• The Korea Journal of Herbology
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• v.35 no.4
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• pp.45-50
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• 2020

Objective : This study was performed to evaluate the toxicity after a single oral administration of black raspberry extract to male and female Sprague-Dawley (SD) rats and to determine the approximate lethal dose (ALD). Methods : We previously showed that the black raspberry extract repressed the simvastatin-mediated expression of Proprotein convertase subtilisin/kexin type 9 (PCSK9) and improved Low-Density Lipoprotein cholesterol (LDL-C) uptake by hepatocytes through the induction of the Low-Density Lipoprotein Receptor expression in hepatocytes. The groups consisted of black raspberry extract groups, as an oral dose of 2,000 mg/kg and a control group. 5 weeks SD rats were randomly assigned to 4 groups of 5 rats. Each male and female SD rats were administered orally once. For 14 days after the administration, mortality, clinical signs, changes in body weight, and necropsy findings were observed according to the "Standard for Toxicity Study of Pharmaceuticals" of Korea Food and Drug Administration (KFDA) guideline and "Acute Oral Toxicity- Fixed Dose Procedure" of OECD Test Guideline. Results : There were no cases of mortality in the group administered with 2,000 mg/kg of male and female, and no abnormalities in body weight change and clinical signs. Also, no gross abnormalities were observed at the autopsy. Conclusions : As a result of a single oral administration of the black raspberry extract to SD rats, the ALD was determined to exceed 2,000 mg/kg for both male and female SD rats.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6225-6229
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• 2015

Faecal pH and cholate are two important factors that can affect colon tumorigenesis, and can be modified by diet. In this study, the effects of two Chinese traditional cooking oils (pork oil and canola/rapeseed oil) on the pH and the cholic acid content in feces, in addition to colon tumorigenesis, were studied in mice. Kunming mice were randomized into various groups; negative control group (NCG), azoxymethane control group (ACG), pork oil group (POG), and canola oil Ggroup (COG). Mice in the ACG were fed a basic rodent chow; mice in POG and COG were given 10% cooking oil rodent chow with the respective oil type. All mice were given four weekly AOM (azoxymethane) i.p. injections (10mg/kg). The pH and cholic acid of the feces were examined every two weeks. Colon tumors, aberrant crypt foci and organ weights were examined 32 weeks following the final AOM injection. The results showed that canola oil significantly decreased faecal pH in female mice (P<0.05), but had no influence on feces pH in male mice (P>0.05). Pork oil significantly increased the feces pH in both male and female mice (P<0.05). No significant change was found in feces cholic acid content when mice were fed 10% pork oil or canola oil compared with the ACG. Although Kunming mice were not susceptible to AOM-induced tumorigenesis in terms of colon tumor incidence, pork oil significantly increased the ACF number in male mice. Canola oil showed no influence on ACF in either male or female mice. Our results indicate that cooking oil effects faecal pH, but does not affect the faecal cholic acid content and thus AOM-induced colon neoplastic ACF is modified by dietary fat.

• Journal of Acupuncture Research
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• v.26 no.3
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• pp.93-101
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• 2009

Objectives : This study was conducted to know how different Body mass index(BMI) were, according to age group, drinking, amount of smoking, fast blood sugar. Methods: We measured the Body mass index(BMI) in 5573 male, using Inbody 2.0(Biospace Co. Ltd, Korea), and then we analysed the 4 factors - age group, amount of drinking, smoking, fast blood sugar - which are related to BMI of male. Results: 1. BMI according to age group increased from -30 years group at the lowest to 41-50 years group at the highest and decreased after 51-60 years. 2. BMI according to amount of drinking increased from Nondrinker group(men who don't drink) years at the lowest to Drinker IT group(men who drink more than 4 bottles of Soju(360ml, 21%, distilled liquor) for a week) at the highest. 3. BMI according to amount of smoking increased from Smoker I group(men who smoke 1-10 pieces for a day) at the lowest to Smoker N group(men who smoke more than 31 pieces for a day) at the highest except Nonsmoker group(men who don't smoke). 4. BMI of group that not exceed 110mg/d${\ell}$ in fast blood sugar was lower in the group that exceed 110 mg/d${\ell}$ in fast blood sugar. Conclusions: We analysed the 4 factors - age group, amount of drinking, smoking, fast blood sugar - which are related to BMI of male.

• Korean Journal of Veterinary Research
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• v.49 no.4
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• pp.355-359
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• 2009

A miniature schnauzer (8 years old, male castrated), diagnosed as diabetes mellitus 6 months ahead, were referred to the Veterinary Medical Teaching Hospital of our University with hindlimb stiffness, facial rubbing and tetany. Serum chemistry showed severe hypocalcemia, hypomagnesemia, and measured iPTH (intact pharathyroid hormone) concentration was low (< 3.0 pmol/L). Consistent rate injection of calcium gluconate (282 mg/kg over 30 min) resulted in prompt relief of the tetany. Then typical treatment for hypoparathyroidism (calcium gluconate and dihydrotachysterol per os) with magnesium administration could control the neuromuscular signs. Diabetes mellitus is being controlled by insulin therapy and prescription diet. Hypomagnesemia in diabetic dog may be induced hypoparathyrodism.

• The Korean Journal of Zoology
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• v.12 no.1
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• pp.13-21
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• 1969

韓國産 陸棲貧毛類의 分類學的 硏究의 일련으로서 1965年 $\\sim$ 1966年 및 1968年에 採集된 울릉도 産을 調査한 結果 3科 5屬 10種(Allolobophora caliginosa trapezoides, Eisenia foetida, Pheretima agrestis, Ph. heteropoda, Ph. hilgendorfi, Ph. hupeiensis, Ph. phaselus, Ph. serrata, Ph. sp. 1 Ph. sp. 2)을 報告하였다. 울릉도의 陸棲貧毛類에 관해서는 지금까지 報告된 바 없으므로 이들은 全部 울릉도 未記錄이 되고 이중 Pheretima heteropoda Goto et Hatai 는 韓國 未記錄種이고 Phertima hilgendorfi 는 male pore를 가진 點이 本土産과 比較해서 若干 特異하였다.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2006.06a
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• pp.15.2-16
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• 2006

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2002.10a
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• pp.172-172
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• 2002

Previously, we reported a novel polymeric micellar solubilizer, Aceporol 330, that showed relatively low toxic effects when it was compared with that of Cremophor EL which is currently being used for paclitaxel. In this study, we have developed a new micellar solubilizer, Aceporol 460, that has 3-4 times higher loding capacity for paclitaxel than Aceporol 330. The single-dose and the repeated-dose toxicity of Aceporol 460 were evaluated in ICR mice. For single dose toxicity test, male and female mice were randomly assigned to one of five study groups to receive, and injected intravenously with dosages of 0, 3, 4mL Cremophor EL/kgbody weight, and 3, 4mL Aceporol 460/kg body weight, respectively. In both male and female mice, LD50 for Aceporol 460 can not he determined even at the maximal administrable dosage, 4mL/kg due to the high viscosity of chemical and there was no significant change in body weight, hematological and serum biochemical analysis, organ weight, and histopathological examination compared with that of Cremophor EL. For the repeated dose toxicity test, male and female mice were given the dosage of 0, 1.6mL Cremophor EL/kgbody weight/day, and 1.6mL Aceporol 460/kg body weight/day for 2 weeks. Results of repeated dose toxicity tests for 2 weeks suggested that Aceporol 460 treated group show no significant toxicological findings with body weight, hematological and serum biochemical analysis, organ weight, urinalysis, and ophthalmoscopic and histopathological examination compared with that of Cremophor EL. These results indicate that Aceporol 460 have higher paclitaxeL-loading capacity than Aceporol 330 and less toxic effects than Cremophor EL in male and female mice.

• Animal Bioscience
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• v.35 no.8
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• pp.1129-1140
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• 2022

Objective: With improvements in living standards and increase in global population, the demand for meat products has been increasing; improved meat production from livestock could effectively meet this demand. In this study, we examined the differences in the muscle traits of different male crossbred sheep and attempted to identify key genes that regulate these traits. Methods: Dubo sheep×small-tailed Han sheep (DP×STH) and Suffolk×small-tailed Han sheep (SFK×STH) were selected to determine meat quality and production performance by Masson staining. Transcriptome sequencing and bioinformatic analysis were performed to identify differentially expressed genes (DEGs) related to meat quality. The presence of DEGs was confirmed by real-time polymerase chain reaction. Results: The production performance of SFK×STH sheep was better than that of DP×STH sheep, but the meat quality of DP×STH sheep was better than that of SFK×STH sheep. The muscle fiber diameter of DP×STH sheep was smaller than that of SFK×STH sheep. Twenty-two DEGs were identified. Among them, four gene ontology terms were related to muscle traits, and three DEGs were related to muscle or muscle fibers. There were no significant differences in the number of single nucleotide mutations and mutation sites in the different male parent cross combinations. Conclusion: This study provides genetic resources for future sheep muscle development and cross-breeding research.

• Korean Journal of Community Nutrition
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• v.14 no.1
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• pp.12-21
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• 2009

The study was performed to investigate the relationship of regular exercise to body composition and nutrient intakes of male college students by comparing anthropometric measurements and one-day dietary intakes by 24-hour recall of physical education (PE) majors and non-major male college students. The subjects were 253 students residing in the Gyeonggi area. Only 64.1% and 32.1% of PE majors and non-major students exercised over 4 times a week and PE major students did stronger exercise than the non-major students did. Mean BMI and WHR (Waist Hip Ratio) of the two groups were not different. But percentages of body fat and lean body mass in PE major students were lower and higher, respectively, than those of non-major students. PE major students consumed significantly more energy and other nutrients except iron, niacin, vitamin C, and vitamin E than non-major students. Nutrients consumed less than KRDA was calcium in PE major students and energy, calcium, zinc, vitamin $B_{12}$, folate, and vitamin C in non-major students. Mean adequacy ratio (MAR) of PE major students (1.00) was significantly higher than that of non-major students (0.94). Index of Nutritional Quality (INQ) of all nutrients except vitamin A of PE major students was also significantly higher than that of non-major students. Nutrients below 1.00 in INQ of both groups were calcium, zinc, vitamin B2, and folate. Our data supports that regular exercise may positively influence on body composition and increase diet quality in male college students. Therefore, an educational program focused on regular exercise along with proper dietary behavior would be needed.

• Journal of Korean Public Health Nursing
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• v.34 no.3
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• pp.368-379
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• 2020

Purpose: This study aimed to identify factors influencing nicotine dependence among male college students intending to quit smoking on the basis of the PRECEDE model. Methods: A cross-sectional survey of smokers, enrolled at the Smoking Cessation Support Center in W city in Korea was conducted between September 2015 and December 2016. Data was analyzed using the SPSS program for descriptive statistics, bivariate analyses, and hierarchical multiple regression. Results: The mean score of nicotine dependence was determined to be 2.9. Tobacco craving (β =.34, p<.001), social smoking (β =-.23, p=.004), allowance (β =.22, p=.010) and age of smoking initiation (β =-.20, p=.022) were factors that predicted nicotine dependence of male college students. The final model explained 28.3% of the variation in nicotine dependence (adjusted R2=.28), and was significant (F=7.22, p<.001). Conclusions: We determined that to support smoking cessation, it is necessary to develop anti-smoking programs that consider the social and cultural factors of male college students as well as their personal psychological characteristics.