• Title/Summary/Keyword: theory synthesis

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Study on the Attributive Channel Theory by the Pharmacodynamic Research of I-131 labelled Curcumin (I-131 표지 Curcumin의 약동력학적 분석을 통한 귀경(歸經)연구)

  • Yun, Hong-Il;Ham, In-Hye;Cho, Jung-Hyuck;Yu, Kook-Hyun;Park, Jung-Hoon;Choi, Ho-Young
    • The Korea Journal of Herbology
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    • v.22 no.2
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    • pp.181-188
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    • 2007
  • Objectives : This study was to verify the Attributive Channel theory of herbal medicine. Methods : [13lI]iodocurcumin was synthesized, separated, and refined from curcumin, the major component of Curcuma species, followed by observing the biodistribution in an organism. Especially, from the fact that curcumin has shown to possess potent anti-carcinogenic properties, the biodistribution in the carcinogenesis organism was analyzed. Result : Iodocurcumin 23mg was obtained through column chromatography after a reaction with 50mg of Curcumin and ICl. The nominal yield of [13lI]iodocurcumin synthesis was 35% when checked with radioactive layer of chromatography. [13lI]iodocurcumin was most largely distributed in the stomach of a BALB/c mouse and a C57BL/6 mouse transplanted with Lewis lung carcinoma cell. Conclusion : The fact that [13lI]iodocurcumin was most largely distributed in the stomach was related with the Attributive Channel theory. And there was no significant finding related to tumor cells.

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Applying Theory Informed Global Trends in a Collaborative Model for Organizational Evidence-based Healthcare

  • Lockwood, Craig
    • Journal of Korean Academy of Nursing Administration
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    • v.23 no.2
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    • pp.111-117
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    • 2017
  • Getting evidence in to practice tends to focus on strategies, theories and studies that aim to close the gap between research knowledge and clinical practice. The evidence to practice gap is more about systems than individual clinician decision making. The absence of evidence for administration and management in the organization of healthcare is persistent. Teaching nurses and providing evidence as the solution to evidence-based healthcare is no longer axiomatic. Previous studies have concluded that unit level strategies integrate multi-professional teams with organizational needs and priorities. This 'best fit' approach that characterizes how healthcare is structured and delivered. The published literature shows that increased readiness for change is aligned with integrated approaches informed by conceptual models. The Joanna Briggs Collaboration is the largest global collaboration to integrate evidence within a theory informed model that brings together academic centres, hospitals and health systems for evidence synthesis, transfer and implementation. The best approaches to implementation are tailored to local culture and context, benchmark against international evidence, combine a theory informed model and stakeholder perspectives to improve the structure and processes of health care policy and practice.

A Systematic Review Exploring the Current State of Fashion Criticism -A Focus on the Fashion Designer Exhibition Reviews of Fashion Theory-

  • Choi, Kyung-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.44 no.2
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    • pp.273-294
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    • 2020
  • Considering the complex relationship between fashion curating and the critical approach of fashion exhibition reviews, this study explores the current state of fashion criticism in museology, focusing on fashion designer exhibition reviews of Fashion Theory. The author selected eighteen exhibition reviews of individual fashion designers' works from 1997 on to the current 2020 issues of Fashion Theory, which provides an interdisciplinary forum to analyze fashion as a cultural construction. The author performed a systematic review that qualitatively summarizes and/or synthesizes the findings of the studies on the topic with the process of a systematic review, such as key question formulation, analytic framework building, evidence mapping, critical appraisal, and evidence synthesis. The results of this study are as follows. First, the exhibition reviews included almost all stages of the inclusive fashion criticism model, based on an artifact study. Second, they reflected various critical discourses that offered current interpretations of historical and contemporary fashion. Third, they showed that fashion criticism in the museum context is the result of an interdisciplinary collaboration of various fashion agents. Finally, they offered a bridge for crossing the boundaries of various scholarly fields, as they combine multidisciplinary scholarship with object-based methods.

Hardware Synthesis From Coarse-Grained Dataflow Specification For Fast HW/SW Cosynthesis (빠른 하드웨어/소프트웨어 통합합성을 위한 데이타플로우 명세로부터의 하드웨어 합성)

  • Jung, Hyun-Uk;Ha, Soon-Hoi
    • Journal of KIISE:Computer Systems and Theory
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    • v.32 no.5
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    • pp.232-242
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    • 2005
  • This paper concerns automatic hardware synthesis from data flow graph (DFG) specification for fast HW/SW cosynthesis. A node in BFG represents a coarse grain block such as FIR and DCT and a port in a block may consume multiple data samples per invocation, which distinguishes our approach from behavioral synthesis and complicates the problem. In the presented design methodology, a dataflow graph with specified algorithm can be mapped to various hardware structures according to the resource allocation and schedule information. This simplifies the management of the area/performance tradeoff in hardware design and widens the design space of hardware implementation of a dataflow graph compared with the previous approaches. Through experiments with some examples, the usefulness of the proposed technique is demonstrated.

Newton's Huristics of the Discovery of Dynamics - Transformation and Synthesis (뉴턴의 발견법 - 변형재구성)

  • Park, Mi-Ra;Yang, Kyoung-Eun
    • Journal of Korean Philosophical Society
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    • v.148
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    • pp.157-181
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    • 2018
  • The aim of this essay is to identify elements of methodologies to investigate the development of Newtonian dynamics. This methodology involves the transformation and synthesis of preceding theories. My essay attempts to confirm my assertion by analyzing historical case of Newton's discovery of his dynamics. While discovering his mechanistic theory, Newton reconstructed theoretical concepts and structures of intellectual predecessors, such as Aristotle, Descartes, Galileo, and Kepler. Newton's synthesis was possible only after carefully reconstructing the appropriate and useful ideas of previous natural philosophers' ideas. As a result, Newtonian dynamics are completed with these modified and integrated concepts incorporated into Newton's law of motion and space-time concepts. This study consists of two parts. First, Lakatos' research program has been applied in order to analyze the structure of Newtonian dynamics. Second, the aforementioned methodologies of discovery are distilled from the case study.

Effect of nonlinear FG-CNT distribution on mechanical properties of functionally graded nano-composite beam

  • Zerrouki, Rachid;Karas, Abdelkader;Zidour, Mohamed;Bousahla, Abdelmoumen Anis;Tounsi, Abdelouahed;Bourada, Fouad;Tounsi, Abdeldjebbar;Benrahou, Kouider Halim;Mahmoud, S.R.
    • Structural Engineering and Mechanics
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    • v.78 no.2
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    • pp.117-124
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    • 2021
  • This work focused on the novel numerical tool for the bending responses of carbon nanotube reinforced composites (CNTRC) beams. The higher order shear deformation beam theory (HSDT) is used to determine strain-displacement relationships. A new exponential function was introduced into the carbon nanotube (CNT) volume fraction equation to show the effect of the CNT distribution on the CNTRC beams through displacements and stresses. To determine the mechanical properties of CNTRCs, the rule of the mixture was employed by assuming that the single-walled carbon nanotubes (SWCNTs)are aligned and distributed in the matrix. The governing equations were derived by Hamilton's principle, and the mathematical models presented in this work are numerically provided to verify the accuracy of the present theory. The effects of aspect ratio (l/d), CNT volume fraction (Vcnt), and the order of exponent (n) on the displacement and stresses are presented and discussed in detail. Based on the analytical results. It turns out that the increase of the exponent degree (n) makes the X-beam stiffer and the exponential CNTs distribution plays an indispensable role to improve the mechanical properties of the CNTRC beams.

A Lower Bound Estimation on the number of LUT′s in Time-Multiplexed FPGA Synthesis (시분할 FPGA 합성에서 LUT 개수에 대한 하한 추정 기법)

  • Eom, Seong-Yong
    • Journal of KIISE:Computer Systems and Theory
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    • v.29 no.7
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    • pp.422-430
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    • 2002
  • For a time-multiplexed FPGA, a circuit is partitioned into several subcircuits, so that they temporally share the same physical FPGA device by hardware reconfiguration. In these architectures, all the hardware reconfiguration information called contexts are generated and downloaded into the chip, and then the pre-scheduled context switches occur properly and timely. Since the maximum number of the LUT's required in the same time determines the size of the chip used in the synthesis, it needs to be minimized, if possible. Many previous work use their own approaches, which are very similar to either scheduling method in high level synthesis or multi-way circuit partitioning method, to solve the problem. In this paper, we propose a method which estimates the lower bound on the number of LUT's without performing any actual synthesis. The estimated lower bounds help to evaluate the results of the previous work. If the estimated lower bound on the number of LUT's exactly matches the number of LUT's of the result from the previous work, the result must be optimal. In contrast, if they do not match, the following two cases are expected : the more exact lower bound may exist, or we might find the new synthesis result better than the result from the previous work. Experimental results show that our lower bound estimation method is very accurate. In almost al] cases experimented, the estimated lower bounds on the number of LUT's exactly match those of the previous synthesis results respectively, implying that the best results from the previous work are optimal as well as our method predicted the exact lower bound for those examples.

Synthesis, Crystal Structure and Theoretical Calculation of a Novel Nickel(II) Complex with Dibromotyrosine and 1,10-Phenanthroline

  • Huang, Guimei;Zhang, Xia;Fan, Yuhua;Bi, Caifeng;Yan, Xingchen;Zhang, Zhongyu;Zhang, Nan
    • Bulletin of the Korean Chemical Society
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    • v.34 no.10
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    • pp.2889-2894
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    • 2013
  • A new complex [$Ni(phen)(C_9H_8Br_2NO_3)_2{\cdot}2CH_3OH{\cdot}2H_2O$] [phen: 1,10-phenanthroline $C_9H_8Br_2NO_3$: 3,5-dibromo-L-tyrosine] was synthesized and characterized by IR, elemental analysis and single crystal X-ray diffraction. X-ray crystallography shows that Ni(II) ion is six-coordinated. The Ni(II) ion coordinates with four nitrogen atoms and two oxygen atoms from three ligands, forming a mononuclear Ni(II) complex. The crystal crystallizes in the Orthorhombic system, space group $P2_12_12$ with a = 12.9546 ${\AA}$, b = 14.9822 ${\AA}$, c = 9.9705 ${\AA}$, V = 1935.2 ${\AA}$, Z = 1, F(000) = 1008, S = 0.969, ${\rho}_{calcd}=1.742g{\cdot}cm^{-3}$, ${\mu}=4.688mm^{-1}$, $R_1$ = 0.0529 and $wR_2$ = 0.0738 for 3424 observed reflections (I > $2{\sigma}(I)$). Theoretical study of the title complex was carried out by density functional theory (DFT) method and the B3LYP method employing the $6-3l+G^*$ basis set. The energy gap between HOMO and LUMO indicates that this complex is prone to interact with DNA. CCDC: 908041.

Changes in photosynthesis and carbohydrate synthesis in response to elevated UV-B environment (고 자외선 환경에서 식물의 광합성, 기공조절 및 탄수화물 합성)

  • Yun, Hyejin;Sung, Jwakyung;Lee, Suyeon;Lee, Yejin;Ha, Sangkeun;Sonn, Yeonkyu
    • Korean Journal of Agricultural Science
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    • v.41 no.4
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    • pp.275-281
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    • 2014
  • The ozone depletion has caused plants to be exposed to an increased penetration of solar ultraviolet-B (UV-B) radiation. Enhanced UV-B radiation may have influence on biological functions of plant in many aspects including inhibition of photosynthesis. It is evident that UV-B can potentially impair the performance of all three main component processes of photosynthesis, the photophosphorylation reactions of the thylakoid membrane, the $CO_2$-fixation reactions of the Calvin cycle and stomatal control of $CO_2$ supply. Owing to these depressed reactions, the production and allocation of carbohydrates might be markedly affected, and therefore, the growth and development of plant are distinctly reduced. In this review paper, we provide basic theory and further researches in terms of photosynthesis and carbohydrate synthesis in response to elevated UV-B radiation.