• 제목/요약/키워드: total cholesterol HDL-

검색결과 2,062건 처리시간 0.026초

신령버섯 균사체 액체배양액이 고콜레스테롤혈증 흰쥐의 지질대사에 미치는 영향 (Effects of Liquid Culture of Agaricus blazei Murill on Lipid Metabolism in Rats Fed Cholesterol Diet.)

  • 고진복;김재영
    • 생명과학회지
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    • 제14권4호
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    • pp.531-536
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    • 2004
  • 신령버섯 균사체 액체배양액이 고콜레스테롤 식이를 섭취한 흰쥐의 지질대사에 미치는 영향을 조사하고자, 생후 7주령의 숫쥐에 표준식이를 급여한 정상군, 표준식이에 15% 돈지와 0.5% 콜레스테롤을 첨가한 식이를 급여한 대조군, 대조식이에 신령버섯 균사체 액체배양액을 음료수에 30% 및 40%로 혼합 급여한 군(30% 및 40% 신령버섯군) 등 4군으로 나누어 6주간 사육한 결과는 다음과 같다. 실험동물의 체중 증가량, 식이섭취량 및 식이효율은 대조군과 30%와 40% 신령버섯군이 유사하였다. 간, 신장 및 부고환지방의 무게는 대조군과 신령버섯군들이 비슷하였다 간의 콜레스테롤 농도, 간과 혈청의 중성지질 농도는 대조군과 신령버섯군들이 비슷한 수준으로 감소효과가 나타나지 않았다. 혈청의 총 콜레스테롤과 LDL-콜레스테롤 농도 및 동맥경화지수는 대조군에 비해 30% 및 40% 신령버섯군이 유의하게 감소되었다. 총콜레스테롤에 대한 HDL-콜레스테롤의 비율은 대조군에 비해 신령버섯군들이 유의하게 증가되었다. HDL-콜레스테롤 농도는 대조군과 신령 버섯군들이 비슷한 수준으로 신령 버섯섭취에 따른 영향은 나타나지 않았다. 분으로 배설된 지방은 대조군에 비해 40% 신령버섯군이 유의하게 증가되었다. 이상의 결과로 보아 고콜레스테롤 식이를 급여한 흰쥐에 신령버섯 균사체 액체배양액을 30%나 40% 급여시 혈청의 총 콜레스테롤, LDL-콜레스테롤 농도 및 동맥경화지수를 낮추고, 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율을 증가시키는 것으로 나타났다.

한국 노인의 대사증후군 예측인자로서 혈중 Non HDL 콜레스테롤과 중성지방/HDL 콜레스테롤 비의 의의 (Significance of Non HDL-cholesterol and Triglyceride to HDL-cholesterol Ratio as Predictors for Metabolic Syndrome among Korean Elderly)

  • 홍승복;신경아
    • 대한임상검사과학회지
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    • 제50권3호
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    • pp.245-252
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    • 2018
  • 한국 노인을 대상으로 대사증후군 예측인자로서 혈중 Non HDL-콜레스테롤과 중성지방/HDL-콜레스테롤 비율의 임상적용 가능성을 평가하고자 하였다. 2015년 1월부터 2017년 12월까지 경기지역 종합병원의 건강검진센터를 내원하여 건강검진을 실시한 65세 이상 노인을 1,543명을 대상으로 하였다. 대사증후군은 American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI)기준에 따라 진단하였다. 복부비만은 World Health Organization (WHO) West Pacific Region에서 제시하는 아시아-태평양인의 기준을 적용하였다. Non HDL-콜레스테롤은 총콜레스테롤과 HDL-콜레스테롤의 차이로 계산하였다. 대사증후군 예측력은 Non HDL-콜레스테롤보다 중성지방/HDL-콜레스테롤 비율이 높게 나타났다. 관련요인을 보정한 후 중성지방/HDL-콜레스테롤 비율은 1사분위수보다 4사분위수의 대사증후군 발병 위험이 높았다. 또한 대사증후군 발병을 예측하는 중성지방/HDL-콜레스테롤 비율의 적정 기준값은 2.8이었다. 중성지방/HDL-콜레스테롤 비율은 대사증후군 위험을 평가하는 간단하고 실용적인 지표가 될 수 있겠다.

식이내 지방의 종류와 수준이 혈장 콜레스테롤 및 조직내 콜레스테롤 함량에 미치는 영향 (Effect of Dietary Fat Sources and Levels on Plasma and Tissue Cholesterol)

  • 임현숙;김강화
    • Journal of Nutrition and Health
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    • 제17권2호
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    • pp.85-93
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    • 1984
  • The present studies were designed to compare the effects of dietary fat sources and levels on plasma and tissue cholesterol. Changes in plasma total cholesterol and HDL-cholesterol, cholesterol concentration in aortas, liver and intestines were determined in young rats fed diets providing dietary fat as corn-oil or butter and levels as 10%, 20% or 30% of calories respectively 1) Plasma total cholesterol and HDL-cholesterol levels were little sensitive to the modification of dietary fat sources and levels. 2) Dietary cholesterol increased the levels of plasma total cholesterol and this effect was accentuated by feeding butter. But dietary cholesterol did not increase the levels of HDL-cholesterol in the butter-fed groups, but decreased in the corn-oil-fed groups. 3) Liver cholesterol concentrations were significantly higher in rats fed diets of corn-oil than those fed diets of butter. On the contrary, cholesterol concentrations of intestines were significantly higher in the butter-fed groups than the corn-oil-fed groups. However, in aortas, no significant differences were found.

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한국인의 일부 도시인에서 비만, 이상혈당, 이상지질혈증의 집락과 고혈압의 관련성 (Association of Hypertension with Cluster of Obesity, Abnormal glucose and Dyslipidemia in Korean Urban Population)

  • 이강숙;김정아;박정일
    • Journal of Preventive Medicine and Public Health
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    • 제31권1호
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    • pp.59-71
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    • 1998
  • To examine the association of hypertension with cluster of obesity, abnormal glucose and dyslipidemia in Korean urban population, we conducted this cross-sectional study among 3027 men and 2127 women age 20-85 years who visited a prevention center between May 1991 and June 1995 for a multiphasic health check at St. Mary's Hospital, Seoul. By the self-administered questionnaire, the informations of educational attainments, monthly income, alcohol consumption, cigarette smoking, and physical excercise level were obtained. Height, weight, and blood pressure were measured by a trained nurse. The fasting blood sugar (FBS), total cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride were tested by enzyme method. Low density lipoprotein (LDL) cholesterol was calculated by 'total cholesterol - HDL cholesterol - triglyceride/5'. For testing the differences of cardiovascular risk factors between hypertension and normotension group, 1-test and $\chi^2$-test were performed. For the age adjusted odds ratios of hypertension in persons with obesity, abnormal glucose, and dyslipidemia compared with normal, logistic regression was performed by using SAS pakageprograme. The results obtained were as follows: 1. Age, weight, body mass index(BMI), blood glucose, total cholesterol, LDL cholesterol, and triglyceride of hypertension group in men and women were significantly higher than normotension group, but height and HDL cholesterol of hypertension group only in women significantly lower than normotension group. The frequency of obesity $(BMI\geq25kg/m^2)$, abnormal glucose $(\geq\;120mg/dl)$, hypercholesterolemia $(\geq\;240mg/dl)$, lower HDL cholesterol (<45 mg/dl in women only), higher LDL cholesterol $(\geq\;160mg/dl)$, and hyper hypertriglyceridemia $(\geq\;250mg/dl)$ in hypertension group of men and women were significantly higher than normotension group. 2. Systolic and diastolic blood pressure were negatively correlated with hight, but positively with age, weight, BMI, total cholesterol, LDL cholesterol, and triglyceride in men and women. BMI was positively correlated with fasting blood sugar, total cholesterol, LDL cholesterol and triglyceride but negatively with HDL cholesterol. 3. The age adjusted odds ratios of hypertension were as follows in men and women : among persons who were obese compared with those nonobese, 2.53 (95% Confidence Intervals [C.I.] 2.08-3.07) and 2.22 (95%C.I. 1.71-2.87): among persons who were abnormal glucose compared with those normoglycemic, 1.43 (95%C.I 1.13-1.82) and 2.01 (95%C.I 1.36-2.94): and among persons who were dyslipidemia (hypercholesterolemia or lower HDL cholesterol or higher LDL cholesterol or hypertriglyceridemia) compared with those normal lipid, 1.59 (95%C.I 1.30-1.95) and 1.51 (95%C.I 1.16-1.96). After combined more than one risk factor, the odds ratios were increased. Among persons with cluster of obesity, abnormal glucose, and dyslipidemia, the odds ratio of hypertension was 2.25 (95%C.I 1.47-3.37) in men and 3.02 (95%C.I 1.71-5.30) in women. In conclusion, it was suggested that hypertension was associated with cluster of obesity, abnormal glucose, dyslipidemia in this Korean urban population.

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셀룰로오스, 펙틴 및 알긴산 수준이 흰쥐의 혈청지질 농도에 미치는 영향 (Effect of Cellulose, Pectin and Alginic Acid Level on Serum Lipid Composition in Rats)

  • 황은희;서은숙;이형자
    • 동아시아식생활학회지
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    • 제9권1호
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    • pp.27-34
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    • 1999
  • This study was carried out to investigate the effects of the kinds and the amounts of dietary fiber on serum lipid composition in rats. Seventy-two male Sprague-Dawley rats weighting 160$\pm$10g were fed diets containing 1.0%, 3.6%, 6.0% and 10.0% $\alpha$-cellulose, pectin and alginic acid fer 4 weeks. Daily food intake of experimental groups was significantly higher in the u-cellulose 10.0% group than in the other groups. Increasing the dietary fiber level decreased the food efficiency ratio of the $\alpha$-cellulose, pectin and alginic acid groups. Serum triglyceride concentration was significantly lower in the rats fed the alginic acid diet. Serum total cholesterol concentration showed no significant difference in the kind and the amount of three dietary fibers. Serum HDL-cholesterol concentration was higher in $\alpha$-cellulose and pectin diet. HDL-cholesterol/total cholesterol ratio was higher in u-cellulose and pectin diet than alginic acid diet. In conclusion, alginic acid is good for the serum triglyceride decrease, pectin is good for HDL-cholesterol increase, $\alpha$-cellulose and alginic acid are good for HDL-cholesterol/total cholesterol ratio increase. But the different effects according to the dietary fiber's contents did not show a significant trend.

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한국여승(韓國女僧)의 영양섭취(營養攝取)와 혈청(血淸) Lipoprotein, Cholesterol 및 단백량(蛋白量)의 관계(關係) (Daily Nutritional Intake and Serum Levels of Lipoprotein, Cholesterol and Protein -A Study of Buddhist Nuns-)

  • 김난희;윤진숙;주영은;이원정
    • The Korean Journal of Physiology
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    • 제16권2호
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    • pp.195-207
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    • 1982
  • 장기적(長期的)인 채식섭취(菜食攝取)가 혈청(血淸)의 lipoprotein, cholesterol 및 단백량(蛋白量)에 미치는 영향(影響)을 알아보기 위하여 결은 여승(女僧) 45명(名)($20{\sim}35$세)과 대조군(對照群)으로 여대생(女大生) 29명(名)($20{\sim}22$세)을 연구대상(硏究對象)으로 하였다. 하루 열량섭취(熱量攝取)는 여승(女憎)들이 1,945 kcal 였고 여대생(女大生)은 1,815 kcal 였다. 열량구성비율(熱量構成比率)은 여승(女僧)들이 탄수화물(炭水化物) : 단백질(蛋白質) : 지방(地方)=84 : 11 : 5였고 학생(學生)은 70 : 15 : 15였으며 이는 여승(女僧)들의 탄수화물(炭水化物) 편중(偏重) 및 지방섭취부족(脂肪攝取不足)을 보여준다. 신체계측결과(身體計測結果) 여승(女僧)들은 여대생(女大生)보다 신장(身長)을 제외(除朴)하고, 체중(體重), 지방층(脂肪層)두께, 체표면적(體表面積) 및 비만도계수(肥滿度係數)가 모두 높았다. 수축기(收縮期) 및 이완기혈압(弛緩期血壓)은 여승(女憎)과 여대생(女大生)이 거의 같았다. 혈청(血淸)의 총지방(總脂肪), cholesterol 및 단백량(蛋白量)은 여승(女憎)과 여대생간(女大生間)에 유의(有意)한 차이(差異)가 없었다. 그러나 전기영동(電氣泳動)으로 분획(分劃)하여 혈청(血淸)의 high density lipoprotein(HDL), very low density lipoprotein(VLDL) 및 low density lipoprotein(LDL)량(量)을 비교(比較)해 본 결과(結果), 여승(女憎)들의 HDL은 여대생(女大生)보다 낮았으나 LDL은 유의(有意)하게 높았다. Cholesterol분획결과(分劃結果)도 역시 여승(女憎)들의 HDL-cholesterol값은 여대생(女大生)보다 유의(有意) 하게 낮은 반면(反面) LDL-cholesterol은 유의(有意)하게 높았다. Lipoprotein과 cholesterol간(間)의 상관계수(相關係數)(r)를 계산(計算)한 결과(結果) LDL과 LDL-cholesterol(r=0.40), VLDL과 VLDL-cholesterol(r=0.85), HDL과 HDL-cholesterol(r=0.45), 혈청총지방량(血淸總脂防量)과 cholesterol(r=0.66) 및 혈청(血淸) 총(總) cholesterol과 LDL-cholesterol(r=0.79) 간(間)에는 유의(有意)한 상관관계(相關關係)를 보여주었다. 그러나 혈청(血淸) cholesterol과 음식섭취(飮食攝取) 및 신체계측결과간(身體計測結果間)에는 유의(有意)한 상관관계(相關關係)가 나타나지 않았다. 혈청단백량(血淸蛋白量)은 여승(女憎)과 여대생간(女大生間)에 차이(差異)가 없었다. 이상(以上)의 결과(結果)는 여승(女憎)들의 장기적(長期的)인 채식섭취(菜食攝取)로 인(因)해 인체(人體)의 lipoprotein 및 cholesterol 대사(代謝)에 영향(影響)이 있음을 시사(示唆)해 주고 있다.

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Effects of red ginseng-crude saponin on plasma liqid levels in rats fed on a diet high in cholesterol and triglyceride

  • Moon, Chang-Kiu;Kang, Nae-Young;Yun, Yeo-Pyo;Lee, Soo-Hwan;Lee, Hyun-Ah;Kang, Tak-Lim
    • Archives of Pharmacal Research
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    • 제7권1호
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    • pp.41-45
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    • 1984
  • The effect of Red ginseng saponin on plasma lipid levels in Wistar rats fed on a diet high in cholesterol and triglyceride was determined. A dose of Red ginseng-crude saponin (150 mg/kg/day) was administered orally for 4 weeks to Wistar rats fed on a diet containing 2% cholesterol and 10% olive oil. Plasma levels of total cholesterol, HDL-cholesterol and triglyceride were measured and lipoproteins were analyzed by using electrophoretic technique. Red ginseng saponin showed no significant changes of HDL-cholesterol level but it lowered plasma levels of total cholesterol and elevate those of triglyceride intensively.

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마금탕(麻芩湯)이 흰쥐의 고지혈증 병태에 미치는 영향 (Effects of Mageum-tang on the Hyperlipidemia in Rats)

  • 노승원;김정범
    • 동의생리병리학회지
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    • 제24권2호
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    • pp.319-327
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    • 2010
  • This study was designed to investigate the hyperlipidemia-healing effect of liquid extract from Mageum-tang(麻芩湯), it was performed on the hyperlipidemia of rats induced by high cholesterol diet and Triton WR-1339. We prepared two types of hyperlipidemia model in rats induced by high cholesterol diet and Triton WR-1339. The amount of total cholesterol, HDL-cholesterol, LDL -cholesterol, triglyceride, phospholipid, free fatty acid, the activity of superoxide dismutase(SOD), and glutathione were measured. The liquid extract from Mageum-tang showed significant decreasing effects on total cholesterol, LDL- cholesterol, triglyceride, phospholipid, free fatty acid in the both model. And it showed significant increasing effects on HDL-cholesterol, the activity of SOD in both model and amount of glutathione in Triton WR-1339 model. These results suggest that liquid extract from Mageum-tang has healing efficacy on hyperlipidemia induced by high cholesterol diet and Triton WR-1339.

석류가 뇌혈류 및 비만에 미치는 실험적 효과 (The Experimental Effects of Pomegranate on the Cerebral Blood Flow and Obesity in Rats)

  • 정현우;전병관
    • 한국식품영양학회지
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    • 제20권2호
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    • pp.143-149
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    • 2007
  • To examine the effects of pomegranate on cerebral blood flow and obesity, we observed regional cerebral blood flow in normal rats, as well as body weight, serum total cholesterol, serum HDL-cholesterol, serum LDL-cholesterol, serum triglycerides, serum total lipids, serum phospholipids and serum free fatty acid levels in rats fed a high fat diet. The results were as follows. Pomegranate seed extract significantly increased regional cerebral blood flow and the peel extract increased regional the cerebral blood flow in a dose dependent manner. In addition, the pomegranate extracts(seed, peel, juice) decreased body weight, serum total cholesterol, serum LDL-cholesterol, serum triglycerides, serum total lipids, serum phospholipids and serum free fatty acid levels, and increased serum HDL-cholesterol in the rats fed a high fat diet. More specially the seed extract significantly decreased serum total cholesterol, serum triglycerides and serum phospholipid levels.

Lipoprotein Lipase Polymorphism rs10503669 is Associated with High-density Lipoprotein Cholesterol Levels in Korean Population

  • Sull, Jae Woong;Eom, Yong-Bin;Jee, Sun Ha
    • 대한의생명과학회지
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    • 제20권4호
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    • pp.221-226
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    • 2014
  • High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated Lipoprotein lipase (LPL) as possibly being causal. Herein, the association between single nucleotide polymorphism (SNP) rs10503669 in the LPL gene and HDL cholesterol levels and triglyceride levels was tested in the Korean population. A total of 994 subjects from Seoul City were included in a replication study with LPL SNP rs10503669. SNP rs10503669 in the LPL gene was associated with mean HDL cholesterol levels (effect per allele 3.13 mg/dL, P<0.0001) and triglyceride levels (effect per allele -18.0 mg/dL, P=0.0026). Subjects with the CA/AA genotype had a 0.42-fold (range 0.23~0.77-fold) lower risk of having abnormal HDL cholesterol levels (<40 mg/dL) than subjects with the CC genotype. When analyzed by gender, the association of LPL was stronger in men than in women. This study clearly demonstrates that genetic variants in LPL influence HDL cholesterol levels and triglyceride levels in Korean adults.