• Journal of Ginseng Research
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• 제14권2호
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• pp.157-161
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• 1990

We have been isolating various physiologically active substances from non-saponin fraction of Korean Red Ginseng. These are adenosine, pyre-glutamic acid, dencichine and acidic polysaccharide. Adenosine and pyre-glutamic acid are known to inhibit epinephrine-induced lipolysis in fat cells and stimulate the insulin-mediated lipogenesis. In addition to these actions, adenosine was found to inhibit both norepinephrine- and histamine-induced aorta constriction, and pyre·glutamic acid inhibits angiotensin-converting enzyme. Dencichine stimulated histamine-induced aorta constriction. Finally, acidic polysaccharide was found to inhibit both lipolytic and anorexigenic actions of Toxohormone-L. Based on these experimental results, I presented a briefreview on these compounds isolated from non-saponin fraction of Korea Red Ginseng.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1987년도 Proceedings of Korea-Japan Panax Ginseng Symposium 1987 Seoul Korea
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• pp.20-28
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• 1987

To clarify central mechanisms of ginsenosides, changes in ingestive and ambulatory behaviors were investigated in rats after single or continuous infusion into the third cerebroventricle or various hypothalamic loci. Following single infusion into the third cerebroventricle, ginsenoside Rbl at doses of 0.05, 0.10 and 0.20 $\mu$mol dose-dependently decreased food intake. None of the doses tested affected ambulation. Drinking suppression was only observed at the maximum dose of 0.20 $\mu$mol. Equimolar injections into the peritoneum had no effects on ingestive behavior or ambulation. These findings indicated that ginsenoside Rbl specifically and centrally inhibited food intake. According to analyses of daily feeding patterns, this feeding suppression was the result of a decrease in meal size, not from changes in the postprandial intermeal interval or eating speed. The suppressed food intake was accompanied by hyperglycemia, leaving plasma insulin unaffected. Unilateral micro injection of 0.01 u mot ginsenoside Rb, into the ventromedial hypothalamus specifically decreased food intake, although equimolar injection into the lateral hypothalamic area did not affect food intake. Following continuous infusion of Rg, into the third cerebroventricle, the feeding inhibition due to surgical operation was attenuated. Rbs administered by the same procedure abolished the toxic effect of toxohormone-L on food intake. Taken together, these findings suggest that ginsenoside as a whole may have pharmacological potency to maintain feeding at a certain physiological level.