• Title/Summary/Keyword: time-course analysis

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A Review of Cluster Analysis for Time Course Microarray Data (시간 경로 마이크로어레이 자료의 군집 분석에 관한 고찰)

  • Sohn In-Suk;Lee Jae-Won;Kim Seo-Young
    • The Korean Journal of Applied Statistics
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    • v.19 no.1
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    • pp.13-32
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    • 2006
  • Biologists are attempting to group genes based on the temporal pattern of gene expression levels. So far, a number of methods have been proposed for clustering microarray data. However, the results of clustering depends on the genes selection, therefore the gene selection with significant expression difference is also very important to cluster for microarray data. Thus, this paper present the results of broad comparative studies to time course microarray data by considering methods of gene selection, clustering and cluster validation.

A Study of HME Model in Time-Course Microarray Data

  • Myoung, Sung-Min;Kim, Dong-Geon;Jo, Jin-Nam
    • The Korean Journal of Applied Statistics
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    • v.25 no.3
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    • pp.415-422
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    • 2012
  • For statistical microarray data analysis, clustering analysis is a useful exploratory technique and offers the promise of simultaneously studying the variation of many genes. However, most of the proposed clustering methods are not rigorously solved for a time-course microarray data cluster and for a fitting time covariate; therefore, a statistical method is needed to form a cluster and represent a linear trend of each cluster for each gene. In this research, we developed a modified hierarchical mixture of an experts model to suggest clustering data and characterize each cluster using a linear mixed effect model. The feasibility of the proposed method is illustrated by an application to the human fibroblast data suggested by Iyer et al. (1999).

The Development of a Variety of Blended Global Courses and Their Comparative Analysis (블렌디드 글로벌 강좌 유형 개발 및 비교 분석)

  • Kim, Seong-Baeg;Kwon, Sang-Chul;Park, Chan-Jung
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.6 no.5
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    • pp.173-185
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    • 2016
  • As a dual-degree program/exchange student program becomes widespread, the faculty and students consisting of a course are being globalized. Recently, there has been an online or blended learning-based course, which is evolved from a conventional offline course. However, the course has no consideration of a dual-degree program or exchange student program because it is limited to a domestic university. To create and manage a global course, there have several of difficulties in the aspects of cost or effectiveness. As a solution to tackle them, it is necessary to do research on providing blended global courses with a fusion approach of online and offline. In this paper, we studied and presented a model of blended global courses. To create and maintain overseas scholar-oriented courses, we devised eight types of blended global courses depedning on their opening time and the cooperative relation between online and offline and made their comparative analysis. The blended global course proposed in this paper can be applied to cultivating global human resources in universities.

Quantitative Analysis of Lung Contusion (폐좌상의 정량분석)

  • 오중환
    • Journal of Chest Surgery
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    • v.27 no.10
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    • pp.833-837
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    • 1994
  • Lung contusion due to blunt chest trauma is the most common lung injury and correlated with the clinical course and prognosis. Its diagnosis by CT[Computerized Tomogram] gives a more clear and understandable three dimensional view, by which we are able to measure the volume of the contused and entire lung. Other variables are arterial blood gas, number of rib fracture, presence of hemopneumothorax, sternal fracture and clavicle fracture, number of associated non-thoracic injuries, ventilator time and presence of pulmonary complication. Percentage[%] of lung contusion are expressed as mean $\pm$ standard deviation and data analysis was performed by means of multivariate repeated measures analysis of variance to detect significant differences in variables between positive thoracic injury group and negative group. The paired t-test was used. Differences of percentage of lung contusion between groups were assessed by one-way analysis of variance. Simple linear regression was used to perform correlation analysis in the number of rib fracture and ventilator time. A p value less than 0.05 was considered statistically significant. Pneumothorax and the number of associated other injuries affect the amount of lung contusion and pulmonary complication group has more contused lung volume. Arterial blood gas study shows no correlation with the amount of lung contusion statistically. The number of rib fracture correlated with the amount of lung contusion, which also correlated with ventilator time[r=0.56, p<0.05]. In conclusion, quantitative anlysis of lung contusion by CT predicts the clinical course and treatment such as ventilator care.

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Comparing Job Satisfaction with Professional Self-Concept of RN-BSN Students (간호학사 특별과정생의 직업만족도와 전문직 자아개념)

  • Kim Chun-Gil;Noh Choon-Hee
    • The Journal of Korean Academic Society of Nursing Education
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    • v.5 no.2
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    • pp.250-266
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    • 1999
  • This study was conducted to compare the level of RN-BSN students' job satisfaction and professional self-concept (PSCNI) prior to RN-BSN course and upon graduation The study was designed to investigate the degree of job satisfaction and PSCNI, and to test the correlation between job satisfaction and professional self-concept. The subjects were 68 students in Chunchon, who entered to H University (RN-BSN course) in March 1997. The data was gathered by self-reported questionnaire job satisfaction(48 items) and professional self-concept nurses instrument (PSCNI: 27 items) The instruments used for this study were the nurse Job satisfaction scale developed by Stamps et al., and Arthur's PSCNI. The reliability of two questionnaires were relatively high (Job satisfaction Cronbach's $\alpha$=0.88, 0.89, PSCNI Cronbach's $\alpha$=0.80, 0.96) The data was analyzed frequency, mean, t-test, ANOVA, Duncan's multiple range test, Pearson's corelation, and multiple regression analysis through SAS program. Research findings were as follows : 1. The average item score of job satisfaction was 119.50(prior to RN-BSN course) 124.16 (upon graduation). PSCNI' average item score was 75.37/77.21 at each. 2. The job satisfaction scores were significantly higher at the graduation than at the entrance(t=2,10, P=.040). But PSCNI's scores had no significant difference. 3. The relationship between job satisfaction and PSCNI of entering time was high R=.60, P=.000) The relationship of the two at graduation time was not high(R=.29, P=.018). 4. The factors contributing to the job satisfaction & PSCNI as follow: job satisfaction(prior to RB-BSN course), PSCNI(prior to RB-BSN course), The factors contributing to the job satisfaction & PSCNI were as follow: PSCNI(prior to RN-BSN course) In conclusion, we recognized that RN-BSN course influenced job satisfaction of students. Also this study Eave a information for necessity to develop curricula promoting PSCNI. Nurse-educator should explore further research to enlighten the nursing profession.

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A Study on the Learner's Satisfaction of on-line Classes in Liberal Arts course - Focusing on on-line recorded video lectures (교양 과목에서의 온라인 수업 학습자 만족에 관한 연구 - 녹화 동영상 수업을 위주로)

  • Jun, Byoungho
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.17 no.4
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    • pp.197-207
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    • 2021
  • The threat of COVID-19 pandemic put many universities in Korea to develop and implement various types of non-face-to-face on-line classes, such as on-line real time class and on-line recorded video class. Online education has been recognized as one of the effective educational methods because of its ubiquitous and flexible educational environments. Even though COVID-19 led to many problems such as faculty's burden and stress during the early stage of COVID-19, both students and faculties have gradually become familiar with on-line environment. As students have got accustomed to the online environment, on-line recorded lectures are shown to be more preferred rather than on-line real time class. Researches regarding the learner's satisfaction of on-line classes during the COVID-19 indicate that systematic and good quality contents and interaction by instructor are important factors. This study, therefore, investigate the learner's satisfaction of online classes in Liberal Arts course using recorded video contents in terms of contents and interaction. The results of empirical analysis reveal that systematic and good quality contents are likely to predict learner's satisfaction and interaction plays a great role in providing those contents. These findings provide insights that preparing systematic contents and interaction are key to enhancing learner's satisfaction of on-line classes in Liberal Arts course.

Exploring Online Learning Profiles of In-service Teachers in a Professional Development Course

  • PARK, Yujin;SUNG, Jihyun;CHO, Young Hoan
    • Educational Technology International
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    • v.18 no.2
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    • pp.193-213
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    • 2017
  • This study aimed to explore online learning profiles of in-service teachers in South Korea, focusing on video lecture and discussion activities. A total of 269 teachers took an online professional development course for 14 days, using an online learning platform from which web log data were collected. The data showed the frequency of participation and the initial participation time, which was closely related to procrastinating behaviors. A cluster analysis revealed three online learning profiles of in-service teachers: procrastinating (n=42), passive interaction (n=136), and active learning (n=91) clusters. The active learning cluster showed high-level participation in both video lecture and discussion activities from the beginning of the online course, whereas the procrastinating cluster was seldom engaged in learning activities for the first half of the learning period. The passive interaction cluster was actively engaged in watching video lectures from the beginning of the online course but passively participated in discussion activities. As a result, the active learning cluster outperformed the passive interaction cluster in learning achievements. The findings were discussed in regard to how to improve online learning environments through considering online learning profiles of in-service teachers.

Time Course Changes in Hepatic Fat Accumulation in High Fat Diet-fed C57BL/6 Mice: Comparison Analysis to the Markers of Systemic Insulin Resistance (고지방식이 섭취 마우스에서 간 중성지방 축적의 시간에 따른 변화: 인슐린저항성 지표들과의 상관관계 분석)

  • Bae, Eun Ju
    • YAKHAK HOEJI
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    • v.56 no.6
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    • pp.364-365
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    • 2012
  • Liver is the major organ to regulate the systemic glucose homeostasis and insulin resistance. Excess energy intake leads to triglyceride accumulation in adipose tissue first and subsequent accumulation in liver, resulting in obesity and type 2 diabetes. The representative pathological animal model for obesity associated insulin resistance is a high fat diet (HFD) fed mice model. Given the essential role of liver fat accumulation in developing systemic insulin resistance in obesity, I measured the liver triglyceride contents in HFD fed mice as a function of time. As such, in this report, I show the cause and effect relationship with regard to time during a HFD feeding between a variety of factors that are related to systemic insulin resistance including glucose intolerance, plasma insulin level and inflammatory gene expression in liver and adipose tissue.

Comparison of Functions for Filtering Time Course Gene Expression Data with Flat Patterns (무 변화 패턴을 갖는 시간경로 유전자발현자료를 제거하기 위한 함수들의 비교)

  • Kim, Kyung-Sook;Oh, Mi-Ra;Baek, Jang-Sun;Son, Young-Sook
    • The Korean Journal of Applied Statistics
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    • v.20 no.2
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    • pp.409-422
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    • 2007
  • Filtering genes that do not appear to contribute to regulation prior to the statistical analysis of time course gene expression data can reduce the dimensions of data and the possibility of misinterpretation due to noise or lack of variation. In this paper, we compare six different functions for filtering genes with flat pattern under the percentile criterion on an observed sample and that on a bootstrap sample. The result of applying to the yeast cell cycle data shows that the variance function is most similar in both samples.

An Analysis of the Quantitative Changes of Elements on Golf Courses - With Special Reference to the Membership Golf Courses in Capital Area, Korea - (한국 골프 코스 구성 요소의 정량적 변화 분석 - 수도권 회원제 골프장을 대상으로 -)

  • Rho, Joon-Taek;Cho, Se-Hwan
    • Journal of the Korean Institute of Landscape Architecture
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    • v.40 no.6
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    • pp.112-126
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    • 2012
  • The theme is to analyze the time-series changes of design elements on golf courses and golf country club and its factors influencing to the changes with regard to 81-membership country club located in the Capital Area of Seoul, created in the periods from 1964 until 2011. The research methods is to analyze the time-series changes of environmental factors influencing to the changes of the elements on the golf course by book review, and to compare and speculate the results of the analysis on the environmental factors with the time-series changes on the golf course elements of statistical analysis as like regression analysis. The research results were as follows. The first, the environmental factors influencing to the change of golf course elements were analyzed as the five elements of the golf-related policies and regulations, the economy, the numbers of golfers, PGA and KPGA golf tournaments, the golf instruments. The second, the type and scale of the location of the golf course were showing trends of transformation from flat ground to mountainous one and from small scale to large one. The third, it was analyzed that he golf course elements as like the sizes, length, numbers of golf course elements as like fairway, green, bunker, teeing ground and pond were influenced by the law and regulation, the increase of amateur golfers, the promotion of techniques of golfers, the increase of the chance of foreign course designer's involvement to domestic market through the opening of PGA and KPGA tournaments etc. The fourth, the promotion of golf instruments and the flying distance were the factors influencing to the numbers of bunker, the lengths of holes. The fifth, it was revealed that the trends of increase of sizes of ponds influenced by enacting environmenal friendly laws and regulations, considering of landscaping, reflecting of design trends followed by the opening of PGA tournaments. Finally, it was proposed that the further research would be introduced with regard to the qualitative analysis onto the changes and influential factors of golf course design.