• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.74-81
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• 2006

Molecular targeting may be defined as the specific concentration of a diagnostic or therapeutic tracer by its Interaction with a molecular species that is distinctly present or absent in a disease state. Monoclonal antibody (mAb) is one of the successful agents for targeted therapy in cancer. To enhance the therapeutic effect, the concept of targeting radionuclides to tumors using radiolabeled mAbs against tumor-associated antigens, radioimmunotherapy, was proposed. The efficacy of radioimmunotherapy, however, has to be further optimized. Several strategies to improve targeting of tumors with radiolabeled mAbs have been developed, such as the use of mAb fragments, the use of high-affinity mAbs, the use of labeling techniques that are stable in vivo, active removal of the radiolabeled mAb from the circulation, and pretargeting strategies. Until now, however, there are many kinds of obstacles to be solved in the use of mAb for the targeted therapy. Major technical challenges to molecular targeting are related to the rapid and specific delivery of tracers to the target, the elimination of unwanted background activity, and the development of more specific targets to create a cytocidal effect. further development of this field will be determined by success in solving these challenges.

• Safety and Health at Work
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• v.2 no.4
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• pp.375-379
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• 2011

Control Banding (CB) strategies to prevent work-related illness and injury for 2.5 billion workers without access to health and safety professionals has grown exponentially this last decade. CB originates from the pharmaceutical industry to control active pharmaceutical ingredients without a complete toxicological basis and therefore no occupational exposure limits. CB applications have broadened into chemicals in general - including new emerging risks like nanomaterials and recently into ergonomics and injury prevention. CB is an action-oriented qualitative risk assessment strategy offering solutions and control measures to users through "toolkits". Chemical CB toolkits are user-friendly approaches used to achieve workplace controls in the absence of firm toxicological and quantitative exposure information. The model (technical) validation of these toolkits is well described, however firm operational analyses (implementation aspects) are lacking. Consequentially, it is often not known if toolkit use leads to successful interventions at individual workplaces. This might lead to virtual safe workplaces without knowing if workers are truly protected. Upcoming international strategies from the World Health Organization Collaborating Centers request assistance in developing and evaluating action-oriented procedures for workplace risk assessment and control. It is expected that to fulfill this strategy's goals, CB approaches will continue its important growth in protecting workers.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.05a
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• pp.271-272
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• 2014

As E-discovery in criminal investigation is increasing, the importance of Forensic Tools which can legally extract data with high effectiveness is getting higher. Digital products are growing fast. Therefore, Forensic Tools should be implemented readily to suit users and events well. Although forensic industry and governments use expensive forensic tools, some have suggested limitations to its use, such as memory limitations and the limits of post-audit. We need to develop open source forensic tools that can implement a variety of forensic tool fast. This research studies digital forensics technical skills which are commercialized currently and suggests applicable strategies of the open digital forensics to help overcome these limitations.

• International conference on construction engineering and project management
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• 2020.12a
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• pp.103-113
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• 2020

The construction industry is undergoing a digital transformation in which Building Information Modelling (BIM) is a key technology. The potential of BIM in several areas such as design optimization, time management, cost management, and asset management/facility management (AM/FM) is widely acknowledged by the AECO (Architecture, Engineering, Construction, and Operation) industry around the world. However, BIM implementation in construction projects is faced with problems such as project delay and cost overruns. The lack of identification of risks in BIM projects and standard guidelines on mitigation techniques furthers poor performance, dissatisfaction, and disputes between employers and project participants, which results in low BIM adoption rates. Therefore, the objective of this paper is to identify the potential risks in BIM implementation under the primary categories - (1) technical, (2) contractual, (3) management-related, and (4) personnel-related risks in BIM projects and present solutions to reduce, manage, and mitigate risks. To meet the objective of this paper, a survey was designed and conducted in the Hong Kong construction industry in which over 140 respondents from different disciplines, with experience in BIM projects, have participated. Based on the analysis of the survey data, the most severe and frequently occurring BIM risks and their potential mitigation strategies were identified and discussed in this paper.

• Journal of the Korean Society for Library and Information Science
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• v.44 no.2
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• pp.263-283
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• 2010

Free Use License is an effective means of allowing many people to freely use works in the public domain. It can also prevent copyright infringement problems. This article analyzes the current service and domestic and foreign technology as it applies to free use license. It then proposes a plan which incorporates diverse requirements including technical aspects. Strategies are formulated from the technical, service and the resources connection perspectives for applying license in addition to searching and using licensed works. This article suggests a three-stage utilization plan to encourage the use of free use license. First, a connection plan between digital archiving and free use license, is developed. Then, a connection plan between UCI identifier and free use license is developed, and finally, the plan for the use of public resources is presented.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2006.04a
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• pp.103-112
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• 2006

제지 기계의 습부 공정을 안정화시키고, 또한 종이의 지필도에 악영향을 끼치지 않으면서 종이의 기계방향 물성의 변이를 줄이기 위해서, 보류도와 지필도 공정을 동시에 제어하기 위한 제어전략들이 개발되었다. 보류도와 지필도에 미치는 주 변수들에 관한 연구를 양이온성팜(CPAM)/벤토나이트 보류제와 파일럿 제지 기계를 사용하여 수행하였다. 마이크로파티클 보류제 첨가량이 보류도와 지필도에 미치는 영향을 설명하기 위해서 deposition efficiency 모델과 bridging strength 모델을 개발하였다. 제지 기계 보류 공정의 동특성 모델을 질량수지분석을 사용해서 개발하였다. 지료화학 변수의 효과를 모델에 포함하기 위해서, 보류도를 작업조건들에 의존하는 변수로 모델에 포함시켰다. 또한 지필도의 실험적 모델을 개발하고 보류공정을 위한 동특성 모델들과 연계해서 지필도의 동특성을 모사하였다. 여러 제어 전략들이 시뮬레이션상에서 실험되어졌다. 평량과 종이의 회분율 대신에 종이내의 펄프 질량과 충전제 질량을 제어하면 decouper를 사용하지 않고도 두 제어 루프간 상호작용을 줄일 수 있음을 보였다. 지필도의 제어를 위해서, 헤드박스 펄프 농도제어와 폴리머유량과 벤토나이트 유량의 비율제어를 제안하였다. 지종 변경시 백수농도의 설정값을 계산하는 문제를 해결하였다. 또한, 평량, 회분율, 백수농도 및 헤드박스 펄프 농도의 다변수제어가 논의되었다.

• The Journal of the Korea Contents Association
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• v.9 no.2
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• pp.462-470
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• 2009

As the learning space has expanded, the distance education has become a recent scholarship in teaching-learning method, and also a great type of media, technologies and strategies to support distance education are attracting a fair amount of attention. However in order to manage a distance education system, it is necessary to be endowed user with technical ability and operational expenses. On the other hand, although a web-based system that makes simple may cut cost, it is difficult to analyze learner's behaviors. Therefore, in this paper, we developed a interactive distance system based on individualized questioning, which relies upon learner's knowledge state and applies a efficient individualized learning method. Additionally, this study is instrument to reduce users' technical ability and operational expenses.

• Journal of Information Technology Applications and Management
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• v.15 no.1
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• pp.117-137
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• 2008

Using the service innovation system model, the development of Korean online game industry is analyzed. The model proposed by Gallouj (2002) is modified in order to reflect IT service characteristics such as network externalities. Success factors and innovations patterns of Korean online game industry are examined. First, at the early stage of her growth, Korean online game industry was not supported or coordinated by any Government policies unlike DRAM, CDMA or TFT-LCD. Many parts of technical and service innovations were unintentionally initiated by online game developing ventures without predeterminde strategies. Second, the online game industry is basically a service industry so that users' needs and technical and service characteristics are intertwined to produce innovation. The innovation system of the online game industry is quite different from conventional product technological innovation systems in a sense that there are no blueprints for innovation as well as major players in the system. Third, Government's policies for promotion of IT industry such as the broadband infrastructure installation policy, the hi-tech venture promotion policy and the military exemption policy contributed greatly to development of the online game industry. However, these policy tools were not intended for online game industry but in the end gave a great impact on the service innovation system of the online game industry.

• Earthquakes and Structures
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• v.18 no.5
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• pp.555-565
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• 2020

The main objective of seismic codes is to prevent structural collapse and ensure life safety. Collapse probability of a structure is usually assessed by making a series of analytical model assumptions. This paper investigates the effect of finite element modeling (FEM) assumptions on the estimated collapse capacity of a reinforced concrete (RC) frame building and points out the modeling limitations. Widely used element formulations and hysteresis models are considered in the analysis. A full-scale, three-story RC frame building was utilized as the experimental model. Alternative finite element models are established by adopting a range of different modeling strategies. Using each model, the collapse capacity of the structure is evaluated via Incremental Dynamic Analysis (IDA). Results indicate that the analytically estimated collapse capacities are significantly sensitive to the utilized modeling approaches. Furthermore, results also show that models that represent stiffness degradation lead to a better correlation between the actual and analytical responses. Results of this study are expected to be useful for in developing proper models for assessing the collapse probability of RC frame structures.

• Environmental Engineering Research
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• v.24 no.4
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• pp.618-629
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• 2019

Along with growing population and economic development, increasing waste generation rates in developing countries have become a major issue related to the negative impacts of waste management on the environment. Currently, the business-as-usual waste management practices in Myanmar are largely affecting the environment and public health. Therefore, this study developed an alternative approach to waste management for reducing the environmental impacts in Myanmar by highlighting the greenhouse gas (GHG) emissions from business-as-usual practices and three proposed scenarios during 2018-2025. The calculation methods of the Intergovernmental Panel on Climate Change and Institute for Global Environmental Strategies were used for estimating the GHG emissions from waste management. It was estimated that the current waste management sector generated approximately 2,000 gigagrams of CO₂-eq per year in 2018, trending around 3,350 Gg of CO₂-eq per year in 2025. It was also observed that out of the proposed scenarios, Scenario-2 significantly minimized the environmental impacts, with the lowest GHG emissions and highest waste resource recovery. Moreover, the GHG emissions from business-as-usual practices could be reduced by 50% by this scenario during 2018-2025. The target of the similar scenario could be achieved if the local government could efficiently implement waste management in the future.