• 대한수의학회지
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• 제39권2호
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• pp.318-326
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• 1999

Respiratory pathogenic effects of several porcine reproductive and respiratory syndrome virus(PRRSV) isolates were examined in swine tracheal ring(STR) cultures by examining their effect on ciliary activity. One high and one low pathogenic PRRSV isolates were then selected and their pathogenicity investigated in 3-week-old conventional PRRSV-seronegative pigs. Ten pigs each were inoculated intranasally with the high or low pathogenic PRRSV isolate and 6 pigs were sham inoculated as negative controls. Two pigs each from the inoculated group and one pig each from negative control group were killed on 4, 7, 14, 21 and 28 days postinoculation(pI). At necropsy, degrees of gross lung lesion was determined. Turbinate, tonsil, trachea and lung samples were collected for virus isolation or histopathology. Gross lung lesions were observed mainly on 14 days PI with high and low pathogenic isolates inducing moderate diffuse and mild gross lung lesions, respectively. Inoculation of either the high or low pathogenic virus resulted in loss of cilia in ciliated epithelium of turbinates and trachea between 7 and 28 days PI. High pathogenic virus caused increased number of Goblet cells in the tracheal epithelial layer between 4 and 21 days PI whereas the low pathogenic virus did it between 14 and 28 days PI and with a lesser degree. Although both viruses produced interstitial pneumonia, the lesion was less severe with the low pathogenic virus. The isolation of high pathogenic virus from tissues and sera was earlier and more consistent than that of the low pathogenic virus. The agreement between in vitro and in vivo tests indicates that STR cultures may be used as a routine method to determine the respiratory pathogenicity of PRRSV isolates.

• Applied Biological Chemistry
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• 제25권3호
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• pp.150-154
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• 1982

중질소요소(重窒素尿素)를 사용(使用) 3품종(品種)에 대(對)한 분시시험(分施試驗)을 폿드에서 수행하였다. 2회분시(回分施)는 4회분시(回分施)보다 통일계(統一系)에 월등히 좋았다. 시비효율(Fe), 이용율(利用率) 및 흡수시비질소효율(吸收施肥窒素效率)(Ef)은 4회분시(回分施)보다 2회분시(回分施)에서 월등히 컸다. Fe의 순위는 Ef의 순위와 같았다. 수량(收量)과 중질소과잉율(重素窒過利率)은 통일계(統一系)가 생육초기(生育初期)에 시용질소(施用窒素)를 많이 흡수(吸收)하여 후기(後期)에 상당히 재전류(再轉流)시킴을 나타내었다. 흡수시비질소(吸收施肥窒素)에 대(對)한 토양질소흡수증가량(土壤窒素吸收增加量) $({\Delta}Ns/Nf)$은 시비(施肥)로 인(因)한 토양질소이용율(土壤窒素利用率)의 지표(指標)가 될 수 있다.

• Applied Biological Chemistry
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• 제25권3호
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• pp.142-149
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• 1982

유수형성기추비(幼穗形成期追肥)(30%)한 표식질소(慓識窒素)의 이용율(利用率)은 $23{\sim}61%$(5개포장(個圃場))였으며 품종간차이(品種間差異)가 없었다. 고수답(高收沓)에서 추비질소(追肥窒素)의 이용율(利用率)이 컸으며 식물체내비료(植物體內肥料) 유래질소(由來窒素)의 50% 이상(以上)이 유수형성기이후(幼穗形成期以後)에 흡수(吸收)된 것으로 보였다. 정조(正租)에서 중질소과잉율(重窒素過剩率)이 가장 컸으며 이는 추비(追肥)된 질소(窒素)가 정조(正租)로 쉽게 전류(轉流)됨을 나타낸다. 일반계(一般系)보다 통일계(統一系)에서 정조(正租)와 엽간(葉間)의 중질소과잉율(重窒素過剩率)의 차이(差異)가 커서 통일계(統一系)에서 질소(窒素)의 전류(轉流)가 빠른것을 나타낸다. 지상부추비유래질소(地上部追肥由來窒素)는 $14{\sim}27%$였다. 특별(特別)한 관리(管理)를 한다면 포장조건(圃場條件)에서 중질소이용(重窒素利用)한 시험(試驗)은 처리당(處理當) 2구(區)에 구당(區當) 3주(株)로 충분(充分)할 것 같다.

• 대한두경부종양학회지
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• 제15권2호
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• pp.166-171
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• 1999

Background and Objectives: The aim of our study was to describe the appearance of recurrent and residual lesions in the head and neck tumors, and to evaluate the usefullness of CT and MRI. Materials and Methods: CT(n=42) and MRI(n=4) of 44 patients with recurrent head and neck tumors were reviewed retrospectively. Primary tumor sites were larynx/hypopharynx in 15, oral cavity/floor of mouth in 13, base of tongue/tonsil in 5, nasopharynx in 4, palate in 2, and others in 5 patients. Therapeutic modalities included sugery and radiotherapy in 23, radiotherapy in 11, surgery in 5, chemotherapy and radiotherapy in 4, and chemotherapy in 1 patient. Results: The patterns of tumor recurrence were nodal recurrence(n=17), primary tumor bed recurrence combined with nodal recurrence(n=12), primary tumor bed recurrence(n=10) and residual primary tumors(n=5). The most common appearance of residual/recurrent primary tumor on CT was focal or diffuse heterogenous mass with or without surrounding fat or muscle infiltration(25/27). On MRI, the recurrent lesions showed intermediate signal intensity on T1 weighted image and high signal intensity on T2 weighted image with heterogenous enhancement in the most cases(n=3). 38 out of 44 nodal recurrences(86%) which had been pathologically or clinically proved were more than 1 cm in diameter or contained central low density on CT scan. Conclusion: Although CT and MRI findings of recurrent and residual tumors of the head and neck were nonspecific, in the majority the lesions manifested as a mass at primary tumor bed and/or nodal disease including contralateral side of the neck. And CT and MRI are valuable for revealing above lesions.

• 대한기관식도과학회지
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• 제1권1호
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• pp.116-121
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• 1995

The foreign bodies in the ENT field are very common disease. The kind of foreign bodies are closely related with our life style and was represented according to culture, habit, and economical status. We analyzed retrospectively 272 cases with foreign bodies in the upper aerodigestive tract and the external auditory canal which were diagnosed and managed at the Department of Otolaryngology Chungbuk National University from Jan. 1992 to Dec. 1994. We could divided 272 cases to the three groups; Group I was 212 cases(77.9%) that the patients had foreign bodies in the external auditory canal, nasal cavity, and pharynx which didn't need to be admitted, Group II was 57 cases(22%) that the patients had esophageal foreign bodies, and Group III was 3 cases(1.1%) that the patients had bronchial foreign bodies. The most prevalent age group was under 5 years old(32.3%). The overall ratio of male and female was 1.24 : 1, and the overall ratio of urban and rural ratio was 2.31 : 1. The ratio of esophageal foreign bodies and bronchial foreign bodies was 19 : 1. The incidence of sorts of foreign bodies in Group I was fish bone(41.07%), insect(25.9%), plastic bullet(8.0%), in order of frequency. The locations of foreign bodies in Group I was external auditory canal(36.8%), the tonsil(26.9%), nasal cavity(17.0%), tongue base(10.4%) in order of frequency. The incidence of sorts of foreign bodies in Group II was coin(49.1%), chicken bone(17.5%), fish bone(15.8%), in order of frequency. The main location of foreign bodies in Group II was the first narrowing(78.9%). In the Group III, the foreign bodies were corn, peanut, and apple. One patient who was arrived too late was died.

• IMMUNE NETWORK
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• 제13권6호
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• pp.240-248
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• 2013

In this study, we compared the immune cell populations in rheumatoid arthritis (RA) synovial fluid, which shows lymphoid tissue-like structure, with those in tonsils, which are normal secondary lymphoid tissues. Firstly, we found that $CD4^-CD11b^+$ macrophages were the major population in RA synovial fluid and that B cells were the major population in tonsils. In addition, synovial fluid from patients with osteoarthritis, which is a degenerative joint disease, contained $CD4^+CD11b^+$monocytes as the major immune cell population. Secondly, we categorized three groups based on the proportion of macrophages found in RA synovial fluid: (1) the macrophage-high group, which contained more than 80% macrophages; (2) the macrophage-intermediate group, which contained between 40% and 80% macrophages; and (3) the macrophage-low group, which contained less than 40% macrophages. In the macrophage-low group, more lymphoid tissue inducer (LTi)-like cells were detected, and the expression of OX40L and TRANCE in these cells was higher than that in the other groups. In addition, in this group, the suppressive function of regulatory T cells was downregulated. Finally, CXCL13 expression was higher in RA synovial fluid than in tonsils, but CCL21 expression was comparable in synovial fluid from all groups and in tonsils. These data demonstrate that increased lymphocyte infiltration in RA synovial fluid is correlated with an increase in LTi-like cells and the elevation of the chemokine expression.

• 대한소아치과학회지
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• 제33권1호
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• pp.62-69
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• 2006

본 연구의 목적은 소아의 비만도가 진정요법의 효과에 미치는 영향을 알아보는 것이다 삼성서울병원 소아치과에 내원한 환자 중 ASA I 또는 II에 해당하는 40명의 환아 (평균연령 30.5개월, 평균신장 91.3cm, 평균체중 14.3kg)를 대상으로 chloral hydrate(60mg/kg) 및 hydroxyzine(25mg)을 사용하여 진정요법을 시행하였다. 환아의 체중과 신장을 이용하여 환아 각각의 비만도를 계산하였고 Broadsky's scale을 이용하여 편도선의 크기를 측정하였다. 진정요법에 대한 결과는 Houpt's scale(수면, 움직임, 울음, 전반적인 행동지수)을 이용하여 평가하였다. 환아의 비만도는 진정효과중 움직임과 울음에 대하여는 통계학적으로 유의한 차이를 만들지 않았으나 비만도가 증가할수록 전반적인 행동지수가 유의하게 나빠지는 결과를 보였다.

• 한국응용곤충학회지
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• 제17권1호
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• pp.15-22
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• 1978

1. "Kresek" 유발균주(K균주)는 품종에 따라서 발현에 차이가 있었으며 지상부 또는 지하부에 접종하여도 "Kresek"을 유발시킬 수 있었으나 대조균주(N균주)는 전연 유발되지 않았다. 2. 엽백의 도관직경은 밀양 23이 유신이나 통일보다 현저히 작았으며 이들간에 고도의 통계적인 유의차가 인정되었다. 3. 밀양 23의 즙액에서 K균주들은 N균주들보다 세균의 증식이 왕성하였으며 통일에서는 균주들간에 증식의 차이가 없었다. 4. 밀양 23의 즙액친서는 K균주의 Dead phase가 정종 9일째부터 N균주는 4일째부터 시작되었으며 통일에서는 모두 3일째부터 시작되었다. 5. 밀양 23즙액의 경우 pH 3.0-4.0 범위에서 다량의 침전물이 형성되었으나 동일의 증액에서는 극히 소량의 침전물을 관찰할 수가 있었다.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1993년도 제27차 학술대회 초록집
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• pp.98-98
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• 1993

편도선의 염증반응은 세균이 편도상피세포에 부착되는 것으로부터 시작되며 부착된 세균은 증식하여 집락을 형성한 후 독소를 분비하여 점막 장벽을 뚫고 조직에 손상을 일으킨다. 저자들은 급성편도선염의 병태를 이해하기 위하여 생체내에서 급성편도선염 환자군과 정상인에서 상피세포의 세균부착성에 대한 차이를 알아보고자 본 실험을 시행하였다. 급욍편도선염 환자군 20례와 정상인 대조군 20례를 대상으로 편도선부위를 면봉으로 문지른후 세포혼합물을 Acridine orange로 염색하여 형광현미경하에서 관찰하였다. 50개의 편도상피세포에서 부착된 세균수를 계산하였다. 또한 동시에 근배양을 시행하였다. 급성편도선염군은 대조군보다 상피세포에서 10% 이상 부착된 세균수가 많았으며 (p<0.05), 상피세포에 부착된 세균수는 연령과 유의한 상관관계를 보여주었다.

• 한방안이비인후피부과학회지
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• 제11권1호
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• pp.269-283
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• 1998

Paranasal sinusitis, especially chronic is one of the most common diseases in the field of otolaryngology. It is similar to Bee Yeun(鼻淵) in oriental medicine. Most cases of sinusitis are due to anatomical abnormalities within ostiomeatal unit or disturbed mucocilliary flow. The ostiomeatal unit is the first place of contact with bacteria and allergens during aspiration, and it can be obstructed easily by minute mucosal swelling due to anatomical narrowness. Therefore the treatment of paranasal sinusitis is not easy and often leads to recurrences in spite of long term treatment or surgical therapy. We studied 83 patients who had visited our hospital with complaints of nasal symptoms; they had been diagnosed as having paranasal sinusitis through an endoscopy or CT scan in another hospital and were diagnosed as the paranasal sinusitis through a PNS series. The results were as follows: 1. Age and sex distribution: The most common occurence was found between 6-10 and 1-5 years old. The Males Were 52($62.7\%$) and Females were 31($37.3\%$). 2. By residence 58 cases lived in apts: 25 lived in houses. 3. The longest duration of disease varied from a lower of 13 to a higher of 36 months in 22 cases and from 7 to 12 months in 21 cases. 4. The most common complication & past history with otolaryngologic or allergic disease were adenoid or tonsil hypertrophy & tonsillectomy and adenoidectomy (21 cases). In decreasing order the others were atopic dematitis, otitis media with effusion and allergic rhinitis. 5. Distribution of paranasal sinus disease was most common in both maxillary sinuses in 52 cases. 12 cases showed a normal PNS X-ray series but these had been diagnosed as paranasal sinusitis with an endoscopy or CT scan in another hospital. 6. Common sinusitis - related symptoms were from highest incidence to lowest nasal obstruction, postnasal drip rhinorrhea, frontal headache, cough with sputum. 7. The most administered of prescription was Gamibangpoongtongsungsan and Sunbangpaedoksan extract. 8. In 26 cases the subjects showed significant improvement symptoms in PNS X-ray series : In 21 case showed partial improvement symptoms.