• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.694-703
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• 2019

This study was to investigate the effect of therapeutic exercise with electrical stimulation on knee joint pain, range of motion and muscle strength in patients who underwent anterior cruciate ligament reconstruction. The subjects of this study were recruited who diagnosed with anterior cruciate ligament rupture and undergoing anterior cruciate ligament reconstruction, total of 20 patients were randomly divided to the 10 control groups and 10 experimental groups. The therapeutic exercise was carried out for 3 weeks with three exercises made by referring to the previous study. The measurement tools used were knee joint pain measurements were made using the visual analogue scale, range of motion was measured using a goniometer, and the muscle strength was measured using a handheld dynamometer. In the statistical analysis, to compare about pre and post test the difference in each same groups was accomplished by using the paired t-test, and compare the difference between the different each groups was accomplished by using the independent t-test. The results of the study showed that the experimental group showed significantly enhanced results than the control group(p<.05). Based on these results, it is concluded that it is effective for the recovery of the patient if the therapeutic exercise with electrical stimulation in parallel with knee joint therapy are performed for the patients with anterior cruciate ligament reconstruction.

• Korean Journal of Veterinary Research
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• v.55 no.4
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• pp.253-257
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• 2015

Oregano (Origanum vulgare) is an aromatic herb belonging to the Lamiaceae family. This study evaluated the therapeutic effect of oregano essential oil (OEO) on clinical bovine mastitis caused by Staphylococcus (S.) aureus and/or Escherichia (E.) coli. Thirty-two quarters from 18 lactating cows with subclinical mastitis were selected from a dairy farm and were divided into 4 groups (8 quarters/group): negative control (CON), positive control (GEN) and two OEO-treated groups (OEO-1 and OEO-2). Each group was intramammarily treated with saline, 10 g/tube of gentamicin ointment, and single and double doses of 0.9 mL OEO ointment twice a day for three days, respectively. After the treatments, physical udder conditions were greatly improved in GEN and OEO groups. In CON group, somatic cell counts (SCCs), number of white blood cells (WBC) and bacteria were increased. However, in OEO groups, SCCs and number of WBC were significantly decreased and S. aureus and E. coli were not detected in milk as compared with those before the treatments as well as GEN group. These results suggest that OEO may be a useful alternative to antibiotics for the control of subclinical bovine mastitis caused by S. aureus and/or E. coli.

• Journal of Veterinary Science
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• v.24 no.3
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• pp.23.1-23.16
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• 2023

Background: Irritable bowel syndrome (IBS) is a functional bowel disorder (FBD). Objectives: To assess the therapeutic effects of paeoniflorin (PF) on IBS in rats. Method: Sixty male Sprague-Dawley rats were randomly divided into normal, model, positive drug, low-dose PF, medium-dose PF and high-dose PF groups (n = 10). After gavage for 2 consecutive weeks, the effect of PF on abdominal pain symptoms was assessed based on the abdominal withdrawal reflex (AWR) score, fecal water content and pathological changes in colon tissues. D-lactate, interleukin-1β (IL-1β), transforming growth factor-β (TGF-β) and tumor necrosis factor-α (TNF-α) were detected by enzyme-linked immunosorbent assay, and phosphorylated nuclear factor kappa B (p-NF-κB) p65 was detected by Western blotting. The abundance and diversity changes of intestinal flora were explored using 16S ribosomal RNA sequencing. Result: In PF groups, the mucosal morphology of colon tissues was intact, and the glands were arranged neatly and structured clearly, without obvious inflammatory cell infiltration. Compared with the model group, PF groups had significantly elevated pain threshold, and mRNA and protein levels of zonula occludens-1 (ZO-1) and occludin, decreased AWR score at 20 mmHg pressure, fecal water content, mRNA levels of IL-1β, TGF-β, and TNF-α, protein level of p-NF-κB p65 and level of serum D-lactate, and reduced levels of serum IL-1β, TGF-β, and TNF-α (p < 0.05, p < 0.01). PF groups had higher abundance of Lactobacillus, Akkermansia, Alistipes, and Bacteroides, but lower abundance of Desulfovibrio, Parasutterella, and Enterococcus than those of the model group. Conclusions: PF exerts therapeutic effects on IBS in rats probably by regulating the intestinal flora, and then up-regulating the expressions of ZO-1 and occludin in colon tissue while down-regulating the levels of IL-1β, TGF-β, TNF-α, D-lactate and p-NF-κB p65.

• Journal of Veterinary Clinics
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• v.25 no.6
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• pp.471-475
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• 2008

The present study was performed to elucidate the therapeutic effect by aquapuncture with bee-venom (apitoxin) for treatment of canine pyoderma. The total 8 dogs with pyoderma were divided into 2 groups as control (antibiotics group: 4 dogs) and experimental groups (apitoxin group: 4 dogs). Antibiotics group was treated with bathing and antibiotics, while apitoxin group was treated with bathing and aquapuncture with apitoxin at Fei Shu (BL13), Wei Zhong (BL40), Da Zhui (GV14), Zu San Li (ST36), He Gu (LI04), Qu Chi (LI11), and San Yin Jiao (SP06). Based on the results of changes in clinical symptoms, total leukocyte counts, neutrophil/lymphocyte ratios and histopathological findings, antibiotics and apitoxin groups were all effective for treatment of canine pyoderma, and significant differences were not detected between the groups. It was suggested that apitoxin might be used as an alternative method to antibiotics for treatment of canine pyoderma.

• Journal of Nutrition and Health
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• v.33 no.8
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• pp.824-832
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• 2000

In Sasang constitutional medicine, a part of oriental medicine, there are beneficial foods of harmful foods according to the each constitutions. Until now, most of the studies have investigated the classification of foods according to the each constitutions, The clinical usage of the constitutional diets in now in the beginning. The purpose of this study is to investigate the therapeutic effects of the constitutional diets in comparison with general therapeutic diets in the patients with hyperlipidemia. From January to August, 1999, the 65 hyperlipidemic patients admitted to Kyung Hee Oriental Medical Center were studied. Therapeutic diet for hyperlipidemic patients or each constitutional diets were given to the subjects 3 meals a day for 6 weeks. The Sasang constitutional classification, food habits were assessed. The anthropometric assessment and blood analysis were carried out before and after taking each experimental diets. The results are as folow ; 1) The mean age of the objects was 62.4${\pm}$6.5 years, the distribution of their constitution were Tae-eumin :63.0%, So-yangin :26.2% So-eumin: 10.8%. 2) The mean body weight and BMI of Tae-eum were significantly higher than those of So-eum and So-yang. 3) Food habits of each constitutional groups were very similar to those described by sasang medicine. 4) The therapeutic and constitutional diets lowered the serum levels of total lipid(from 756.4mg/dl to 692.3mg/dl) triglyceride(from 244.4mg/dl to 212.mg/dl) and VLDL-cholesterol(from 48.9mg/dl to 42.5mg/dl). The therapeutic diet decreased the HDL-cholesterol level(from 49.0mg/dl to 41.7mg/dl) but the constitutional diet did not. 5) The effects of the therapeutic and constitutional diets were the highest in Tae-eum group. In the So-yang group, the constitutional diet lowered the levels of total lipid and LDL-cholesterol but the therapeutic diet did not. But the therapeutic and constitutional diets did not change the blood lipid levels significantly in the So-eum group.(Korean J Nutrition 33(8) : 824-832, 2000)

• Korean Journal of Acupuncture
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• v.28 no.4
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• pp.59-66
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• 2011

Objectives : This study is aimed to evaluate and objectify the therapeutic effect of moxibustion on muscle fatigue recovery. Methods : To evaluate the therapeutic effect on the muscle fatigue recovery, we compared the fatigue recovery of two groups (non-stimulation group and moxibustion group) by analyzing the EMG and peak torque after strenuous knee exercise of isokinetic contraction. Results : The median frequency (MF) of the moxibustion group was recovered faster than that of the non-stimulation group. However, the peak torques of both groups were not restored until after 20 minutes. Nevertheless, the moxibustion group's peak torque was regained higher than that of the non-stimulation group. Conclusions : We confirmed the therapeutic effect of moxibustion and found that the moxibustion can used as prevention method for musculoskeletal disease.

• Journal of muscle and joint health
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• v.29 no.1
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• pp.11-17
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• 2022

Purpose: This study aimed to provide objective and basic data for an effective treatment method by examining changes in the mechanical properties of muscles and the degree of tenderness when a combination of stretching exercise and ultrasound therapy is applied to patients with tension headaches. Methods: The participants were classified into two groups based on the intervention received: the therapeutic ultrasound combined with suboccipital stretching (n=15, experimental group) and infrared combined with suboccipital stretching (n=15, control group) groups. The intragroup differences in mechanical muscle properties and modified total tenderness score were compared and analyzed. Results: The comparison and analyses of the changes in muscle tone and stiffness revealed statistically significant intragroup decreases in the upper trapezius and suboccipitalis in the experimental group. Similarly, the comparison and analyses of the changes in muscle stiffness revealed statistically significant intragroup decreases in the upper trapezius in the control group. Conclusion: Therapeutic ultrasound combined with suboccipitalis stretching effectively increased the flexibility of the muscles around the cervical vertebrae and reduced muscle tension and stiffness in tension-type headache patients

• Proceedings of the Ginseng society Conference
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• 1998.06a
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• pp.300-311
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• 1998

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), one of the most notorious toxic environmental pollutants, induces various toxic effects in many organs including testes and is regarded as an endocrine disruptor. Korean ginseng, on the other hand, has been well known for its preventive effects on lox- ins, diabetes melltus and hyperlipidemia. We investigated, histopathologically, the effect of Korean Red ginseng water extract (KR-WE) on guinea pig testes damaged by TCDD. Ninety guinea pigs were divided into 6 groups: normal control (NC) group received vehicle and saline; TCDD,1191kg b.w., was administered intraperitoneally to the single dose TCDD-treated (77) group; 100 mghg b.w.16 and 200mg1kg b.w./d KR-WE were injected intraperitoneally to the preventive groups (PIOO and P2OO, respectively) for 28 days from 1 week before TCDD injection, and to the therapeutic groups (CIOO and C2OO, respectively) for 14 days since 1 week after TCDD administration. Increment of body weight was retarded to a larger extent by TCDD. Moreover, body weight of the 77 group decreased significantly 7 days after TCDD exposure, while that of preventive groups kept increasing. Decrease in body weight was not observed in KR-WE-treated groups. Weight decrease in testes caused by TCDD was remarkably protected by KR-WE. Testicles in 77 group displayed decreased tubular size and maturation arrest at the primary or secondary spermatocyte stage. On the other hand, maturation arrest in germ cells by TCDD was improved in KR-WE treated groups. Almost complete protection of the testes was observed in PIOO and P2OO groups. In addition, the therapeutic effect was noticed in C 100 and C2OO groups. These results provided strong evidence that Korean Red ginseng might be a useful agent for the prevention and treatment of testicular damage induced by environmental pollutants.

• Biomolecules & Therapeutics
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• v.9 no.4
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• pp.244-248
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• 2001

This study was performed to investigate therapeutic effects of Carthami Semen, Paeoniae Raidx extracts and chitosan on the growth and differentiation of human periodontal ligament cell. We found that co-treatment of methanol extracts of Carthami Semen and chitosan significantly increased the growth of human periodontal ligament cell. However, the sigle treatment groups of the extracts showed only 20-30% of the growth increase. Alkaline phosphase activity, one of differentiation markers, was increased approximately 1.5- fold by co-treatment of methanol extract of Carthami Semen and chitosan and calcified nodule formation was also increased at the similar levels as the alkaline phosphatase. But the single treatment groups showed only 20-30% increases. These results suggest that Carthami Semen and chitosan co-treatment can be used efficiently for periodontium regeneration.

• Journal of Radiation Protection and Research
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• v.26 no.4
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• pp.367-374
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• 2001

The study was designed to evaluate the response of sucralfate against the esophageal damage of rat by irradiation. Sixty Sprague-Dawley rats weighing 200-250 gm were divided into six groups including only sucralfate group, the group of 10 Gy or 20 Gy radiation alone, the groups of 10 Gy or 20 Gy radiation-sucralfate combination, and control. Each group was sacrificed at 3, 7, 14, and 28 days after irradiation. For evaluation of the radiation-induced esophageal lesions, there were examined the change of body weight, barium-esophagogram and histopathologic findings. Mean body weight gain was decreased in the groups with 10 Gy or 20 Gy radiation alone and 10 Gy or 20 Gy radiation-sucralfate combination as comparing with control (p=0.03, p=0.02, p=0.04, p=0.02), but there was no difference between the groups of 10 Gy or 20 Gy radiation alone and the groups of 10 Gy or 20 Gy radiation-sucralfate combination. In the 10 Gy and 20 Gy radiation alone groups, barium esophagograms showed diffuse narrowing and stiffness through the entire esophagus from 7 days after irradiation, but there was similar pattern of esophagograms between the groups of 10 Gy radiation-sucralfate combination and the control. Histopathoiogic lesion scores of 10 Gy and 20 Gy radiation groups were significantly higher than the control (p=0.03, p=0.008). In the 10 Gy radiation group, there were significantly higher lesion scores at 3 and 7 days after irradiation as comparing with those in the group of radiation-sucralfate combination (p=0.04, p=0.03). These results suggest that sucralfate might be played as a role of protection from acute radiation-induced esophagitis within the limit of tolerable radiation doses.