• Asian Pacific Journal of Cancer Prevention
• /
• 제15권4호
• /
• pp.1817-1822
• /
• 2014

Objective: The aim of this study was to screen for possible biomarkers of metastatic osteosarcoma (OS) using a DNA microarray. Methods: We downloaded the gene expression profile GSE49003 from Gene Expression Omnibus database, which included 6 gene chips from metastatic and 6 from non-metastatic OS patients. The R package was used to screen and identify differentially expressed genes (DEGs) between metastatic and non-metastatic OS patients. Then we compared the expression of DEGs in the two groups and sub-grouped into up-regulated and down-regulated, followed by functional enrichment analysis using the DAVID system. Subsequently, we constructed an miRNA-DEG regulatory network with the help of WebGestalt software. Results: A total of 323 DEGs, including 134 up-regulated and 189 down-regulated, were screened out. The up-regulated DEGs were enriched in 14 subcategories and most significantly in cytoskeleton organization, while the down-regulated DEGs were prevalent in 13 subcategories, especially wound healing. In addition, we identified two important miRNAs (miR-202 and miR-9) pivotal for OS metastasis, and their relevant genes, CALD1 and STX1A. Conclusions: MiR-202 and miR-9 are potential key factors affecting the metastasis of OS and CALD1 and STX1A may be possible targets beneficial for the treatment of metastatic OS. However, further experimental studies are needed to confirm our results.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권12호
• /
• pp.5087-5094
• /
• 2016

mTOR, the mammalian target of rapamycin, is a conserved serine/threonine kinase which belongs to the phosphatidyl-linositol kinase-related kinase (PIKK) family. It has two complexes called mTORC1 and mTORC2. It is well established that mTOR plays important roles in cell growth, proliferation and differentiation. Over-activation of the mTOR pathway is considered to have a relationship with the development of many types of diseases, including polycystic ovary syndrome (PCOS) and ovarian cancer (OC). mTOR pathway inhibitors, such as rapamycin and its derivatives, can directly or indirectly treat or relieve the symptoms of patients suffering from PCOS or OC. Moreover, mTOR inhibitors in combination with other chemical-molecular agents may have extraordinary efficacy. This paper will discuss links between mTOR signaling and PCOS and OC, and explore the mechanisms of mTOR inhibitors in treating these two diseases, with conclusions regarding the most effective therapeutic approaches.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권20호
• /
• pp.8719-8724
• /
• 2014

Background: Breast cancer incidence is increasing among South Asian migrants to the United States (US). However, their utilization of cancer screening services is poor. This study characterizes attitudes of South Asians towards breast health and screening in a community sample. Materials and Methods: A cross-sectional survey based on the Health Belief Model (HBM) was conducted among South Asians (n=124) in New Jersey and Chicago. The following beliefs and attitudes towards breast cancer screening were assessed-health motivation, breast self-examination confidence, breast cancer susceptibility and fear, and mammogram benefits and barriers. Descriptive statistics and Spearman rank correlation coefficients were computed for HBM subscales. Findings: Mean age of participants was 36 years with an average 10 years stay in the US. Most women strived to care for their health ($3.82{\pm}1.18$) and perceived high benefits of screening mammography ($3.94{\pm}0.95$). However, they perceived lower susceptibility to breast cancer in the future ($2.30{\pm}0.94$). Conclusions: Increasing awareness of breast cancer risk for South Asian women may have a beneficial effect on cancer incidence because of their positive attitudes towards health and breast cancer screening. This is especially relevant because South Asians now constitute one of the largest minority populations in the US and their incidence of breast cancer is steadily increasing.

• 한국지구과학회지
• /
• 제43권1호
• /
• pp.23-29
• /
• 2022

열대저기압이 한반도로 접근할 때 중심최대풍속이 34 knot보다 약해졌더라도(weak tropical cyclone; WTC) 수도권 지역으로 상륙하면 상당한 피해를 일으키지만 WTC만 독립적으로 조사한 학술연구는 거의 없다. 본 연구에 따르면 WTC 활동은 Pacific Decadal Oscillation (PDO)와 관련되어 있는 것으로 보인다. PDO가 음의 위상일 때는 양의 위상일 때보다 95% 신뢰구간에서 유의하게 더 많은 WTC가 한반도에 영향을 미치는 것으로 나타났다. PDO 양의 위상에 비해 음의 위상 시기에는 북서태평양 북부에서 양의 상대소용돌이 아노말리가 나타난 반면, 북서태평양 남부에서는 강한 연직바람시어와 음의 상대소용돌이 아노말리가 나타났다. 이런 조건 하에서 열대저기압의 발생위치가 보다 북쪽으로, 즉 동아시아 대륙에 더욱 근접할 수 있었던 것으로 보이며 이에 따라 열대저기압의 전체 생애가 짧아졌을 것이다. 게다가 PDO 음의 위상 시기에 일본열도 상공에 자리한 고기압성 아노말리는 열대저기압의 진로를 좀 더 서쪽으로 밀어내어 육지에 의한 마찰과 황해 저층 냉수대의 영향도 증가하였을 것이다. 이에 따라 열대저기압의 생애최대강도와 상륙 시 강도가 약해져 PDO 음의 위상 때 WTC 활동이 한반도에서 증가한 것으로 분석된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권4호
• /
• pp.2439-2442
• /
• 2013

We investigated the possible association of interleukin-10 (IL-10) single nucleotide polymorphisms (SNPs) and susceptibility to acute myeloid leukemia (AML) in 115 patients and 137 healthy controls. Genetic analysis of IL-10 SNPs at -819 and -592 was carried out with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. The IL-10 mRNA expression of AML patients and controls with different genotype was detected by real-time quantitative polymerase chain reaction (RT-PCR). Genetic analysis of IL-10 revealed that the -819AA genotype frequencies and the -819A allele frequencies in the AML group were higher than in the controls (59.1% vs 40.9%; 75.6% vs 63.9%, respectively); there were remarkable differences in -819T/C and -592A/C gene distribution (P<0.05) and the TA haploid frequencies were higher in the AML group (75.6% vs 63.9%, P<0.05). IL-10 mRNA expression in incipient AML patients was obvious higher than the non-tumor group and the remission group ($7.78{\times}10^{-3}$ vs $2.43{\times}10^{-3}$, $3.64{\times}10^{-3}$, P<0.05).The study suggested that the haploid TA and genotype TA/TA may be associated with AML in Han people in Hunan province.The IL-10 SNPs at -819 and -592 sites were associated with AML and may affect IL-10 mRNA expression in AML patients.

• 아태비즈니스연구
• /
• 제3권1호
• /
• pp.1-9
• /
• 2012

The Index of Learning Styles (ILS) instrument based on the Felder-Silverman Learning Style Model was used to determine distribution of learning styles of 125 South Korean business students enrolled in a South Korean institution of higher education. Results show that greater proportion of South Korean business students surveyed in this study prefer sensing over intuitive, visual over verbal, reflective over active, and global over sequential learning styles. The majority of business students have a balanced learning style in all four dimensions of the Felder-Silverman model. Among the students that do not have a balanced learning style, students with sensing, visual, reflective, and global learning styles dominate. Gender difference in learning style preference was not statistically significant for any of the four dimensions.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권9호
• /
• pp.3741-3745
• /
• 2015

Background: A moderate dose of radiation is the recommended treatment for solitary plasmacytoma (SP), but there is controversy over the role of surgery. Our study aimed at comparing different treatment modalities in the management of SP. Materials and Methods: Data from 38 consecutive patients with solitary plasmacytoma, including 16 with bone plasmacytoma and 22 with extramedullary plasmacytoma, were retrospectively reviewed. 15 patients received radiotherapy alone; 11 received surgery alone, and 12 received both. The median radiation dose was 50Gy. All operations were performed as radical resections. Local progression-free survival (LPFS), multiple myeloma-free survival (MMFS), progression-free survival (PFS) and overall survival (OS) were calculated and outcomes of different therapies were compared. Results: The median follow-up time was 55 months. 5-year LPFS, MMFS, PFS and OS were 87.0%, 80.9%, 69.8% and 87.4%, respectively. Univariate analysis revealed, compared with surgery alone, radiotherapy alone was associated with significantly higher 5-year LPFS (100% vs 69.3%, p=0.016), MMFS (100% vs 51.4%, p=0.006), PFS (100% vs 33.7%, p=0.0004) and OS (100% vs 70%, p=0.041). Conclusions: Radiotherapy alone can be considered as a more effective treatment for SP over surgery. Whether a combination of radiotherapy and surgery improves outcomes requires further study.

• Child Studies in Asia-Pacific Contexts
• /
• 제4권2호
• /
• pp.127-136
• /
• 2014

The number of multicultural families with children are growing in South Korea. When it comes to childrearing, co-existence of two different cultures in these families pose unique challenges as husbands and wives navigate differences in norms and practices. The goal of this study was to examine what predicts involvement in child care among South Korean fathers in multicultural families. We hypothesized that the degree of wives' adaptation to South Korea and husbands' cultural characteristics, such as family ideology and cultural competence, would influence father involvement in child care. The sample consisted of 138 Korean fathers and their wives from China. Participants completed a questionnaire. Results showed that South Korean fathers engaged in a moderate level of child care activities. As hypothesized, their Chinese wives' level of adaptation to South Korea and their own cultural characteristics were significantly associated with their involvement in child care. South Korean fathers were more likely to get involved in child care when their wives were less acculturated. Also, culturally considerate and less traditional men in terms of family ideology were more likely to perform child care.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권1호
• /
• pp.367-372
• /
• 2013

Effects of the Epstein-Barr virus (EBV) on cellular protein expression are essential for viral pathogenesis. To characterize the cellular response to EBV infection, differential proteomes of gastric epithelial AGS cells were analyzed with two-dimensional gel electrophoresis (2-DE) followed by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) and liquid chromatography electrospray/ionization ion trap (LC-ESI-IT) mass spectrometry identification. Mass spectrometry identified 9 altered cellular proteins, including 5 up-regulated and 4 down-regulated proteins after EBV infection. Notably 2-DE analysis revealed that EBV infection induced increased expression of heat shock cognate 71 kDa protein, actin cytoplasmic 1, pyridoxine-5'-phosphate oxidase, caspase 9, and t-complex protein 1 subunit alpha. In addition, EBV infection considerably suppressed those cellular proteins of zinc finger protein 2, cyclin-dependent kinase 2, macrophage-capping protein, and growth/differentiation factor 11. Furthermore, the differential expressional levels of partial proteins (cyclin-dependent kinase 2 and caspase 9) were confirmed by Western blot analysis.Thus, this work effectively provided useful protein-related information to facilitate further investigation of the mechanisms underlying EBV infection and pathogenesis.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 2008년도 International Symposium on Remote Sensing
• /
• pp.285-288
• /
• 2008

We analyzed evaporation data in the Japanese Ocean Flux Data Sets with Use of Remote Sensing Observations (J-OFURO) Ver.2. There exists huge evaporation in Gulf Stream, Kuroshio Extension, the ocean dessert and the southern part of the Indian Ocean. The temporal variation of evaporation is overwhelmingly large, of which the standard deviation is more than 120(mm), in the Kuroshio Extension region. Also, the result of harmonic analysis gives that this large variation is closely related to annual variation. In addition, the first EOF mode shows long-term variation showing the maximum amplitude between 1992 and 1994 and remarkable decrease after 1994, and large amplitude in the equatorial region and northeast of Australia. The second and third modes were strongly influenced by El Nino. Moreover, we compared J-OFURO2 evaporation product with other products. We used six kinds of data sets (HOAPS3 and GSSTF2 of satellite data, NRA1, NRA2, ERA40 and JRA25 of reanalysis data) for comparison. Most products show underestimation in the most regions, in particular, in the northern North Pacific, mid-latitudes of the eastern South Pacific, and high-latitudes of the South Pacific compared with J-OFUR02. On the other hand, JRA25 and NRA2 show large overestimation in the equatorial regions. RMS difference between NRA2 and J-OFURO2 in the Kuroshio Extension was significantly large, more than 120(mm).