• Journal of Nutrition and Health
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• 제36권5호
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• pp.437-445
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• 2003

As obesity is known to be related to hyperlipidemia, insulin and leptin resistance, and other chronic diseases, much recent research has focused on functional food materials and their anti-obesity activity. This study was performed to study the effects of Artemisia Iwayomogi oligosaccharide AIPI on the anti-obesity function in normal rats and diet-induced obese (DIO) rats. F344 male rats were divided into four groups: Normal-control (CONT), normal-AIPI, DIO-CONT and DIO-AIPI. The groups were provided with water (in the CONT groups) or another drink for 4 weeks. The final body weights of rats in the DIO-AIPI group were lower than those in the CONT group. Abdominal adipose tissue weight per kg of body weight in the DIO-AIPI group was significantly lower than that in the DIO-CONT group. Also, the final levels of serum-triglyceride, serum-total cholesterol and serum-low density lipoprotein cholesterol in the DIO-AIPI group were lower than those in the DIO-CONT group. Moreover, the serum-high density lipoprotein cholesterol level in the normal-AIPI group was significantly higher than that in the normal-CONT group. Finally, the serum-leptin concentration was significantly lower in the DIO-AIPI group. Total lipid, triglyceride, and total cholesterol contents in the feces of the DIO-AIPI group were as high as 142％, 199％, and 165% of the respective values of the DIO-CONT GROUP. These results indicate that orally administered Artemisia Iwayomogi oligosaccharide not only has hypotriglycemic and hypocholesterolemic effects, but also has the effect of reducing the body weight and the abdominal adipose tissue weights obese rats. Therefore, we expect that Artemisia Iwayomogi oligosaccharide AIPI may have an anti-obesity function in F344 diet-induced obese rats. (Korean J Nutrition 36(5): 437∼445, 2003)

• 대한본초학회지
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• 제27권3호
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• pp.107-112
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• 2012

Objectives : This study was designed to investigate the effects of Tong Xin Lou (TXL) on lipid accumulation in liver tissue in Hypercholesterolemic mice. TXL is new drug, which is one of Cardiotonic Pills. TXL is used for activating the blood flow in the restoration stage of cerebral infarction, and for alleviation of angina pectoris including the symptoms as chest oppressed and stabbing pain. Methods : Hyperlipidemia was induced by providing high fat diet for 6 weeks. Normal group was provided with normal rodent diet. TXL was administered orally in the concentration of 10 mg/day for 2 weeks (TXL group). D/W was administered orally in CTL group for 2 weeks. We observed histopathological changes in liver and heart tissues, and also investigated the effect on body weights, and levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride in serum. Results : In this study, TXL did not affects weight gain in hypercholesterolemic mice. TXL group showed downward tendency of lipid accumulation compared with CTL group. In addition, oral administration of TXL lowered levels of total cholesterol (P < 0.05) and triglyceride (P < 0.05), which were elevated by induction of hypercholesterolemia. Conclusion : These results suggest that TXL can prevent lipid accumulation in liver tissue through regulation of dyslipidemia.

• 한국지역사회생활과학회지
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• 제27권1호
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• pp.137-145
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• 2016

This study evaluated the effect of Allium hookeri roots on lipid metabolism of the serum, liver, and adipose tissues induced by a high-fat diet in male Sprague-Dawley rats. The rats were divided into four groups with 8 rats per group for 4 weeks: the normal-diet group (N), the high-fat diet (HFD) group, the HFD containing 3% Allium hookeri (HFD-A3) group, and the HFD containing 5% Allium hookeri (HFD-A5) group. The results showed that the body weight gain and food intake of rats in the HFC-A3 and HFC-A5 groups were significantly decreased compared with those in the HFD group. The epididymal adipose tissue weight in the HFD-A5 group was significantly decreased compared with those in the HFD group, and adipose tissue weights of liver and mesenteric adipose tissues in the HFD-A3 and HFD-A5 groups were significantly decreased compared with those in the HFD group. Serum triglyceride, total cholesterol and LDL cholesterol concentrations, atherogenic index, and cardiac risk factor were significantly lower in the HFD-A3 and HFD-A5 groups than in the HFD group. Serum lipid profiles, as well as ALT and AST activities did not show any difference in all groups. Serum ALP and LDH activities were suppressed in the HFD-A5 group compared with those in the HFD group. The hepatic triglyceride and total cholesterol levels of rats in the HFD-A5 group was significantly lower than those in the HFD group. Moreover, triglyceride and total cholesterol in the epididymal and mesenteric adipose tissues were significantly lower in the HFD-A5 group than in the HFD group. These results demonstrated that the intake of Allium hookeri showed a hypolipidemic effect, changing the lipid metabolsim of a high-fat diet induced rats.

• Journal of Nutrition and Health
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• 제32권4호
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• pp.353-368
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• 1999

This study was performed to investigate the effects of Korean native plant diets on lipid and cadmium (Cd) metabolisms and also antioxidative enzyme activities in rats. Seventy male Sprague-Dawley rats weighing 210.3$\pm$2.7g were blocked into ten groups according to body weight. Rats were raised for four weeks with diets containing 0 or 0.04%(w/w) cadmium chloride and 5%(w/w) plant powder-Ssook(Artemisia princeps var. orientalis HARA), Chamchwi(Aster scaber THUNB), Gomchwi(Lingularia fischeri TUBCZ). or Solbeerum (Portulaca oleracea LINNE). Food intake, weight gain, food efficiency ratio, and weights of liver, kidney, spleen and epididymal fat were significantly lower in Cd-exposed groups, food efficiency ratio, and weights of liver, kidney, spleen and epididymal fat were significanlty lower in Cd-exposed groups. Plasma total lipid level, liver total lipid, cholesterol and triglycerde concentrations, and fecal total lipid, cholesterol and triglyceride excretions were decreased by Cd administration. Total lipid and triglyceride concentration in plasma and liver were lower in Chamchwi groups together with increased fecal total lipid and triglyceride excretions. Cholesterol concentration in plasma and liver were lower in Gomchwi groups with increased fecal cholesterol excretions. Activities of red-blood-cell superoxide dismutase(SOD), and liver catalase, SOD and glutathione peroxidase (GSH-px) were decreased significantly by Cd administration. Thiobarbituric acid reactive substance(TBARS) concentrations of plasma and liver were increased by Cd administration. Thiobarbituric acid reactive substance(TBARS) concentration of plasma and liver were increased by Cd administration. Administration of plant diets decreased plasma and liver catalase, SOD and GSH-px activities in Cd-free diet groups and increased them in Cd-administered groups. Plasma and liver TBARS concentrations were decreased in animals fed plant diets, with Chamchwi showing the most effective antioxidative capacity. The concentration of Cd accumulated in blood and tissue decreased in Cd-exposed groups fed plant diets. Liver Cd concentration were lower in the Chamchwi and Gomchwi groups, and kidney Cd levels were lower in the Ssook and Chamchwi groups. Among them, Chamchwi was the most effective in Cd detoxification. In conclusion, Chamchwi and Gomchwi were effective in lowering tissue lipid levels, with Chamchwi having the greatest antioxidative and detoxifying effects.

• Korean Journal of Acupuncture
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• 제24권1호
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• pp.113-129
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• 2007

Objectives : This research was performed to investigate the effect of acupuncture using invasive low level laser therapy (LLLT) at Yolgyol (LU7) + Yogu (LR5) on weight gain, food intake, food efficiency, lipid metabolism, atherogenic index, HTR (HDL-cholesterol to total cholesterol ratio) and morphological change of hepatic tissue in hyperlipdemia rats. Methods : Experimental groups were divided into high fat diet group (Control group), high fat diet and acupuncture therapy group at LU7 + LR5 (AT group), high fat diet and acupuncture group using 10 mW LLLT at LU7 +LR5 (LA10 group), high fat diet and acupuncture group using 20 mW LLLT at LU7+LR5(LA20 group), high fat diet and acupuncture group using 60 mW LLLT at LU7 + LR5 (LA60 group), once per 3 days during 9 weeks. Results : Body weight was decreased significantly in AT and LA20 groups compared with Control group. Food intake was increased significantly in LA60 group compared with Control group. Food efficiency was decreased significantly in LA10, LA20 and LA60 groups compared with control group. In the lipid metabolism, total cholesterol was decreased significantly in AT, LA10, LA20 and LA60 groups, triglyceride was decreased significantly in LA10, LA20 and LA60 groups, TG/HDL-cholesterol ratio was decreased significantly in LA 60 group compared with control group. In the morphological change, hepatic tissue were not showed balloning degeneration and irregular arrangement of hepatic cell in LA10 and LA20 groups with control group. Conclusions : Acupuncture using LLLT at LU7+LR5 can manage hyperlipemia by controlling body weight, food intake, food efficiency ratio and lipid metabolism.

• Preventive Nutrition and Food Science
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• 제16권3호
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• pp.202-209
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• 2011

This study was initiated to investigate the effects of lyophilized purslane (Portulaca oleracea) powder (5% and 10%) on lipid levels in rats fed a hypercholesterolemia-inducing diet (1% cholesterol). During the four week study, there were no significant differences in either weight change or the food efficiency ratio between the group fed the hypercholesterol diet alone (HC) and the groups fed the purslane powder (HCPO-I and HCPO-II, 5% and 10% purslane, respectively). In serum, the levels of total lipid, total cholesterol and LDL-C decreased significantly for the group fed the 10% purslane powder (HCPO-II) in comparison with the group fed the 5% purslane powder (HCPO-I). The atherogenic index (AI) was reduced by about 51% for the group fed the 10% purslane powder (1.47) in comparison with the HC group (3.03). The activities of GOT, GPT, ALP and LDH decreased significantly for the groups fed the purslane powder in comparison with the HC group. Regarding liver tissue, the levels of total lipid, total cholesterol and triglyceride decreased significantly for the purslane powder-fed rats compared to the HC group. The fecal lipid profiles increased significantly as the amount of purslane powder was increased. Compared to the HC group, the fecal total cholesterol and triglyceride levels were higher in the group fed the 10% purslane powder by about 2.8 times and 2.3 times, respectively. For the serum and liver tissue, the content of lipid peroxide decreased significantly in the groups fed purslane powder compared to the HC group. The data from this experiment show an increase in the lipid levels discharged in feces, suggesting that the supplementation of purslane powder to a hypercholesterolemia-inducing diet reduces lipid levels.

• 대한한방내과학회지
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• 제32권2호
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• pp.243-258
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• 2011

Objectives : This study investigated the hypolipidemic and antioxidant effects of Curcuma radix using a rat model induced by poloxamer 407 injection. Methods : Serum lipid parameters and oxidative stress-associated biomarkers were determined. Additionally, hepatic cholesterol and triglyceride as well as lipid metabolism-associated gene expressions were observed in hepatic tissue. Results : 1. Curcuma radix ameliorated elevation of serum cholesterol, triglyceride, LDL-cholesterol, MDA, hepatic cholesterol level, and reduction of serum TAC, SOD, GSH, GSH-reductase level. 2. Curcuma radix augmented up-regulated ACAT gene expression. 3. Curcuma radix almost completely ameliorated down-regulated CYP-7A1 but up-regulated HMG-CoA gene expression. Conclusions : The hypolipidemic and antioxidant properties of Curcuma radix were evidenced. This study provides a scientific basis for the clinical application of Curcuma radix and development of hypolipidemics using this herb in the future.

• Journal of Nutrition and Health
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• 제31권6호
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• pp.981-990
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• 1998

The effects of indigestible dextrin on lipids in serum, tissue, and feces were investigated in two experiments carried out with 64 male Sprague-Dawley rats for eight weeks. Experiment I diet(normal fat diet) containing 5% corn oil and experiment II diet(high fat diet) containing 18% fat(13% beef tallow and 5% corn oil) and 1% cholesterol were divided into four groups with 0.5% cellulose(0.5CL : control), 10% cellulose(10CL), 10% Indigestible dextrin I(ID-I) and 10% indigestible dextrin II(ID-II), respectively. ID-I and ID-II diets produced a decrease in serum total lipid and cholesterol concentrations in both normal and high fat diets but more significantly in the groups fed high fat diet. ID-I, ID-II, and 10CL of high fat diet decreased serum glucose concentration. ID-I and ID-II diets also decreased liver cholesterol and triglyceride concentrations in rats fed normal and high fit diets. The fecal excretion of cholesterol in ID-II/high fat diet was significantly higher than that of 0.5CL diet. Bile acid excretion was increased in the rats fed 10CL and ID-II diets of normal and high fat diets. These observations indicat the hypolipidemic and hypocholesterolemic effects of indigestible dextrin on the rats. These effects are mediated by the increase of facal cholesterol and bile acid excretion. (Korean J Nutrition31(6) : 981-990, 1998)

• 한국식품영양과학회지
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• 제43권5호
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• pp.641-649
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• 2014

본 연구는 갯기름나물의 혈청, 간 및 지방조직의 체내 지질대사 개선 및 항산화 효능을 살펴보기 위하여 5주령 된 흰쥐수컷 32마리를 1주일간 적응시킨 후 정상식이군(N), 고지방-고콜레스테롤 식이군(대조군, HFC), 고지방-고콜레스테롤 식이와 5% 갯기름나물 분말 첨가군(HFC-PBL) 및 고지방-고콜레스테롤 식이와 10% 갯기름나물 분말 첨가군(HFC-PBH)으로 나누어 4주간 실시하였다. 체중증가량 및 식이효율은 고지방-고콜레스테롤 식이를 급여한 대조군이 정상식이군에 비하여 유의적으로 증가하였으며, 갯기름나물 분말 첨가군들(HFC-PBL, HFC-PBH)은 대조군에 비하여 유의적으로 감소하였다. 식이섭취량은 대조군이 가장 낮았으나 실험군들 간의 유의차는 나타나지 않았다. 고지방-고콜레스테롤 식이로 증가되어진 간 및 지방조직의 무게는 갯기름나물 분말 첨가로 대조군에 비해 감소하는 경향이었으며, 장간막지방조직 무게는 유의하게 감소하여 정상식이군과 비슷한 경향을 보였다. 갯기름나물 분말 첨가군들의 혈청 중 ALT 및 AST 활성은 대조군에 비하여 유의차는 없었으나 감소하는 경향이었으며, 혈청 중 ALP 활성은 유의적으로 감소하는 경향이었다. 혈청 중 LDH 활성은 갯기름나물 분말 고농도 첨가군(HFC-PBH)은 대조군에 비하여 유의적으로 감소되었다. 혈청 중 중성지방 함량은 갯기름나물 분말 첨가군들이 대조군에 비하여 유의적으로 감소하였고, 혈청 중 총콜레스테롤 함량은 유의차는 없었으나 다소 감소하는 경향이었다. 혈청 중 LDL-콜레스테롤 함량은 정상식이군에 비하여 대조군이 유의하게 증가하였고, 데친 갯기름나물 분말 고농도 첨가군에서 유의한 감소효과를 보였다. 고지방-고콜레스테롤 식이로 증가되어진 간과 지방조직의 중성지방 및 총콜레스테롤 함량은 갯기름나물 분말 첨가로 감소하는 경향이었으며, 부고환지방조직과 장간막지방조직의 중성지방 함량, 간조직과 지방조직 중 총콜레스테롤 함량은 데친 갯기름나물 분말 고농도 첨가군에서 대조군에 비해 유의하게 감소하여 정상식이군과 비슷한 경향이었다. 고지방-고콜레스테롤 식이로 감소되어진 간조직 중 GSH 함량은 갯기름나물 분말 첨가로 유의하게 증가하였으며 증가된 과산화지질 함량은 유의하게 감소하였다. 이상의 실험결과 in vivo에서 고지방-고콜레스테롤 식이와 함께 섭취한 갯기름나물 분말은 체중, 간 및 지방조직의 무게 감소와 더불어 혈청 및 지방조직의 지질대사 개선에 긍정적인 영향을 미치는 것으로 나타났다. 이러한 결과는 갯기름나물에 함유된 항산화 비타민 및 무기질, polyphenol, flavonoid 등 생리활성 물질에 의해 지방조직의 체지방 형성을 억제하고 산화적 스트레스를 완화시킴으로써 체내 지질대사 개선과 심혈관계 질환 예방효과를 나타낼 수 있을 것으로 생각된다.

• 한국자원식물학회지
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• 제29권4호
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• pp.355-362
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• 2016

혈중 LDL 콜레스테롤 농도는 이상 lipoprotein metabolism의 유효한 지표로 간주되고 있으며, 관상동맥질환 및 동맥경화증의 위해성과 직접 연관이 있는 것으로 알려져 있다(Goldstein and Brown, 1983; Venter et al., 1990). 또한 HDL 콜레스테롤은 말초조직에서 간으로의 콜레스테롤의 이동에서 중요한 역할을 하며, 유리형 콜레스테롤의 에스테르화를 촉매하는 효소인 lecithin:cholesterol acetyltransferase (LCAT)를 활성화하여 세포 안으로 콜레스테롤의 유입을 억제함으로써 동맥경화를 막는 역할을 한다(Steinberg and Witztum, 1990). 본 연구 결과 석창포 열수 추출물은 혈중 triglyceride 수준을 유의하게 낮추는 효과가 입증되었다. 또한 석창포 열수 추출물은 혈중 total cholesterol과 HDL-cholesterol 수준을 WKAG-M, WKAG-H군에서 유의하게 감소 시켰으며 LDL-cholesterol 수준은 석창포 열수 추출물 투여에 의해 유의적으로 증가되었다. 또한 이러한 결과로부터 석창포 열수 추출물은 혈중 지질 조절에 의해 동맥 경화 지수를 감소시킬 수 있으며 심장 위험 지수 또한 감소시킬 수 있음을 알 수 있었다. 추후 석창포 열수 추출물 분획 중의 각 성분들이 혈중 지질 성상에 미치는 효과를 규명하는 연구를 수행하여 유효성분에 대한 연구를 계속할 예정이다.