• 대한화장품학회지
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• 제36권4호
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• pp.315-321
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• 2010

본 연구에서는 피부 상재균에 대한 참죽나무 새순 추출물의 항균 작용과 참죽나무 새순 추출물을 함유하는 크림을 제조하여 인체 피부를 대상으로 보습 효능을 측정하였다. 참죽나무 새순 추출물의 네 가지 피부 상재균에 대한 MIC를 측정한 결과, P. acnes과 S. aureus에 대한 MIC는 각각 0.13 %, 0.03 %로 비교 물질인 methyl paraben보다 더 우수한 항균 활성을 나타내었고, P. ovale과 E. coli에 대한 MIC는 모두 0.25 %로 methyl paraben 보다 낮은 MIC를 나타내었다. 피부 보습 효능을 측정하기 위해, 참죽나무 새순 추출물의 ethyl acetate 분획을 0.25 % 함유하는 크림을 제조하고, 이를 14명의 피실험자의 피부에 도포한 후 피부 수분 보유랑과 경표피 수분 손실량을 각각 30 min, 60 min 간격으로 180 min 동안 측정하였다. 피부 수분 보유량은 placebo 크림에 비하여 참죽나무 새순 추출물 함유 크림이 10 ~ 15 % 정도 더 큰 수분 보유량 증가율을 나타내었다. 경표피 수분 손실량을 측정하였을 때, 무도포(control) 상태의 경표피 수분 손실량은 8.9 g/$m^2h$, 추출물 함유 크림은 6.7 g/$m^2h$으로, 추출물을 함유한 크림이 피부 표면의 수분 손실을 감소시킴을 알 수 있었다. 참죽나무 새순 추출물의 ethyl acetate 분획의 항균 활성과 피부 보습효과에 대한 결과로부터 화장품 원료로서의 가능성을 확인하였다.

• 약학회지
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• 제42권1호
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• pp.39-45
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• 1998

Kojic acid, antimelanogenic agent, has been widely used in cosmetics to lighten the skin color. However, it has skin irritancy and instability against pH, temperature and light. To overcome these problems and optimize the molecular structure of kojic acid (KA), a prodrug, kojic acid monostearate(KMS), has been synthesized to modify the topical drug delivery in the point of sustained release of the parent drug via enzymatic hydrolysis during skin absorption. The prodrug was tested for enzymatic hydrolysis with cytosolic fraction of hairless mouse, skin. From the in vitro skin permeation study through hairless mouse skin, we found that KMS was retained in the skin and generated KA continuously by the skin esterase cleavage. In addition, topical formulations of o/w type creams and polyolprepolymer-containing cream were further tested for whitening effects using in vivo yellow skin guinea pig model.

• Journal of Yeungnam Medical Science
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• 제40권4호
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• pp.423-425
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• 2023

Porokeratosis ptychotropica is an uncommon form of porokeratosis, which was initially described in 1995. It is clinically characterized by symmetrical reddish to brown-colored hyperkeratotic, verrucous, or psoriasiform plaques on the perianal and gluteal regions. The lesions tend to integrate and expand centrally, with small peripheral satellite lesions. Early skin biopsy and appropriate diagnosis are essential because malignant change occurs in 7.5% of porokeratotic lesions. Conventional treatment options include topical steroid, retinoid, imiquimod, 5-fluorouracil, isotretinoin, excimer laser, photodynamic therapy, intralesional steroid or bleomycin injection, cryotherapy, carbon dioxide (CO₂) laser, and dermatome and excision, but none seem to achieve complete clearance. A 68-year-old woman presented with diffuse hyperkeratotic scaly lichenoid plaques on the buttocks that had persisted for several years. A skin biopsy of the buttocks revealed multiple cornoid lamellae and intense hyperkeratosis. There were some dyskeratotic cells beneath the cornoid lamellae and the granular layer was absent. Porokeratosis ptychotropica was diagnosed based on the characteristic clinical appearance and typical histopathological manifestations. She was treated with a CO₂ laser in one session and topical application of urea and imiquimod cream for 1 month. The lesions slightly improved at the 1-month follow-up. We herein present a rare case of porokeratosis ptychotropica.

• 대한화장품학회지
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• 제30권3호
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• pp.385-388
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• 2004

최근에 천연성분의 화장품 응용에 대한 관심이 높아지고 식물에 함유하고 있는 피토에스트로겐(Phytoestrogen)의 항노화 물질 연구가 중요해지고 있다. 태국 식물 Pueraria mirifica 추출물을 $4\%$ 함유한 크림제제(PM 크림)를 추출물 성분이 제외된 플라시보 크림과 비교하여 총 30명 여성을 대상으로 16주간 임상시험을 수행하였다. 피부 모사판을 제작하여 주름 측정을 하였고, 피부 탄력과 보습을 기기 평가하였다. 특히 피부 탄력도는 placebo 크림 사용군 대비 추출물 함유 크림 사용군이 통계적으로 유의하게 탄력도가 증가하였다. 주름이나 보습평가는 특이할 만한 결과를 나타내지는 못했다. Pueraria mirifiaca는 피부 탄력 개선을 주는 항노화 화장품 개발에 응용될 수 있을 것이라 기대된다.

• 한국임상수의학회지
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• 제41권1호
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• pp.49-53
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• 2024

A two-year-old, spayed female, 22.5 kg Pungsan was referred with chronic crusts and erosion on the nose. A referring veterinarian prescribed an anti-inflammatory dose (0.5-1 mg/kg/day) of oral glucocorticoids for 5 months, but skin lesions showed no meaningful improvement. A dermatological evaluation revealed a crust, depigmentation, erosion, and erythematous lesion over the nasal planum with a loss of the normal cobblestone texture. Also, firm and multifocal plaques over the thigh, groin, axilla, and dorsum were detected. A cytology examination on the nose, thigh, groin, axilla, and dorsum revealed moderate neutrophilic inflammation and bacterial infection. Abdominal radiography and ultrasonography revealed subcutaneous calcified materials along the thigh, groin, axilla, and dorsum. Calcinosis cutis was suspected because of the adverse effect of previous prolonged corticosteroid therapy. A histopathology examination of the nose lesion revealed moderate to severe degenerative or apoptotic changes of the basal layer and lymphoplasmacytic interface dermatitis. Facial discoid lupus erythematosus (FDLE) was diagnosed based on the history and the clinical, cytological, and histopathological results. Minocycline (7 mg/kg PO q 12 h) and niacinamide (500 mg/dog PO q 12 h) were prescribed as initial treatment. Glucocorticoids were not administered due to the presence of calcinosis cutis induced by previous corticosteroid treatment. After 6 weeks of treatment, the clinical signs on the nose were mildly improved. At this time, topical 1% pimecrolimus cream (twice daily) was initiated, while minocycline and niacinamide were continued at the same dose. The nasal planum markedly improved after 6 weeks of additional treatment, hence minocycline and niacinamide were prescribed for an additional 2 weeks and stopped, and the patient was continued solely on topical pimecrolimus. The dog's skin lesion has been maintained in clinical remission with topical 1% pimecrolimus twice daily for more than 5 months.

• Natural Product Sciences
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• 제12권1호
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• pp.50-54
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• 2006

The wound healing activity of plumbagin and the chloroform extract of Plumbago rosea Linn. (Yoot), incorporated into ointments with yellow soft paraffin, have been investigated on rats. Wound healing activity was studied using excision and incision wound models in rats following topical application. Both plumbagin and the Plumbago rosea root extract produced a significant response in both of the wound models studied. The wound contracted in 14 days in the case of plumbagin (0.1%) and 16 days in case of Plumbago rosea root extract (0.5%), as against in 22 days in the case of control animals. The results were also comparable to those of a standard drug, framycetin sulphate cream (1% w/w) in terms of wound contracting ability, wound closure time, tensile strength of wound and regeneration of tissues at the wound site. Histological studies revealed evidences for the healing process by formation of fibrovascular tissue, epithelization and increased collagenization when compared to control.

• Clinical and Experimental Pediatrics
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• 제46권12호
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• pp.1271-1273
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• 2003

저자들은 5개월 영아에서 음순 유착이 관찰되어 에스트로겐 크림의 국소 도포와 도수 분리로 3주만에 호전을 보인 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• The Korean Journal of Pain
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• 제28권3호
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• pp.177-184
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• 2015

Herpes zoster (HZ) is a transient disease caused by the reactivation of latent varicella zoster virus (VZV) in spinal or cranial sensory ganglia. It is characterized by a painful rash in the affected dermatome. Postherpetic neuralgia (PHN) is the most troublesome side effect associated with HZ. However, PHN is often resistant to current analgesic treatments such as antidepressants, anticonvulsants, opioids, and topical agents including lidocaine patches and capsaicin cream and can persist for several years. The risk factors for reactivation of HZ include advanced age and compromised cell-mediated immunity (CMI). Early diagnosis and treatment with antiviral agents plus intervention treatments is believed to shorten the duration and severity of acute HZ and reduce the risk of PHN. Prophylactic vaccination against VZV can be the best option to prevent or reduce the incidence of HZ and PHN. This review focuses on the pathophysiology, clinical features, and management of HZ and PHN, as well as the efficacy of the HZ vaccine.

• 대한화장품학회지
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• 제38권3호
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• pp.263-273
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• 2012

최근 연구에서 잠재적 피부 색소침착 경감제로서 파라-쿠마린산(PCA)의 주목되는 특성이 발견되었다. 본 연구의 목적은 이 물질의 자외선 차단 효과를 탐구하는 것이다. 자외선에 노출된 HaCaT 세포의 생존율에 대한 PCA의 영향을 in vitro에서 조사하고, 자외선 흡수 스펙트럼이 유사한 방향성 아미노산 대사물들의 작용과 비교하였다. In vivo시험으로는 PCA 크림(1.5 %)과 크림 베이스를 SKH-1 무모 쥐의 등 피부에 도포하고 UVB에 의한 염증 반응으로 나타나는 피부색(홍반) 및 두께 변화(부종)를 측정하였다. 크림 도포-자외선 조사는 2일 간격으로 총 12회 반복하였다. HaCaT 세포를 UVB에 노출시켰을 때 광량 의존적으로 세포 생존율이 감소하였다. 자외선 노출(10 mJ $cm^{-2}$)에 의한 세포 생존율감소는 100 ${\mu}M$의 PCA, cinnamic acid, urocanic acid, 그리고 indole acrylic acid에 의해 각각 39, 27, 39, 31 %가 억제되었다. 무모 쥐의 등 부위에 도포된 PCA크림(10 ${\mu}g\;cm^{-2}$)은 자외선(150 mJ $cm^{-2}$)-노출 피부의 색 지수, 즉 $L^*$, $a^*$ 및 $b^*$ 값, 그리고 두께의 변화를 각각 59, 50, 58, 53 %씩 억제하였다. 본 연구의 결과는 PCA의 멜라닌 생성 억제 작용을 밝힌 선행 연구와 함께 PCA가 자외선에 노출된 피부의 색소 이상 침착과 염증 반응을 막아줄 수 있음을 시사하였다.

• 대한수의학회지
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• 제49권1호
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• pp.17-22
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• 2009

The effect of Bu-Zhong-Yi-Qi-Tang (BZYQT) on the changes of ultraviolet (UV) light B radiation-induced apoptotic sunburn cell (SBC) and epidermal ATPase-positive dendritic cell (DC) in SKH1- hr or ICR mouse were investigated. The mice were treated with UVB (200 mJ/$cm^2$) and were sacrificed 24 h later. BZYQT (50 mg/kg of body weight) or vehicle (saline) was given i.p. at 36 and 12 h before irradiation, and 30 min after irradiation or BZYQT cream (0.2%) or cream base (vehicle) was topically treated at 24 h and 15 min before irradiation, and immediately after irradiation. The skin of SKH1-hr mouse prepared from the back of untreated mice exhibited about 0.3 SBC/cm length of epidermis, and 24 h after UV irradiation, the applied areas show an increased number of SBCs. But the frequency of UVB-induced SBC formation was reduced by intraperitoneal injection of BZYQT extract (p < 0.01). The numbers of DC in normal ICR mouse were 628.00 ${\pm}$ 51.56 or 663.20 ${\pm}$ 62.58 per $mm^2$ of ear epidermis. By 1 day after UVB treatment, the number of ATPase-positive cells/$mm^2$ were decreased by 39.0% or 27.1% in i.p. or topical application group with vehicle. Treatment of BZYQT was associated with increase of 33.9% in i.p. group (p < 0.05) or 2.7% in topical application group in the number of ATPase positive cells compared with the irradiation control group. The results presented herein that BZYQT administration could reduce the extent of skin damages produced by UVB.