• Title/Summary/Keyword: technology transfer and commercialization

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Single Nucleotide Polymorphism (SNP) Discovery and Kompetitive Allele-Specific PCR (KASP) Marker Development with Korean Japonica Rice Varieties

  • Cheon, Kyeong-Seong;Baek, Jeongho;Cho, Young-il;Jeong, Young-Min;Lee, Youn-Young;Oh, Jun;Won, Yong Jae;Kang, Do-Yu;Oh, Hyoja;Kim, Song Lim;Choi, Inchan;Yoon, In Sun;Kim, Kyung-Hwan;Han, Jung-Heon;Ji, Hyeonso
    • Plant Breeding and Biotechnology
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    • v.6 no.4
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    • pp.391-403
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    • 2018
  • Genome resequencing by next-generation sequencing technology can reveal numerous single nucleotide polymorphisms (SNPs) within a closely-related cultivar group, which would enable the development of sufficient SNP markers for mapping and the identification of useful genes present in the cultivar group. We analyzed genome sequence data from 13 Korean japonica rice varieties and discovered 740,566 SNPs. The SNPs were distributed at 100-kbp intervals throughout the rice genome, although the SNP density was uneven among the chromosomes. Of the 740,566 SNPs, 1,014 SNP sites were selected on the basis of polymorphism information content (PIC) value higher than 0.4 per 200-kbp interval, and 506 of these SNPs were converted to Kompetitive Allele-Specific PCR (KASP) markers. The 506 KASP markers were tested for genotyping with the 13 sequenced Korean japonica rice varieties, and polymorphisms were detected in 400 KASP markers (79.1%) which would be suitable for genetic analysis and molecular breeding. Additionally, a genetic map comprising 205 KASP markers was successfully constructed with 188 $F_2$ progenies derived from a cross between the varieties, Junam and Nampyeong. In a phylogenetic analysis with 81 KASP markers, 13 Korean japonica varieties showed close genetic relationships and were divided into three groups. More KASP markers are being developed and these markers will be utilized in gene mapping, quantitative trait locus (QTL) analysis, marker-assisted selection and other strategies relevant to crop improvement.

A Comparative Study on Institutions for Technology Transfer of Korea and the U.S. : Exploring Cases of KAIST and the University of California (한국과 미국의 기술이전 제도 비교 연구 : KAIST와 캘리포니아대학교를 중심으로)

  • Kim, Sang-Tae;Hong, Woon-Sun
    • Journal of Korea Technology Innovation Society
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    • v.16 no.2
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    • pp.444-475
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    • 2013
  • This study explores the trajectories of institutionalization for technology transfer both in the U.S. and Korea, particularly focusing on two universities: Korea Advanced Institute of Science and Technology (KAIST), and the University of California (UC). By comparing the diverging paths of the two universities in setting up institutions, this paper examines the limits of and lessons for technology transfer policies both to Korean government and universities in Korea. The University of California was involved in designing rules and codes, on one hand, to stimulate its members' engagements with technology transfer activity and, on the other hand, to keep its academic integrity since, no later than, the 1960s. The efforts and consequences range from its rules of patenting system to its codes of conducts. Through making rules formal and resolving conflicts on technology transfer activity, the U.S., and the University of California have decreased uncertainties for its members' engagements with industries. By contrast, KAIST has not built up such range of rules or codes due to its shorter experience and its constraining legal contexts. Korea introduced the legal format of the US Bayh-Dole Act in 2002, and its central government has led the initiatives for technology transfer, not allowing much latitude for its universities. This study implies a set of policy recommendations to the Korean government and KAIST: to build entrepreneurial universities, the government should give greater latitude to universities, so universities should be more rigorously engaged in developing their own rules and routines; the government, rather, should focus on providing bridging R&D funds like the Small Business Innovation Research (SBIR), so researchers could draw on resources to move their basic research into next phases; KAIST would be better to promote its members to engage with industries, and introduce conduct codes that allow its academics to engage in industrial activity, rather than building up its commercialization facilities.

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An Analysis of FCCL Shielding Effect for EMF Attenuation to On-Line Electric Vehicle (On-Line Electric Vehicle의 EMF 저감을 위한 FCCL 차폐효과 분석)

  • Shim, Hyung-Wook;Kim, Jong-Woo;Cho, Dong-Ho
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.63 no.6
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    • pp.770-775
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    • 2014
  • According to ICNIRP guidelines for limiting exposure to time-varying electric, magnetic and electromagnetic fields up to 300GHz, magnetic flux density which range from 3Hz to 150kHz are regulated to lower than $6.25{\mu}T$. In order to comply with its standard, OLEV(On-Line Electric Vehicle) have been designed considering EMF(Electro-Magnetic Field) reduction. However, if a current flowing in power line would be bigger for increasing power transfer efficiency, the established shield system no longer acts their role properly. In this paper, therefore, FCCL(Flexible Copper Clad Laminate) is applied to power line and pick-up devices to solve the problems. Though, the FCCL is normally utilized to insulator on circuit board, because of its high heat resistance characteristic, flexibility and thin properties, it makes effectiveness in the shielding device as well. 4 types of FCCL shielding structure are introduced to power line and pick-up devices. From the results, the FCCL which are placed in proposed positions shows maximum EMF reduction compared to the established shielding structure. Henceforth, if OLEV is applied FCCL shielding structure in practice, it will not only be more safe but also step forward to commercialization near future.

Construction and Monitoring of Test bed in Urban Sediment Disaster Prevention Technology (도심지 토사재해 방어기술 테스트베드 구축 및 모니터링 연구)

  • Lee, Jung-min;Kim, Hyo-Jin;Lee, Yoon-Sang;Jin, Kyu-Nam
    • Land and Housing Review
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    • v.8 no.3
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    • pp.161-169
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    • 2017
  • In this study, sediment transfer and precipitation analysis of the test bed watershed was conducted through the model for the application and practical use of the urban sediment disaster prevention technology, and used this as an aid to design to secure reliability. In addition, conducted the test bed monitoring with the defense technology, analyzed the effect, and established the maintenance plan. Analyzed the change of soil deposition volume through arbitrary slope adjustment for the currently installed stormwater conduit of the test bed watershed. As a result, it is important to reduce the total sedimentation amount in the adjustment of the slope of the entire pipeline, but it is important that the sedimentation depth of each sediment does not rise to such a degree as to threaten the performance of the pipeline. Considering these matters, it is necessary to design the pipeline to prevent the clogging of the soil from the viewpoint of the reliability of the entire pipeline. The sediment disaster defense technology test bed is divided into a new city and an old city, and old city test bed is under construction. The result obtained through the monitoring of the test bed in the new city, sediment disasters such as debris can delay the time to reach the downtown area, and it is possible to secure the golden time, such as evacuation and rescue through the warning system. Also, the maintenance of the test bed application was suggested. Continuous and systematic monitoring is required for securing the reliability of element technology and successful commercialization.

Advances in Food Irradiation and It's Potential Roles in Korea (한국에 있어서 식품조사 기술의 진보와 식품산업에서의 역할)

  • 권중호
    • Proceedings of the Korean Society of Food Hygiene and Safety Conference
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    • 1994.03a
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    • pp.35-49
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    • 1994
  • Based on the safety of irradiated foods which was demonstrated from the toxicological, microbiological and nutritional points of view, irradiation has been identified as a viable technology for food preservation and processing, having a potential both of reducing storage losses by controlling spoilage organisms, sprouting and ripening, and of improving hygienic quality of raw and processed products. Research and development over decades in the field of food irradiation have led to the regulatory approval in 37 countries and of them 25 countries including Korea are commercially utilizing food irradiation process. Although progress towards acceptance of food irradiation by the industry is slow, actual market trials have shown that once consumers have understood this technology, they are willing to buy irradiated foods. Considering recent advances in food irradiation and restrictions in the use of chemical fumigants, it is expected that food irradiation is in the process of "taking off". This paper deals with up-to-date progress in food irradiation with particular reference to domestic activities in legislation, consumer perception, commercialization, and potential applications in the food industry.

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The Newest Technology Development and Commercialization Status of Coal Gasification (석탄가스화 기술의 최신 개발 동향 및 상업화 현황)

  • Lee, Jin-Wook;Yun, Yongseung;Kang, Won-seok
    • Journal of Energy Engineering
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    • v.24 no.3
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    • pp.150-163
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    • 2015
  • Gasification technology is one of the representative next-generation fossil fuel utilization technologies, converting low grade fossil fuels such as coal, heavy residue oil, pet-coke into highly clean and efficient energy sources. Accordingly, related market demand for gasification technology is ever increasing steadily and rapidly. A few years ago, conventional pulverized coal utilization technology had an edge over the gasification technology but the most significant technical barrier of limited capacity and availability has been largely overcome nowadays. Futhermore, it will be more competitive in the future with the advancement of related technologies such as gas turbine, ion transfer membrane and so on. China has recently completed a commercialization-capable large-scale coal gasification technology for its domestic market expansion and foreign export, rapidly becoming a newcomer in the field and competing with existing US and EU technical leadership at comparable terms. Techno-economic aspect deserves intensive attention and steady R&D efforts need to continue in organized, considering that gasification technology is quite attractive combined with $CO_2$ capture process and coal to SNG plant is economically viable in Korea where natural gas is very expensive. In the present paper, recent technology development and commercialization trend of many leading companies with coal gasification expertise have been reviewed with significant portion of literature cited from the recently held '2014 Gasification Technology Conference'.

Cloning Livestock from Cultured Cells Creates New Opportunities for Agriculture

  • Wells, D.N.
    • Proceedings of the Korean Society of Developmental Biology Conference
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    • 2003.10a
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    • pp.29-48
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    • 2003
  • It is remarkable that nuclear transfer using differentiated donor cells can produce physiologically normal cloned animals, but the process is inefficient and highly prone to epigenetic errors. Aberrant patterns of gene expression in clones contribute to the cumulative losses and abnormal phenotypes observed throughout development. Any long lasting effects from cloning, as revealed in some mouse studies, need to be comprehensively evaluated in cloned livestock. These issues raise animal welfare concerns that currently limit the acceptability and applicability of the technology. It is expected that improved reprogramming of the donor genome will increase cloning efficiencies realising a wide range of new agricultural and medical opportunities. Efficient cloning potentially enables rapid dissemination of elite genotypes from nucleus herds to commercial producers. Initial commercialization will, however, focus on producing small numbers of high value animals for natural breeding especially clones of progeny-tested sires, The continual advances in animal genomics towards the identification of genes that influence livestock production traits and human health increase the ability to genetically modify animals to enhance agricultural efficiency and produce superior quality food and biomedical products for niche markets. The potential opportunities in animal agriculture are more challenging than those in biomedicine as they require greater biological efficiency at reduced cost to be economically viable and because of the more difficult consumer acceptance issues. Nevertheless, cloning and transgenesis are being used together to increase the genetic merit of livestock; however, the integration of this technology into farming systems remains some distance in the future.

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A facile synthesis of transfer-free graphene by Ni-C co-deposition

  • An, Sehoon;Lee, Geun-Hyuk;Jang, Seong Woo;Hwang, Sehoon;Yoon, Jung Hyeon;Lim, Sang-Ho;Han, Seunghee
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.129-129
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    • 2016
  • Graphene, as a single layer of $sp^2$-bonded carbon atoms packed into a 2D honeycomb crystal lattice, has attracted much attention due to its outstanding properties. In order to synthesize high quality graphene, transition metals, such as nickel and copper, have been widely employed as catalysts, which needs transfer to desired substrates for various applications. However, the transfer steps are not only complicated but also inevitably induce defects, impurities, wrinkles, and cracks of graphene. Furthermore, the direct synthesis of graphene on dielectric surfaces has still been a premature field for practical applications. Therefore, cost effective and concise methods for transfer-free graphene are essentially required for commercialization. Here, we report a facile transfer-free graphene synthesis method through nickel and carbon co-deposited layer. In order to fabricate 100 nm thick NiC layer on the top of $SiO_2/Si$ substrates, DC reactive magnetron sputtering was performed at a gas pressure of 2 mTorr with various Ar : $CH_4$ gas flow ratio and the 200 W DC input power was applied to a Ni target at room temperature. Then, the sample was annealed under 200 sccm Ar flow and pressure of 1 Torr at $1000^{\circ}C$ for 4 min employing a rapid thermal annealing (RTA) equipment. During the RTA process, the carbon atoms diffused through the NiC layer and deposited on both sides of the NiC layer to form graphene upon cooling. The remained NiC layer was removed by using a 0.5 M $FeCl_3$ aqueous solution, and graphene was then directly obtained on $SiO_2/Si$ without any transfer process. In order to confirm the quality of resulted graphene layer, Raman spectroscopy was implemented. Raman mapping revealed that the resulted graphene was at high quality with low degree of $sp^3$-type structural defects. Additionally, sheet resistance and transmittance of the produced graphene were analyzed by a four-point probe method and UV-vis spectroscopy, respectively. This facile non-transfer process would consequently facilitate the future graphene research and industrial applications.

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The Korean Strategy for the Science and Technology Park of the Developing Countries : The cases of Ecuador and Kazakhstan (개발도상국의 과학기술단지(STP) 건립을 위한 한국의 전략 : 에콰도르, 카자흐스탄의 사례를 중심으로)

  • Kim, Jong Jin;Choi, Jong In
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.7 no.4
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    • pp.131-141
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    • 2012
  • The miracle of Korean economic development is the benchmarking for the developing countries. Among them, the STP of Science and technology area is very important case they tring to learn from Deadeok, Korea. Ecuador and Kazakhstan have the huge natural resources and they have interested in the model of Daedeok STP. This paper study about their needs and Daedeok's capability, and effective implementing factors. This paper suggest a six one based on the Daedeok Innopolis experiences for the successful local STP. First, most important thing is human resource development strategy for the knowledge and technology transfer. Second, the construction of Engineering Center for the collaboration of industry and academy is needed. This is important to have a bargaining power to the appropriate technology transfer. Third, they need a hardware and software infrastructure to the technology commercialization. It include a incubator, manager, and complimentary asset. Fourth, they have to connect with market closely for the venture creation and growth. Fifth, the clustering is realized by the STP construction. Lastly, leadership is critical factor to the absorptive capacity.

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Microplant Module (마이크로 플랜트 모듈)

  • Seo J.H.;Shon J.M.;Cho J.Y.;Kwon Y.W.;Choe J.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.06a
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    • pp.211-215
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    • 2005
  • Microsystems combine several microcomponents, optimized an entire system, to provide several specific technical functions by the shape of the microstructure. Microfabrication and micromachining techniques have played the key role in the fast development and commercialization of microsystems. Microreaction technology based on microsystems is a powerful tool for the evaluating new process and reaction pathways in chemical engineering. Because of the small characteristic dimensions of microreaction devices, mass and heat transfer processes are enhanced and, in addition, reaction conditions can be precisely controlled for optimizing yield and selectivity. The paper will report on the mixer design principle and explore several application fields of microreaction technology in the chemical synthesis

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