• Molecules and Cells
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• 제20권1호
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• pp.17-29
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• 2005

Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical product category after vaccines. Antibodies have been engineered by a variety of methods to suit a particular therapeutic use. This review describes the structural and functional characteristics of antibody and the antibody engineering for the generation and optimization of therapeutic antibodies.

• 대한방사선치료학회지
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• 제2권1호
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• pp.87-92
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• 1987

The authors have intended to measure intrinsic dose distribution by Farmer dosimeter in irregularly shaped fields such as L, M, T,-shape model in order to determine dose inhomogeneity in those models. We made 2 off-axis points in each model and measured the depth dose at 1.5,5, and 9cm below surface. The results showed $1-3\%$ dose discrepancy between 2 points. We also measured the depth dose by geometric approximation and computer calculation in those models, and came to the conclusion that computer calculation using Clarkson's principle is simpler and the measurements are to the ideal data obtained by the experiment in those three models of irregularly shaped fields than those of geometric approximation method.

• 아동학회지
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• 제26권3호
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• pp.111-125
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• 2005

The Korean version of the therapeutic relationship scaled for parents was administered to 156 Korean parents and 51 therapists. Statistical analysis of the data showed that highly educated parents who graduated from university had the most negative emotional perceptions against therapists. Working class parents made more positive therapeutic helping relationships as assistants though they also had negative emotional relationships. Differences in perception of emotional relationships between parents and therapists were found even when there were no differences in the therapeutic helpfulness of the relationship. That is, when effectiveness of the therapeutic relationship was held constant, perceptual disagreement about the emotional relationship between parents and therapists was more prevalent than agreement about the emotional relationship.

• The Journal of Korean Physical Therapy
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• 제13권3호
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• pp.751-760
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• 2001

Therapeutic exercise had developed with human being. It depend upon development of physiology, anatomy, kinesiology and biomechanics. There are two categories in therapeutic exorcise. One is classical therapeutic exercise which is a activity of one muscle group, one axis and one plane motion. It is ROM, FRE. osteokinematics, arthrokinematics. Another is neurophysiological approach which is multi muscle group, multi axis and plane exercise. It is PNF and Bobath that start from 1940 to early 1950. Classical therapeutic exorcise develop from ROM to osteokinematics and arthrokinematics. It is foundation of the joint mobilization and orthopaedic manual physical therapy. Neurophysiological therapeutic approaching has more theory and skills than before. Bobath methods had changed from reflex-inhibiting posture to key points of control and added the theory of musculoskeletal, biomechanics, motor behaviour and cognition. We call it motor control.

• BMB Reports
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• 제43권12호
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• pp.773-780
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• 2010

Cancers are still difficult targets despite recent advances in cancer therapy. Due to the heterogeneity of cancer, a single-treatment modality is insufficient for the complete elimination of cancer cells. Therapeutic strategies from various aspects are needed. Gene therapy has been expected to bring a breakthrough to cancer therapy, but it has not yet been successful. Gene therapy also should be combined with other treatments to enhance multiple therapeutic pathways. In this view, gene delivery vector itself should be equipped with intrinsic anti-cancer activities. HVJ (hemagglutinating virus of Japan; Sendai virus) envelope vector (HVJ-E) was developed to deliver therapeutic molecules. HVJ-E itself possessed anti-tumor activities such as the generation of anti-tumor immunities and the induction of cancer-selective apoptosis. In addition to the intrinsic anti-tumor activities, therapeutic molecules incorporated into HVJ-E enabled to achieve multi-modal therapeutic strategies in cancer treatment. Tumor-targeting HVJ-E was also developed. Thus, HVJ-E will be a novel promising tool for cancer treatment.

• The Journal of Korean Physical Therapy
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• 제12권1호
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• pp.133-139
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• 2000

Neurophysiological therapeutic exercise had started 1940-1960 that used for CNS patient's rehabilitation is the world. In America, PNF, Bobath, Brunnstrom technique are reviewed through the NUSTEP and II STEP on 1967. The NUSTEP provide common interest of neurophysiological therapeutic exercise. The II STEP provide new concept of neurophysiological therapeutic exercise from scholar, professor and clinician. New concept include not only using the reflex but also motor learning, motor control and motor behavior. It is including neurobiologic interaction, biomechanics and motor science. Therefore, neurophysiological therapeutic exercise have to change with the purpose of the therapeutic exercise.

• KIEAE Journal
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• 제4권2호
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• pp.57-64
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• 2004

Apartments recently built have been strategically designed in many ways, and one of the most striking aspects is to utilize the idea of environmental friendliness and the application to the living environment. Especially, the number of environmentally friendly apartments that concern the health of residents have been increasing and their landscape is notably differentiated. The purpose of this research study was to examine the landscape of the environmentally friendly apartments that have been built in the past five years, and to assess its features in the aspects of therapeutic garden. Based upon the review of previous studies, this study constructed a checklist that was used to evaluate the planning components of the landscape during site visits. This study found that overall landscape selected in the study was well-planned. However, it was suggested that more features of therapeutic garden such as vegetation area which both encourages interaction with residents and produces therapeutic benefits be adopted in planning the advanced therapeutic garden of environmentally friendly apartments.

• Child Health Nursing Research
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• 제24권4호
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• pp.517-526
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• 2018

Purpose: This study compared nursing frequency, nursing time, and nursing intervention priorities depending on the method of neonatal induced hypothermia. Methods: We observed 15 neonatal subjects receiving therapeutic hypothermia for 3 days each. Forty-five nurses experienced with nursing neonatal patients under therapeutic hypothermia provided responses about nursing intervention priorities. Analyses with the chi-square, the Fisher exact test, the paired t-test, the Wilcoxon signed rank test, and the Wilcoxon rank-sum test were performed on the data using SAS version 9.4. Results: The frequency of nursing activities was higher for selective head therapeutic hypothermia (SHTH) than for systemic therapeutic hypothermia (STH), and nursing time was also significantly longer. In terms of nursing intervention priorities, there were priority differences in "risk for ineffective thermoregulation" and "risks for impaired skin integrity" for SHTH compared to STH. Conclusion: Since SHTH for neonatal therapeutic hypothermia requires more nursing time and frequent nursing activities than STH, STH is therefore recommended if the therapeutic efficacy is similar. Appropriate nursing personnel should be allocated for neonatal SHTH nursing. Nurses should be aware of nursing interventions for therapeutic hypothermia as the priorities are different for different methods of neonatal therapeutic hypothermia.

• 대한정형도수물리치료학회지
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• 제13권2호
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• pp.55-68
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• 2007

Object: to evaluate the effects of two different treatments-joint mobilization and therapeutic exercise on difference for length of lower limbs. Method: The subjects were participated twenty six who has difference for length of lower limbs more 10mm. All subjects randomly assigned to Joint mobilization group(n=13) and therapeutic exercise group. Joint mobilization group received joint mobilization for 2 minutes, Therapeutic exercise group received for 15 minutes per day and 3 times a week during 4 week period. Tape measure method was used to measure the difference for length of lower limbs. Biodex was used to measure the muscle power of lower limbs(Knee flexion, extension). Finger to floor test was used to measure the mobility of spinal column. All measurement of each subjects were measured at pre-experiment, after 2weeks and post-experiment. Result: The result of this study were summarized as follows : 1. Both treatment decreased difference for length of lower limbs while joint mobilization more decreased difference for length of lower limbs than therapeutic exercise. 2. Both treatment increased mobility of spinal column while joint mobilization more increased mobility of spinal column than therapeutic exercise. 3. Joint mobilization increased muscle power while therapeutic exercise decreased muscle power. Conclusion: in a group-wise comparison joint mobilization is more effective than therapeutic exercise.

• 대한예방한의학회지
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• 제4권2호
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• pp.25-56
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• 2000

Trace element are involved in enzymatic activities, immunological reactions. physiological mechanisms. Deficiency in some trace elements, such as iron and iodine. is still an important health problem, The role of trace elements deficiency is suspected in various clinical situations and is now confirmed by well designed supplementation studies. However, the importance of trace elements as chinese herbal constituents is not sufficiently appreciated by the oriental medical profession, although in recent years a significant increase of new finding on their essential character in chinese herbal medicine occurred. It is well known that herbal medicine contains a variety of trace elements which would show therapeutic effects with active components in herbal medicine . In china, recent work showed some positive correlation between trace element and traditional chinese medicine (TCM) in terms of therapeutic effects even if their role in therapeutic effects is still obscure. In korea, not much attention has been on the therapeutic importance of trace element contained in herbal medicine Here, the therapeutic effects of trace element in TCM were reviewed and summarized. 1. Iron, copper, zinc and manganese are mainly contained in TCM. In addtion, chromium, magnesium, molybdenum, nickel, alminium, cobalt, arsenic and selenium has been studied for their therapeutic effects 2. Zinc, is decreased in patients who have deficiency of kindney(腎虛) and chronic disease. Fe is decreased in patients who have deficiency of blood(血虛). However copper is increased in patients who have chronic disease and hepatic disease.3 Iron concentration is high in herbs used for tonifying and nourishing yin or blood(補陰補血藥) Zinc concentration is high also in herb used for tonifying kidiney and vital essence(補腎補精藥). In addition. copper concentration Is high in herb used for replenishing qi(補氣藥) 4 In herbal drugs, the therapeutic substances in TCM are not only organic but also inorganic. It seems that trace elements would be one of components in herb for its therapeutic effects. This indicates that therapeutic effects of TCM should be extended not only to herb itself, bur also to trace elements contained in herb.