• 한국실내디자인학회논문집
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• 제25권6호
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• pp.52-60
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• 2016

Observation about space is looked steady in an instant, but in continuous movement, one's observation unconsciously stays at different points. In department store, customer actually observes around the store for buying, not focusing on certain point. By studying customer's movement and observation feature, buying desire and interest can be found. For analysis of the different searching-features according to the continuous-observation depending on sex, the study is set up to record movements of customers at women in Department store. The following are the findings. First, Men observed 0.2-0.4 units more in I-II section which are assumed as predominant. The result shows that men can focus on more section (around +0.4%) and longer (around +5.7%) than women do. Second, the same feature of observation depending on sex is that both men and women observe left and right section while keep focusing on middle section. Third, according to the fact that right-focused observation magnificently occurred in the image curved to right, the Space-composition has influenced on the observation of both men and women on the space. Forth, excessive number of display can cause avoidance of observation. Moreover, observation does not stay on the coverage due to wall or post, but is attracted to the brand name. As brand name causes right-focused observation in the image [(8)], brand name can be one of the reasons to attract observation in women apparel store. To sum up, this study is noticeable as it researches about continuous-observation. Furthermore, verifying the result that the composition of space and the placement of products can cause big differences in the observation feature is meaningful outcome.

• 대한약침학회지
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• 제25권3호
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• pp.209-215
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• 2022

Objectives: Aqueous leaf extract of Tridax procumbens (ALETP) has potent relaxant activity. However, this relaxant activity in respiratory smooth muscle remains uninvestigated. This study investigates the effect of ALETP on the contractile activity of tracheal smooth muscle (TSM) in adult male Wistar rats. Methods: Twelve male Wistar rats divided into 2 groups and were treated with either 100 mg/kg of ALETP (ALETP treatment group) or vehicle (distilled water; control group) through oral gavage for 4 weeks. Dose responses of TSM from the 2 groups to acetylcholine (10^-9 to 10^-5 M), phenylephrine (10^-9 to 10^-5 M), and potassium chloride (KCl; 10^-9 to 10^-4 M) were determined cumulatively. Furthermore, cumulative dose responses to acetylcholine (10^-9 to 10^-5 M) after pre-incubation of TSM with atropine (10^-5 M), L-NAME (10^-4 M), indomethacin (10^-4 M), and nifedipine (10^-4 M), were determined. Results: Treatment with ALETP substantially inhibited TSM contraction stimulated by cumulative doses of acetylcholine, phenylephrine, and KCl. Furthermore, preincubation of TSM from the 2 groups in atropine significantly inhibited contractility in TSM. Incubation in L-NAME and indomethacin also significantly inhibited contractility in TSM of ALETP-treated rats compared to that of controls. Contractile activity of the TSM was also inhibited significantly with incubation in nifedipine in ALETP-treated rats. Conclusion: ALETP enhanced relaxant activity in rat TSM primarily by blocking the L-type calcium channel and promoting endothelial nitric oxide release. ALETP contains agents that may be useful in disorders of the respiratory tract.

• Korean Circulation Journal
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• 제52권8호
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• pp.640-640
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• 2022

• 동의생리병리학회지
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• 제18권3호
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• pp.627-645
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• 2004

The purpose of this studies was to examine the difference of the original text in Dongeuibogam and the text of reference books in Dongeuibogam. So, we selected the part of the Ong-Juh(carbuncle) Gathering of Dongeuibogam, made a comparative study of the original text and the text af reference books cited in Dongeuibogam. The results are as follows; The Chapters Name cited from Somun(素問) were 'Somun-sengitongchungron'(素問·生氣通天論), 'Somun-Kiguelron'(素問·氣厥論), 'Somun-kihulron'(素問·氣穴論) 'Somun-megyojungmiron'(素問·脈要精微論), 'Somun-yungyangbulron(素問·陰陽別論), 'Somun-yungyangung sangderon'(素問·陰陽應象大論), etc. The Chapters Name cited Youngchu(靈樞) were 'Youngchu-ong-juh(靈樞·癰疽),' Youngchu-okphan'(靈樞·玉版), 'Youngchu-mekdo'(靈樞·脈度), etc. There were seven errors in the name of reference books. The original text of reference books was not cited as it were and some paragraph and characters were omitted as far as the meaning was not changed or added to make the meaning clearer We though it was supposed that 'yorjatu(女子妬)' was changed to 'yorjagu' in 'Jungongjuhsajibubun(定癰疽死之部分) , 'megraechaesab'(脈來滯澁) was changed to 'megraedaesab' in 'ongjuhmeg'(癰疽脈). The drugstuffs consisted of the prescription were mainly arranged in quantity order.

• 동의생리병리학회지
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• 제16권1호
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• pp.62-66
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• 2002

Hypertension is not only a well-established cardiovascular risk factor but also increase the risk of atherosclerosis. Most studies conducted to investigate the effectiveness of treatment for cardiovascular disease such as hypertension have focused primarily on conventional drug and physiotherapeutic treatments. BanhabackchulChunma-tang(半夏白朮天麻湯:BCT) is popular herbal medicine used in clinic for the treatment of various symptoms of drulatory disorders and weakness of digestive system, including anorexa and nausea with vertigo, severe headache, vomiting and so on. However, the mechanisms underlying its efficacy are unknown. This study investigated the effects of BCT as an alternative medication on the contraction induced by phenylephrine and KCI in rat thoratic aorta. BCT revealed siginificant relaxation on phenylephrine-induced arterial contraction, but revealed noncompetitive effect on concentration responses of phenylephrine-induced contraction. Treatment of N-L/sup ω/ -argine methyl ester(L-NAME) and methylene blue(MB)(10/sup -5/M) reduced the relaxation of BCT. BCT also increased in vitro NO production. It suggest that the relaxation effect of BBT is related with NO pathway, becausse the effect of L-NAME and MB are due to inhibition of NO synthesis from endothelial cells. These results indicate that BCT would be effective in hypertension treatment and its mechanism of relaxtion on arterial contraction is likely to be related with NO production, blocking of α-receptor and signal transduction after receptor activation.

• Ocean and Polar Research
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• 제29권3호
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• pp.273-282
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• 2007

For an efficient management and utilization of marine biodiversity information, we made an attempt to develop the Korea Marine Biodiversity Information System (KoMBIS), building a species name inventory of Korea marine organisms. The inventory includes 17 organism groups: phytoplankton, zooplankton, algae and halophyte, sponges, cnidarians, rotifers, nematodes, bryozoans, brachiopods, molluscs, echiurans, annelids, arthropods, echinoderms, urochordates and fish. The species names were collected from 37 different references and reviewed for validity by taxonomists, which resulted in 9,798 valid names in addition to 1,845 synonyms. The Korea marine species inventory is the first one of this kind, for previous Korean species name inventories were mostly composed of terrestrial and freshwater organisms. KoMBIS, the information system developed, contains not only the species name but also information on morphological and ecological characteristics such as distribution, DNA barcode, and references. This system is convenient for the inputting of new data and servicing users through the internet, so that management and utilization of the biodiversity information is more efficient. Linking the DNA barcode data with species information provides an objective measure for identification of a species, which accommodates the recommendation of Consortium for the Barcode of Life, and makes the Korea marine biodiversity information compatible with international databases. Considering the frequent exchange of marine organisms internationally via ballast water and such issues as climate change, this information system will be useful in many areas of marine biodiversity.

• 대한한방내과학회지
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• 제27권2호
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• pp.471-479
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• 2006

Backgrounds & Objectives: Banhasasimtang granule(BHSST) has been used for the treatment of functional dyspepsia regarded as one of the gastric dysmotility disease. but its mechanisms of action are not well known yet: So we investigated the effects of BHSST on gastric emptying and its mechanisms of action in rats. Methods: Gastric emptying was measured by glass beads(1mm in diameter) expelled from the stomach for 60 min after administration of normal saline(NS) or BHSST 31mg/kg or 93mg/kg in rats. And by the same method gastric emptying was measured after administration of NS or BHSST 93mg/kg in rats treated with atropine sulfate(1mg/kg, s.c.), quinpirol HCI(0.3mg/kg, i.p.), NAME(NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin(10mg/kg, i.p.) to make delayed gastric emptying. Results: BHSST 93mg/kg improved gastric emptying more than NS or BHSST 31mg/kg(p=0.016). Under the delayed gastric emptying, BHSST 93mg/kg improved gastric emptying in the group treated with NAME$(5.00{\pm}3.101\;vs\;9.00{\pm}3.51,\;p\;=0.046)$, but aggravated it With atropine sulfate$(5.71{\pm}3.45\;vs\;2.57{\pm}1.62,\;p\;=0.050)$ and cisplatin$(12.7{\pm}2.29\;vs\;8.57{\pm}5.06,\;p\;=0.072)$. Conclusions: BHSST improves the gastric emptying through cholinergic and 5-hydroxytryptamine 3 receptors. Especially it is effective to improve gastric emptying delayed by NAME. So we expect that it would be effective in functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation.

• The Korean Journal of Physiology and Pharmacology
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• 제22권4호
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• pp.409-417
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• 2018

Pre-eclampsia (PE) is a pregnancy disorder that is characterised by severe hypertension and increased risks of foetal and maternal mortality. The aetiology of PE not completely understood; however, maternal nutrition and oxidative stress play important roles in the development of hypertension. The treatment options for PE are currently limited to anti-hypertensive drugs. Punicalagin, a polyphenol present in pomegranate juice, has a range of bioactive properties. The effects of supplementation with punicalagin on angiogenesis and oxidative stress in pregnant rats with induced hypertension were investigated. The pregnant rats were randomly divided into five experimental groups (n=12 per group). Hypertension was induced using an oral dose of NG-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg/day) on days 14-19 of pregnancy. Punicalagin (25, 50 or 100 mg/kg) was given orally on days 14-21 of pregnancy. Punicalagin treatment at the tested doses significantly reduced diastolic, systolic, and mean arterial blood pressure in L-NAME treated rats from day 14. Punicalagin also restored angiogenic balance by increasing the expression of vascular endothelial growth factor and downregulating vascular endothelial growth factor receptor-1/fms-like tyrosine kinase-1. Punicalagin, significantly increased the placental nitric oxide levels as compared to PE group. The increased levels of oxidative stress in rats with PE were markedly decreased by treatment with punicalagin. Punicalagin at the tested doses markedly (p<0.05) enhanced the placental antioxidant capacity in L-NAME-treated rats. The raised catalase activity observed following L-NAME induction was significantly (p<0.05) and restored to normal activity levels in punicalagin treatment. Further, 100 mg dose of punicalagin exhibited higher protective effects as compared to lower doses of 25 and 50 mg. This study shows that supplementation with punicalagin decreased blood pressure and oxidative stress and restored angiogenic balance in pregnant rats with induced PE.

• 한국자원식물학회지
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• 제25권1호
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• pp.48-62
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• 2012

강원도 내륙 북부지역에 대한 민속식물을 파악하기 위하여 2010년 4월부터 10월까지 수행되었다. 9개 시 군지역의 35개소에서 조사한 자료를 분석한 결과 강원도 내륙북부지역에서 파악되고 수집된 민속식물은 73과 185속 225종 2아종 30변종 4품종으로 총 261분류군으로 정리되었다. 조사된 261분류군 중에는 한국특산식물 3분류군, 희귀식물 11분류군, 그리고 귀화식물 9분류군이 포함되어 있었다. 용도별 이용 현황은 식용 378건, 약용 53건, 염료용 8건, 관상용 7건, 연료용 6건, 향신료용 5건, 향료용 3건, 밀원용 2건, 그리고 기타 41건으로, 식용으로의 이용 빈도가 가장 높았다. 이용 부위로는 잎, 식물체 전체, 뿌리의 순으로 나타났다. 연령별 표준식물명과 지방명의 일치도는 20대가 가장 높았으며, 80대가 가장 낮았다.

• 대한한의학회지
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• 제39권1호
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• pp.55-62
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• 2018

Objectives: This study aims to investigate on the nomenclature of acupoints for the Healthcare Terminology Standard. Methods: We investigated the name of acupoints in "Standard Acupuncture Nomenclature (Second Edition)" of WHO, "WHO Standard Acupuncture Point Locations in The Western Pacific Region", "Principles of Meridians & Acupoints", "Details of Meridians & Acupoints" and "Acupuncture Medicine". Results: In books, we found that the name of acupoints was used differently in LI19, TE22, HT3, SI8, ST16, SI16, GB16 and BL8 acupoints. Conclusions: 口禾髎(LI19), 耳和髎(TE22), 少海(HT3), 小海(SI8), 膺窗(ST16), 天窗(SI16), 目窗(GB16), 絡卻(BL8) and 淵腋(GB22) in confused acupoints have been established as the terms of acupoints for the Healthcare Terminology Standard.