• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권3호
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• pp.162-169
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• 2014

Purpose: To study temporal pattern of serum liver enzymes levels in newborns with hepatic injury associated with birth asphyxia (BA). Methods: Singleton term newborns with BA and ${\leq}72$ hours of age admitted to neonatal intensive care unit were prospectively enrolled. Term newborns with physiological jaundice and without BA were studied as controls. Serum liver enzymes were measured at <24 hours, 24-72 hours, and at 6-12 days of age for cases and at 1-6 days of age for controls. BA was defined by 1 minute Apgar score <7 or delayed or absent cry with hypoxic ischemic encephalopathy. BA-associated liver injury was defined as serum alanine aminotransferase (ALT) elevation beyond +2 standard deviation (ALT > +2 SD) above the mean of control subjects at any of the three time points. Results: Sixty controls and 62 cases were enrolled. Thirty-five cases (56%) developed BA-associated liver injury (ALT>81 IU/L). They had higher serum levels of ALT, aspartate aminotransferase, lactate dehydrogenase than the control infants, with peak at 24-72 hours. In controls, serum liver enzyme levels were significantly higher in appropriate-for-date (AFD) babies than small-for-date (SFD) babies. Serum enzyme pattern and extent of elevation were comparable between SFD and AFD babies. Degree of serum liver enzyme elevation had no relationship with severity of hypoxic encephalopathy. Conclusion: Serum liver enzyme elevation is common in BA; it peaks at 24-72 hours followed by a sharp decline by 6-12 days of age. Pattern and extent of enzyme elevation are comparable between SFD and AFD babies.

• 한국재난정보학회 논문집
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• 제10권2호
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• pp.238-243
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• 2014

최근 세계적으로 환경오염이 심각해짐에 따라 환경보호의 일환으로 자원 재활용과 연관하여 시멘트의 대체 재료로서 산업부산물에 대한 관심이 높아졌으며, 특히 최근 경제성, 치수안정성 및 신뢰성이 우수한 고품질의 콘크리트 개발이 크게 요구되고 있는데 이를 증명하기 위한 실험을 수행한 결과는 다음과 같다. (1) 고로슬래그 미분말과 플라이애쉬 같은 혼화재를 혼합하여 사용할 경우 유동성이 개선되고 수화열 감소하는 효과가 있다. (2) 고로슬래그 미분말과 플라이애쉬 같은 혼화재의 량을 증가하면 장기강도 증진되고 건조수축이 감소한다, (3) 고로슬래그 미분말과 플라이애쉬 같은 혼화재의 혼입량을 증가시키면 수밀성 및 내구성 향상 등에 효과가 있는 것으로 나타나고 있다. 본 연구에서는 고로슬래그 미분말 및 플라이애쉬의 각각의 치환율과 혼입에 따른 콘크리트의 공학적 특성 및 혼입량의 임계치를 추정하고 현장 적용가능성을 검증하는데 목적이 있다.

• Korean Journal of Radiology
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• 제21권11호
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• pp.1248-1255
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• 2020

Objective: To analyze long-term follow-up sonographic findings of intrathyroidal thymus in children. Materials and Methods: Among 1259 patients with congenital hypothyroidism under 15 years of age who underwent thyroid ultrasonography (US), 41 patients were diagnosed with an intrathyroidal thymus based on US criteria, i.e., hypoechoic solid lesion with punctate and linear echogenicity. In 26 patients aged one to 14 years old, the last follow-up US was performed after 6 to 132 months and compared with the initial US. The lesion was considered to decrease in size if there was a change of more than 2 mm in any dimension. The margin change was divided into well-defined and indistinct, blurred. When the echogenicity changed to a hyperechoic from a characteristic thymic echogenicity pattern, the pattern was considered a hyperechogenic. The changes in size were compared with the changes in shape, margin, and echogenicity pattern. The changes in size, shape, margin, and echogenicity were analyzed the association with the age of last follow-up. Statistical analysis was conducted using the chi-squared test and logistic regression. Results: Fifteen (57.7%) cases were stable in size, and 11 (42.3%) decreased in size, including one that disappeared. Ten (38.5%) cases changed to indistinct margins from initially well-defined margins including one case of initially indistinct margin. Six (23.1%) changed to hyperechogenic, from initially characteristic thymic echogenicity patterns. When follow-up change was compared, decreases in size were significantly associated with lesion changes to indistinct margins (p = 0.004). The age at last follow-up was significantly associated with change to hyperechogenicity (odd ratio, 2.141; 95% confidence interval, 1.144-4.010, p = 0.017). Conclusion: On follow-up US, an intrathyroidal thymus may be decreased in size, with indistinct margins, or show changes to a hyperechoic mass. Decreases in size may be associated with changing to indistinct margins, and changes to hyperechogenicity may be associated with increasing age.

• 한국치위생학회지
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• 제9권1호
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• pp.169-180
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• 2009

This study grasped recognition on a system of long-term care insurance for the elderly targeting dental professionals who are working at dental hospitals and clinics where are located in Daejeon Metropolitan City. It developed and utilized materials available for educating the care staff in a system of long-term care insurance for the elderly and the dental professionals who participate in the oral hygiene service. It carried out the effective duty performance for the elderly in a situation of long-term care protection. Thus, the purpose of this study was to contribute to the early settlement in a system of long-term care insurance for the elderly. The following conclusions were obtained as a result of having carried out self-administered questionnaire research targeting 238 people from August 1 to August 30 in 2008. 1. In the general characteristics of the research subject, the present working place was indicated to be 22.7% for dental hospital, 71.8% for dental clinic, and 5.5% for others. As for the main duty field, the medical treatment & cooperative duty was indicated to be the highest with 61.8%, and was statistically significant(p=0.000). 2. The necessity for a system of long-term care insurance for the elderly was indicated to be 77.7% for 'necessary' and 1.7% for 'unnecessary,' and was statistically significant(p=0.016). 3. In the item of dividing the service of long-term care insurance for the elderly, the dental hygienists showed higher recognition than non-dental hygienists, and indicated significant difference(p=0.010). 4. As for recognition on a system of long-term care insurance for the elderly in dental professionals who responded as saying of 'knowing name and contents' about a system of long-term care insurance for the elderly, the recognition level was high in recognition of subjects' age(p=0.000), division in services(p=0.012), contents in at-home care service(p=0.000), execution in oral-hygiene service(p=0.004), procedure of using the long-term care insurance for the elderly(p=0.016), item of judging grade of long-term care insurance for the elderly(p=0.013), medical charge by service according to judging grade of long-term care insurance for the elderly(p=0.015), burden of cost for a system of long-term care insurance for the elderly(p=0.011), qualification of care staff(p=0.002), and contents of oral-hygiene service(p=0.027), and showed significant difference. 5. The service of long-term care insurance for the elderly and the oral-hygiene service indicated the statistically significant correlation. Accordingly, all of dental professionals need to make a desperate effort to improve dental professionals' knowledge on a system of long-term care insurance for the elderly enough to be required a system of long-term care insurance for the elderly. The more systematic and standardized professional education and materials are thought to be needed to be developed aiming at the success in oral-hygiene service within a system of long-term care insurance for the elderly, by strengthening professionalism in dentists and dental hygienists.

• 법제연구
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• 제41호
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• pp.87-123
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• 2011

평균수명의 증가 및 출산율의 저하와 함께 수반되는 급격한 인구고령화는 단기간에 우리나라의 경제 사회 문화 전 분야에 걸쳐 중대한 변화를 야기하고 있다. 단순히 노인의 비율이 늘어나는 것뿐만 아니라 평균수명이 계속해서 증가하여 많은 국민들이 장기간의 노후생활을 영위해야 하는 상황이다. 이와 같은 배경에서 노인들이 인간으로서의 존엄과 가치를 유지하면서 품위 있게 인생을 마무리할 수 있도록 노인복지 관련법제의 역할과 기능이 특별히 강조될 수밖에 없으며, 사회보험 및 공공부조와 기능적 연계성을 토대로 사회복지서비스를 목적으로 하는 노인복지법의 역할도 점차 중요해지고 있다. 노인복지법은 노인을 위한 사회복지서비스의 내용을 제시하고 있는데, 그중에서도 소득보장, 보건의료서비스, 요양 및 주거복지를 중심으로 하는 복지조치 그리고 일자리 등 사회참여지원 등을 핵심요소로 하며, 그와 같은 복지서비스의 유기적 결합을 통하여 노인이 살아가는데 적합한 생활조건을 실현할 수 있게 된다. 이를 위하여 노인복지법은 기초노령연금법과 노인장기요양보험법 등 관련법제와 밀접한 규범적 네트워크를 형성하면서 효율적인 노인복지시스템을 구축하게 된다. 그러나 우리 현행 노인복지법 및 관련법제는 21세기의 고령사회, 장수사회를 대비하는데 여전히 미흡하다고 하지 않을 수 없다. 노후소득보장과 다양하고 수준 높은 노인의 사회참여의 결합, 보건 의료와 요양의 효율적 연계 및 국가 또는 지방자치단체의 비용부담수준, 복지조치의 효과성 제고를 통한 품위 있고 존중받는 노인복지의 실현을 위해 더 많은 노인들을 포괄할 수 있는 다양하고 구체적인 개선방안이 마련되어야 할 것이다.

• Food Science and Biotechnology
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• 제16권3호
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• pp.404-408
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• 2007

In this study, we investigated the effects by age of long-tenn supplementation of Epimedium koreanum Nakai (EKN)-containing water on the in vivo antioxidant capacities of rats. All rats were reared in a conventional system, and none of the rats showed any signs of aversion to the EKN solution. Neither the mean nor maximum life spans of the rats were extended by long-tenn administration of the solution. The EKN extract caused decreases in the levels of serum thiobarbituric acid reactive substances in the rats. The activities of superoxide dismutase, catalase, and glutathione (GSH) peroxidase within the liver cytosol decreased with age in both the control and EKN-supplemented groups. GSH peroxidase activity, however, was higher at old age in the EKN-supplemented group. The activities of GSH reductase and GSH-S-transferase, and the levels of free-sulfhydryl (SH) and total-SH group gradually decreased with age in both groups. However, there was some tendency for higher levels in the EKN supplemented group at a corresponding age. These results indicate that long-tenn supplementation of EKN water extracts alone does not exhibit discernible adverse effects in rats, and has some enhancing effects on the antioxidant capacities of the blood and liver, but it does not have life-prolonging effects.

• 생명과학회지
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• 제9권5호
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• pp.548-555
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• 1999

Long-term effects of Ganoderma lucidum (GL) on memory and oxidative stress of senescence-accelerated mice (SAM) were investigated. Senescence-resistant (R1) and prone (P8) strains of SAM were fed GL diets, premixed with low (20 mg/kg/day, T1) or high (200 mg/kg/day, T2) levels of GL powder for 9 months starting from young (3 months of age) or for 5 months starting from old (7 months of age). After the final feeding at 12 months of age, all animals were subjected to passive avoidance test for the evaluation of memory function. In addition, the changes in hepatic thiobarbituric acid-reactive substance (TBARS) and glutathione were analyzed. SAMP8 fed GL diets from old age (7 months) exhibited the improvement of memory, although GL rather inhibited the memory function of both SAMR1 and SAMP8 mice fed diets from young (3 months of age). Hepatic TBARS contents were decreased in SAMP8 fed high GL diet for 9 months and in SAMR1 fed low GL diet for 5 months. Hepatic glutathione content was also remarkably increased in SAMR1 following both feeding periods, and less extent in SAMP8 fed diet for 5 months of age. Taken together, it is proposed that GL extracts may play an anti-aging role through antioxidant action, and thereby may improve the senescence-related memory dysfunction.

• 한국정밀공학회지
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• 제26권12호
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• pp.131-137
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• 2009

Recent technological advances made a vehicle more intelligent to increase safety and comfort. An intelligent vehicle provides drivers with safety warning information through audible sounds, visual displays, and tactile devices. However, elderly drivers have been known to decrease the physical and cognitive abilities such as muscular strength, hearing, eyesight, short term memory, and spatial perception. Therefore, possible age-related deficits should be considered to design an effective warning system. This paper aims to evaluate the impact of advancing age on response performance on audible safety warnings which are widely used for alerting driving hazards. In order to understand the effect of age-related hearing loss and movement slowing, three sound characteristics (frequency, intensity, and period) and three age groups (younger, middle, and older) are considered. Data was drawn from 38 drivers who drove a simulated rural road in a driving simulator. Experimental results show that age influences driver's response performance. In conclusion, the appropriate range of a warning sound is suggested.

• 디지털융복합연구
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• 제14권9호
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• pp.379-387
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• 2016

본 연구는 우리나라 출생아 전수(n=617,867)를 대상으로 산모 연령과 영아 사망과의 관련성을 파악하고자 시행하였다. 연구자료는 인구동태통계자료와 영아사망조사자료를 연계하여 사용하였고, 산모 연령에 따른 영아 사망 위험을 파악해 보기 위해 출생아의 성별과 다태 여부, 출생순위, 저체중아 여부, 선천성기형 여부를 보정한 다중 로지스틱 회귀분석을 시행하였다. 여러 혼란요인을 보정한 분석 결과, 25-29세 산모에 비해 20세 미만 산모(Odds ratio [OR], 5.29, 95% confidence interval [CI], 3.51-7.98)와 20-24세 산모(OR, 1.44, 95% CI, 1.23-1.69), 35-39세 산모(OR, 1.28, 95% CI, 1.11-1.46), 40세 이상 산모(OR, 1.94, 95% CI, 1.53-2.45)에서 영아 사망 오즈가 통계적으로 유의하게 높았다. 결론적으로, 이번 연구를 통해 35세 이상 고 연령 산모와 25세 미만의 저 연령 산모에서 영아 사망 위험이 높은 것을 확인할 수 있었고, 이들에서 영아 사망 위험이 높은 이유는 저체중아나 미숙아의 출산이 많기 때문으로 보인다. 산전관리 시 고령 산모의 경우 생물학적인 문제를 극복할 수 있는 관리정책이 만들어져야 할 것으로 보이고, 저 연령 산모의 경우 사회경제적인 부분과 사회적 편견 문제를 해결할 수 있는 관리정책이 만들어져야 할 것으로 보인다.

• 농촌지도와개발
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• 제1권2호
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• pp.95-103
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• 1994

Recently Korean government has proceeded to reorganize agricultural extension system as a part of reduction plan of national governmental body. Function and characteristics of agricultural extension system under the localization was presented in the view of long term agricultural development policy.