepts, introduce the justification problem of oriental medical diagnosis, and is concluded with the problem of diagnostic concepts which should be modified and.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.229-234
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• 2006

To develop the Korean standard differentiation of the symptoms and signs for the stroke(KSDS), the committee on Stroke Diagnosis Standardization of traditional Korean medicine(TKM) was organized dy nineteen experts in college of Korean medicine. On July 9th 2005, the second consultation meeting was held in Daejeon, Korea. Fifteen experts of the committee attended the meeting and they discussed the KSDS and came to a consensus. The 15-member committee consensus was as follows: First, board members defined the stroke on the basis of TKM. Second, they divided the symptoms and signs of stroke into five categories- fire and heat, dampness and phlegm, blood stasis, qi deficiency, yin deficiency. Third, the symptom indicator of each differentiation type for the stroke was recommended. KSDS-1 will be applied to the clinical practice and revised.

• Clinical and Experimental Reproductive Medicine
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• v.49 no.4
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• pp.239-247
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• 2022

Objective: Asafoetida is a gum derived from Ferula assa-foetida, which is used in traditional Iranian medicine to treat some reproductive system disorders. The effects of asafoetida on ovarian tissue, expression of certain genes associated with polycystic ovary syndrome (PCOS), and levels of liver, kidney, and blood cell factors after treatment in a rat model were investigated. Methods: Thirty rats were divided into five groups: normal, polycystic, and treatment with three doses of asafoetida (12.5, 25, and 50 mg/kg for 3 weeks after PCOS induction). PCOS was induced by letrozole at a dose of 1 mg/kg administered orally for 3 weeks. Blood samples were taken, and the ovaries were removed and prepared for histomorphometric examination. Liver and kidney parameters were measured. The mRNA expression levels of luteinizing hormone receptor, CYP11A1, adenosine monophosphate-activated protein kinase, adiponectin, and adiponectin receptors 1 and 2 were also measured by real-time polymerase chain reaction. Results: The levels of liver, kidney, and blood parameters did not significantly differ between the treatment groups and the control group. At doses of 25 and 50 mg/kg, ovarian histopathology, especially the thicknesses of the theca and granulosa layers, was significantly improved relative to the PCOS group. The expression of target genes also improved in the 25 and 50 mg/kg treatment groups. Conclusion: Asafoetida can be used to treat PCOS as a complementary approach to conventional therapies. Asafoetida appears to act by regulating and activating metabolic and ovarian cycle enzymes.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.19 no.1
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• pp.55-63
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• 2015

Objectives In order to the review of the Yoon Gil-Young's theory on the "differentiation of syndromes", we studied on the his method and system of classification on the "differentiation of syndromes". Methods We reviewed on "The Clinical Formula Science Traditional Korean Medicine 東醫臨床方劑學", "A study on the Methodology of Traditional Korean Medicine 東醫學의 方法論硏究" "The theory of SaSang Constitution Medicine 四象體質醫學論". From a connected standpoint with the basic theory and clinical medicine, considered on the Yoon Gil-Young's theory of "differentiation of syndromes". Results Yoon Gil-Young's theory of differentiation of syndromes and treatment was widespread so much that he studied on the learning field of Traditional Korean Mediciine and ingenious as well. The main principles of differentiation of syndromes was summarized the three representative syndrome-complexes; BON-HER(original deficiency syndrome), BON-HAN(orginal cold excess syndrome), BON-YEOL(original heat excess syndrome). And also the three representative syndrome-complexes was previously carried out the details of differentiation of syndromes and assigned represent prescription one by one. Conclusions As the results, Yoon Gil-Young insisted the system of differentiation of syndromes closely connecting with Traditional Korean Medical physiology, pathology, diagnosis and prescriptions. And therefore he was a frontier of the field of Traditional Korean Medicine.

• Journal of Ginseng Research
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• v.48 no.3
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• pp.245-252
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• 2024

Ginseng is a traditional herbal medicine used for prevention and treatment of various diseases as a tonic. Recent scientific cohort studies on life prolongation with ginseng consumption support this record, as those who consumed ginseng for more than 5 years had reduced mortality and cognitive decline compared to those who did not. Clinical studies have also shown that acute or long-term intake of ginseng total extract improves acute working memory performance or cognitive function in healthy individuals and those with subjective memory impairment (SMI), mild cognitive impairment (MCI), or early Alzheimer's disease (AD) dementia who are taking AD medication(s). Ginseng contains various components ranging from classical ginsenosides and polysaccharides to more recently described gintonin. However, it is unclear which ginseng component(s) might be the main candidate that contribute to memory or cognitive improvements or prevent cognitive decline in older individuals. This review describes recent clinical contributors to ginseng components in clinical tests and introduces emerging evidence that ginseng components could be novel candidates for cognitive improvement in older individuals, as ginseng components improve SMI cognition and exhibits add-on effects when coadministered with early AD dementia drugs. The mechanism behind the beneficial effects of ginseng components and how it improves cognition are presented. Additionally, this review shows how ginseng components can contribute to SMI, MCI, or early AD dementia when used as a supplementary food and/or medicine, and proposes a novel combination therapy of current AD medicines with ginseng component(s).

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.898-902
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• 2010

This study is performed to report that oriental medical treatment was effective to the patient with piriformis syndrome after traffic accident. The patient was diagnosed as piriformis syndrome by considering clinical symptom, clinical history, physical examination, radiologic study and NCV EMG study. We applied acupuncture, herbal medicine, cupping, Chuna manipulation and exercise to the patient. After treatment, VAS decreased, and physical examination sign was disappeared. This result suggest that oriental medical treatment can be effective to piriformis syndrome.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.6
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• pp.311-321
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• 2019

In this paper, we try to define and classify the concepts of Convergent Research of Korean-Western Medicine (CRKWM) to clarify the goals of research. In addition, some suggestions that are necessary to promote the CRKWM were made. The results are as follows. First, the CRKWM should be used as a concept that refers to 'interdisciplinary research' jointly conducted by experts in both Korean and Western medicines beyond their own fields. Second, True CRKWM is an "eclectic combination of East-West" that combines the advantages of traditional Korean medicine and western medicine to create a new field; it is necessary to redefine the concept of 'Integrative medicine', which is used in different context by the traditional Korean medicine and western fields in Korea, as an "eclectic combination of East-West" type. Third, In order to promote the CRKWM, it is necessary to convert the current dual medical system of relativism to one of pluralism. Forth, In order for CRKWM to be promoted, methodologies, theories, and models that become the backbones of convergence should be developed. As of now, systems medicine and network science are the best fit. Fifthly, In order to promote convergent clinical research, the development of Korean-Western diagnostic model that integrates the pathologies of Western medicine and symptoms of Korean medicine is urgent. Lastly, Mutual understanding between Korean and Western medicine fields should be preceded in order for CRKWM to be stimulated.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1789-1792
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• 2006

To develop the Korean Standard Differentiation of the symptoms and signs for the Stroke(KSDS), the committee on Stroke Diagnosis Standardization of Korean Traditional Medicine was organized by nineteen experts in College of Korean Medicine, The Consensus of the second Consultation Meeting was as follows : First is the definition of the stroke on the Korean Traditional Medicine. Second is the five categories to the Differentiation of the symptoms and signs for the Stroke - fire and heat, dampness and phlegm, blood stasis, qi deficiency, yin deficiency. Third is the indices of the Differentiation of the symptoms and signs for the Stroke respectively. KSDS-1 will be applied to the clinical practice and revised. The Consensus of the third Consultation Meeting had agreed 81 symptoms indexes of KSDS.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.5
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• pp.845-850
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• 2002

This paper suggest a methodology for representation of findings which can be called as signs and symptoms. A finding consists of unit signs and unit symptoms, and moreover findings which appear in one individual patient have so many different relationship each other. So, it is nat appropriate to list all of possible findings as medical standard or to fill findings as independent things in paper for medical record. We try to distinguish finding item from finding list, and suggest the methodology by which we can make finding list from finding items. That is, we suggest finding item[Concept], value types, relationship, logical operator, and syntax as a component of representation. And by using urinary symptom, we make the example for representation methodology. Finally, we mention the background knowledge, brief research process of related area.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.3
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• pp.229-237
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• 2024

Cough is a common symptom of several respiratory diseases. However, frequent coughing from acute to chronic often causes great pain to patients. It may turn into cough variant asthma, which seriously affects people's quality of life. For cough treatment, it is dominated by over-the-counter antitussive drugs, such as asmeton, but most currently available antitussive drugs have serious side effects. Thus, there is a great need for the development of new drugs with potent cough suppressant. BALB/c mice were used to construct mice model with cough to investigate the pharmacological effects of pectolinarigenin (PEC). Hematoxylin-eosin and Masson staining were used to assess lung injury and airway remodeling, and ELISA was used to assess the level of inflammatory factor release. In addition, inflammatory cell counts were measured to assess airway inflammation. Airway hyperresponsiveness assay was used to assess respiratory resistance in mice. Finally, we used Western blotting to explore the potential mechanisms of PEC. We found that PEC could alleviate lung tissue injury and reduce the release of inflammatory factors, inhibit of cough frequency and airway wall collagen deposition in mice model with cough. Meanwhile, PEC inhibited the Ras/ERK/c-Fos pathway to exhibit antitussive effect. Therefore, PEC may be a potential drug for cough suppression.