• Wind and Structures
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• v.26 no.4
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• pp.205-214
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• 2018

In this paper, the thermo-mechanical buckling characteristics of functionally graded (FG) size-dependent Timoshenko nanobeams subjected to an in-plane thermal loading are investigated by presenting a Navier type solution for the first time. Material properties of FG nanobeam are supposed to vary continuously along the thickness according to the power-law form and the material properties are assumed to be temperature-dependent. The small scale effect is taken into consideration based on nonlocal elasticity theory of Eringen. The nonlocal governing equations are derived based on Timoshenko beam theory through Hamilton's principle and they are solved applying analytical solution. According to the numerical results, it is revealed that the proposed modeling can provide accurate critical buckling temperature results of the FG nanobeams as compared to some cases in the literature. The detailed mathematical derivations are presented and numerical investigations are performed while the emphasis is placed on investigating the effect of the several parameters such as material distribution profile, small scale effects and aspect ratio on the critical buckling temperature of the FG nanobeams in detail. It is explicitly shown that the thermal buckling of a FG nanobeams is significantly influenced by these effects. Numerical results are presented to serve as benchmarks for future analyses of FG nanobeams.

• International Journal of Oral Biology
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• v.40 no.4
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• pp.223-228
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• 2015

6-Gingerol exerts anti-tumor effects in various cancer cell models. We evaluated the effect of 6-gingerol on the growth of MCF-7 breast cancer cells and MCF-10A breast epithelial cells to determine whether any growth-inhibitory effects found were attributable to apoptosis, and to elucidate the underlying mechanism of action. 6-Gingerol inhibited the viability of both cell lines in a dose- and time-dependent manner; however, the degree of inhibition was greater in MCF-7 than MCF-10A cells. By flow cytometry, induction of dose- and time-dependent apoptosis was found, and the magnitude of apoptosis was also markedly greater in MCF-7 than MCF-10A cells. Expression of caspase-3 and poly (ADP-ribose) polymerase (PARP) was observed in MCF-7 cells treated with 6-gingerol, and further cleavage of PARP occurred in these cells. We suggest that 6-gingerol induces apoptosis in human breast cancer cells mainly by promoting caspase-3 expression and subsequent degradation of PARP.

• Nuclear Engineering and Technology
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• v.33 no.6
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• pp.566-584
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• 2001

In this paper, the progressive deformation and the creep-fatigue damage for the conceptually designed reactor internals of KALIMER(Korea Advanced Liquid MEtal Reactor) are carried out by using the elastic analysis method in the RCC-MR code for normal operating conditions including the thermal load, seismic load (OBE) and dead weight. The maximum operating temperature of this reactor is 53$0^{\circ}C$ and the total service lifetime is 30 years. Thus, the time- dependent creep and stress-rupture effects become quite important in the structural design. The effects of the thermal induced membrane stress on the creep-fatigue damage are investigated with the risk of the elastic follow-up. To calculate the thermal stress, detailed thermal analyses considering conduction, convection and radiation heat transfer mechanisms are carried out with the ANSYS program. Using the results of the elastic analysis, the progressive deformation and creep-fatigue damages are calculated step by step using the RCC-MR in detail. This paper ill be a very useful guide for an actual application of the high temperature structural design of the nuclear power plant accounting for the time-dependent creep and stress-rupture effects.

• Advances in nano research
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• v.7 no.3
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• pp.169-180
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• 2019

Plasmonic effects of gold and platinum alloy nanoparticles (Au-Pt NPs) and their comparison to size was studied. Various factors including ratios of gold and platinum salt, temperature, pH and time of addition of reducing agent were studied for their effect on particle size. The size of gold and platinum alloy nanoparticles increases with increasing concentration of Pt NPs. Temperature dependent synthesis of gold and platinum alloy nanoparticles shows decrease in size at higher temperature while at lower temperature agglomeration occurs. For pH dependent synthesis of Au-Pt nanoparticles, size was found to be increased by increase in pH from 4 to 10. Increasing the time of addition of reducing agent for synthesis of pure and gold-platinum alloy nanoparticles shows gradual increase in size as well as increase in heterogeneity of nanoparticles. The size and elemental analysis of Au-Pt nanoparticles were characterized by UV-Vis spectroscopy, XRD, SEM and EDX techniques.

• Journal of Pharmacopuncture
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• v.25 no.4
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• pp.344-353
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• 2022

Objectives: Auraptene is the most abundant natural prenyloxycoumarin. Recent studies have shown that it has multiple biological and therapeutic properties, including antioxidant properties. Erythrocytes are constantly subjected to oxidative damage that can affect proteins and lipids within the erythrocyte membrane and lead to some hemoglobinopathies. Due to the lack of sufficient information about the antioxidant effects of auraptene on erythrocytes, this study intended to evaluate the potential of this compound in protecting radical-induced erythrocytes damages. Methods: The antioxidant activity of auraptene was measured based on DPPH and FRAP assays. Notably, oxidative hemolysis of human erythrocytes was used as a model to study the ability of auraptene to protect biological membranes from free radical-induced damage. Also, the effects of auraptene in different concentrations (25-400 µM) on AAPH-induced lipid/protein peroxidation, glutathione (GSH) content and morphological changes of erythrocytes were determined. Results: Oxidative hemolysis and lipid/protein peroxidation of erythrocytes were significantly suppressed by auraptene in a time and concentration-dependent manner. Auraptene prevented the depletion of the cytosolic antioxidant GSH in erythrocytes. Furthermore, it inhibited lipid and protein peroxidation in a time and concentration-dependent manner. Likewise, FESEM results demonstrated that auraptene reduced AAPH-induced morphological changes in erythrocytes. Conclusion: Auraptene efficiently protects human erythrocytes against free radicals. Therefore, it can be a potent candidate for treating oxidative stress-related diseases.

• Nuclear Engineering and Technology
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• v.56 no.2
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• pp.526-535
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• 2024

This paper proposes a safety-critical standby component unavailability model that contains aging effects caused by the elapsed time from installation, component degradation due to surveillance tests, and imperfect maintenance actions. An application of the model to a Motor-Operated Valve and a Motor-Driven Pump involved in the HPIS of a VVER/1000-V446 nuclear power plant is demonstrated and compared with other existing models at component and system levels. In addition, the effects of different unavailability models are reflected in the NPP's risk criterion, i.e., core damage frequency, over five maintenance periods. The results show that, compared with other models that do not simultaneously consider the full effects of degradation and maintenance impacts, the proposed model realistically evaluates the unavailabilities of the safety-related components and the involved systems as a plant age function. Therefore, it can effectively reflect the age-dependent CDF impact of a given testing and maintenance policy in a specified time horizon.

• Archives of Pharmacal Research
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• v.26 no.12
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• pp.1102-1108
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• 2003

We studied the effects of phytolaccosides, saponins from Phytolacca americana, on the intestinal absorption of heparin in vitro and in vivo. The absorption enhancing activity of these compounds (phytolaccosides B, $D_2$, E, F, G and I) was determined by changes in transepithelial electrical resistance (TEER) and the transport amount of heparin disaccharide, the major repeating unit of heparin, across Caco-2 cell monolayers. With the exception of phytolaccoside G, all of them decreased TEER values and increased the permeability in a dose-dependent and time-dependent manner. In vitro, phytolaccosides B,$D_2$, and E showed significant absorption enhancing activities, while effects by phytolaccoside F and I were mild. In vivo, phytolaccoside E increased the activated partial thromboplastin time (APTT) and thrombin time, indicating that phytolaccoside E modulated the transport of heparin in intestinal route. Our results suggest that a series of phytolaccosides from Phytolacca americana can be applied as pharmaceutical excipients to improve the permeability of macromolecules and hydrophilic drugs having difficulty in absorption across the intestinal epithelium.

• Steel and Composite Structures
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• v.18 no.4
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• pp.909-924
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• 2015

This paper investigates the vibration phenomenon of a nanobeam subjected to a time-dependent heat flux. Material properties of the nanobeam are assumed to be graded in the thickness direction according to a novel exponential distribution law in terms of the volume fractions of the metal and ceramic constituents. The upper surface of the functionally graded (FG) nanobeam is pure ceramic whereas the lower surface is pure metal. A nonlocal generalized thermoelasticity theory with dual-phase-lag (DPL) model is used to solve this problem. The theories of coupled thermoelasticity, generalized thermoelasticity with one relaxation time, and without energy dissipation can extracted as limited and special cases of the present model. An analytical technique based on Laplace transform is used to calculate the variation of deflection and temperature. The inverse of Laplace transforms are computed numerically using Fourier expansion techniques. The effects of the phase-lags (PLs), nonlocal parameter and the angular frequency of oscillation of the heat flux on the lateral vibration, the temperature, and the axial displacement of the nanobeam are studied.

• Management Science and Financial Engineering
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• v.12 no.2
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• pp.19-35
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• 2006

We use the hierarchical Bayesian approach to describe the transition probabilities of a binary nonhomogeneous Markov chain. The Markov chain is used for describing the transition behavior of emotionally disturbed children in a treatment program. The effects of covariates on transition probabilities are assessed using a logit link function. To describe the time evolution of transition probabilities, we consider two modeling strategies. The first strategy is based on the concept of exchangeabiligy, whereas the second one is based on a first order Markov property. The deviance information criterion (DIC) measure is used to compare models with two different time dependent structures. The inferences are made using the Markov chain Monte Carlo technique. The developed methodology is applied to some real data.

• International Journal of High-Rise Buildings
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• v.4 no.1
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• pp.39-44
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• 2015

This paper presents the structural health monitoring (SHM) of Shanghai Tower. In order to provide useful information for safety evaluation and regular maintenance under construction and in-service condition, a comprehensive structural health monitoring (SHM) system is installed in Shanghai Tower, which is composed of a main monitoring station and eleven substations. Structural responses at different construction stages are measured using this SHM system and presented in this study. Meanwhile, a detailed finite element model (FEM) is created and comparison of results between SHM and FEM is carried out. Results indicate that the time-dependent property of concrete creep is of great importance to structural response and the measured data can be used in FEM updating to obtain more accurate FEM models at different construction stages. Therefore, installation of structural health monitoring system in super-tall buildings could be considered as an effective way to assure structural safety during the construction process.