• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.07a
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• pp.643-644
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• 2005

New methods of nano-sized material and composite coating preparations have been considered on the base of mathematical model of abrasion-reaction interaction of milling and grinding bodies in planetary centrifugal mill. The essence of the method is the abrasive and oxidative wear of the milling bodies and amorphous (better inert) additives. Interactions between them has been supplied the necessary impulse of pressure and temperature on the impact-frictional contacts and promoted chemical processes. The offered method can find application for such processing as sintering and geological minerals opening.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.8 no.4
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• pp.197-201
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• 1975

다랭이 주낚의 양승방식에는 방향의 양승(On-tracing retrieve)방식과 역방향의 양승(Back-tracing retrieve) 방식의 두가지 방식이 있다. 순방향의 양승은 최초에 투승된 주낙끝에서부터 양승하기 시작하여 투승한 순과 같은 순으로 양승하는 것이고 역방향의 양승은 최후에 투승된 주낚끝에서부터 양승하기 시작하며 투승한 순과 반대순으로 양승하는 것이다. 주낚의 조업소요시간을 변갱하지 않고 양승방식만 변갱한다면 주낚의 평균침지시간은 변하지 않고 다만 침지시간의 분포구간만 변한다. 투승작업시간을 $\tau_1$, 투승작업이 끝나고 양승작업을 시작하기까지의 대기시간을 $\tau_2$, 양승작업시간을 $\tau_3$하면 주낚의 침지시간분포범위는 양승방식에 따라 다음과 같이 서로 다르다. $\tau_2$부터 $\tau_1+\tau_2+\tau_3$까지의 범위 역방향으로 양승할 때 $\tau_1+\tau_2$부터 $\tau_2+\tau_3$까지의 범위 임의시의 낚시 어획성능은 $F_0\varrho-^{-zt}$ ($F_0$는 초기어획성능, z는 감소계수, t는 투승후 경과시간)으로 나타낼 수 있고 침지시간 t인 낚시 Hro의 어획미수는 $H_{F_0}\frac{1-\varrho^{-zt}}{z}$로 나타낼 수 있으므로 주낙조업에서 낚시수 $H_G$개 이고 침지시간이 $\tau_\alpha$와 $\tau_\beta$ 범위내에서 분포하면 어획미수는 $C_G$는 다음과 같이 나타낼 수 있다. $$C_G=\frac{H_G}{\tau_\beta-\tau_\alpha}{\cdot}\frac{F_0}{Z}\int^{\tau_\beta}_{\tau_\alpha}(1-\varrho^{-zt})dt$$ $\tau_\alpha,\;\tau_\beta$의 값은 순방향의 양승에 있어서는 $\tau_\alpha=\tau_1+\tau_2,\;\tau_\beta=\tau_2+\tau_3$, 역방향은 양승에 있어서는 $\tau_\alpha=\tau_2,\;\tau_\beta=\tau_1+\tau_2+\tau_3$. 따라서 다랭이 주낚의 어획미수는 그 양승방식에 따라 차가 있고 순방향의 양승으로 더 많은 어획미수를 얻을 수 있다.

• Nuclear Engineering and Technology
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• v.53 no.1
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• pp.282-293
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• 2021

This paper examines gamma-ray shielding properties of SBC-Bx glass system with the chemical composition of 40SiO₂-10B₂O₃-xBaO-(45-x)CaO- yZnO- zMgO (where x = 0, 10, 20, 30, and 35 mol% and y = z = 6 mol%). Mass attenuation coefficient (µ/ρ) which is an essential parameter to study gamma-ray shielding properties was obtained in the photon energy range of 0.015-15 MeV using PHITS Monte Carlo code for the proposed glasses. The obtained results were compared with those calculated by WinXCOM program. Both the values of PHITS code and WinXCOM program were observed in very good agreement. The (µ/ρ values were then used to derive mean free path (MFP), electron density (N_eff), effective atomic number (Z_eff), and half value layer (HVL) for all the glasses involved. Additionally, G-P method was employed to estimate exposure buildup factor (EBF) for each glass in the energy range of 0.015-15 MeV up to penetration depths of 40 mfp. The results reveal that gamma-ray shielding effectiveness of the SBC-Bx glasses evolves with increasing BaO content in the glass sample. Such that SBC-B35 glass has superior shielding capacity against gamma-rays among the studied glasses. Gamma-ray shielding properties of SBC-B35 glass were compared with different conventional shielding materials, commercial glasses, and newly developed HMO glasse. Therefore, the investigated glasses have potential uses in gamma shielding applications.

• Journal of Pharmaceutical Investigation
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• v.41 no.5
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• pp.309-315
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• 2011

A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the analysis of ambroxol (active moiety of acebrophylline). After acetonitrile precipitation of proteins from plasma samples, ambroxol and the domperidone (internal standard, IS) were eluted on a C18 column. The isocratic mobile phase was consisted of 10 mM ammonium acetate and methanol (10 : 90, v/v), with flow rate at 0.2 mL/min. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z 379.2${\rightarrow}$264.0 and the m/z 426.2${\rightarrow}$175.1 transitions for ambroxol and the IS, respectively. Twenty four healthy Korean male subjects received two capsules (100 mg ${\times}$ 2) of either the test or the reference formulation of acebrophylline HCl in a 2 ${\times}$ 2 crossover study, this was followed by a 1week washout period between either formulation. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 (e.g., log 0.8964 - log 0.9910 for $AUC_{0-t}$ log 0.8690 - log 1.0750 for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of Korea Food and Drug Administration for bioequivalence indicating that Acephyll$^{(R)}$ capsule (test) is bioequivalent to Surfolase$^{(R)}$ capsule (reference).

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.06a
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• pp.113-114
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• 2008

• Communications for Statistical Applications and Methods
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• v.4 no.3
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• pp.891-901
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• 1997

The objective of this research is to investigate the problem of goodness of fit testing based on nonparametric density estimation with a data-driven smoothing parameter. The small and large smaple properties of the proposed test statistic $Z_{mn}$ are investigated with the minimizer $\widehat{m}$ of the estimated mean integrated squared error by the Diggle and Hall (1986) method.

• Proceedings of the Korean Vacuum Society Conference
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• 2003.08a
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• pp.195-195
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• 2003

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.310.1-310.1
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• 2003

SD-2007 ia an apicidin analogue, possessing a potent histone deacetylase inhibiting activity. A rapid and senstive LC/MS method was developed for the determination of SD-2007 and its major active metabolite. apicidin. in rat serum. SD-2007 and apicidin was extracted by liquid-liquid extraction using methyl t-butyl ether. SD-2007 and apicidin were monitored in a SIM mode at m/z of 679 and 622, respectively. (omitted)

• Korean Journal of Microbiology
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• v.45 no.2
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• pp.215-221
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• 2009

Site-specific incorporation of unnatural amino acids into proteins in vivo can be achieved by co-expression of an orthogonal pair of suppressor tRNA and engineered aminoacyl-tRNA synthetase (ARS) that specifically ligates an unnatural amino acid to the suppressor tRNA. As a step to establish this technique, here we generated an Escherichia coli reporter strain DH10B(Tn:lacZam) by integrating amber mutated lacZ gene into the chromosome of E. coli DH10B strain. In vivo expression of E. coli amber suppressor $tRNA^{Gln}$ produced blue colonies in culture plates containing X-Gal as well as dramatically increased $\beta$-galactosidase activity. In addition, expression of an orthogonal pair of Saccharomyces cerevisiae suppressor $tRNA^{Tyr}$ and tyrosyl-tRNA synthetase also produced blue colonies as well as moderate increase of $\beta$-galactosidase activity. These data demonstrate that our reporter strain will provide an efficient method to assess amber suppression in both qualitative and quantitative manners.

• Korean Journal of Crystallography
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• v.4 no.1
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• pp.1-5
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• 1993

The crystal structure of N-(2'-chloro-4'-vitrophenyl)-5-chlorosalicylamide( Niclosamide ) monohydrate has been determined from 1976 sig- nificant independent reflections collected on an automated CAD4 diffractometer using graphitemonochromated Mo-Ka radiation. The crystal is monoclinic, space group P211c, with unit cell dimensions, a=11.331 (3), b=16.964(2), c=7.347(4)A , P =98.20(3)° and Z=4 at T=293k. The structure was solved by direct method using seminvariants of ggg Parity group and refined by the full-matrix least-square method, resulting model with reliability factor, R=0.046. The feature of the molecule show planar structure in parallel to the ab crystal plane.