Background: As the third generation of platinum-based antineoplastic agent aginst gastrointestinal cancer, oxaliplatin is considered to be associated with severe sensory neurotoxicity. Acorrding to previous studies, vitaminE, intravenous Ca/Mg and glutamine may partly reduce the incidence and severity of oxaliplatin-induced neurotoxicity. The aim of this study was to investigate the safety and efficacy of analgecine for preventing oxaliplatin-induced neurotoxicity in the patients with gastrointestinal tumors. Method: In this study, patients undergoing oxaliplatin-based chemotherapy were assigned to analgecine (experimental) group or control group. Analgecine 6ml was administered once a day for seven days from the day of oxaliplatin treatment. The National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE; version 3) was used to evaluate oxaliplatin-induced neurotoxicity. The incidence rates and grade of neurotoxicity of patients were assessed before and during (after four and eight cycles) treatment. Results: Totally, 82 patients were enrolled in this study, 42 in experimental group and 40 in control group. The occurrence of each grade neurotoxicity in the experimental group was significantly lower than that in control group. The overall occurrence rate was 31% vs 55% (P=0.043) after 4 cycles and 52% vs 75% (P=0.050) after 8 cycles. Conclusion: Analgecine appears could be effective in reducing oxaliplatin-induced neurotoxicity and be applicated for patients with gastrointestinal tumors who would be treated with oxaliplatin-based chemotherapy.
Kim, Yongseok;Shim, Kyo-Moon;Jung, Myung-Pyo;Choi, In-tae
Korean Journal of Agricultural and Forest Meteorology
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v.19
no.3
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pp.86-92
/
2017
In this study, a model to classify frost occurrence and frost free day was developed using the digital weather forecast data provided by Korea Meteorological Administration (KMA). The minimum temperature, average wind speed, relative humidity, and dew point temperature were identified as the meteorological variables useful for classification frost occurrence and frost-free days. It was found that frost-occurrence date tended to have relatively low values of the minimum temperature, dew point temperature, and average wind speed. On the other hand, relatively humidity on frost-free days was higher than on frost-occurrence dates. Models based on machine learning methods including Artificial Neural Network (ANN), Random Forest(RF), Support Vector Machine(SVM) with those meteorological factors had >70% of accuracy. This results suggested that these models would be useful to predict the occurrence of frost using a digital weather forecast data.
Proceedings of the Korean Institute of Building Construction Conference
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2006.11a
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pp.123-126
/
2006
Existing Deck Plate for a one of system forms, there is various advantage and application actual results increasing rapidly. But design of deck is depending on engineering data collections or design data on deck manufacture ordinarily. When construct, is responsible for deflection occurrence, And Because confirmation of crack occurrence region is impossible, there is difficulty of repair, reinforcement about crack and water leakage. According to got following conclusion as result that economic performance, preservation administration and repair reinforcement develops easy using steel truss snap tie by wedge pin on coating plywood that is slab Panel Wood System Form method of construction there is Deck Plate's advantage. (1) In stab lower part is exposed disjointing in which a criminal is fastened to be interrogated after construction acceptance and repair, reinforcement of crack is possible (2) Construction cost curtailment effect of about 29.2% than conventional type and about 10% than deck plate (3) Construction period reduction of about 3 day than conventional type and about 0.3 day than deck plate (4) Labor curtailment effect more than about $29{\sim}50%$ from conventional type
This study was conducted to investigate the changes in moth occurrence of striped rice barer, Chilo suppressalis (Walker), in relation to climatic factors, rice varieties, and cultural practices. The light trap data from 41 forecasting stations for 14 years from 1966 to 1979 were analyzed by means of the changes in the time and amount of borer occurrence in connection with the introduction of new rice varieties, the accumulated effective day-degree and its variation for completing one generation, and the climatic factors affecting the moth occurrence. The total number of moths caught by light traps in both spring and summer generations were considerably decreased with the wide cultivation of new rice varieties. In fact, the spring moths were remarkably decreased since the new varieties were introduced in 1972. The occurrence ratio of summer moths against the preceeding spring moths was higher in the middle region and middle southern mountainous area than the other regions. Its high ratio of regions was annually expanded from the middle region to the southern region. The $50\%$ emergence dates of both generations were later in the southeastern region than in the middle region. The ecological characteristics were clearly shown between the northern and southern region of Chupungryeong in terms of the occurrence of summer moths, the ratio of occurrence of summer moths to the preceeding spring moths, and $50\%$ emergence dates of the summer moths during the years of $1977\~1979$. The ratio of the summer moth occurrence to the preceeding generation was negatively correlated with the average temperature in lune and July, respectively, and the average precipitation in late June. The ratio of spring moth occurrence over the preceeding generation was positively correlated with the average temperature in September, October, November, and March, respectively, whereas it was negatively correlated with the average precipitation in early September and March, and the average humidity in early May. The effective day-degree for one generation was in the range from 600 to 900 DD at upper threshold $30^{\circ}C$ and lower threshold $10^{\circ}C$.
Journal of the Korean Society of Fisheries and Ocean Technology
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v.12
no.2
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pp.37-42
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1976
Each term of heat badget equation in the eastern Yellow Sea was calculated and the variation in relation to meteorological condition was shown for the period from September 1973 to February 1974, At Mal-do near Gunsan the maximum heat exchange occurred at the last ten days of December (--522 1y/day), while at Sunmi-do near Incheon it occurred at the middle ten days of November (--665 1y /day), The contribution of the sensible heat to total heat exchange increased rapidly, while the effect of cloudiness decreased to be negligible in winter. The values of the heat exchange fluctuated considerably with the periodic occurrence of the cold Siberiaa air mass. The mean evaporation heat estimated indirectly from the aerological data was 32 ly/day at the northern part and 269 ly/dlY at the southern part of the Yellow Sea in December 1973.
Background: Spontaneous pneumothorax is a common respiratory condition and has been postulated that it develops because of rupture of subpleural blebs. Although the morphology and ultrastructure of causative lesions are well known, the reason for rupture of sbupleural blebs is not absolutely clear. Broad consensus concerning the role of meteorological factors in spontaneous pneumothorax dose not exist. The aim of the study was to examine the influence of change of atmospheric pressure and temperature on the occurrence of spontaneous pneumothorax. Material and Method: One hundred twenty eight consecutive spontaneous pnemothorax events that occurred between January 2003 and December 2004 were selected. Changes of meteorological factors of particular days from the day before for 5 consecutive days were calculated and compared between the days with pneumothorax occurrence (SP days) and the days without pneumothorax occurrence (Non SP days). The correation between change of pressure and temperature and the occurrence of SP was evaluated. Result: SP occurred on 117 days (16.0%) in the 2-year period. Although there was no significant differences in change of pressure factors prior 4 days of SP occurrence compare to the 4 days prior Non SP day, change of mean pressure was higher (+0.934 vs. -0.191hPa, RR 1.042, Cl $1.003{\sim}1.082$, p=0.033), and change of maximum pressure fall was lower (3.280 vs. 4.791 hPa, RR 1.051, Cl $1.013{\sim}l.090$, p=0.009) on the 4 days prior SP day. There were significant differences in change of temperature factors prior 2 days and the day of SP, Changes of mean temperature (-0.576 vs.+$0.099^{\circ}C$, RR 0.886, 95% Cl $0.817{\sim}0.962$, p=0.004) and maximum temperature rise (7.231 vs. $8.079^{\circ}C$, RR 0.943 Cl $0.896{\sim}0.993$, p=0.027) were lower on the 2 days prior SP. But changes of mean temperature (0.533 vs. $-0.103^{\circ}C$, RR 1.141, Cl $1.038{\sim}l.255$, p=0.006) and maximum temperature rise (9.209 vs. $7.754^{\circ}C$, RR 1.123, Cl $1.061{\sim}1.190$, p=0.006) and maximum temperature rise (9.209 vs. $7.754^{\circ}C$ RR 1.123, Cl $1.061{\sim}l.190$, p=0.000) were higher on the SP days. Conclusion: Charge of atmospheric pressure and temperature seems to influence the chance of occurrence of SP. Meteorological phenomena that pressure rise 4 day prior to SP and following temperature fall and rise might explain the occurrence of SP. Further studies should be continued in the future.
Journal of Korean Society of Coastal and Ocean Engineers
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v.34
no.3
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pp.47-57
/
2022
We carried out studies on prediction in concentration of dissolved oxygen (DO) with LSTM model and prediction in occurrence of hypoxia water mass (HWM) with decision tree. As results of study on prediction in DO concentration, a large number of Hidden node caused high complexity of model and required enough Epoch. And it was high accuracy in long Sequence length as prediction time step increased. The results of prediction in occurrence of HWM showed that the accuracy of nonHWM case was 66.1% in 30 day prediction, it was higher than 37.5% of HWM case. The reason is that the decision tree might overestimate DO concentration.
Eum, Sun Jung;Byun, Mi Soon;Goo, Dae Hoe;Kim, Kiu Weon
FLOWER RESEARCH JOURNAL
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v.16
no.3
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pp.161-167
/
2008
Eight species of Korean native lilies were used as plant materials and investigated for the effect of temperature, day length, and sucrose on enlargement of bulblet in vitro. enlargement of bulblet was enhanced at $25^{\circ}C$ in most of Korean native lilies tested, meanwhile it was promoted at $20^{\circ}C$ in L. davuricum and L. hansonii. Moreover, enlargement of bublet was promoted under dark in L. concolor var. parthneion, L. distichum, L. amabile, and L. davuricum, to the contrary fresh weight was increased under longer day length in L. hansonii and L. maximowitzii. That of L. concolor var. parthneion and L. cernuum was not affected by light or dark condition. Fresh weight of the bulblets produced in vitro of most Korean native lilies tested was increased with increasing sucrose concentration and best at $120g{\cdot}L^{-1}$ sucrose in medium. However, enlargement of bublet was promoted by $60g{\cdot}L^{-1}$ sucrose in L. tsingtauense and L. cernuum and by $90g{\cdot}L^{-1}$ in L. davuricum. Bulblet enlargement tended to promote by lower rate of scaly leaf occurrence or separating bulblet and it was affected by occurrence of scaly leaf rather than separation of bulblet. However, occurrence of scaly leaf, separation of bulblet, and enlargement of bulblet were more significantly affected by genetic factors, species rather than culture conditions.
When the negative event is published, the company tends to go through the negative impact on the firm performance. Especially, with the SNS, the negative event is instantly spread on indefinite region so the impact seems bigger than the period before the SNS media appearance. It seems that everyone considers the SNS media impact on the firm performance quite big. However, there has been no empirical study on the impact comparison on the firm performance between pre and post SNS media occurrence periods. This study tries to empirically compare the impact of the negative event on the firm performance between pre and post SNS media appearance. Our study starts fromthe basic but not verified question; Does really the negative event have more negative impact in the post-SNS-occurrence period than in the pre-SNS-occurrence period? In order to examine the impact of the negative publicity on firm performance in two eras, pre and post SNS media appearance, we used CAR (Cumulative Abnormal Resturns) model. By using this model, we could verify the statistical significance of cumulative abnormal returns in market between before and after the events. For event samples, we focused on food manufacturers and collected the negative events from 1991 to 2003 for pre-SNS occurrence period, and from 2010 to 2013 for post-SNS occurrence period. Based on the listed food companies at KOSPI, we researched Naver News Library (newslibrary.naver.com) and Naver News (news.naver.com) for all the individual negative events published for both periods. Firm returns data were collected from TS 2000 (KOCO Info) and market portfolio data were collected from KRX Exchange. Through our empirical analysis, our finding is interesting to note that the type of events differently influences on the firm performance. With the SNS, the health-related events have influence on the firm performance 'after the event day' whereas the company behavior trust events have influence 'before the event day'. Our findings have implications for management. When a negative event directly related to or threatening customers or their life such as health, it is crucial to fix up the situation right after the event occurs. On the other hand, when a negative event is not publicly available information such as company behavior trust, it is important for marketers to strengthen the firms' trust reputation and control the bad WOM before the event.
There is a large difference between purchasing patterns in an online shopping mall and in an offline market. This difference may be caused mainly by the difference in accessibility of online and offline markets. It means that an interval between the initial purchasing decision and its realization appears to be relatively short in an online shopping mall, because a customer can make an order immediately. Because of the short interval between a purchasing decision and its realization, an online shopping mall transaction usually contains fewer items than that of an offline market. In an offline market, customers usually keep some items in mind and buy them all at once a few days after deciding to buy them, instead of buying each item individually and immediately. On the contrary, more than 70% of online shopping mall transactions contain only one item. This statistic implies that traditional data mining techniques cannot be directly applied to online market analysis, because hardly any association rules can survive with an acceptable level of Support because of too many Null Transactions. Most market basket analyses on online shopping mall transactions, therefore, have been performed by expanding the co-occurrence criteria of traditional association rule mining. While the traditional co-occurrence criteria defines items purchased in one transaction as concurrently purchased items, the expanded co-occurrence criteria regards items purchased by a customer during some predefined period (e.g., a day) as concurrently purchased items. In studies using expanded co-occurrence criteria, however, the criteria has been defined arbitrarily by researchers without any theoretical grounds or agreement. The lack of clear grounds of adopting a certain co-occurrence criteria degrades the reliability of the analytical results. Moreover, it is hard to derive new meaningful findings by combining the outcomes of previous individual studies. In this paper, we attempt to compare expanded co-occurrence criteria and propose a guideline for selecting an appropriate one. First of all, we compare the accuracy of association rules discovered according to various co-occurrence criteria. By doing this experiment we expect that we can provide a guideline for selecting appropriate co-occurrence criteria that corresponds to the purpose of the analysis. Additionally, we will perform similar experiments with several groups of customers that are segmented by each customer's average duration between orders. By this experiment, we attempt to discover the relationship between the optimal co-occurrence criteria and the customer's average duration between orders. Finally, by a series of experiments, we expect that we can provide basic guidelines for developing customized recommendation systems.
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