• Journal of Dental Rehabilitation and Applied Science
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• v.27 no.2
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• pp.247-251
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• 2011

Botulinum toxin type A (BoNT-A) is used for treating bilateral masseter hypertrophy since 1994. Recently there have been more clinical studies in this area, with some authors reporting that BoNT-A can reduce the size of the masseter muscle, as documented by photography, ultrasonography, computed tomography, and 3D(three dimensional) laser scan. However, earlier studies were only for bilateral masseter hypertrophy cases, not for unilateral masseter hypertrophy cases. The aim of this study was to use 3D laser scanning to evaluate changes in the external facial contour induced by unilateral BoNT-A injection. BoNT-A was injected into hypertrophic masseter muscle unilaterally in 10 patients with asymmetric masseter hypertrophy. The clinical effects of unilaterally injected BoNT-A were evaluated before the injection and 4, 8, and 12weeks after the injection using 3D laser scan. And the mean values of both sides (injection and non-injection sides) were compared with. At injection side, mean values of the volume and the bulkiest height at each time point diminished significantly between pre-injection and 4, 8, and 12weeks post-injection. At non-injection side, in contrast, mean values of the volume and the bulkiest height diminished also but less than that of injected side, and there was no statistical significance. In this limited study, we concluded that the unilaterally BoNT-A injection side showed greater mean values of the reduction of muscle volume than non-injection side at 4, 8, and 12 weeks after the injection.

• Journal of Life Science
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• v.22 no.9
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• pp.1145-1151
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• 2012

Aspirin and its deacetylated form, sodium salicylate (NaSal), have been shown to exert chemopreventive activities against many human cancers including those of the colon, lung, and breast. Previously, we showed that combined treatment of NaSal and genistein synergistically induced apoptosis in A549 lung cancer cells, indicating that these two natural chemicals could be used in combination for cancer therapy. In this study, we examined effects of NaSal/genistein combined treatment on other cancer cells and in three-dimensional multicellular tumor spheroid (MTS) and in an in vitro solid tumor model. We found that the combined treatment induces apoptosis in the HCT116 cells and the A549 cells, but not in the MCF-7 cells. Interestingly, the MCF-7 cells responded to the NaSal/genistein combined treatment by undergoing cell death when they were cultivated as MTS. The combined treatment induced apoptosis at an earlier stage in the MCF-7 MTS culture. However, when the MCF-7 MTS was cultivated for a longer period, it induced necrosis rather than apoptosis. We further found that the apoptotic pattern observed in MCF-7 MTS was incomplete: the chromatins were condensed and fragmented, but the nuclear membrane was still intact. Taken together, these results demonstrate that the NaSal/genistein combined treatment induces incomplete apoptosis and necrosis in the MCF-7 MTS culture system.

• Physical Therapy Korea
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• v.16 no.3
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• pp.9-15
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• 2009

The purpose of this study was to examine contraction of abdominal muscles on surface electromyographic (EMG) activity of superficial cervical flexors, rib cage elevation and angle of craniocervical flexion during deep cervical flexion exercise in supine position. Fifteen healthy subjects were participated for this study. All subjects performed deer cervical flexion exercise with two methods. The positions of two methods were no volitional contraction of abdominal muscles in hook-lying position with 45 degree hip flexion (method 1) and 90 degrees hip and knee flexion with feet off floor for inducing abdominal muscle contraction (method 2). Surface EMG activities were recorded from five muscles (sternocleidmastoid, anterior scaleneus, recuts abdominis, external oblique, internal oblique). And distance of rib cage elevation and angle of craniocervical flexion were measured using a three dimensional motion analysis system. The EMG activity of each muscle was normalized to the value of reference voluntary contraction (%RVC). The EMG activities, distance of rib cage elevation. and angle of craniocervical were compared using a paired t-test between two methods. The results showed that the EMG activities of sternocleidmastoid and anterior scaleneus during deep cervical flexion exercise in method 2 were significantly decreased compared to method 1 (p<.05). Distance of rib cage elevation and angle of craniocervical flexion were significantly decreased in method 2 (p<.05). The findings of this study indicated that deep cervical flexion exercise with contraction of abdominal muscles could be an effective method to prevent substitute motion for rib cage elevation and contraction of superficial neck flexor muscles.

• Journal of the Korea Convergence Society
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• v.11 no.5
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• pp.209-217
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• 2020

The background of the research is the following. With the prosperity of drone industry, the government has been actively promoting measures to nominate 'drone photographing free areas'. However, existing laws, and procedures are rather unclear with related environmental factors in discordance with one another. Hence, voices in need for establishing a clear precondition for nominating drone photography free area have been rising. The purpose of the research is to provide measures for the preconditions to establish photography free areas for convenient drone photographing. The research utilizes literary methods, conducting focus group interviews to coordinate with specialists who can participate and discuss so that they can provide improvement measures. The research renders improvement measures in different sectors including 2x items in aviation security law, 8x items in free area nomination and procedure, 4x items in infrastructure establishment and information management area. The expected effects are the following: by attaching drone photography with aviation security law, nominating photography free area can be linked up with the Ministry of Land Infrastructure and Technology. Secondly, by enlarging photography restricted area to upper mid-air, a three dimensional drone security will be possible. Thirdly, by providing a 'Yongin area standard model', free area nomination will become more easy. Future research will focus on enhancing aviation security law regarding drone photographing. In addition, the promotion to nominate free areas for 33x responsible areas in accordance with the National Intelligence service will be required.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.8
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• pp.1552-1565
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• 1992

Three dimensional numerical calculations were carried out for two different combustion chambers with the offset valve in order to investigate the swirl and the squish effects on the flow fields. The modified K-.epsilon. turbulence model considering the change of the density under the condition of the rapid compression and expansion of the pistion was used. During the compression process, it was found that the squish flow which controls the subsequent combustion process was produced due to the piston bowl in the bowl piston type combustion chambers but not for the flat piston type. The swirl velocity close to the solid body rotation was maintained in the flat piston type combustion chambers, but for the bowl piston type a resulting from the change of the solid body rotation was generated in the radial-circumferential plane. For the swirl ratio effect, as the swirl ratio increases, it was found that a large and strong vortex was generated in the radial-circumferential plane of bowl piston type combustion chambers because of the strong inward flows from the combustion chamber wall. These computational results were compared with the results of LDA measurement.

• Journal of the Korean Society for Marine Environment & Energy
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• v.6 no.1
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• pp.44-59
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• 2003

The three-dimensional eco-hydrodynamic model was applied to estimate the effect of water quality improvement by the effluent treatment of landbase-seawater culture system in the Kamak bay The computed residual currents were dominated southward flow at the northern narrow strait and eastward flow and clockwise water circulation at the mouth of the bay, strongly. The mean relative errors of DIP, DIN and COD between the simulated and observed results at 9 stations in the Kamak bay were shown 14.3％, 25.8％ and 14.4％, respectively. There were high concentrations of DIP, DIN and COD at the northwestern bay which is influenced by pollution loads. The simulations were performed using an ecosystem model under the conditions of DIP 90％, DIN 80％ and COD 60％ treatment efficiency by the ozone treatment system of landbase-seawater culture system. As a results of simulation, the improvement effects of DIP, DIN and COD are 34.4~54.0％ (average 46.4％), 0.4~25.4％(average 8.4％) and 15.6~29.4％(average 22.7％), respectively. Therefore the area of seawater quality grade I based on COD was extended in the bay.

• Korean Journal of Applied Biomechanics
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• v.24 no.2
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• pp.173-180
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• 2014

The purpose of this study was to investigate the effect of combined exercise on injury risk factors of lower extremity during landing. Ten sports talented athletes participated in this study. Sports talented athletes participated in a combined exercise (sports talented exercise, coordination) for 16 weeks. A three-dimensional motion analysis was performed using eight infrared cameras (sampling rate of 100 Hz), one force plate, and electromyography system (sampling rate of 1000 Hz) during landing. Kinetic, and kinematics analysis including average impulsive force, angle of lower extremity, vertical stiffness, onset of muscle activation were calculated by Matlab2009a software. Paired t-test was performed at alpha=.05. The average impulsive force in landing phase was not statistically significant (t=-.748, p=.474). The hip joint angle was more decreased in post test compared to pre test (E1: t=2.682, p=.025, E2: t=5.609, p=.000, E3: t=2.538, p=.032). The knee joint (E1: t=-.343, p=.739, E2: t=1.319, p=.220, E3: t=.589, p=.570) and ankle joint (E1: t=.081, p=.937, E2: t=.784, p=.453, E3: t=.392, p=.704) angle were tended to decrease after combined exercise. The vertical stiffness was tended to decrease after combined exercise (t=1.972, p=.080). Onset of quadriceps femoris (t=.698, p=.503) and medial gastocnemius (t=1.858, p=.096) were tended to be faster than biceps femoris (t=-.333, p=.747) after combined exercise. Although thses findings were not statistically significant except on a hip joint angle, risk factors of lower extremity such as joint angle, vertical stiffness and onset of quadriceps femoris, medial gastrocnemius were positively changed after the combined exercise but an additional training for improved onset of biceps femoris would be required in the future.

• Applied Chemistry for Engineering
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• v.31 no.2
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• pp.220-225
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• 2020

Hair is made of proteins containing various amino acids. Ultraviolet (UV) radiation is believed to be responsible for the most damaging effects of sunlight, and also plays an important role in hair aging. The purpose of this study was to investigate the changes in morphological and chemical structures after ultraviolet B (UVB) irradiation of human hair. The UVB-irradiated hair showed characteristic morphological and structural changes, compared to those of the normal hair. The result from a scanning electron microscope (SEM) equipped with an energy dispersive X-ray diffractometer (EDX) showed that the scale of UV-irradiated hair appeared to be rough and the amount of oxygen element was higher than that of the normal hair. Fluorescence and three dimensional (3D) topographical images were obtained by a confocal laser scanning microscope (CLSM). In 3D images, the green emission intensity of normal hair was much higher than that of fluorescing UVB-irradiated hair. The intensity of green emission reflects the intrinsic fluorescence of hair protein. Also, a fluorescent imaging method using fluorescamine reagent was used to identify the free amino groups resulting from a peptide bond breakage in UVB-irradiated hair. Strong blue fluorescence of UVB-irradiated hair, which indicates a very high level of amino groups, was observed by CLSM. Therefore, the fluorescamine as an extrinsic fluorescence could provide a useful tool to identify the peptide bond breakage in UVB-irradiated hair. Infrared image mapping was also employed to assess the cross-sections of normal and UVB-irradiated specimens to examine the oxidation of disulfide bonds. The degree of peak areas with strong absorbance for the disulfide mono-oxide was spread from the outside to the inside of hair. The spectroscopic techniques used alone, or in combination, launch new possibilities in the field of hair cosmetics.

• Journal of the Korean GEO-environmental Society
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• v.16 no.6
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• pp.13-22
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• 2015

In the current work, a series of three-dimensional (3D) numerical modelling has been performed in order to study the effects of the relative locations of tunnels with respect to the position of pile tips which governs the behaviour of pre-existing, adjacent single piles. In the numerical analyses, several governing factors, such as tunnelling-induced pile head settlements, relative displacements, volume losses, axial pile forces, interface shear stresses and apparent factors of safety have been analysed. When the pile tips are inside the tunnelling influence zone, of which the pile tip location is considered with respect to the tunnel position, tunnelling-induced pile head settlements are larger than the ground surface settlements, resulting in tunnelling-induced tensile pile forces. On the contrary, when the pile tips are outside the influence zone, compressive pile forces associated with downward shear stresses at the upper part of the piles are developed. Based on computed load and displacement relation of the pile, the apparent factors of safety of the piles inside the tunnelling influence zone have been reduced by 36% in average. The shear transfer mechanism based on the relative tunnel locations has been analysed in great detail by considering tunnelling-induced pile forces, interface shear stresses and the apparent factors of safety.

• Journal of the Society of Naval Architects of Korea
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• v.30 no.3
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• pp.116-126
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• 1993

The finite element method(FEM) has been commonly used for structural dynamic analysis. However, the direct global application of FEM to large complex structures such as ships and offshore structures requires considerable computational efforts, and remarkably more in structural dynamic optimization problems. Adoption of the component-mode synthesis method is an efficient means to overcome the above difficulty. Among three classes of the component-mode synthesis method, the free-interface mode method is recognized to have the advantages of better computational efficiency and easier implementation of substructures' experimental results, but the disadvantage of lower accuracy in analytical results. In this paper, an advanced method to improve the accuracy in the application of the free-interface mode method for the vibration analysis of large complex structures is presented. In order to compensate the truncation effect of the higher modes of substructures in the synthesis process, both residual inertia and stiffness effects are taken into account and a frequency shifting technique is introduced in the formulation of the residual compliance of substructures. The introduction of the frequency shrift ins not only excludes cumbersome manipulation of singular matrices for semi-definite substructural systems but gives more accurate results around the specified shifting frequency. Numerical examples of typical structural models including a ship-like two dimensional finite element model show that the analysis results based on the presented method are well competitive in accuracy with those obtained by the direst global FEM analysis for the frequencies which are lower than the highest one employed in the synthesis with remarkably higher computational efficiency and that the presented method is more efficient and accurate than the fixed-interface mode method.