• 대한한의학회지
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• 제31권5호
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• pp.64-81
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• 2010

Objectives: The object of this study was to observe the suppressive effects of Yijintang-gamibang (YJGMB), Yijintang being traditionally used in the Korean Medicine for treating various digestive diseases, on the rat reflux esophagitis (RE) as compared with omeprazole, a well-known proton pump inhibitor. Methods: Three different dosages of YJGMB, 50, 100 and 200 mg/kg, were orally pretreated once a day for 28 days before pylorus and forestomach ligation. Seven groups of 8 rats each were used in the study. Six hrs after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, invasive lesion percentages, fundic mucosa, esophageal submucosa and total thicknesses were measured by histomorphometry. The results were compared with omeprazole 10 and 30 mg/kg treated groups in which the effects on RE were already confirmed. Results: As results of pylorus and forestomach ligation, marked increases of esophageal and gastric mucosa lesion areas, gastric volumes, acid outputs, pepsin outputs were observed with histopathological changes of RE, such as hemorrhages, ulcerative lesions and edematous changes on the esophageal and fundic mucosa. However, these pylorus and forestomach ligation induced RE were dose-dependently inhibited by treatment of 50, 100 and 200 mg/kg of YJGMB. YJGMB 50 mg/kg showed similar suppressive effects as 30 mg/kg of omeprazole, but more favorable effects were observed as compared with omeprazole 10 mg/kg. Conclusion: The results suggest that YJGMB showed favorable suppressive effects on the RE induced by pylorus and forestomach ligation. It is therefore expected that YJGMB will show favorable effects on RE as corresponds to the suggestion of traditional Korean medicine. However, more detailed mechanism studies should be conducted in future with the screening of the biological active chemical compounds in herbs.

• 농업생명과학연구
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• 제45권6호
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• pp.81-88
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• 2011

산양삼 재배를 위한 기초자료를 제공할 목적으로 9개도 18 재배지를 대상으로 입지환경, 토양환경, 생육과정, 재배방법과 시기를 조사 분석하였다. 산양삼 재배 입지환경은 활엽수림, IV영급 기준 ha당 잔존본수 500~1,000본, 해발 500 m 미만, 경사 $25^{\circ}$ 이하, 재배사면은 북, 북동, 동, 북서방향에서 주로 재배되는 것으로 나타났다. 토양은 유기물함량 3.43~24.07%, pH 3.8~5.7, 토성은 사토~사양 토로 재배지 간에 많은 차이를 나타내었다. 생육과정은 발순, 개엽, 개화, 결실, 홍숙, 낙과, 낙엽까지 조사되어 평균 98일의 생육기간이 소요되었다. 재배방법은 파종과 이식 형태로 증식되고 있었으며, 파종은 개갑처리(발아촉진처리)와 직파형태로 파종하고 있으며 각각 70%, 30%로 처리되는 것으로 나타났다.