• Communications for Statistical Applications and Methods
• /
• v.25 no.3
• /
• pp.321-328
• /
• 2018

In clinical trials with repeated measurements, the time-averaged difference (TAD) may provide a more powerful evaluation of treatment efficacy than the rate of changes over time when the treatment effect has rapid onset and repeated measurements continue across an extended period after a maximum effect is achieved (Overall and Doyle, Controlled Clinical Trials, 15, 100-123, 1994). The sample size formula has been investigated by many researchers for the evaluation of TAD in two treatment groups. For the evaluation of TAD in multi-arm trials, Zhang and Ahn (Computational Statistics & Data Analysis, 58, 283-291, 2013) and Lou et al. (Communications in Statistics-Theory and Methods, 46, 11204-11213, 2017b) developed the sample size formulas for continuous outcomes and count outcomes, respectively. In this paper, we derive a sample size formula to evaluate the TAD of the repeated binary outcomes in multi-arm trials using the generalized estimating equation approach. This proposed sample size formula accounts for various correlation structures and missing patterns (including a mixture of independent missing and monotone missing patterns) that are frequently encountered by practitioners in clinical trials. We conduct simulation studies to assess the performance of the proposed sample size formula under a wide range of design parameters. The results show that the empirical powers and the empirical Type I errors are close to nominal levels. We illustrate our proposed method using a clinical trial example.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.18 no.4
• /
• pp.1031-1038
• /
• 1994

Characteristics of pulsatile flow and heat transfer have been studied numerically in the constant heat flux curved tube with periodic pressure gradient. As the Womersley number increases, the phase difference between the pressure gradient and the cross section averaged axial velocity becomes larger. In case of the Womersley number $\beta = 2$, when cross section averaged axial velocity reaches periodic state with time, the reverse and the natural flow coexist at phase angle, $\lambda = 1.44\pi$ and $\lambda =1.96\pi$. For all the Womersley numbers of present investigation, the time variation of wall temperature near inner wall is higher than that of near outer wall, independent of phase angle.

• Water for future
• /
• v.27 no.2
• /
• pp.73-83
• /
• 1994

The unproper development of the nearshore zone can enhance the diffusion of pollutant in the nearshore zone resulting in unbalanced sediment budget of beach which causes alteration of beach topography. Therefore, it is required to predict the effects of the envirnmental change quantitatively. In this paper, the depth-averaged and time-averaged energy balance equation is selected to acount for the wave transformation such as refraction, shoaling effect, the surf zone energy disipation, wave breaking index and bore, due to wave breaking in the shore region.(Numerical solutions are obtained by a finite difference method, ADI and Upwind. For the calculation of the wave-induced current, the unsteady nonlinear depth-averaged and time-averaged governing equation is derived based on the continuity and momentum equation for imcompressible fluid.) Numerical solutions are obtained by finite difference method considering influences of factors such as lateral mixing coefficient, bed shear stress, wave direction angle, wave steepness, wave period and bottom slope. The model is applied to the computation of wave transformation, wave-induced current and variation of mean water leel on a uniformly sloping beach.

• Journal of Korea Water Resources Association
• /
• v.38 no.10 s.159
• /
• pp.811-824
• /
• 2005

The ADCP is an instrument based on Doppler effect, which measures discharge of a river in a short time while crossing it. In this study we aim to make a comparison of the discharge results from a moving-vessel ADCP with those measured by velocity-area method at the same cross-section, and to investigate the characteristics of velocity and discharge data using ADCP. Bathymetry measured by ADCP almost coincides with that by direct depth measurements. Because velocity data from ADCP are essentially instantaneous, individual velocity profiles obtained by ADCP are rather different from time-averaged velocity profiles. But spatially averaged velocity profiles of the individual ADCP data near the comparable verticals have similar vertical velocity pattern with the time-averaged ones. The average velocity profile from repeatedly crossed data is also similar with the time-averaged one. In case of the velocity distribution, individual and spatially averaged data for the sub-width of mid-section method Have good agreement with those by velocity-area method. Discharge data determined by averaging several ADCP measurement transects have $0.1\%{\~}9.3\%$ of difference with those from velocity-area method, and as the number of measurement increases, the relative difference to the velocity-area method decreases.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.24 no.7
• /
• pp.569-574
• /
• 2014

In order to investigate low frequency swishing noise of wind turbines, acoustic source model using a singularity in circular motion is introduced to derive analytic solution of Lowson acoustic analogy in time domain. Results in time and frequency domains computed by the solution show apparent modulation of amplitude and frequency. The solution indicates that time histories of acoustic pressure at receiver points varied significantly according to receiver's directional location, even when the retarded time distributions are similar. However, the corresponding time-averaged spectra of sound pressure at the receiver locations where the retarded time distributions are almost same are not significantly different. It can be inferred from these results that the time-averaged sound pressure spectra which cannot take into account the detailed difference in the time-variation of wind turbine noise may not represent the sound quality of wind turbines due to its swishing. Finally, as an introduction of procedure to quantify low frequency swishing noise level, relative variation of overall sound pressure level is obtained using tonal low frequency noise model.

• Journal of the Society of Naval Architects of Korea
• /
• v.51 no.2
• /
• pp.171-177
• /
• 2014

A two-dimensional particle image velocimetry (2D PIV) system in a towing tank is employed to measure a wake field of a very large crude oil carrier model with rotating propeller in self propulsion condition, to identify characteristics of wake of a propeller working behind a ship. Phase-averaged and time-averaged flow fields are measured for a horizontal plane. Scale ratio of the model ship is 1/100 and Froude number is 0.142. By phase-averaging technique, trajectories of tip vortex and hub vortex are identified and characteristic secondary vortex distribution is observed in the hub vortex region. Propeller wake on the starboard side is more accelerated than that on the port side, due to the difference of inflow of propeller blades. The hub vortex trajectory tends to face the port side. With the fluctuation part of the phase-averaged velocity field, turbulent kinetic energy (TKE) is also derived. In the center of tip vortex and hub vortex region, high TKE concentration is observed. In addition, a time-averaged vector field is also measured and compared with phase-averaged vector field.

• Journal of the Korean earth science society
• /
• v.37 no.6
• /
• pp.359-372
• /
• 2016

The time-series of Walker circulation index (WCI) in this study shows the strengthening of the Walker circulation in recent years. To further understand the large-scale features related to the WCI strengthening, a difference between the averaged meteorological variables in two time periods 1999-2013 and 1984-1998 is analyzed. The difference in 850 hPa stream flows between the two periods shows that the anomalous easterlies (anomalous trade wind) are dominant due to the strengthening of anomalous anticyclonic circulations at the subtropical Pacific of both hemispheres. The difference between the averaged zonal atmospheric circulations over $5^oS-5^oN$ in the two periods confirms that upward flows are strengthened at the tropical western Pacific and downward flows are strengthened at the tropical central and eastern Pacific in recent years. It matches the WCI strengthening in recent years. The time-series of tropical cyclone (TC) genesis frequency from July to September shows that a mean TC genesis frequency from 1999-2013 decreases compared to that of the time period 1984-1998. The monsoon trough in the period 1984-1998 was located in the further east direction and stronger than that in the period 1999-2013. TCs in the recent period that are generated in further west than TCs in the past period moved from the west. Thus, the TC intensity along the coasts in East Asia becomes weaker in recent period. The intensification of Walker circulation in recent years is related to the weaker TC intensity in East Asia through strengthened anomalous anticyclones at the subtropical western Pacific.

• Journal of the Korea Society for Simulation
• /
• v.13 no.2
• /
• pp.1-12
• /
• 2004

This paper estimated the arrival angle and electric wave delay time using the space method law and the directions of arrival (DOA) estimation algorithm in case of signal correlation. Space method law is the method used to repress cross correlation before applying the weight value to the receiving signal. The values of the diagonal elements in the correlation matrix were averaged to replace as the diagonal elements value. In the area of wireless communication or mobile communication, there are high correlations in case of low delay time difference in multiple waves. This causes the quality of the communication to drop due to interference with the desired signal elements. This paper estimated the arrival angle and electric wave delay time using the space method law and the MUSIC algorithm. With the arrival angle algorithm, the arrival angle cannot be estimated below 5 in case of signal correlations because the angle resolution capacity decreases accordingly. The super resolution capacity was estimated to determine the arrival angle below 5 in this paper. In addition, the proposed algorithm estimated the short delay time difference to be below 20ns.

• Journal of Korean Ophthalmic Optics Society
• /
• v.13 no.1
• /
• pp.15-20
• /
• 2008

Purpose: To study on the confidence of dry eye diagnosis methods which need to prescribe contact lens. Methods: Non-invasive tear film break-up time (NIBUT) and tear film break-up time (TBUT) were measured in forty healthy subjects in their 20s, and then the subjects were classified into normal eye and dry eye. The results of McMonnies questionnaire, tear prism height measurement, Hardtack test, blink rate measurement and Schirmer test were compared with the results of NIBUT and TBUT. Results: The results of NIBUT and TBUT were as follows; 20 subjects had normal eyes, 10 subjects had dry eyes in both NIBUT and TBUT, and 10 subjects showed different results. In McMonnies questionnaire, the score of normal eye group averaged 8.2 and that of dry eye group averaged 18.5, which showed statistically significant difference. Furthermore, 100% of normal eye group classified by the results of NIBUT and TBUT corresponded with the result of McMonnies questionnaire and 90% of dry eye group showed the correspondence. Tear prism height of normal eye group averaged 0.32 mm and that of dry eye group averaged 0.23 mm, which were significantly different. Hardtack test, blink rate measurement and Schirmer test without local anesthesia showed no statistically significant difference between normal eye group and dry eye group. Conclusions: On dry eye diagnosis methods, the results of McMonnies questionnaire and tear prism height measurement had close correlation with the results of NIBUT and TBUT.

• ETRI Journal
• /
• v.27 no.2
• /
• pp.227-230
• /
• 2005

A specific anthropomorphic mannequin (SAM) model was used to investigate the relation between local specific absorption rate (SAR) and head size. The model was scaled to 80 to 100% sized models at intervals of 5%. We assumed that the shell of the SAM model has the same properties as the head-equivalent tissue. Five handsets with a monopole antenna operating at 835 MHz were placed in the approximate cheek position against the scaled SAM models. The handsets had different antenna lengths, antenna positions, body sizes, and external materials. SAR distributions in the scaled SAM models were computed using the finite-difference time-domain method. We found that a larger head causes a distinct increase in the spatial peak 1-voxel SAR, while head size did not significantly change the peak 1-g averaged-SAR and 10-g averaged-SAR values for the same power level delivered to the antenna.