• 한국임상수의학회지
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• 제17권1호
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• pp.129-133
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• 2000

Based on pathological findings, 5 German shepherds, revealed a mean age of 7.6 years, showing no clinical signs were diagnosed as tracheopathia osteochondroplastica(TOC). Grossly, multiple small-sizecd nodules, appeared as cobble-stones, on the cartilage rings situated in the anterior trachea and the mucosal surface of the epiglottis were showed. Numerous tiny nodules were scattered on the pleural surface of the lung. The vascular walls of the heart were irregular and coarse apearance with calcification. Histopathologically, nodules in the trachea represented an irregular expansion of the underlying tracheal ring with protrusion into the submucosa and consisted of proliferated and calcified cartilage and bone with marrow spaces containing numbers of hematopoietic cells. Pulmonary calcinosis and calcification of the vascular walls of the heart were observed. Our observations suggested that TOC arises form eccondroses and exostoses of the tracheal cartilage rings.

• The Korean Journal of Physiology
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• 제11권2호
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• pp.33-39
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• 1977

It has been reported that administration of Ginseng powder to the Guinea pig reduces anaphylactic shook induced by horse serum (Lee, 1939). However, Lee et al. (1960) and Paik et al. (1976) have demonstrated that Ginseng increases capillary permeabilites and histamine release from the mast cell. These facts suggest that Ginseng acts directly on the bronchial muscle causing it to dilate. Recently, a number of investigators(Kidakawa & Iwasiro 1963; Takagi et al. 1973) have reported that Ginseng reverses acetylcholine- or histamine- induced contraction in the isolated Guinea pig ileum. We, therefore, undertook the present study to examine if Ginseng relaxes the spasm of bronchial muscle induced by acetylcholine or histamine. We have also attempted to identify the mechanism of the Ginseng effect. Male Guinea Pig was sacrificed by a blow on the head, The trachea was removed and sectioned with scissors into about 12 rings. After the 'C' shaped ring of cartilage was sectioned the one end of ring was tied to the bottom of the incubation bath and the other end was connected to a force transducer (FTO 3C) to record tension on a Polygraph. When the antispasmodic action of Ginseng effect was first examined in the normal trachea which was not treated by the drug. And then the Ginseng effect was tested in the muscle treated by histamine hydrochloride, acetylcholine hydrochloride or barium chloride. The results indicate that Ginseng alcohol extract relaxes the contraction of isolated tracheal muscle induced by histamine $(1{\mu}g/ml{\sim}10{\mu}g/ml)$, acetylcholine $(1{\mu}g/ml{\sim}5{\mu}g/ml)$ and barium chloride (1.5 mg/ml). The mechanism of this action is in Pa.1 due to nonspecific antimuscarinic and antihistaminic effect and in part by predominant action in the adrenergic ${\beta}-receptor$ although the ${\alpha}-receptor$ is also involved. We, therefore, conclude that Ginseng can be act as a bronchodilator.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1982년도 제16차 학술대회연제순서 및 초록
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• pp.12-12
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• 1982

기관절개술은 1649년 Fienus가 처음으로 호흡곤란 환자에게 시술하고 Tracheotomy라 명명한 이래 기도확보, 기관 및 기관지로 부터 분비물 제거 및 산소공급을 목적으로 이용되어 많은 생명을 구하고 있다. 그러나 기관절개술후 성문하부의 협착, 기관연화, 기관절개공주위의 육아조직, 기관점막의 부종, 정신적인 의존 및 제 1기관륜 상부의 절개등으로 인한기관 Cannula 발거곤란증이 수반되기도 한다. 저자들은 1980년 4월 산업재해로 인한 두개내혈종 및 다발성늑골골절등으로 진단되어 타종합병원에서 개두술과 기관절개술을 받은 21세 남자환자에서 기관 Cannula 발거곤란증을 경험하였기에 중간보고하는 바이다. 1981년 11월 본원 이비인후과에 전원시 간접후두경 검사상 성대 및 가성대에 심한 부종이 있었으며 성대는 부정중위로 고정되어 있었고 기관지경검사상 성문하부에 협착이 인지되어 Jackson 식도 Bougie를 이용하여 3차에 걸쳐 Bougination으로 기관확장을 시도하였으나 효과가 없었다. 1981년 2월 협착부위의 기관륜과 윤상연골에 수직절개를 한 후 직경 1. 2cm의 Teflon tube를 협착부위에 삽입하고 9개월간 유치시킨 후 제거하고 Corking을 하여 현재 양호한 경과를 취하고 있다.