• 응용통계연구
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• 제21권1호
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• pp.65-80
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• 2008

소규모 경시적 마이크로어레이 실험이란 시점의 개수가 적은 경시적 마이크로어레이 실험으로서 현재까지 보고된 경시적 마이크로어레이 실험의 약 80%를 차지한다. 최근 들어 소규모 경시적 마이크로어레이 실험을 대상으로 하는 통계적 분석 방법이 몇 가지 제안되었다. 최근에 제안된 세 가지 방법들을 실제 소규모 경시적 마이크로어레이 실험자료에 적용하여 분석하고 모의실험 자료를 생성하여 각 방법들의 검정력과 위양성율을 비교해 보았다. 그 결과 낮은 위양성율을 보이는 STEM방법이 다른 방법에 비해서 우위에 있음이 드러났다.

• Molecules and Cells
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• 제26권4호
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• pp.338-343
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• 2008

An embryonic stem cell is a powerful tool for investigation of early development in vitro. The study of embryonic stem cell mediated neuronal differentiation allows for improved understanding of the mechanisms involved in embryonic neuronal development. We investigated expression profile changes using time course cDNA microarray to identify clues for the signaling network of neuronal differentiation. For the short time course microarray data, pattern analysis based on the quadratic regression method is an effective approach for identification and classification of a variety of expressed genes that have biological relevance. We studied the expression patterns, at each of 5 stages, after neuronal induction at the mRNA level of embryonic stem cells using the quadratic regression method for pattern analysis. As a result, a total of 316 genes (3.1%) including 166 (1.7%) informative genes in 8 possible expression patterns were identified by pattern analysis. Among the selected genes associated with neurological system, all three genes showing linearly increasing pattern over time, and one gene showing decreasing pattern over time, were verified by RT-PCR. Therefore, an increase in gene expression over time, in a linear pattern, may be associated with embryonic development. The genes: Tcfap2c, Ttr, Wnt3a, Btg2 and Foxk1 detected by pattern analysis, and verified by RT-PCR simultaneously, may be candidate markers associated with the development of the nervous system. Our study shows that pattern analysis, using the quadratic regression method, is very useful for investigation of time course cDNA microarray data. The pattern analysis used in this study has biological significance for the study of embryonic stem cells.

• 한국IT서비스학회지
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• 제20권6호
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• pp.125-139
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• 2021

To explore college students' course satisfaction over the course of the semester during which a full-scale digital transformation was in progress due to COVID-19 pandemic, this study analyzed student survey data from a university located in the metropolitan area. To minimize the respondents' burden to answer long list of detailed questions in repetition, the study utilized a pulse survey method and students were asked to answer a brief and regular set of online questions 5 times throughout the semester. The number of survey respondents ranged from 1,640 to 4,116, with an average of more than 3,700. The main results and implications of this study are summarized as follows. First, the survey data indicated that the overall student satisfaction with online courses was above average (3.46/5). Vast majority of students have chosen pre-recorded, contents-based course over real-time, video-based course as their preferred course delivery method and this tendency remained the same throughout the semester. Second, the results of keyword network analysis of open-ended questions indicated that technical issues, increased workload (e.g., course assignments and course attendance) were main causes of online course dissatisfaction. And students suggested an unified online course platform and more interactive course design to further improve online courses in the future.

• 한국운동역학회지
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• 제29권1호
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• pp.1-8
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• 2019

Objective: The purpose of this study was to confirm that the cross-country ski sprint course in PyeongChang, where the 2018 Winter Olympics course was to utilize wearable devices equipped with inertial measurement unit (IMU), global positioning system (GPS) and heart rates sensor. Method: For the data collection, two national level cross-country (XC) skiers performed classic technique on the entire sprint course. We analyzed cycle characteristics, range of motion on double poling (DP) technique, average velocity, and displacement of 3 points according to the terrain. Results: The absolute cycle time gradually decreased during starting, middle and finish sections. While the length of the DP increased and the heart rates tended to increase for men skier. In addition, the results indicated that range of motion of knee joint during starting and finish section decreased more than middle section. The errors of latitude and longitude data collected through GPS were within 3 m from 3 points. Conclusion: Through the first case study in Korea, which analyzed the location and condition of XC skiers in the entire sprint course in real time, confirmed that feedback was available in the field using various wearable sensors.

• 응용통계연구
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• 제24권4호
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• pp.623-631
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• 2011

시간경로 마이크로어레이 자료 분석의 주요 목적 중의 하나는 유전자들의 시간에 따른 발현수준의 변화를 고려함으로써 발현패턴에 기초한 유전자들의 그룹을 찾기 위한 것으로, 군집분석을 위한 다양한 알고리즘들이 제안되었다. 본 연구에서 시간경로 마이크로어레이 자료에 대한 군집분석을 위해 두 약물제제 간 생물학적 동등성을 평가하기 위한 약동학 시험에서 사용되는 약동학적 파라미터 값에 기초한 군집분석을 제안하였으며 이를 실제 데이터 및 모의실험 자료에 적용하여 유용성을 검토하였다.

• 스마트미디어저널
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• 제12권5호
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• pp.88-101
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• 2023

As the definition and role of design changes over time with the times and society, design education needs to update teaching methods to match it. The course design in this study began with an optimisation of the learning model based on previous research and analysis, followed by in-depth interviews, the application of the interview results to the final curriculum design, and finally a questionnaire to verify the positive effects of this teaching model. This teaching model has been applied to teach a pilot class in a university of applied sciences in China. The main characteristics of the course design are Project-Based Learning (PJBL) oriented, team cooperation centric, and an educational model developed based on peer assessment. In every stage of the UI design course, realistic project simulations are adopted, enhancing students' abilities through practical experience, teamwork, and peer assessment. The innovation lies in validating the effectiveness and advantages of this model at every stage of the UI design course, innovating existing teaching methods, optimizing learning models, and combining practice with evaluation. This research found that a project-oriented team course design based on PJBL has a high degree of effectiveness and relevance in each stage of the UI design course, significantly improving students' overall competence. It is expected that the results of this study can be applied in various ways to the course design of the courses that similar to design majors.

• 대한의생명과학회지
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• 제11권2호
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• pp.221-225
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• 2005

To investigate the spectroscopic findings of embolized lesions induced with a fat-emulsion technique with magnetic resonance images (MRI). A fat emulsion was made with 0.1 ml of triolein and 20 ml of normal saline. In 12 cats, the internal carotid artery was infused with the fat emulsion. Contrast-enhanced T1-weighted MRI and multivoxel spectroscopy were obtained at 1 hour, 1 and 4 days, and 1 week after embolization. NAA (N-acetylaspartate), Cr (creatine) and Cho (choline) were evaluated on the spectroscopy. Statitistical analysis wsperformed at the embolized and contralateral normal hemisphere in the integral and amplitude of NAA, Cr and Nho in time course. Also NAA/Cr and Cho/Cr were compared in both hemisphere and in time course. The emboli zed lesions showed contrast enhance ments on Gd-enhanced Tl-weighted i~ages at 1 hour. This contrast enhancement was decreased at day 1, and id not appear agter day 4. In spectroscopy, the embolized hemisphere showed no statistical difference to the normal contralateral side at 1 hour and in time course. NAA/Cr and Cho/Cr were not significantly different in both hemispheres at 1 hour and in time course. Cerebral-fat embolism induced by a triolein emulsion in cats revealed no statistical difference on MR spectroscopy. Triolein-emulsion can be used in the study of blood-brain barrier.

• 척추신경추나의학회지
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• 제5권1호
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• pp.157-168
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• 2010

Objectives: The aim of this study was to investigate the curriculum of Chuna manual medicine (CMM)-related subjects in oriental medicine college and to let CMM have opportunities to develope current curriculum and basic circumstance for CMM. Methods: Questionnaire was obtained from 11 oriental medicine college and 1 school of Korean medicine, Pusan National University, bye-mail. If there was any insufficient information from response, we asked more information by direct call. Results and Conclusions: The findings from our study can be summarized as follows: 1. There are three CMM-related subjects, CMM, Oriental Rehabilitation Medicine (ORM) and Neuromusculoskeletology(NMS). All curriculums of 8 colleges belonged to classification I have CMM and DRM courses. Curriculums of 4 colleges belonged to classification II, have ORM or NMS course without CMM course. 2. 10 colleges of 11 ones which have ORM course, have major compulsory courses, 1 college has a major optional course. 5 colleges of 8 ones which have CMM course, have major compulsory courses, 3 colleges have major optional courses. 2 colleges have only part-time lecturers for CMM course, other 2 college have cooperation of specialized professors and part-time lecturers, another 8 colleges have only specialized professors. 3. Most CMM-related subjects is teached at 3 or 4 grade of medical course. The units taken for CMM-related subjects is minimum 4 units to maximum 8 units in total about 160 units. 4. Total class hour for CMM-related subjects is minimum 120 hours to maximum 225 hours, and practice hours is about minimum 30 hours to maximum 75 hours. 5. The systematic regulation and financial support is needed for patients to get the best CMM treatment, because the present curriculum of CMM is insufficient for carrying out the best manual therapy for patients.

• 문화기술의 융합
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• 제6권4호
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• pp.693-701
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• 2020

본 논문에서는 현재 운영되는 수강신청 시스템에서의 데이터베이스 성능을 향상시키기 위하여 SQL문 분석을 하였다. 수강신청 업무와 관련된 트랜잭션들에서 사용 중인 SQL문장들을 실행계획을 통하여 현행 데이터베이스 성능을 측정하였으며, SQL 분석을 통하여 보완한 SQL문장들이 성능이 향상된 결과를 확인하였다. 전반적으로 실행계획 분석을 통하여 수강신청 데이터베이스 시스템의 성능을 향상시켰으며, 수강신청 SQL 의 일부 개선방법을 시험결과로 보였다. 개선된 방법은 데이터베이스 튜닝 작업을 통하여 수강신청과 관련된 테이블들과 인덱스 테이블들을 재조정하고, SQL의 기능을 활용함으로서 성능이 향상된 수강신청 데이터베이스 시스템으로 진화한 최적화된 시스템을 구현할 수 있게 되었다. 제안된 방법으로 재조정된 수강신청 시스템은 이전에 운영하던 수강신청시스템에 비하여 성능적 측면에서 우수한 결과를 나타내었으며, 통합 성능 시험 결과 1.8배 ~ 18배의 응답시간 단축을 가져왔다.

• 현장농수산연구지
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• 제10권1호
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• pp.137-151
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• 2008

This research was conducted to suggest a policy plan for intensive major course in recurrent education system of KNAC. A survey was answered by students, graduates, field professors and (full-time) professors. The results are summarized as follows; 1. In the item of educational operation system, there were some differences in preference among 4 examinee groups. Students preferred 'semester system', graduates and field professors did 'once per week system', and professors 'cyber+centralized training system'. 2. As entering time, students and graduates preferred 'immediately after graduation'. However, field and full-time professors preferred '1 to 3 years after graduation' that became reality. 3. As board and lodging, all examinee groups wanted 'dormitory in college'. Students and graduates were open to pay educational expenses as a level of national colleges. 4. As a curriculum, the most preferred subject by all groups was 'major field technique', which was followed by 'marketing/sale' and 'farm management' in the order of preference.