• Title/Summary/Keyword: telephenol

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Synthesis and biological activity of spirobenzopyranone derivative as analogs of thelepin, isolated from the marine annelid Thelepus setosus (항균성물질 thelepin의 spirobenzopyranone 유도체의 합성과 생물활성)

  • Ko, Byoung-Seob;Oritani, Takayuki
    • Applied Biological Chemistry
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    • v.35 no.6
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    • pp.470-474
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    • 1992

  • For the further development of thelepin analog as antibiotic agents, we undertook the synthesis of spirobenzopyranone derivative ${\underline{5}}$ as thelepin analog by oxidative phenol coupling. The spirobenzopyranone analog ${\underline{5}}$ showed high activity against Bacillus subtilis (IFO 3108) in $5\;{\mu}g/disc$.

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