• 한국육종학회지
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• 제40권3호
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• pp.314-317
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• 2008

"다미" 품종은 작물과학원 호남농업연구소에서 2006년도에 육성한 중만생 고품질 내병성 품종으로 주요특성과 수량성을 요약하면 다음과 같다. 1. 출수기는 보통기 보비재배에서 8월 15일로 남평벼와 같은 중만생종이다. 2. 쌀은 심백이 약간 있으나 단백질 함량이 낮고 밥맛이 매우 좋은 편이다. 3. 도열병, 흰잎마름병 레이스$K_{1-3}$에는 저항성 반응을 보였으나 줄무늬잎마름병 멸구 및 매미충류에는 약한 반응을 보였다. 4. 유묘내냉성은 남평벼와 비슷하나 임실율은 약간 낮다. 5. 쌀수량은 보통기 보비재배에서 5.92 MT/ha로 남평벼보다 9% 증수되었으나 이모작재배에서는 4.91 MT/ha로 남평보다 9% 적었고, 만식재배에서는 5.48 MT/ha로 남평벼 보다 5% 증수되었다. 6. 다미는 충남이남 평야지 1모작 답에 알맞은 품종이다.

• 한국육종학회지
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• 제49권3호
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• pp.250-255
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• 2017

일품벼의 주요 농업적 특성에 모로베레칸의 수당립수와 내도 복성을 조절하는 유전자가 이입된 근동질계통을 육성하기 위해 일품벼와 모로베레칸을 교배하고, 계속적인 여교배와 MAS를 병행 실시하여 유망한 계통 CR28-30-2 계통을 선발하였다. 생산력검정 시험 결과 조사된 형질 중 수당립수와 간기경 등을 제외한 기타 형질에서는 일품벼와 유사한 근동질계통으로, 품종보호출원 조건에 부합하여 화원7호로 명명하고 품종보호원을 출원하였다. 1. 화원7호는 출수기가 보통기재배에서 8월 15일로 일품벼보다 4일 정도 빠른 중만생종 품종이다. 2. 천립중은 23.8g으로 일품벼보다 무거웠으나 통계적인 유의한 차이는 없었다. 3. 흰잎마름병과 줄무늬잎마름병에는 이병성이다. 4. 완전미율은 일품벼에 비해 약간 낮았고, 아밀로스 함량은 일품벼보다 높았으나 통계적인 차이는 없었다. 5. 화원7호의 정조수량은 '10-'11년 2개년간 실시한 생산력검정 시험에서 평균 6.20 MT/ha 로 일품벼와 유사하였으나, 예산에서는 6.48 MT/ha로 일품벼 대비 104% 수준이었다. 6. 화원7호는 일품벼에 비해 수당립수가 많았다 그리고 간기경이 두꺼운 특성을 보였는데 이는 모로베레칸의 APO1 유전자의 영향으로 판단된다.

• Clinical and Experimental Reproductive Medicine
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• 제38권1호
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• pp.37-41
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• 2011

Objective: To compare the effectiveness and convenience of a pen device for the self-administration of follitropin ${\beta}$ with a conventional syringe delivering follitropin ${\beta}$ solution in patients undergoing IVF-ET. Methods: GnRH agonist long protocol was used for controlled ovarian stimulation (COS) in all subjects. A total of 100 patients were randomized into the pen device group or the conventional syringe group on the first day of COS. Local tolerance reactions were assessed within 5 minutes, at 1 hour and at 3 hours after each injection. On the day of hCG injection, patients were asked to rate their overall pain and convenience experienced with self-injection on a visual anlaogue scale (VAS). Results: There were no differences in patients' characteristics between the two groups. The duration of COS was significantly shorter in the pen device group than in the conventional syringe group. Patients included in the pen device group needed a significantly smaller amount of follitropin ${\beta}$. However, no differences between the two groups were found in IVF results and pregnancy outcome. The incidence of local pain within 5 minutes, at 1 hour and at 3 hours after the injection was significantly lower in the pen device group. VAS scores indicated that injections using the pen device were significantly less painful and more convenient. Conclusion: The pen device for self-administration of follitropin ${\beta}$ is less painful, safer and more convenient for the patients, and can be more effective because of the shorter duration and smaller dose of follitropin ${\beta}$ when compared with the conventional syringe.

• 한국토양비료학회지
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• 제37권1호
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• pp.19-24
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• 2004

염류장애의 생리적 반응을 검토하고자 강피(Echinochloa hispidula) 종자를 고농도의 NaCl과 KCl 조건하에서 발아시켰다. 발아의 기간과 진전속도를 측정하였으며, 염류스트레스 조건에서의 지질과산화와 폴리아민 생합성양상을 분석하였다. 고농도 염류처리 자체는 비록 발아를 상당히 지연시킬 수는 있지만 발아를 억제하지 못하는 것으로 나타났다. 지질과산화와 폴리아민 생합성에 견주어볼 때, 강피는 염류에 내성이 것으로 사료되었다. 지질과산화와 putrescine 함량의 증가는 염류처리 후 1일 동안만 지속되었다. 이러한 결과는 초기 putrescine 증가와 지질과산화수소의 생성이 단기간 동안의 염류 내성 기작과 밀접한 관계가 있다고 결론 내릴 수 있는 근거가 되었다.

• The Korean Journal of Pain
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• 제31권2호
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• pp.102-108
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• 2018

Background: Nefopam is a non-opioid, non-steroidal analgesic drug with fewer adverse effects than narcotic analgesics and nonsteroidal anti-inflammatory drugs, and is widely used for postoperative pain control. Because nefopam sometimes causes side effects such as nausea, vomiting, somnolence, hyperhidrosis and injection-related pain, manufacturers are advised to infuse it slowly, over a duration of 15 minutes. Nevertheless, pain at the injection site is very common. Therefore, we investigated the effect of warmed carrier fluid on nefopam injection-induced pain. Methods: A total of 48 patients were randomly selected and allocated to either a control or a warming group. Warming was performed by diluting 40 mg of nefopam in 100 ml of normal saline heated to $31-32^{\circ}C$ using two fluid warmers. The control group was administered 40 mg of nefopam dissolved in 100 ml of normal saline stored at room temperature ($21-22^{\circ}C$) through the fluid warmers, but the fluid warmers were not activated. Results: The pain intensity was lower in the warming group than in the control group (P < 0.001). The pain severity and tolerance measurements also showed statistically significant differences between groups (P < 0.001). In the analysis of vital signs before and after the injection, the mean blood pressure after the injection differed significantly between the groups (P = 0.005), but the heart rate did not. The incidence of hypertension also showed a significant difference between groups (P = 0.017). Conclusions: Use of warmed carrier fluid for nefopam injection decreased injection-induced pain compared to mildly cool carrier fluid.

• Journal of Nutrition and Health
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• 제27권8호
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• pp.805-818
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• 1994

This study investigated the effect of enteral nutrition supplementation on glucose and lipid metabolism in non-insulin dependent diabetes mellitus(NIDDM) patients(n=29). Nutrition formula(400kcal/day) were supplied daily for eight weeks as a substitute for a snack or a meal. Subjects were divided into three groups based on changes of fasting blood glucose(FBG), glucose response area(GRA) on oral glucose tolerance test(OGTT), before and after intake of nutrition formula : group 1(the group of a decrease in FBG and GRA, n=20), group 2(the group of a decrease in FBG and an increase in GRA, n=4), and group 3(the group of an increase in FBF and GRA, n=5). Before nutrition supplementation, group 3 showed a longer tendency of DM duration and a lower tendency of insulin and C-peptide response are than those of group 1 and 2. At 8 weeks after nutrition supplementation, group 1 showed a significant increase in insulin and C-peptide response areas but group 2 and 3 showed no change in those areas. After nutrition supplementation, all three groups showed a tendency of decrease in glycated hemoglobin and no significant changes in the levels of serum triglycerides, HDL, LDL, total cholesterol, albumin, transferrin, creatinine, GOT and GPT. The results suggest that using an enteral nutrition formula in NIDDM patients is a good substitute for a meal or snack and could improve blood glucose control without any changes in lipid levels, and liver and kidney functions. The beneficial effect of nutrition supplementation on glycemic control resulted from components of nutrition formula had such as additional fiber and high monounsaturated fatty acid as the source of fat to be helpful 세 glycemic control in diabetics.

• 한국위성정보통신학회논문지
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• 제7권3호
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• pp.26-29
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• 2012

본 논문에서는 상향링크에서 낮은 PAPR(Peak to Average Power Ratio)을 가지면서 사용자 간 동기 오차 범위를 크게 확장한 MCDS CDMA(Multiple Carrier Direct Spread Code Division Multiple Acceess) 형태의 SC-FDMA(Single Carrier Frequency Division Multiple Access) 기법을 제안한다. 제안하는 기법은 상향링크 준동기 환경에 강한 특성을 가진 MC DS CDMA 기법의 높은 PAPR을 갖는 단점을 보완하기 위해 부분 IFFT(Inverse Fast Fourier Transform) 연산 이전에 부분 DFT(Discrete Fourier Transform)연산을 수행한다. 제안하는 기법은 ${\pm}1$칩 준동기 상황에서 '0'상관도를 갖는 PSW(Properly Scrambled Walsh) 부호를 시간 도메인으로 스프레딩하여 레인징 절차를 수행하지 않고서도 사용자 간 최대 ${\pm}1$ OFDM 심벌 길이 이내의 시간 오차이내에서는 MAI(Multiple Access Interference)가 발생하지 않게 한다. 실험결과에서는 준동기 상황을 개선하기 위해 제안된 기존의 SC-FDMA 방식에 비해 사용자 간 동기 오차에 강한 특성이 있음을 보인다.

• 대한후두음성언어의학회지
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• 제18권2호
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• pp.108-112
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• 2007

Otolaryngological manifestations of acid reflux include a wide range of pharyngeal and laryngeal symptoms ; and the constellation of symptoms has been called laryngopharyngeal reflux (LPR). In the absence of definite diagnostic criteria, LPR disease remains a subjective entity. A diagnosis of LPR is usually based on response of symptoms to empirical treatment. Investigative modalities such as pH monitoring and, more recently, impedance studies are generally reserved for treatment failures. LPR usually requires more aggressive and prolonged treatment to achieve regression of both symptoms and laryngeal findings. The suppression of gastric acid and secretion with anti-secretary agents has been the mainstay of medical treatment for patients with acid-related disorders. The suppression of gastric acid secretion achieved with Hz-receptor antagonist $(H_2RA)$ has proved suboptimal for relief of reflux symptoms. The rapid development of tolerance and rebound acid hypersecretion after the with-drawal of $H_2RA$ limit their clinical use. Proton pump inhibitors (PPI) have been proved to be very effective for suppressing intragastric acidity, but the optimal dose and duration is unknown. Current evidence indicates that pharmacologic intervention should include, at a minimum, a 3 month trial of twice daily PPI. Symptoms of LPR improve over 2 months of therapy. The physical findings of LPR resolve more slowly than the symptoms and this continues through out at least 6 months of treatment. For most patients with LPR, twice daily dosing with a PPI is usually recommended for an initial treatment for a period of no less than 6 months treatment, and lifetime treatment may be required.

• 대한한방종양학회지
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• 제9권1호
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• pp.99-108
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• 2003

Recently, the proportion of the population older has increased rapidly. As the aged population is increasing, the prevalence of malignancy rises with age, too. We believe that the potential benefits of approach to cancer care in the elderly are self-evident. In order to investigate the characteristics of cancer in the elderly, we reviewed literature related with the biology of the aged with cancer. The elderly undergo age-related changes in their physiology which may result in altered tolerance to disease and to the requirements of the management of illness. The possible reasons for the increased prevalence of cancer in the elderly are a longer potential duration of exposure to carcinogens, a reduced ability of repair DNA and reduced host defences against malignancy. In general, cancer patients in the elderly have a shorter survival. Because it is impossible to offer the active treatment of cancer in the elderly. Also, they have the problems that the psychosocial change and reduce of physiological function such as absorption, metabolism and excretion. We hope that other groups will further research cancer in the elderly in future.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1089-1092
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• 2013

Background: Elderly patients with acute myeloid leukemia (AML) have a poor outcome because of co-morbidities, poor tolerance to intensive chemotherapy and inherently more resistant disease. Clofarabine is a second generation nucleoside analogue which has shown promising activity in elderly patients with AML. This study was conducted to review the outcome of treatment with clofarabine in a group of such patients. Methods: The records of 5 elderly patients who were diagnosed to have AML and treated with clofarabine over a 12 month period were reviewed retrospectively. Results: There were 2 female and 3 male patients with a median age of 68 years (range 65-82). At the time of treatment, 2 patients had newly diagnosed AML not considered suitable for intensive therapy, while 3 patients had partial or no response to conventional chemotherapy. The overall response rate was 100%, all patients achieving a complete remission. Induction and consolidation were well tolerated. All patients developed neutropenia with a median duration of 20 days (range 17-42). One patient developed hand and foot syndrome and a generalized rash but recovered. There was no mortality and all patients remained in remission after a median follow-up of 5.2 months (Range 3-10). Conclusion: Clofarabine (alone or in combination) is active in elderly AML patients with an acceptable safety profile and should be considered a potential option in this group.