• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권2호
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• pp.99-115
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• 2023

Purpose: Exclusive breastfeeding promotes gut microbial compositions associated with lower rates of metabolic and autoimmune diseases. Its cessation is implicated in increased microbiome-metabolome discordance, suggesting a vulnerability to dietary changes. Formula supplementation is common within our low-income, ethnic-minority community. We studied exclusively breastfed (EBF) neonates' early microbiome-metabolome coupling in efforts to build foundational knowledge needed to target this inequality. Methods: Maternal surveys and stool samples from seven EBF neonates at first transitional stool (0-24 hours), discharge (30-48 hours), and at first appointment (days 3-5) were collected. Survey included demographics, feeding method, medications, medical history and tobacco and alcohol use. Stool samples were processed for 16S rRNA gene sequencing and lipid analysis by gas chromatography-mass spectrometry. Alpha and beta diversity analyses and Procrustes randomization for associations were carried out. Results: Firmicutes, Proteobacteria, Bacteroidetes and Actinobacteria were the most abundant taxa. Variation in microbiome composition was greater between individuals than within (p=0.001). Palmitic, oleic, stearic, and linoleic acids were the most abundant lipids. Variation in lipid composition was greater between individuals than within (p=0.040). Multivariate composition of the metabolome, but not microbiome, correlated with time (p=0.030). Total lipids, saturated lipids, and unsaturated lipids concentrations increased over time (p=0.012, p=0.008, p=0.023). Alpha diversity did not correlate with time (p=0.403). Microbiome composition was not associated with each samples' metabolome (p=0.450). Conclusion: Neonate gut microbiomes were unique to each neonate; respective metabolome profiles demonstrated generalizable temporal developments. The overall variability suggests potential interplay between influences including maternal breastmilk composition, amount consumed and living environment.

• 헤리티지:역사와 과학
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• 제57권1호
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• pp.54-79
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• 2024

본 연구는 한국의 발해학계에서 박물관 전시를 인식하는 논점이 중국에만 편중되어온 공백을 메우기 위해 작성되었다. 따라서 러시아 박물관에서 개최된 발해사 전시구성 및 운영정책의 특징과 변화를 분석하여, 국가 간 발해사 이해를 넓힐 수 있는 해석과 표출에 대한 자료를 공유하고자 한다. 이에 러시아의 발해사 전시를 대표하는 아르세니예프 V.K 국립극동역사보호지구 통합박물관의 상설전시 및 기획전시를 대상으로 시론적 연구를 시도해보았다. 우선 전시구성을 살펴보면, 상설전시는 지역사의 통시적 구성으로, 제1회 및 2회 기획전시는 러시아과학원 주요 소장유물을 포함한 발해사 주제별 구성으로 기획되었다. 전시 운영정책은 박물관 운영규정, 전시 운영인력, 전시 홍보전략을 통해 살펴보았다. 다음으로 전시가 개최된 배경과 역할 변화를 살펴보기 위해, 발해사 전시 개최 분기에 따른 지역사회의 정치·사회·문화적 이슈를 검토하였다. 그 결과, 상설전시 개편분기에는 국제정상회의 개최지역에 대한 역사인식을 제고하고, 제1회 기획전시 분기에는 다양한 정책주체들에 의해 한·러 합작 문화관광 현안을 견인하였으나, 제2회 기획전시 분기에는 국내외적 외교전략 변화 등과 맞물려 홍보 및 연계행사가 활성화되지 않은 것으로 추론해보았다. 마지막으로, 전시 내러티브의 특징을 살펴보기 위해, 지역사 교과서 및 발해사 개설서를 분석틀로 삼고 전시 내용과 상호 비교해보았다. 그 결과, 시대별 내러티브에서는 교과서에서 분리되었던 말갈족과 발해국의 통합 연출이 확인된다. 주제별 내러티브 중 정치사 주제에서는 변방의 말갈족 전사 대신 발해의 중앙 관리로 연출된 변화를 파악할 수 있었다. 특히 발해 영역도는 실증적인 조사자료 축적의 중요성을 시사한다. 물질문화 주제에서는 농업·수렵을 보여주는 동식물유체 자료의 보강을 제안해보았고, 대외 관계 주제에서는 통일신라 교류와 투르크계 주민 구성을 시사하는 내러티브를 살펴보았다. 사상문화 주제에서는 고구려 국가제사의례와 관련된 내러티브가 나타나는데, 이는 한국학계에서 아직 주목하지 못했던 새로운 자료이므로 추후 논의가 필요함을 지적해보았다. 결론적으로, 본 연구는 러시아 박물관의 발해사 전시 연구에 대한 공백을 메우고, 전시가 변화해온 맥락과 전시 내러티브의 특징을 고찰하여 시사점을 제시했다는 의의가 있다.

• 대한의료기공학회지
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• 제10권1호
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• pp.130-157
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• 2007

The purpose of this research is to seek for efficient health maintenance device and to suggest desirable daily habit, based on the inquiry on interrelationship between workers' daily lives and their heartbeat change level. The paper survey about general features, case history and daily habits was conducted on workers during medical examination in Jeollabukdo, and examined their change of heartbeat as well. The results of research deducted from data analysis are as follows; 1. There found very positive interrelations between time-domain analysis and frequency-domain analysis, and MHR and LF/HF ratio had negative connection with other analyses. 2. The recipient showed high time-domain analysis when they are younger, have worked shorter or have spouse, and it contributes to stable sympathetic nerve and parasympathetic nerve as it stimulates autonomic nervous system. 3. According to the result of frequency-domain analysis, recipients showed higher TP and LF when they are younger, and the highest HF when they are under 34.The level of VLF was higher for university graduates than the ones who finished high school. The recipients showed higher TP and HF when they don't have spouse, and lower TP, LF and HF when they have worked longer. 4. The level of RMSSD and TSRD was high for the people who don't have case history, and HF was high when they don't have any disease in progress. 5. According to the result concerning correlation of daily habits with time-domain analysis and frequency-domain analysis, cigarette, alcohol and sleeping hours don't affect heartbeat change, but the ones who regularly workout showed higher result in every analysis. It shows that the autonomic nervous system of recipients who regularly exercise response more actively. The result mentioned above suggests that the change of heartbeat is a direct index which shows the change of autonomic nervous system, and it depends on the exercise the most. Thus, workout is proved to be the best method in order for workers to take care of their health.

• Earthquakes and Structures
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• 제15권5호
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• pp.453-462
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• 2018

Damages to buildings affected by a near-fault strong ground motion are largely attributed to the vertical component of the earthquake resulting in column failures, which could lead to disproportionate building catastrophic collapse in a progressive fashion. Recently, considerable interests are awakening to study effects of earthquake vertical components on structural responses. In this study, detailed modeling and time-history analyses of a 12-story code-conforming reinforced concrete moment frame building carrying the gravity loads, and exposed to once only the horizontal component of, and second time simultaneously the horizontal and vertical components of an ensemble of far-field and near-field earthquakes are conducted. Structural responses inclusive of tension, compression and its fluctuations in columns, the ratio of shear demand to capacity in columns and peak mid-span moment demand in beams are compared with and without the presence of the vertical component of earthquake records. The influences of the existence of earthquake vertical component in both exterior and interior spans are separately studied. Thereafter, the correlation between the increase of demands induced by the vertical component of the earthquake and the ratio of a set of earthquake record characteristic parameters is investigated. It is shown that uplift initiation and the magnitude of tensile forces developed in corner columns are relatively more critical. Presence of vertical component of earthquake leads to a drop in minimum compressive force and initiation of tension in columns. The magnitude of this reduction in the most critical case is recorded on average 84% under near-fault ground motions. Besides, the presence of earthquake vertical components increases the shear capacity required in columns, which is at most 31%. In the best case, a direct correlation of 95% between the increase of the maximum compressive force and the ratio of vertical to horizontal 'effective peak acceleration (EPA)' is observed.

• 한국지진공학회논문집
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• 제15권4호
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• pp.33-43
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• 2011

이 논문은 원전구조물의 내진설계에 적용되는 인공지진파의 강진지속시간과 포락함수에 대한 현행 국내 설계기준의 개선과 보완을 위해서 필요한 기반연구에 관한 내용을 다루고 있다. USNRC와 ASCE 4-98에서 제안한 응답스펙트럼과 강진지속시간에 대한 규정이 현재 통상적으로 사용되고 있으며, 첫 번째로 두 기준에 대한 비교와 검토를 수행하였다. 다음으로 총 209개의 암반사이트에서 실제 계측된 규모 5.0 이상인 강진기록을 ASCE 4-98의 강진지속시간기준에 적용한 결과를 통계 처리하여 지진규모에 대한 함수로 표현되는 강진지속시간의 실험적 예측모델을 제시하였다. 마지막으로 강진지속시간이 원전구조물의 지진응답특성에 미치는 영향을 파악하기 위하여 6초에서 20초까지 약 2초 간격으로 강진지속시간을 달리하는 10가지 Case에 대한 인공지진파를 각 30개씩 작성하고, 이들을 적용하여 대만 Hualien 지진시험구조물과 국내 울진 원자력발전소 원자로 격납구조물에 대한 광범위한 지진응답해석을 수행하고 그 결과를 분석하였다.

• 한국지진공학회논문집
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• 제14권2호
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• pp.1-13
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• 2010

본 논문에서는 비선형 지진격리교량의 최적 설계 방법을 제시하였다. 최적설계를 위한 목적함수로는 교각과 지진격리장치의 파괴확률을 고려하였으며, 상충하는 두 목적함수를 동시에 최적화하는 다수의 해를 효율적으로 검색하고자 유전자 알고리즘에 기반한 다목적 최적화기법을 도입하였다. 또한, 최적화 과정에서 요구되는 다수의 비선형 시간이력해석을 수행하지 않고도 교량의 확률적 응답을 효율적으로 예측할 수 있는 추계학적 선형화 방법을 접목하였다. 제시하는 방법의 효율성을 검증하기 위한 수치 예로서 실제 교량인 남한강교를 고려하였고, 제안하는 방법과 기존 비선형 시간이력해석을 이용한 생애주기비용 기반 설계법을 각각 적용하여 내진성능을 비교하였다. 내진성능을 비교한 결과, 제시하는 방법이 기존의 비용에 기반한 최적설계보다 우수한 성능 및 경제성을 보임을 검증하였다. 또한, 다양한 지진하중에 대해서도 제안된 방법이 보다 개선된 성능을 보임을 확인하였다.

• Nuclear Engineering and Technology
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• 제52권2호
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• pp.381-396
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• 2020

Investigations of the commercial aircraft impact effect on nuclear island infrastructures have been drawing extensive attention, and this paper aims to perform the safety assessment of Generation III nuclear power plant (NPP) buildings subjected to typical commercial aircrafts crash. At present Part I, finite element (FE) models establishment and validations for both the aircrafts and NPP buildings are performed. (i) Airbus A320 and A380 aircrafts are selected as the representative medium and large commercial aircrafts, and the corresponding fine FE models including the skin, beam, fuel and etc. are established. By comparing the numerically derived impact force time-histories with the existing published literatures, the rationality of aircrafts models is verified. (ii) Fine FE model of the Chinese Zhejiang Sanao NPP buildings is established, including the detailed structures and reinforcing arrangement of both the containment and auxiliary buildings. (iii) By numerically reproducing the existing 1/7.5 scaled aircraft model impact tests on steel plate reinforced concrete (SC) panels and assessing the impact process and velocity time-history of aircraft model, as well as the damage and the maximum deflection of SC panels, the applicability of the existing three concrete constitutive models (i.e., K&C, Winfrith and CSC) are evaluated and the superiority of Winfrith model for SC panels under deformable missile impact is verified. The present work can provide beneficial reference for the integral aircraft crash analyses and structural damage assessment in the following two parts of this paper.

• 한국안전학회지
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• 제26권3호
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• pp.52-58
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• 2011

지진별 특성이 사회간접시설에 미치는 영향을 평가하는 것은 내진성능의 향상을 위해 중요한 검토사항이다. 이 연구에서는 근거리 및 원거리 지진의 특성을 고려하여 장주기 골조구조물의 구조거동을 합리적으로 평가하는 방법을 비교분석하였다. 이를 위해서 입력지진동의 영향을 명확하게 반영할 수 있는 대상구조물을 선정하여 탄성 및 비탄성 시간이력해석을 수행하였다. 수치해석결과를 바탕으로 지진특성에 따른 전단력, 모멘트, 가속도 및 변위응답의 분포양상을 검토하고 차이점을 분석하였다. 또한 대상구조물의 비탄성 거동을 파악하기 위해서 소성힌지의 발생순서를 모사운용하여 붕괴발생모드를 해석하였다. 이 연구결과는 장주기 골조구조물의 내진안전성 평가를 위한 효율적인 방법을 제시하고 근거리 지진의 안전성에 미치는 영향을 분석하였다.

• Nuclear Engineering and Technology
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• 제53권1호
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• pp.44-60
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• 2021

In this paper, we validate the decay heat calculation capability via a two-step method to analyze spent nuclear fuel (SNF) discharged from pressurized water reactors (PWRs). The calculation method is implemented with a lattice code STREAM and a nodal diffusion code RAST-K. One of the features of this method is the direct consideration of three-dimensional (3D) core simulation conditions with the advantage of a short simulation time. Other features include the prediction of the isotope inventory by Lagrange non-linear interpolation and the use of power history correction factors. The validation is performed with 58 decay heat measurements of 48 fuel assemblies (FAs) discharged from five PWRs operated in Sweden and the United States. These realistic benchmarks cover the discharge burnup range up to 51 GWd/MTU, 23.2 years of cooling time, and spanning an initial uranium enrichment range of 2.100-4.005 wt percent. The SNF analysis capability of STREAM is also employed in the code-to-code comparison. Compared to the measurements, the validation results of the FA calculation with RAST-K are within ±4%, and the pin-wise results are within ±4.3%. This paper successfully demonstrates that the developed decay heat calculation method can perform SNF back-end cycle analyses.

• Computers and Concrete
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• 제23권1호
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• pp.1-10
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• 2019

The use of non-linear analysis of structures in a functional way for evaluating the structural seismic behavior has attracted the attention of the engineering community in recent years. The most commonly used functional method for analysis is a non-linear static method known as the "pushover method". In this study, for the first time, a cyclic pushover analysis with different loading protocols was used for seismic investigation of curved bridges. The finite element model of 8-span curved bridges in plan created by the ZEUS-NL software was used for evaluating different pushover methods. In order to identify the optimal loading protocol for use in astatic non-linear cyclic analysis of curved bridges, four loading protocols (suggested by valid references) were used. Along with cyclic analysis, conventional analysis as well as adaptive pushover analysis, with proven capabilities in seismic evaluation of buildings and bridges, have been studied. The non-linear incremental dynamic analysis (IDA) method has been used to examine and compare the results of pushover analyses. To conduct IDA, the time history of 20 far-field earthquake records was used and the 50% fractile values of the demand given the ground motion intensity were computed. After analysis, the base shear vs displacement at the top of the piers were drawn. Obtained graphs represented the ability of a cyclic pushover analysis to estimate seismic capacity of the concrete piers of curved bridges. Based on results, the cyclic pushover method with ISO loading protocol provided better results for evaluating the seismic investigation of concrete piers of curved bridges in plan.