• 한국임상수의학회지
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• 제37권6호
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• pp.311-316
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• 2020

Biomarkers used in dogs with heartworm disease include N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI), which are associated with damage to the myocardium. Pulmonary hypertension is one of the clinical signs of canine heartworm disease. The purpose of this study is to investigate the change in the concentration of each biomarker, severity of pulmonary hypertension and the correlation between biomarkers according to the severity of clinical signs. Five healthy dogs and 10 heartworm-infected dogs were recruited for the study. The heartworm-infected group was classified based on the history, clinical signs, and blood assay, thoracic radiography, and echocardiography after confirming the infection according to the results of the commercial ELISA kit (SNAP test, IDEXX Laboratories, Maine, USA). NT-proBNP was higher in the severely infected group than the control group (p < 0.05); cTnI was also higher in the severely infected group than the control group (p < 0.05). The pressure gradient of pulmonary hypertension was higher in the severe group than the mild group (p < 0.05). The severity of pulmonary hypertension was correlated with NT-proBNP (r = 0.818, p < 0.01), cTnI (r = 0.894, p < 0.01). When the correlation of the two serum values for each group was examined, a correlation was not found in the mild group (r = 0.707, p = 0.182), but a correlation was found in the severe group (r = 0.9, p < 0.05). NT-proBNP and cTnI were significantly increased and correlated with severe clinical signs. Pulmonary hypertension was significant higher in the severe group than in the mild group (p < 0.05). Evaluation of blood biomarker concentration and severity of pulmonary hypertension and referring to each correlation between these indicators may be helpful to assess the severity of the heartworm disease.

• 대한정형외과학회지
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• 제56권3호
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• pp.266-271
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• 2021

임신 및 수유와 연관된 골다공증은 젊은 여성에서 골다공증성 척추 압박골절을 일으킬 수 있는 희귀한 질환이다. 환자들은 주로 요통을 호소하며, 이는 임신과 출산, 수유에 의한 통증으로 오인되기 쉬워 빠른 진단과 치료가 어렵다. 저자들은 요통을 주소로 내원한 29세 여자 환자와 31세 여자 환자에 대해 신체 진찰, 단순 방사선 검사, 전신 골주사 검사, 자기공명영상 검사, 골밀도 검사, 혈액 검사 등을 통하여 임신과 수유에 연관된 골다공증성 척추 압박골절을 진단하였으며, 테리파라타이드(teriparatide) 주사와 흉요천추 보조기 착용, 칼슘과 비타민 D 제제 복용을 통해 증상이 호전된 2예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Medicine and Life Science
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• 제18권3호
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• pp.61-65
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• 2021

Although re-expansion pulmonary edema (RPE) is rare (incidence rate <1%), it is associated with a mortality rate of >20%; therefore, early diagnosis and treatment are important. We report a case of RPE following chest tube insertion in a patient with spontaneous pneumothorax. We have specifically focused on the mechanism underlying RPE and the possible etiology. An 82-year-old man with a history of chronic anemia, chronic obstructive pulmonary disease, diabetes mellitus, and hypertension was referred to the emergency department for management of recurrent right-sided pneumothorax. We performed emergency closed thoracostomy for suspected tension pneumothorax, which led to stabilization of the patient's vital signs; however, he coughed up frothy pink sputum accompanied by severe right-sided chest pain 30 min postoperatively. The patient showed new-onset right pulmonary consolidation on chest radiography, as well as desaturation, tachycardia, and tachypnea and was diagnosed with RPE. He was transferred to the intensive care unit for mechanical ventilation and supportive treatment using diuretics, ionotropic agents, and prophylactic antibiotics. RPE gradually resolved, and the patient was extubated 3 days after admission. He has not experienced recurrent pneumothorax or pulmonary disease for 4 months. We emphasize the importance of RPE prevention and that aggressive ventilator care and supportive treatment can effectively treat RPE following an accurate understanding of the underlying pathogenetic mechanisms and risk factors.

• 한국임상수의학회지
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• 제40권4호
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• pp.308-313
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• 2023

A 1-year-old castrated male Korean Shorthair cat presented with dyspnea, anorexia, lethargy, and seizures. Physical examination revealed salivation, right forelimb hemiparesis, and rapid breathing. No abnormalities were detected on auscultation. Laboratory findings revealed increased levels of bilirubin, aspartate aminotransferase (AST), globulin, glucose, and a decreased albumin-to-globulin (A:G) ratio. Both N-terminal pro-B-type natriuretic peptide (NT-proBNP) and feline serum amyloid A (fSAA) levels were significantly elevated. Thoracic radiography revealed mild cardiomegaly and diffuse increased interstitial infiltration with soft tissue opacity in the periphery of the right caudal pleural space. Echocardiography and lung ultrasonography were performed to investigate the cause of mild cardiomegaly and soft tissue opacity in the pleural space. Echocardiography revealed a mild amount of echogenic pericardial effusion, and lung ultrasonography showed an echogenic soft tissue mass with no blood signal in the right caudal pleural space, suggestive of a granulomatous lesion. After obtaining 5 mL of pericardial fluid through pericardiocentesis, cytology of the pericardial effusion sample revealed marked neutrophils and macrophages with no bacteria. IDEXX feline infectious peritonitis (FIP) virus real-time reverse transcriptase polymerase chain reaction (RT-PCR) confirmed the presence of the FIP virus biotype in the sample. This case presents a rarely reported atypical mixed form of FIP in a cat diagnosed ante-mortem using pericardial effusion analysis. In this case, ultrasound examination played a crucial role in the definitive diagnosis of FIP by PCR biotyping through pericardiocentesis. Ultrasonography can be highly beneficial in guiding the diagnosis and evaluation of cats with suspected FIP.

• Korean Journal of Radiology
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• 제22권10호
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• pp.1690-1696
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• 2021

Objective: To describe the anatomic locations and imaging features of posterior lung herniation in unilateral pulmonary agenesis and aplasia, focusing on radiograph-CT/MRI correlation. Materials and Methods: A total of 10 patients (seven with pulmonary agenesis and three with pulmonary aplasia, male: female = 1:9, mean age 7.3 years, age range from 1 month to 20 years) were included. Chest radiographs (n = 9), CT (n = 9), and MRI (n = 1) were reviewed to assess the type of lung underdevelopment, presence of anterior and posterior lung herniation, bronchus origin, supplying artery, and draining vein of the herniated lung. Results: Pulmonary agenesis/aplasia more commonly affected the left lung (n = 7) than the right lung (n = 3). Anterior lung herniation was observed in nine of the 10 patients. Posterior lung herniation was observed in seven patients with left pulmonary agenesis/aplasia. Two patients showed posterior lung herniation crossing the midline but not beyond the aorta, and five patients showed the posteriorly herniated right lower lobe crossing the midline to extend into the left hemithorax farther beyond the descending thoracic aorta through the space between the esophagus and the aorta. This anatomical configuration resulted in a characteristic radiographic finding of a radiolucent area with a convex lateral border and a vertical medial border in the left lower lung zone, revealing a tongue-like projection on CT and MRI. Conclusion: Posterior lung herniation occurs in unilateral left lung agenesis/aplasia. Approximately 70% of the cases of posterior lung herniation reveal a unique radiolucent tongue-like projection in the left lower lung zone on imaging studies, which is caused by the extension of the posteriorly herniated right lung farther beyond the descending aorta.

• 한국임상수의학회지
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• 제41권2호
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• pp.117-122
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• 2024

A 3-year-old spayed female Russian blue cat was presented for dyspnea, nasal discharge, and stertorous breathing. Plain thoracic radiography revealed no specific findings. Computed tomography (CT) was performed to differentiate upper airway tract disorders. It revealed the presence of an iso-attenuating mass measuring 10.0 × 7.9 × 15.6 mm, with mild homogeneous contrast enhancement occupying the rostral nasopharynx. The mass was surgically debulked via a longitudinal incision in the soft palate. Histopathological and immunohistochemistry analysis of the surgically excised mass revealed CD3-/CD79a+ B cell lymphoma with an incomplete margin. The patient underwent hypofractionated radiation therapy, receiving a total of 36 Gray (Gy) in 6 Gy fractions over a six-week period. A follow-up CT examination was performed after 27 months of irradiation and the patient was confirmed to have achieved a complete response. There were no complications related to irradiation. The patient was alive for 40 months without recurrence. This study suggests that hypofractionated radiation therapy combined with surgical debulking could be considered as a treatment option for feline nasopharyngeal lymphoma.

• 대한영상의학회지
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• 제82권3호
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• pp.749-755
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• 2021

선천성 심막결손은 대부분의 환자가 무증상을 보이는 드문 질환으로 전체 혹은 부분 심막결손으로 나타난다. 본 논문에서는 기흉 증상으로 인해 우연히 좌측 선천성 심막결손을 진단받은 19세 남성 환자를 보고하고자 한다. 일반 흉부 X선 사진 및 컴퓨터단층촬영에서 외상의 흔적이 없는 무기폐, 상행대동맥의 우측에 비정상적으로 위치한 공기, 좌측 흉부로 전위된 심장, 그리고 납작한 흉곽이 보였다. 뒤이은 흉강경검사에서 좌측 심막결손과 왼쪽 흉강으로의 심장 전위가 확인되었다. 이는 영상의학적 소견과 수술적 소견이 잘 일치하는 자발성 기흉이 동반된 선천성 심막결손에 관한 보고이다.

• Korean Journal of Radiology
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• 제21권10호
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• pp.1150-1160
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• 2020

Objective: To describe the experience of implementing a deep learning-based computer-aided detection (CAD) system for the interpretation of chest X-ray radiographs (CXR) of suspected coronavirus disease (COVID-19) patients and investigate the diagnostic performance of CXR interpretation with CAD assistance. Materials and Methods: In this single-center retrospective study, initial CXR of patients with suspected or confirmed COVID-19 were investigated. A commercialized deep learning-based CAD system that can identify various abnormalities on CXR was implemented for the interpretation of CXR in daily practice. The diagnostic performance of radiologists with CAD assistance were evaluated based on two different reference standards: 1) real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) results for COVID-19 and 2) pulmonary abnormality suggesting pneumonia on chest CT. The turnaround times (TATs) of radiology reports for CXR and rRT-PCR results were also evaluated. Results: Among 332 patients (male:female, 173:159; mean age, 57 years) with available rRT-PCR results, 16 patients (4.8%) were diagnosed with COVID-19. Using CXR, radiologists with CAD assistance identified rRT-PCR positive COVID-19 patients with sensitivity and specificity of 68.8% and 66.7%, respectively. Among 119 patients (male:female, 75:44; mean age, 69 years) with available chest CTs, radiologists assisted by CAD reported pneumonia on CXR with a sensitivity of 81.5% and a specificity of 72.3%. The TATs of CXR reports were significantly shorter than those of rRT-PCR results (median 51 vs. 507 minutes; p < 0.001). Conclusion: Radiologists with CAD assistance could identify patients with rRT-PCR-positive COVID-19 or pneumonia on CXR with a reasonably acceptable performance. In patients suspected with COVID-19, CXR had much faster TATs than rRT-PCRs.

• Tuberculosis and Respiratory Diseases
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• 제63권3호
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• pp.261-267
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• 2007

배경: 삼출성 흉수 환자의 적지 않은 빈도에서 원인이 불명확하다. 삼출성 흉수를 진단하기 위한 다양한 방법 중에서 내과적 흉강경은 국소마취 하에서 시행할 수 있으며 악성 종양이나 결핵에서 진단율이 높으며, 진정제와 국소마취상태에서 시행할 수 있다. 본 연구의 목적은 내과적 흉강경의 진단적 정확성과 안전성에 대해 알아보고자 하였다. 대상 및 방법: 2005년 10월부터 2006년 9월까지 25명의 원인을 알 수 없는 삼출성 흉수 환자를 대상으로 내과적 흉강경을 시행하였다. 성별, 연령 시술 전 폐기능, 흉부 측와위 사진에서 흉수의 두께(LDR) 등의 정보를 얻었다. 내과적 흉강경 시행도중 활력징후를 기록하였고 동맥혈 가스 분석을 5차례 시행하여 혈역학적 상태와 산-염기 균형 상태를 파악할 수 있도록 하였다. 결과: 환자의 평균 연령은 56.8(22-79)세였고, 흉부 측와위 사진에서 흉수의 두께는 27.49 mm이었다. 내과적 흉강경을 이용한 흉막 조직 생검으로 24명(96%)이 진단되었으며, 결핵성 흉막염이 9명(36%), 악성 흉수가 8명(32%), 부폐렴성 흉수가 7명(28%)이었다. 내과적 흉강경으로 흉수의 원인을 알아낼 수 없었던 1명(4%)은 추후에 심장막 조직 생검으로 결핵으로 진단되었다. 내과적 흉강경 중 혈압, 심박동수, 산-염기 상태의 변화는 보이지 않았다(p>0.05). 결론: 내과적 흉강경은 진단율이 높으면서도 안전한 시술이다.

• 한국방사선학회논문지
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• 제17권6호
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• pp.903-909
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• 2023

본 연구는 자동노출제어장치를 이용한 흉부 측방향 검사 시에 환자의 중심위치 변화가 주변 장기의 피폭선량과 화질에 미치는 영향을 탐구하는데 목적이 있다. 실험은 인체모형팬텀을 대상으로 하였다. 바늘침을 팬텀의 관상선 중심 하단부에 부착하였고, 납 자를 검출기 하단부에 부착하여, 50 cm 지점이 AEC 이온챔버의 중앙 하단부에 위치하도록 하였다. 조사조건은 125 kVp, 320 mA, 초점-영상검출기간 거리는 180 cm, 조사야 크기는 14×17 inch를 사용하였다. AEC 이온 챔버는 중앙-하단 1개만 사용했고, Sensitivity 'Middle', Density '0' 으로 설정하여, 중심 X선은 6번째 흉추를 향해 수직입사 하였다. AEC mode를 적용한 상태에서 바늘침과 납 자의 50 cm 지점이 일치되게 위치시킨 후 팬텀을 배 쪽으로 5 cm (F5), 등 쪽으로 5 cm (B5) 씩 이동시킨 후 ESD를 측정하여 선량 인자를 분석하였다. 환자 중심위치 변화에 따른 갑상선의 ESD는 Center의 경우 232.60±2.20 μGy, F5는 231.22±1.53 μGy, B5는 184.37±1.19 μGy로 나타났으며, 유방의 ESD는 Center의 경우 288.54±3.03 μGy, F5는 260.97±1.93 μGy, B5는 229.80±1.62 μGy, 폐 중심부의 ESD는 Center의 경우 337.02±3.25 μGy, F5는 336.09±2.29 μGy, B5는 261.76±1.68 μGy 로 나타났다. 선량 인자의 각 그룹 간 평균값의 차이를 비교한 결과 통계적으로 유의한 차이가 나타났으며(p<0.01), 각각 독립적인 그룹으로 나타났다. 연구의 결과, 환자 중심위치 변화에 따른 갑상선, 유방, 폐 중심부의 선량의 차이는 환자가 전방 5 cm 정도의 움직임에서는 유방(10%)를 제외한 장기에서는 큰 차이가 없었으나, 후방 5 cm 정도의 움직임에서는 각 부위에서 평균 23.7%의 선량 감소를 나타냈다. 또한, 환자 중심위치가 후방으로 이동 시 화질의 저하가 나타났다.